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  1. Headache represents not only an individual disease, but also an important pathology for society because its prevalence in the population is about 50.0%. Its physical, emotional, social and economic impacts ar...

    Authors: Stefania Iannazzo, Maria S. Cattaruzza, Sergio De Filippis, Flora Rossi, Edea Perata, Samanta Di Rollo, Gabriella Coloprisco and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00018
    Content type: SELECTED PRESENTATION Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  2. Although headache is a common complaint, only few sufferers seek specific medical assistance. Migraine is one of the most frequently encountered varieties of headache. The first presentation of migraine is im...

    Authors: Rosario Iannacchero, Umberto Cannistrà, Rita L. Trinchi, Antonio La Vitola, Francesco Peltrone and Emilio De Caro
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00017
    Content type: SELECTED PRESENTATION Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  3. Headache is the most frequent reason for neurological consultation, but also a comorbidity often encountered by GPs. The costs of headache are considerable: direct and indirect costs contribute to varying deg...

    Authors: Antonietta Citterio, Grazia Sances, Giorgio Sandrini, Tiziana Repossi and Giuseppe Nappi
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00015
    Content type: PUBLIC AND LAY ORGANIZATIONS Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  4. Triptans are presently a milestone in the treatment of migraine patients. Because of their effectiveness and safety, they have radically improved migraine treatment but their use has meant a substantial incre...

    Authors: Pietro Folino-Gallo, Fabio Palazzo, Giuseppe Stirparo, Sergio De Filippis and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00013
    Content type: PHARMACOECONOMY Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  5. The EuroMedicines Project created a single drug directory at a single time point (late 1998) to cover most of the member states of the European Union (EU) and some of the candidate states, so as to aid drug r...

    Authors: Tom Walley
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00011
    Content type: PHARMACOECONOMY Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  6. Information on the prevalence and health burden of headache in Africa is scanty. Earlier studies in the 1970s suggested that migraine was a rare condition in the African. This may have been due to an underdia...

    Authors: Redda Tekle Haimanot
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00009
    Content type: SPECIAL LECTURE Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  7. Population-based studies have shown that migraineurs have reduced HRQoL independent of depression. Furthermore, HRQoL is reduced with increasing migraine attack frequency. In both population-based and clinic-...

    Authors: Gisela M. Terwindt, Michel D. Ferrari and Lenore J. Launer
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00007
    Content type: INTANGIBLE COSTING Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  8. Economic evaluation of health care programs or technologies requires distinguishing three types of costs: direct, indirect and human. The first two types do not imply peculiar methodological issues to quantif...

    Authors: Fabio Palazzo, Giuseppe Stirparo and Lorenzo Terranova
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00005
    Content type: INTANGIBLE COSTING Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  9. One-year migraine prevalence rates in the general population for Western countries vary from 4% to 9% in men and from 11% to 25% in women. Non-Western countries report lower figures. Incidence rates for peopl...

    Authors: Gian Camillo Manzoni and Paola Torelli
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00003
    Content type: GLOBAL BURDEN Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  10. Migraine is a highly prevalent headache disorder that has a substantial impact on the individual and on society. Over the past decade, substantial advances in research have increased understanding of the path...

    Authors: Richard B. Lipton, Marcelo E. Bigal, Ann I. Scher and Walter F. Stewart
    Citation: The Journal of Headache and Pain 2003 4(Suppl 1):00001
    Content type: GLOBAL BURDEN Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  12. SUNCT syndrome (shortlasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) is a rare, debilitating headache that is difficult to be treated. We describe a SUNCT patient, in...

    Authors: Piero Meineri, Fiorella Mondino and Enzo Grasso
    Citation: The Journal of Headache and Pain 2002 3:00034
    Content type: BRIEF REPORT Published on:

  13. The focus of this paper is the family factors associated with primary headache in children between 8 and 14 years. We studied the differences in the family ecology between 32 children with headaches and 32 he...

    Authors: Ursula Napoli, Vanna Axia and Pier Antonio Battistella
    Citation: The Journal of Headache and Pain 2002 3:00033
    Content type: ORIGINAL Published on:

  14. Menstrual migraine (MM) pathogenesis has not yet been clarified, even though several hypotheses have been formulated. In the present research, we investigated cerebral blood flow in 15 patients with MM. Brain...

    Authors: Bašak Karakurum, Seniha Naldöken, Hülya Ortapamuk, Serap Üčler and Levent E. İnan
    Citation: The Journal of Headache and Pain 2002 3:00032
    Content type: ORIGINAL Published on:

  15. The blockade of the greater occipital nerve (GON) has been used in the treatment of migraine without aura (MWOA), tension-type headache (TTH) and cervicogenic headache (CH). There have been only a few reports...

    Authors: Tansel Terzi, Bašak Karakurum, Serap Üçler, Levent E. İnan and Cankat Tulunay
    Citation: The Journal of Headache and Pain 2002 3:00031
    Content type: ORIGINAL Published on:

  16. Little has been done to investigate the biochemical basis of chronic daily headache (CDH). Our group has recently demonstrated an increase in the cerebrospinal fluid (CSF) levels of nerve growth factor (NGF) ...

    Authors: Paola Sarchielli, Andrea Alberti, Beatrice Gallai, Francesca Coppola, Antonio Baldi, Ardesio Floridi and Virgilio Gallai
    Citation: The Journal of Headache and Pain 2002 3:00030
    Content type: ENRICO GREPPI AWARD Published on:

  17. Current severity (intensity) grading in headache is based upon a 4-grade category scale that includes the zero grade. For ordinary scientific and practical work, a low-sensitivity scale may suffice. However, ...

    Authors: Ottar Sjaastad, T.A. Fredriksen, H.C. Petersen and L.S. Bakketeig
    Citation: The Journal of Headache and Pain 2002 3:00029
    Content type: SPECIAL ARTICLE Published on:

  20. The objective of our study is to report the frequency and characteristics of cluster headache with aura among the population of patients with cluster headache treated in our outpatient neurology clinic. 254 p...

    Authors: Eva Martínez-Fernández, Roman Alberca, Pablo Mir, Emilio Franco, Enrique Montes and Pilar Lozano
    Citation: The Journal of Headache and Pain 2002 3:00026
    Content type: BRIEF REPORT Published on:

  22. We examined the efficacy of physical therapy and adjunctive botulinum toxin type A (BTX-A) injections in the treatment of cervical headache. We performed a doubleblind, randomised, placebo-controlled study ov...

    Authors: Peter Schnider, Ecaterina Moraru, Marion Vigl, Christian Wöber, Daniela Földy, Joachim Maly, Christian Bittner, Peter Wessely and Eduard Auff
    Citation: The Journal of Headache and Pain 2002 3:00024
    Content type: ORIGINAL Published on:

  23. Based on the knowledge that migraine and tension-type headache (TTH) are associated with reduced effectiveness at work and impairment of function in social roles, we studied the different influences that thes...

    Authors: Konstantinidos Vadikolias, Ioannis Heliopoulos, Grigorios Tripsianis, Athanasios Achtaropoulos, Elias Homsioglou, Nickolaos Artemis, Haritomeni Piperidou and Ioannis Milonas
    Citation: The Journal of Headache and Pain 2002 3:00023
    Content type: ORIGINAL Published on:

  24. Twenty-three patients, aged 18‐66 years and suffering from migraine with or without aura, were randomly selected to receive either vigabatrin or matched placebo tablets first for 12 weeks in a double-blind cr...

    Authors: Karabi Ghose, Brian E. Niven and Dave Berry
    Citation: The Journal of Headache and Pain 2002 3:00022
    Content type: ORIGINAL Published on:

  25. Cluster headache (CH) is the most frequent primary trigeminal autonomic cephalalgia (Goadsby, 2001). Clinical symptoms have been clearly identified and are described in the IHS classification. Cluster-like he...

    Authors: Pierric Giraud, Emmanuel Jouanneau, Françoise Borson-Chazot, Michel Lanteri-Minet and Guy Chazot
    Citation: The Journal of Headache and Pain 2002 3:00021
    Content type: REVIEW Published on:

  26. The clinical questions posed by the advent of acute migraine-specific treatment (triptans) are on which patient to use specific treatment for migraine, and when in the attack to treat patients. Three strategi...

    Authors: Stewart J. Tepper, Alan M. Rapoport and Fred Sheftell
    Citation: The Journal of Headache and Pain 2002 3:00020
    Content type: REVIEW Published on:

  30. Authors: Peter Hallas
    Citation: The Journal of Headache and Pain 2001 2:10020100.10194
    Content type: Published on:

  31. Headache is the most frequent symptom in patients with cerebral venous thrombosis. However, patients presenting with headache due to cerebral venous thrombosis are uncommon. The association between oral contr...

    Authors: Enrico Tessitore, Claudio Schonauer, Francesco Fera and Alessandro Tessitore
    Citation: The Journal of Headache and Pain 2001 2:10020097.10194
    Content type: Case report Published on:

  32. In this study, we evaluated, as far as clinical and functional aspects are concerned, the eventual and precocious improvement obtained with a combined orthognathic and surgical treatment on a group of 27 dysg...

    Authors: Carmen Mortellaro, Davide Giangrandi, Simonetta Gallo, Alessandro Leonardi and Marcella Pavese
    Citation: The Journal of Headache and Pain 2001 2:10020089.10194
    Content type: Original Published on:

  34. The aim of this open study was to make a preliminary estimate of the efficacy and tolerability of intravenously administered magnesium sulfate (1 g) in comparison to subcutaneously administered sumatriptan in...

    Authors: Jasna Zidverc-Trajković, Aleksandra M. Pavlović, Zagorka Jovanović, Nadežda Šternić and Vladimir S. Kostić
    Citation: The Journal of Headache and Pain 2001 2:10020079.10194
    Content type: Original Published on:

  35. The prevalence of patients suffering pain in hospital is high. This situation is censured during congresses on the study and treatment of pain, which highlight how little consideration the problem is given. O...

    Authors: Leonardo Trentin, Marco Visentin, Roberto de Marco and Elisabetta Zandolin
    Citation: The Journal of Headache and Pain 2001 2:10020073.10194
    Content type: Original Published on:

  36. The involvement of nitric oxide (NO) in the pathophysiology of primary headaches was suggested by several authors during the last decade. Migraine, cluster headache, tension headache, and cervicogenic headach...

    Authors: Alessandra Zicari, Mario Giacovazzo and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2001 2:10020067.10194
    Content type: Review Published on:

  37. SUNCT is probably a distinct syndrome, although it shares some common features with cluster headache (CH): male sex preponderance, clustering of attacks, unilaterality of headache without sideshift, pain of n...

    Authors: Piotr Kruszewski, Juan A. Pareja, Ana B. Caminero and Ottar Sjaastad
    Citation: The Journal of Headache and Pain 2001 2:10020057.10194
    Content type: Review Published on:

  39. The Italian Society for the Study of Headaches (SISC) published the first guidelines for diagnosis and treatment of migraine in 1993. In 2000, the Executive Committee of the SISC decided to provide updated dia...

    Authors: Virgilio Gallai and Paola Sarchielli
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):25
    Content type: THERAPY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  40. An association between migraine and menstruation can be ascertained by use of a diary for a minimum of three cycles. The pathophysiological and clinical peculiarities of menstrual migraine indicate that its ma...

    Authors: Franca Moschiano, Licia Grazzi, Domenico D’Amico, Ferdinando Schieroni and Gennaro Bussone
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):23
    Content type: THERAPY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  41. Many drugs are now available for treating migraine attacks, including agents specifically indicated for this condition. Since 1990 sumatriptan, the first 5–HT1B,1D receptor agonist, was introduced and realized a ...

    Authors: Giorgio Zanchin, Filippo Dainese, Federico Mainardi and Ferdinando Maggioni
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):21
    Content type: THERAPY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  42. The introduction of triptans, in the early 1990s, has improved the therapy for acute migraine attack, offering a new quality of life for those patients who suffer from this disabling neurological disorder. Epi...

    Authors: Dario Calderoni, Federica Galli and Vincenzo Guidetti
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):19
    Content type: THERAPY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  43. The current review providesa brief summary of the key pre–clinical and clinical characteristics of the triptans that might influence the choice of drug. Data from extensive clinical trials tentatively suggest ...

    Authors: Alan M. Rapoport and Stewart J. Tepper
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):17
    Content type: KEY NOTE LECTURE Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  44. Migraine is currently considered to be a multifactorial disease in that it is modified by environmental and genetic factors and has a polygenic determination. Familial hemiplegic migraine (FHM), a subtype of m...

    Authors: Pasquale Montagna
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):15
    Content type: MIGRAINE AND PATHOPHYSIOLOGY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  45. We review the main electrophysiological abnormalities emerging from migraine studies and discuss them from the pathophysiological point of view. Considerations range from genetic aspects to the heterogeneous c...

    Authors: Giorgio Sandrini, Alberto Proietti Cecchini, Sonya Ivanova Hristova, Grazia Sances and Giuseppe Nappi
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):13
    Content type: MIGRAINE AND PATHOPHYSIOLOGY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  46. GABA and glutamic acid are the main inhibitory and excitatory neurotransmitters of central nervous system. Among other functions they modulate the pain threshold in the CNS. For this reason it has been hypothe...

    Authors: Giovanni D’Andrea, Franco Granella, Morena Cataldini, Flavio Verdelli and Tiziana Balbi
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):11
    Content type: MIGRAINE AND PATHOPHYSIOLOGY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  47. The theory that hypersensitivity of dopamine (DA) system is involved in the pathogenesis of migraine has been supported by various authors on the basis of clinical, pharmacological and, recently, genetic evide...

    Authors: Alessandra Cherchi, Erminia Stochino, Maria Paola Piccardi and Maria Del Zompo
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):9
    Content type: MIGRAINE AND PATHOPHYSIOLOGY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  48. The periaqueductal gray matter (PAG) is at the center of a powerful descending antinociceptive neuronal network. We studied iron homeostasis in the PAG in episodic migraine patients between attacks and in chro...

    Authors: K. Michael A. Welch, Vijaya Nagesh, Sheena K. Aurora and Neil Gelman
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):7
    Content type: KEY NOTE LECTURE Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  49. Migraine is an heterogeneous disorder. Most patients are disabled both in work and in non–work activities. Different instruments to assess migraine–related disability have been developed. Among these, the migr...

    Authors: Domenico D’Amico, Susanna Usai, Licia Grazzi, Massimo Leone, Andrea Rigamonti, Chiara Nespolo and Gennaro Bussone
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):5
    Content type: MIGRAINE AND DISABILITY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  50. Migraine is one of the most common neurological diseases afflicting 12% of general population but is poorly recognized and largely untreated. Migraine is a disabling disease with very high social costs as it a...

    Authors: Rosanna Cerbo, Marina Pesare, Cinzia Aurilia, Valeria Rondelli and Piero Barbanti
    Citation: The Journal of Headache and Pain 2001 2(Suppl 1):3
    Content type: MIGRAINE AND DISABILITY Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

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