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  1. The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization. Metabotropic glutamate re...

    Authors: Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou and Lixue Chen

    Citation: The Journal of Headache and Pain 2020 21:139

    Content type: Research article

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  2. Post-traumatic headache (PTH) is one of the most common and long-lasting symptoms following mild traumatic brain injury (TBI). However, the pathological mechanisms underlying the development of persistent PTH ...

    Authors: Kelly M. Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman and Fletcher A. White

    Citation: The Journal of Headache and Pain 2020 21:138

    Content type: Research article

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  3. Previous researches have reported gray and white matter microalterations in primary trigeminal neuralgia (TN) with neurovascular compression (NVC). The central mechanism underlying TN without NVC are unknown b...

    Authors: Min Wu, Xiaofeng Jiang, Jun Qiu, Xianming Fu and Chaoshi Niu

    Citation: The Journal of Headache and Pain 2020 21:136

    Content type: Research article

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  4. Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for...

    Authors: Xuan Niu, Lijun Bai, Yingxiang Sun, Yuan Wang, Guanghui Bai, Bo Yin, Shan Wang, Shuoqiu Gan, Xiaoyan Jia and Hongjuan Liu

    Citation: The Journal of Headache and Pain 2020 21:135

    Content type: Research article

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  5. Persistent post-traumatic headache (PTH) is a common sequela of mild traumatic brain injury (TBI) and retrospective assessments have found a migraine-like phenotype to be very frequent. This has raised a discu...

    Authors: Håkan Ashina, Afrim Iljazi, Faisal M. Amin, Messoud Ashina, Richard B. Lipton and Henrik W. Schytz

    Citation: The Journal of Headache and Pain 2020 21:134

    Content type: Research article

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  6. Pain sensitivity may determine the risk, severity, prognosis, and efficacy of treatment of clinical pain. Magnetic resonance imaging studies have linked thermal pain sensitivity to changes in brain structure. ...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Li-Ling Hope Pan and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2020 21:133

    Content type: Research article

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen

    Citation: The Journal of Headache and Pain 2020 21:132

    Content type: Correction

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    The original article was published in The Journal of Headache and Pain 2020 21:128

  8. Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding ...

    Authors: Karin Warfvinge, Diana N. Krause, Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson and Kristian A. Haanes

    Citation: The Journal of Headache and Pain 2020 21:131

    Content type: Research article

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  9. Trigeminal neuralgia (TN) causes severe episodic, unilateral facial pain and is initially treated with antiepileptic medications. For patients not responding or intolerant to medications, surgery is an option.

    Authors: Lasair O’Callaghan, Lysbeth Floden, Lisa Vinikoor-Imler, Tara Symonds, Kathryn Giblin, Chris Hartford and Joanna M. Zakrzewska

    Citation: The Journal of Headache and Pain 2020 21:130

    Content type: Research article

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  10. The Covid-19 pandemic is causing changes in delivery of medical care worldwide. It is not known how the management of headache patients was affected by the lockdown during the pandemic. The aim of the present ...

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen

    Citation: The Journal of Headache and Pain 2020 21:128

    Content type: Research article

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    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:132

  11. Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aur...

    Authors: Kazutaka Sugimoto, Andreia Morais, Homa Sadeghian, Tao Qin, David Y. Chung, Messoud Ashina, Anders Hougaard and Cenk Ayata

    Citation: The Journal of Headache and Pain 2020 21:127

    Content type: Research article

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  12. Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.

    Authors: Cindy Tiseo, Alessandro Vacca, Anton Felbush, Tamara Filimonova, Annalisa Gai, Tatyana Glazyrina, Irina Anna Hubalek, Yelena Marchenko, Lucas Hendrik Overeem, Serena Piroso, Alexander Tkachev, Paolo Martelletti and Simona Sacco

    Citation: The Journal of Headache and Pain 2020 21:126

    Content type: Review article

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  13. Migraine imposes a substantial personal and economic burden to many working age individuals. This study aimed to evaluate the burden and impact of migraine on work productivity in selected workplaces in the Ph...

    Authors: Nel Jason Haw, Ian Theodore Cabaluna, Germaine Erika Kaw, Joanna Feliz Cortez, Maria Pamela Chua and Kristel Guce

    Citation: The Journal of Headache and Pain 2020 21:125

    Content type: Research article

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  14. The introduction of monoclonal antibodies (mAbs) against calcitonin-gene related peptide (CGRP) or CGRP receptors in the treatment of migraine raised concerns on the possible risks associated to the long-term ...

    Authors: Giuseppe Tringali, Catello Vollono, Paolo Calabresi and Pierluigi Navarra

    Citation: The Journal of Headache and Pain 2020 21:124

    Content type: Short report

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  15. Focus on the frequency of migraine pain may undervalue the total burden of migraine as pain duration and severity may present unique, additive burden. A composite measure of total pain burden (TPB; frequency, ...

    Authors: Jessica Ailani, J. Scott Andrews, Mallikarjuna Rettiganti and Robert A. Nicholson

    Citation: The Journal of Headache and Pain 2020 21:123

    Content type: Research article

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  16. Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most con...

    Authors: Rosaria Greco, Roberto De Icco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Grazia Sances, Marta Allena and Cristina Tassorelli

    Citation: The Journal of Headache and Pain 2020 21:122

    Content type: Research article

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  17. Headache is the most common COVID-19-related neurological symptom. We aimed to reveal diagnostic clues of headache for COVID-19 infection and to investigate the course of primary headaches during the pandemic.

    Authors: Özge Uygun, Mustafa Ertaş, Esme Ekizoğlu, Hayrunnisa Bolay, Aynur Özge, Elif Kocasoy Orhan, Arif Atahan Çağatay and Betül Baykan

    Citation: The Journal of Headache and Pain 2020 21:121

    Content type: Research article

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  18. PROMISE-2 was a phase 3, randomized, double-blind, placebo-controlled study that evaluated the efficacy and safety of repeat intravenous (IV) doses of the calcitonin gene-related peptide–targeted monoclonal an...

    Authors: Stephen Silberstein, Merle Diamond, Nada A. Hindiyeh, David M. Biondi, Roger Cady, Joe Hirman, Brent Allan, Susan Pederson, Barbara Schaeffler and Jeff Smith

    Citation: The Journal of Headache and Pain 2020 21:120

    Content type: Research article

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  19. Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mecha...

    Authors: Guoliang Chen, Yansong Li, Zhao Dong, Rongfei Wang, Dengfa Zhao, Ignacio Obeso and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2020 21:119

    Content type: Research article

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  20. A global My Migraine Voice survey was conducted in 31 countries among 11,266 adults who suffered from ≥4 monthly migraine days (MMD). The aim of this retrospective observational survey-based study was to analyse ...

    Authors: Marja-Liisa Sumelahti, Markku Sumanen, Merika S. Sumanen, Samuli Tuominen, Johanna Vikkula, Sanna M. Honkala, Stina Rosqvist and Minna A. Korolainen

    Citation: The Journal of Headache and Pain 2020 21:118

    Content type: Research article

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  21. Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulat...

    Authors: Dimos D. Mitsikostas, Charlotte Blease, Elisa Carlino, Luana Colloca, Andrew L. Geers, Jeremy Howick, Andrea W. M. Evers, Magne A. Flaten, John M. Kelley, Irving Kirsch, Regine Klinger, Antoinette MaassenVanDenBrink, Daniel E. Moerman, Petros P. Sfikakis, Lene Vase, Tor D. Wager…

    Citation: The Journal of Headache and Pain 2020 21:117

    Content type: Consensus article

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  22. Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics. There are currently no evidence-based thera...

    Authors: Andreas Yiangou, James L. Mitchell, Vivek Vijay, Olivia Grech, Edward Bilton, Gareth G. Lavery, Claire Fisher, Julie Edwards, Susan P. Mollan and Alexandra J. Sinclair

    Citation: The Journal of Headache and Pain 2020 21:116

    Content type: Case report

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  23. Since the declaration COVID-19 as a pandemic, healthcare systems around the world have faced a huge challenge in managing patients with chronic diseases. Patients with migraine were specifically vulnerable to ...

    Authors: Jasem Y. Al-Hashel and Ismail Ibrahim Ismail

    Citation: The Journal of Headache and Pain 2020 21:115

    Content type: Research article

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  24. We evaluated the efficacy of fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, in patients with chronic migraine (CM) with and without medication ove...

    Authors: Stephen D. Silberstein, Joshua M. Cohen, Michael J. Seminerio, Ronghua Yang, Sait Ashina and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2020 21:114

    Content type: Research article

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  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin

    Citation: The Journal of Headache and Pain 2020 21:113

    Content type: Correction

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    The original article was published in The Journal of Headache and Pain 2020 21:46

  26. Chronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level depen...

    Authors: Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli and Gianluca Coppola

    Citation: The Journal of Headache and Pain 2020 21:112

    Content type: Research article

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  27. Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functiona...

    Authors: Heng-Le Wei, Jing Chen, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Zhen-Zhen He, Lian Yang, Xindao Yin, Junrong Li and Hong Zhang

    Citation: The Journal of Headache and Pain 2020 21:111

    Content type: Research article

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  28. Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National ...

    Authors: Shoji Kikui, Yirong Chen, Hiroshi Todaka, Keiko Asao, Kenji Adachi and Takao Takeshima

    Citation: The Journal of Headache and Pain 2020 21:110

    Content type: Research article

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  29. The long-term safety and efficacy of fremanezumab were evaluated in a 52-week extension study (NCT02638103). Patient satisfaction with fremanezumab, dosing preferences, and patient-reported outcomes were asses...

    Authors: Dawn C. Buse, Sanjay K. Gandhi, Joshua M. Cohen, Verena Ramirez-Campos, Blaine Cloud, Ronghua Yang and Robert P. Cowan

    Citation: The Journal of Headache and Pain 2020 21:109

    Content type: Research article

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  30. The Global Burden of Disease (GBD) study establishes headache as the second-highest cause of disability worldwide. Because most headache data in GBD are from adults, leading to underestimation of headache-attr...

    Authors: Yared Zenebe Zewde, Mehila Zebenigus, Hanna Demissie, Redda Tekle-Haimanot, Derya Uluduz, Tayyar Şaşmaz, Fatma Bozdag and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:108

    Content type: Research article

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  31. The Global Campaign against Headache collects data from children (7–11 years) and adolescents (12–17 years) both to inform health and education policies and to contribute to the Global Burden of Disease (GBD) ...

    Authors: Otgonbayar Luvsannorov, Tsengunmaa Anisbayar, Munkhzul Davaasuren, Otgonzaya Baatar, Khaliunaa Batmagnai, Khulan Tumurbaatar, Sarantuya Enkhbaatar, Derya Uluduz, Tayyar Şaşmaz, Elif Tuğçe Solmaz and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:107

    Content type: Research article

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  32. Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear.

    Authors: Jaisan Islam, Elina KC, Byeong Ho Oh, Soochong Kim, Sang-hwan Hyun and Young Seok Park

    Citation: The Journal of Headache and Pain 2020 21:106

    Content type: Research article

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  33. Different pain syndromes may be characterized by different profiles of mediators reflecting pathophysiological differences, and these alterations may be measured in a simple saliva sample. The aims of the curr...

    Authors: Hajer Jasim, Bijar Ghafouri, Björn Gerdle, Britt Hedenberg-Magnusson and Malin Ernberg

    Citation: The Journal of Headache and Pain 2020 21:105

    Content type: Research article

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  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U. Bahkt Sultan Shah

    Citation: The Journal of Headache and Pain 2020 21:104

    Content type: Correction

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    The original article was published in The Journal of Headache and Pain 2020 21:68

  35. Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unf...

    Authors: Binbin Lin, Yuting Wang, Piao Zhang, Yanyan Yuan, Ying Zhang and Gang Chen

    Citation: The Journal of Headache and Pain 2020 21:103

    Content type: Review article

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  36. Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study.

    Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Valeria Caponnetto, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

    Citation: The Journal of Headache and Pain 2020 21:102

    Content type: Short report

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  37. Although migraine is one of the most common primary headaches, its therapy is still limited in many cases. The use of animal models is crucial in the development of novel therapeutic strategies, but unfortunat...

    Authors: Klaudia Flóra Laborc, Eleonóra Spekker, Zsuzsanna Bohár, Mónika Szűcs, Gábor Nagy-Grócz, Annamária Fejes-Szabó, László Vécsei and Árpád Párdutz

    Citation: The Journal of Headache and Pain 2020 21:101

    Content type: Methodology

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  38. Psychological distress is highly prevalent among migraineurs during public health emergencies. The coronavirus disease 2019 (nCOV-2019) has created mass panic in China due to its highly contagious by contact a...

    Authors: Mengmeng Ma, Jinghuan Fang, Changling Li, Jiajia Bao, Yang Zhang, Ning Chen, Jian Guo and Li He

    Citation: The Journal of Headache and Pain 2020 21:100

    Content type: Research article

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  39. Migraine is a common and incapacitating condition, with severe impact on the quality of life (QoL) of the afflicted and their families, and negative economic consequences through decreased workforce participat...

    Authors: Amanda Hansson-Hedblom, Isabelle Axelsson, Lena Jacobson, Joakim Tedroff and Fredrik Borgström

    Citation: The Journal of Headache and Pain 2020 21:99

    Content type: Research article

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  40. Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all ...

    Authors: Sabrina Islamoska, Åse Marie Hansen, Hui-Xin Wang, Anne Helene Garde, Per Kragh Andersen, Ellen Garde, Jakob Møller Hansen, Gunhild Waldemar and Kirsten Nabe-Nielsen

    Citation: The Journal of Headache and Pain 2020 21:98

    Content type: Research article

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  41. Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between o...

    Authors: Espen Saxhaug Kristoffersen, Sigrid Børte, Knut Hagen, John-Anker Zwart and Bendik Slagsvold Winsvold

    Citation: The Journal of Headache and Pain 2020 21:97

    Content type: Research article

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  42. Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of t...

    Authors: Nuria García-Magro, Pilar Negredo, Yasmina B. Martin, Ángel Nuñez and Carlos Avendaño

    Citation: The Journal of Headache and Pain 2020 21:96

    Content type: Research article

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  43. We performed a post hoc, subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled study of erenumab for prevention of episodic migraine (STRIVE) to determine the efficacy and safety of eren...

    Authors: Jelena M. Pavlovic, Koen Paemeleire, Hartmut Göbel, Jo Bonner, Alan Rapoport, Risa Kagan, Feng Zhang, Hernan Picard and Daniel D. Mikol

    Citation: The Journal of Headache and Pain 2020 21:95

    Content type: Research article

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  44. Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if pati...

    Authors: Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente…

    Citation: The Journal of Headache and Pain 2020 21:94

    Content type: Research article

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  45. Post-traumatic headache (PTH) is one of the most frequent symptoms following mild traumatic brain injury (mTBI). Neuroimaging studies implicate hypothalamic function connectivity (FC) disruption as an importan...

    Authors: Liyan Lu, Fengfang Li, Peng Wang, Huiyou Chen, Yu-Chen Chen and Xindao Yin

    Citation: The Journal of Headache and Pain 2020 21:93

    Content type: Research article

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  46. We investigated intracerebral fiber bundles using a tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data to verify microstructural integrity in patients with episodic (MO) and ...

    Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

    Citation: The Journal of Headache and Pain 2020 21:92

    Content type: Research article

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  47. Trigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, wi...

    Authors: Rachel O. Coats, Kirsty L. Crossley, Naomi Conlin, Jianhua Wu, Joanna M. Zakrzewska, Sue H. Pavitt, Nicholas Phillips and Mark Mon-Williams

    Citation: The Journal of Headache and Pain 2020 21:91

    Content type: Research article

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  48. According to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days ...

    Authors: Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías, Petr Mikulenka, Olga Tikhonova, Paolo Martelletti and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2020 21:90

    Content type: Review article

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