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  1. The relationship between lifestyle and migraine is complex, as it remains uncertain which specific lifestyle factors play the most prominent role in the development of migraine, or which modifiable metabolic t...

    Authors: Quan Gan, Enfeng Song, Lily Zhang, Yanjie Zhou, Lintao Wang, Zhengming Shan, Jingjing Liang, Shanghua Fan, Songqing Pan, Kegang Cao and Zheman Xiao
    Citation: The Journal of Headache and Pain 2024 25:122
    Content type: Research Published on:

  2. Migraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in opening of pannexin 1 meg...

    Authors: Burak Uzay, Buket Donmez-Demir, Sinem Yilmaz Ozcan, Emine Eren Kocak, Muge Yemisci, Yasemin Gursoy Ozdemir, Turgay Dalkara and Hulya Karatas
    Citation: The Journal of Headache and Pain 2024 25:120
    Content type: Research Published on:

  3. The aim of this paper is to critically re-appraise the published trials assessing propranolol for migraine prophylaxis.

    Authors: Jan Versijpt, Christina Deligianni, Muizz Hussain, Faisal Amin, Uwe Reuter, Margarita Sanchez-del-Rio, Derya Uluduz, Deirdre Boucherie, Dena Zeraatkar, Antoinette MaassenVanDenBrink, Simona Sacco, Christian Lampl and Raquel Gil-Gouveia
    Citation: The Journal of Headache and Pain 2024 25:119
    Content type: Research Published on:

  4. Cluster headache is characterized by activation of the trigeminovascular pathway with subsequent pain signalling in the meningeal vessels, and inflammation has been suggested to play a role in the pathophysiol...

    Authors: Caroline Ran, Felicia Jennysdotter Olofsgård, Katrin Wellfelt, Anna Steinberg and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2024 25:121
    Content type: Research Published on:

  5. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since the diffusion tensor model ca...

    Authors: Yungang Cao, Mei Huang, Fangwang Fu, Keyang Chen, Kun Liu, Jinming Cheng, Yan Li and Xiaozheng Liu
    Citation: The Journal of Headache and Pain 2024 25:118
    Content type: Research Published on:

  6. Migraine, as a complex neurological disease, brings heavy burden to patients and society. Despite the availability of established therapies, existing medications have limited efficacy. Thus, we aimed to find t...

    Authors: Xinyue Sun, Bohong Chen, Yi Qi, Meng Wei, Wanying Chen, Xiaoyu Wu, Qingfan Wang, Jiahao Li, Xiangyu Lei and Guogang Luo
    Citation: The Journal of Headache and Pain 2024 25:117
    Content type: Research Published on:

  7. Migraine is one of the most common diseases worldwide while current treatment options are not ideal. New therapeutic classes of migraine, the calcitonin gene-related peptide (CGRP) antagonists, have been devel...

    Authors: Min Hou, Xiaofeng Luo, Shuangshuang He, Xue Yang, Qing Zhang, Meihua Jin, Pan Zhang, Yang Li, Xiaoting Bi, Juan Li, Caiyi Cheng, Qiang Xue, Haiyan Xing and Yao Liu
    Citation: The Journal of Headache and Pain 2024 25:116
    Content type: Research Published on:

  9. Migraine has been associated with functional brain changes including altered connectivity and activity both during and between headache attacks. Recent studies established that the variability of the blood-oxy...

    Authors: Dániel Veréb, Nikoletta Szabó, Bálint Kincses, Laura Szücs-Bencze, Péter Faragó, Máté Csomós, Szabolcs Antal, Krisztián Kocsis, Bernadett Tuka and Zsigmond Tamás Kincses
    Citation: The Journal of Headache and Pain 2024 25:114
    Content type: Research Published on:

  10. Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the lep...

    Authors: Anna A. Karan, Konstantin A. Gerasimov, Yulia S. Spivak, Elena M. Suleymanova and Lyudmila V. Vinogradova
    Citation: The Journal of Headache and Pain 2024 25:113
    Content type: Brief Report Published on:

  11. Glucagon-like peptide-1 (GLP-1) plays a crucial role in metabolic disorders by enhancing insulin secretion, inhibiting glucagon release, and slowing gastric emptying, thereby improving glycemic control. In rec...

    Authors: Wael Halloum, Yousef Al Dughem, Dagmar Beier and Lanfranco Pellesi
    Citation: The Journal of Headache and Pain 2024 25:112
    Content type: Review Published on:

  12. Pediatric headache is an increasing medical problem that has adverse effects on children’s quality of life, academic performance, and social functioning. Children with primary headaches exhibit enhanced sensor...

    Authors: Michal Pieniak, Berit Höfer, Jenny Knipping, Vanda Faria, Matthias Richter, Valentin A. Schriever, Antje Haehner and Gudrun Gossrau
    Citation: The Journal of Headache and Pain 2024 25:111
    Content type: Research Published on:

  13. New daily persistent headache (NDPH) is a rare primary headache with unclear pathogenesis. Neuroimaging studies of NDPH are limited, and controversy still exists. Diffusion tensor imaging (DTI) is commonly use...

    Authors: Zhilei Li, Yanliang Mei, Wei Wang, Lei Wang, Shouyi Wu, Kaibo Zhang, Dong Qiu, Zhonghua Xiong, Xiaoshuang Li, Ziyu Yuan, Peng Zhang, Mantian Zhang, Qiuling Tong, Zhenchang Zhang and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:110
    Content type: Research Published on:

  14. Management of patients with migraine who have concomitant medication overuse (MO) or medication overuse headache (MOH) is a major problem in clinical practice. Detoxification of acute analgesics before or duri...

    Authors: Armin Scheffler, Jale Basten, Lennart Menzel, Dominik Binz, Wolfgang Alexander Becker, Vincent Breunung, Hannah Schenk, Christoph Kleinschnitz, Michael Nsaka, Diana Lindner and Dagny Holle
    Citation: The Journal of Headache and Pain 2024 25:109
    Content type: Research Published on:

  15. India is a large and populous country where reliable data on headache disorders are relatively scarce. This study in northern India (Delhi and National Capital Territory Region [NCR], including surrounding dis...

    Authors: Debashish Chowdhury, Anand Krishnan, Ashish Duggal, Ritvik Amarchand, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:108
    Content type: Research Published on:

  16. Our recent studies have shown headache disorders to be very common in the central and western sub-Saharan countries of Benin and Cameroon. Here we report headache in nearby Mali, a strife-torn country that dif...

    Authors: Youssoufa Maiga, Seybou H. Diallo, Oumar Sangho, Leon Samuel Moskatel, Fatoumata Konipo, Abdoulaye Bocoum, Salimata Diallo, Awa Coulibaly, Mariam Daou, Housseini Dolo, Modibo Sangaré, Mohamed Albakaye, Zoumana Traoré, Thomas Coulibaly, Adama Sissoko, Guida Landouré…
    Citation: The Journal of Headache and Pain 2024 25:107
    Content type: Research Published on:

  17. Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and trea...

    Authors: Kyung-Hee Cho, Seol-Hee Baek, Sung-Hee Kim, Byung-Su Kim, Jong-Hee Sohn, Min Kyung Chu, Mi-Kyoung Kang, Hee Jung Mo, Sang-Hwa Lee, Hong-Kyun Park, Soohyun Cho, Sun-Young Oh, Jong-Geun Seo, Wonwoo Lee, Ju-Young Lee, Mi Ji Lee…
    Citation: The Journal of Headache and Pain 2024 25:106
    Content type: Research Published on:

  18. Non-steroidal anti-inflammatory drugs (NSAIDs) are considered first-line medications for acute migraine attacks. However, the response exhibits considerable variability among individuals. Thus, this study aime...

    Authors: Heng-Le Wei, Yu-Sheng Yu, Meng-Yao Wang, Gang-Ping Zhou, Junrong Li, Hong Zhang and Zhengyang Zhou
    Citation: The Journal of Headache and Pain 2024 25:104
    Content type: Research Published on:

  19. The development of several experimental migraine provocation models has significantly contributed to an understanding of the signaling mechanisms of migraine. The early history of this development and a view t...

    Authors: Jes Olesen
    Citation: The Journal of Headache and Pain 2024 25:105
    Content type: Review Published on:

  20. The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It is composed of functionally different subdivisions an...

    Authors: Fengfang Li, Di Zhang, Jun Ren, Chunhua Xing, Lanyue Hu, Zhengfei Miao, Liyan Lu and Xinying Wu
    Citation: The Journal of Headache and Pain 2024 25:103
    Content type: Research Published on:

  21. New onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its management poses a suitable means to enhance patients’ participation in professional, social,...

    Authors: Johanna Ruhnau, Max Blücher, Susanne Bahlmann, Almut Zieme, Antje Vogelgesang, Anke Steinmetz and Robert Fleischmann
    Citation: The Journal of Headache and Pain 2024 25:101
    Content type: Research Published on:

  22. Large conductance  calcium-activated potassium (BKCa) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-tra...

    Authors: Haidar M. Al-Khazali, Rune H. Christensen, David W. Dodick, Basit Ali Chaudhry, Anna G. Melchior, Rami Burstein and HÃ¥kan Ashina
    Citation: The Journal of Headache and Pain 2024 25:102
    Content type: Research Published on:

  24. Migraine is a complex neurological condition characterized by recurrent headaches, which is often accompanied by various neurological symptoms. Magnetic resonance imaging (MRI) is a powerful tool for investiga...

    Authors: Eunchan Noh, Jong Young Namgung, Yeongjun Park, Yurim Jang, Mi Ji Lee and Bo-yong Park
    Citation: The Journal of Headache and Pain 2024 25:99
    Content type: Research Published on:

  25. Endogeneous and exogeneous sex hormones can impact the frequency and severity of migraine attacks, but the underlying mechanisms are poorly understood. In this study, we investigate the relationship between fe...

    Authors: Elisabeth Storch, Lucas H. Overeem, Maria Terhart, Mira P. Fitzek, Kristin S. Lange, Uwe Reuter and Bianca Raffaelli
    Citation: The Journal of Headache and Pain 2024 25:98
    Content type: Research Published on:

  26. Mindfulness practice has gained interest in the management of Chronic Migraine associated with Medication Overuse Headache (CM-MOH). Mindfulness is characterized by present-moment self-awareness and relies on ...

    Authors: Davide Fedeli, Giuseppe Ciullo, Greta Demichelis, Jean Paul Medina Carrion, Maria Grazia Bruzzone, Emilio Ciusani, Alessandra Erbetta, Stefania Ferraro, Marina Grisoli, Erika Guastafierro, Domenico D’Amico, Alberto Raggi, Anna Nigri and Licia Grazzi
    Citation: The Journal of Headache and Pain 2024 25:97
    Content type: Research Published on:

  27. Migraine, a neurological disorder with a significant female predilection, is the leading cause of disability-adjusted life years (DALYs) in women of childbearing age (WCBA). There is currently a lack of compre...

    Authors: Jing Cen, Qian Wang, Lin Cheng, Qian Gao, Hongping Wang and Fengjun Sun
    Citation: The Journal of Headache and Pain 2024 25:96
    Content type: Research Published on:

  28. The pathogenesis of migraine remains unclear; however, a large body of evidence supports the hypothesis that immunological mechanisms play a key role. Therefore, we aimed to review current studies on altered i...

    Authors: Woo-Seok Ha and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2024 25:95
    Content type: Review Published on:

  29. Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), t...

    Authors: Jianxiong Gui, Xiaoyue Yang, Chen Tan, Lingman Wang, Linxue Meng, Ziyao Han, Jie Liu and Li Jiang
    Citation: The Journal of Headache and Pain 2024 25:94
    Content type: Research Published on:

  31. Idiopathic intracranial hypertension (IIH) is a debilitating condition characterized by increased intracranial pressure often presenting with chronic migraine-like headache. Calcitonin gene-related peptide (CG...

    Authors: Nik Krajnc, Florian Frank, Stefan Macher, Martin Michl, Nina Müller, Sarah Maier, Sina Zaic, Christian Wöber, Berthold Pemp, Gregor Broessner and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2024 25:92
    Content type: Research Published on:

  33. Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have shown good efficacy in migraine prophylaxis. However, a subset of patients does not respond to the first mAb treat...

    Authors: Ja Bin Hong, Heike Israel-Willner, Andreas Peikert, Peter Schanbacher, Viola Tozzi, Monika Köchling, Uwe Reuter and Bianca Raffaelli
    Citation: The Journal of Headache and Pain 2024 25:90
    Content type: Research Published on:

  34. Medication-overuse headache (MOH), which potentially involves 1–2% of the population, is defined as a headache, on ≥ 15 days a month affected, along with overuse of one or other acute attack medications. MOH p...

    Authors: Helin Gosalia, David Moreno-Ajona and Peter J. Goadsby
    Citation: The Journal of Headache and Pain 2024 25:89
    Content type: Review Published on:

  35. The purpose of this study was to interrogate brain iron accumulation in participants with acute post-traumatic headache (PTH) due to mild traumatic brain injury (mTBI), and to determine if functional connectiv...

    Authors: Simona Nikolova, Catherine Chong, Jing Li, Teresa Wu, Gina Dumkrieger, Katherine Ross, Amaal Starling and Todd J. Schwedt
    Citation: The Journal of Headache and Pain 2024 25:88
    Content type: Research Published on:

  36. Pain, an evolutionarily conserved warning system, lets us recognize threats and motivates us to adapt to those threats. Headache pain from migraine affects approximately 15% of the global population. However, ...

    Authors: Hyeonwi Son, Yan Zhang, John Shannonhouse, Ruben Gomez and Yu Shin Kim
    Citation: The Journal of Headache and Pain 2024 25:87
    Content type: Research Published on:

  37. We recently found headache disorders to be highly prevalent among children (aged 6–11 years) and adolescents (aged 12–17) in Iran (gender- and age-adjusted 1-year prevalences: migraine 25.2%, tension-type head...

    Authors: Mansoureh Togha, Pegah Rafiee, Faraidoon Haghdoost, Shahram Rafie, Seyed Mohammad Hasan Paknejad, Sepideh Amouian, Tayyar ÅžaÅŸmaz, Derya Kale, Derya Uluduz and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:86
    Content type: Research Published on:

  38. The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface ...

    Authors: Jacob C. A. Edvinsson, Caroline Ran, Felicia Jennysdotter Olofsgård, Anna Steinberg, Lars Edvinsson and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2024 25:85
    Content type: Research Published on:

  39. Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebr...

    Authors: Zhengwei Chen, Yueji Liu, Cunxin Lin, Zhining Li, Junjun Shan, Zuowei Duan, Liangqun Rong, Xiue Wei, Lijie Xiao and Haiyan Liu
    Citation: The Journal of Headache and Pain 2024 25:84
    Content type: Research Published on:

  40. Atogepant is an oral calcitonin gene–related peptide receptor antagonist approved for the preventive treatment of migraine in adults. These analyses evaluated the proportions of clinical trial participants who...

    Authors: Richard B. Lipton, Stephanie J. Nahas, Patricia Pozo-Rosich, Tanya Bilchik, Peter McAllister, Michelle Finnegan, Yingyi Liu, Natty Chalermpalanupap, Brett Dabruzzo and David W. Dodick
    Citation: The Journal of Headache and Pain 2024 25:83
    Content type: Research Published on:

  41. Lifestyle are closely related to migraine. However, there is a lack of studies investigating the association between Healthy lifestyle or Life’s Essential 8 (LE8) and the risk of migraine. The objective of thi...

    Authors: Yuexiu Lei, Lili Zhang, Zhengming Shan, Quan Gan, Qingfang Xie, Ying Huang, Wen Yan and Zheman Xiao
    Citation: The Journal of Headache and Pain 2024 25:82
    Content type: Research Published on:

  42. Recent animal and clinical findings consistently highlight the critical role of calcitonin gene-related peptide (CGRP) in chronic migraine (CM) and related emotional responses. CGRP antibodies and receptor ant...

    Authors: Yang Li, Chenhao Li, Qi-Yu Chen, Shun Hao, Jingrui Mao, Wenwen Zhang, Xun Han, Zhao Dong, Ruozhuo Liu, Wenjing Tang, Min Zhuo, Shengyuan Yu and Yinglu Liu
    Citation: The Journal of Headache and Pain 2024 25:81
    Content type: Research Published on:

  43. Migraine lacks biomarkers that can trace the biological pathways of the disease and predict the effectiveness of treatments. Monoclonal antibodies targeting calcitonin gene-related peptide pathway – including ...

    Authors: Raffaele Ornello, Veronica Zelli, Chiara Compagnoni, Valeria Caponnetto, Eleonora De Matteis, Cindy Tiseo, Alessandra Tessitore and Simona Sacco
    Citation: The Journal of Headache and Pain 2024 25:80
    Content type: Research Published on:

  44. Eptinezumab is a monoclonal antibody that targets calcitonin gene-related peptide (CGRP mAb) and is used for migraine prophylaxis. Efficacy data are mainly from clinical trials, real-world data are hardly avai...

    Authors: Armin Scheffler, Pauline Wenzel, Merle Bendig, Astrid Gendolla, Jale Basten, Christoph Kleinschnitz, Michael Nsaka, Diana Lindner, Steffen Naegel, Philipp Burow, Robert Fleischmann and Dagny Holle
    Citation: The Journal of Headache and Pain 2024 25:79
    Content type: Research Published on:

  45. Cross-sectional and longitudinal studies have been conducted to investigate the association between migraine and any headache and white matter hyperintensities (WMH). However, studies are inconsistent regardin...

    Authors: Sara Helena Schramm, I. Tenhagen, M. Jokisch, J. Gronewold, S. Moebus, S. Caspers, Z. Katsarava, R. Erbel, A. Stang and B. Schmidt
    Citation: The Journal of Headache and Pain 2024 25:78
    Content type: Research Published on:

  46. Chronic headache disorders are disabling. The CHESS trial studied the effects of a short non-pharmacological intervention of education with self-management support for people affected by migraine and/or tensio...

    Authors: Siew Wan Hee, Shilpa Patel, Harbinder Sandhu, Manjit S. Matharu and Martin Underwood
    Citation: The Journal of Headache and Pain 2024 25:77
    Content type: Research Published on:

  47. Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of the insular cortex (IC) is thought to involve several neuro...

    Authors: Jaisan Islam, Md Taufiqur Rahman, Elina KC and Young Seok Park
    Citation: The Journal of Headache and Pain 2024 25:76
    Content type: Review Published on:

  48. GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit con...

    Authors: Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay and Yildirim Sara
    Citation: The Journal of Headache and Pain 2024 25:75
    Content type: Research Published on:

  49. Chronic migraine (CM) is a debilitating neurofunctional disorder primarily affecting females, characterized by central sensitization. Central sensitization refers to the enhanced response to sensory stimulatio...

    Authors: Lei Wang, Xiaoming Liu, Chenlu Zhu, Shouyi Wu, Zhilei Li, Lipeng Jing, Zhenchang Zhang, Yuhong Jing and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:74
    Content type: Research Published on:

  50. Management of idiopathic intracranial hypertension (IIH) is complex requiring contributions from multiple specialized disciplines. In practice, this creates considerable organizational and communicational chal...

    Authors: Gabriel Bsteh, Stefan Macher, Nik Krajnc, Wolfgang Marik, Martin Michl, Nina Müller, Sina Zaic, Jürgen Harreiter, Klaus Novak, Christian Wöber and Berthold Pemp
    Citation: The Journal of Headache and Pain 2024 25:73
    Content type: Research Published on:
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