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  1. Trigeminal Neuralgia (TN) is a chronic neurological disease that is strongly associated with neurovascular compression (NVC) of the trigeminal nerve near its root entry zone. The trigeminal nerve at the site o...

    Authors: Judy Alper, Alan C. Seifert, Gaurav Verma, Kuang-Han Huang, Yael Jacob, Ameen Al Qadi, John W. Rutland, Sheetal Patel, Joshua Bederson, Raj K. Shrivastava, Bradley N. Delman and Priti Balchandani

    Citation: The Journal of Headache and Pain 2021 22:112

    Content type: Research article

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  2. Calcitonin gene-related peptide (CGRP) (receptor) antibodies (erenumab, fremanezumab and galcanezumab) are increasingly used in prophylactic treatment of migraine. In the approval studies, severely affected pa...

    Authors: Armin Scheffler, Hannah Schenk, Sebastian Wurthmann, Michael Nsaka, Christoph Kleinschnitz, Martin Glas and Dagny Holle

    Citation: The Journal of Headache and Pain 2021 22:111

    Content type: Research article

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  3. These subgroup analyses of a Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of erenumab 70 mg in Japanese migraine patients with/without prior preventive treatmen...

    Authors: Koichi Hirata, Fumihiko Sakai, Takao Takeshima, Noboru Imai, Yasuhiko Matsumori, Ryuji Yoshida, Yotaro Numachi, Cheng Peng, Daniel D. Mikol and Sunfa Cheng

    Citation: The Journal of Headache and Pain 2021 22:110

    Content type: Research article

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  4. Headache is a frequent symptom following COVID-19 immunization with a typical onset within days post-vaccination. Cases of cerebral venous thrombosis (CVT) have been reported in adenovirus vector-based COVID-1...

    Authors: David García-Azorín, Thien Phu Do, Andreas R. Gantenbein, Jakob Møller Hansen, Marcio Nattan P. Souza, Mark Obermann, Heiko Pohl, Christoph J. Schankin, Henrik Winther Schytz, Alexandra Sinclair, Guus G. Schoonman and Espen Saxhaug Kristoffersen

    Citation: The Journal of Headache and Pain 2021 22:108

    Content type: Short report

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  5. Medication-overuse headache (MOH) is a relatively frequently occurring secondary headache caused by overuse of analgesics and/or acute migraine medications. It is believed that MOH is associated with dependenc...

    Authors: Wei Dai, Enchao Qiu, Yun Chen, Xinbo Xing, Wei Xi, Meichen Zhang, Ke Li, Lixia Tian, Zhao Dong and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2021 22:107

    Content type: Research article

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  6. Migraine is a primary headache disorder characterized by recurrent attacks that may have a significant impact on patients’ daily life. Treatment options must often be re-evaluated in light of efficacy, tolerab...

    Authors: M. Koch, Z. Katsarava, C. Baufeld, K. Schuh, A. Gendolla, A. Straube, W. von Pannwitz, W. E. Hofmann and S. Ortler

    Citation: The Journal of Headache and Pain 2021 22:106

    Content type: Research article

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  7. Calcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely accompanies severe headache attacks. Increased CGRP levels have been observed...

    Authors: Miriam Risch, Birgit Vogler, Mária Dux and Karl Messlinger

    Citation: The Journal of Headache and Pain 2021 22:105

    Content type: Research article

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  8. Neurovascular contact (NVC) is the main cause of primary trigeminal neuralgia (PTN); however, cases of PTN without NVC are still observed. In this study, the Meckel cave (MC) morphology in PTN were analyzed by...

    Authors: Jinzhi Lin, Yong Zhang, Wuming Li, Jianhao Yan and Yiquan Ke

    Citation: The Journal of Headache and Pain 2021 22:104

    Content type: Research article

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  9. In the past decades a plethora of studies has been conducted to explore resting-state functional connectivity (RS-FC) of the brain networks in migraine with conflicting results probably due to the variability ...

    Authors: Marcello Silvestro, Alessandro Tessitore, Giuseppina Caiazzo, Fabrizio Scotto di Clemente, Francesca Trojsi, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi and Antonio Russo

    Citation: The Journal of Headache and Pain 2021 22:102

    Content type: Research article

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  10. While pain freedom at 2 h is a key primary outcome for current trials for acute treatment of migraine, the relationship between the degree of head pain and other efficacy measures at 2 h has rarely been explor...

    Authors: Richard B. Lipton, Simin K. Baygani, Stewart J. Tepper, John H. Krege, Raghavendra Vasudeva, Eric M. Pearlman, Paula M. Hauck and Li Shen Loo

    Citation: The Journal of Headache and Pain 2021 22:101

    Content type: Research article

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  11. Health economic evaluations support health-care decision-making by providing information on the costs and consequences of health interventions. No universally accepted methodology exists for modelling effectiv...

    Authors: Michela Tinelli, Matilde Leonardi, Koen Paemeleire, Dimos Mitsikostas, Elena Ruiz de la Torre and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2021 22:99

    Content type: Research article

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  12. Structural imaging has revealed changes in cortical thickness in migraine patients compared to healthy controls is reported, but presence of dynamic cortical and subcortical changes during migraine attack vers...

    Authors: Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra Raghava, Frauke Wolfram, Henrik B. W. Larsson and Messoud Ashina

    Citation: The Journal of Headache and Pain 2021 22:98

    Content type: Research article

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  13. Coronavirus disease-19 is caused by the severe acute respiratory syndrome coronavirus 2 Headache is a common symptom during and after Coronavirus disease-19. We aimed to study headache character in relation to...

    Authors: Jasem Youssef Al-Hashel, Fathi Abokalawa, Maram Alenzi, Raed Alroughani and Samar Farouk Ahmed

    Citation: The Journal of Headache and Pain 2021 22:97

    Content type: Research article

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  14. Tension-type headache (TTH) has been ranked the second most prevalent health condition worldwide. Non-pharmacological treatments for TTH are widely used as a supplement or an alternative to medical treatment. ...

    Authors: Lotte Skytte Krøll, Henriette Edemann Callesen, Louise Ninett Carlsen, Kirsten Birkefoss, Dagmar Beier, Henrik Wulff Christensen, Mette Jensen, Hanna Tómasdóttir, Hanne Würtzen, Christel Vesth Høst and Jakob Møller Hansen

    Citation: The Journal of Headache and Pain 2021 22:96

    Content type: Review article

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  15. Pathogenesis of COVID-19 -related headache is unknown, though the induction of the trigeminal neurons through inflammation is proposed. We aimed to investigate key systemic circulating inflammatory molecules a...

    Authors: Hayrunnisa Bolay, Ömer Karadas, Bilgin Oztürk, Riza Sonkaya, Bahar Tasdelen, Tuba D. S. Bulut, Özlem Gülbahar, Aynur Özge and Betül Baykan

    Citation: The Journal of Headache and Pain 2021 22:94

    Content type: Research article

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  16. We report the first case of a patient who suffered transient focal neurological deficit mimicking stroke following CoronaVac vaccination. However, instead of an ischemic stroke, motor aura was suspected.

    Authors: Wanakorn Rattanawong, Wasan Akaratanawat, Supatporn Tepmongkol, Aurauma Chutinet, Jarturon Tantivatana and Nijasri Charnnarong Suwanwela

    Citation: The Journal of Headache and Pain 2021 22:93

    Content type: Case report

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  17. Mutations in ATP1A2, the gene encoding the α2 subunit of Na+/K+-ATPase, are the main cause of familial hemiplegic migraine type 2 (FHM2). The clinical presentation of FHM2 with mutations in the same gene varies f...

    Authors: Yingji Li, Wenjing Tang, Li Kang, Shanshan Kong, Zhao Dong, Dengfa Zhao, Ruozhuo Liu and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2021 22:92

    Content type: Research article

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  18. Cluster headache is an excruciating disorder with no cure. Greater occipital nerve blockades can transiently suppress attacks in approximately 50% of patients, however, its mechanism of action remains uncertai...

    Authors: Sonia Medina, Norazah Abu Bakar, Owen O’Daly, Sarah Miller, Elena Makovac, Tara Renton, Steve C. R. Williams, Manjit Matharu and Matthew A. Howard

    Citation: The Journal of Headache and Pain 2021 22:91

    Content type: Research article

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  19. There have been several calls for estimations of costs and consequences of headache interventions to inform European public-health policies. In a previous paper, in the absence of universally accepted methodol...

    Authors: Michela Tinelli, Matilde Leonardi, Koen Paemeleire, Alberto Raggi, Dimos Mitsikostas, Elena Ruiz de la Torre and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2021 22:90

    Content type: Research article

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  20. Considering the involvement of genetics in migraine pathogenesis in diverse ethnic populations, genome-wide association studies (GWAS) are being conducted to identify migraine-susceptibility genes. However, li...

    Authors: Chia-Kuang Tsai, Chih-Sung Liang, Guan-Yu Lin, Chia-Lin Tsai, Jiunn-Tay Lee, Yueh-Feng Sung, Yu-Kai Lin, Kuo-Sheng Hung, Wei-Liang Chen and Fu-Chi Yang

    Citation: The Journal of Headache and Pain 2021 22:89

    Content type: Research article

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  21. the interest of clinical reaseach in polymorphisms and epigenetics in migraine has been growing over the years. Due to the new era of preventative migraine treatment opened by monoclonal antibodies (mAbs) targ...

    Authors: Damiana Scuteri, Maria Tiziana Corasaniti, Paolo Tonin, Pierluigi Nicotera and Giacinto Bagetta

    Citation: The Journal of Headache and Pain 2021 22:87

    Content type: Research article

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  22. Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucag...

    Authors: Feng Jing, Qian Zou, Yangyang Wang, Zhiyou Cai and Yong Tang

    Citation: The Journal of Headache and Pain 2021 22:86

    Content type: Research article

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  23. Hemiplegic migraine (HM) is a rare form of migraine characterized by the presence of a motor and other types of aura. HM can be sporadic or familial. Familial hemiplegic migraine (FHM) is an autosomal dominant...

    Authors: Marina Romozzi, Guido Primiano, Eleonora Rollo, Lorena Travaglini, Paolo Calabresi, Serenella Servidei and Catello Vollono

    Citation: The Journal of Headache and Pain 2021 22:85

    Content type: Case report

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  24. Central sensitization is one of the characters of chronic migraine (CM). Aberrant synaptic plasticity can induce central sensitization. Oxytocin (OT), which is a hypothalamic hormone, plays an important antino...

    Authors: Yunfeng Wang, Qi Pan, Ruimin Tian, Qianwen Wen, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang and Jiying Zhou

    Citation: The Journal of Headache and Pain 2021 22:84

    Content type: Research article

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  25. To investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI).

    Authors: Håkan Ashina, Haidar Muhsen Al-Khazali, Afrim Iljazi, Sait Ashina, Faisal Mohammad Amin, Richard B. Lipton and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2021 22:83

    Content type: Research article

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  26. Changes in speech can be detected objectively before and during migraine attacks. The goal of this study was to interrogate whether speech changes can be detected in subjects with post-traumatic headache (PTH)...

    Authors: Catherine D. Chong, Jianwei Zhang, Jing Li, Teresa Wu, Gina Dumkrieger, Simona Nikolova, Katherine Ross, Gabriela Stegmann, Julie Liss, Todd J. Schwedt, Suren Jayasuriya and Visar Berisha

    Citation: The Journal of Headache and Pain 2021 22:82

    Content type: Research article

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  27. In patients with migraine, overuse of acute medication, including migraine-specific medication (MSM) such as triptans and ergots, can lead to adverse health outcomes, including development of medication overus...

    Authors: Stewart J Tepper, Messoud Ashina, Uwe Reuter, Yngve Hallström, Gregor Broessner, Jo H Bonner, Hernan Picard, Sunfa Cheng, Denise E Chou, Feng Zhang, Jan Klatt and Daniel D Mikol

    Citation: The Journal of Headache and Pain 2021 22:81

    Content type: Research article

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  28. Headache is one of the most common symptoms after concussion, and mild traumatic brain injury (mTBI) is a risk factor for chronic migraine (CM). However, there remains a paucity of data regarding the impact of...

    Authors: Ryotaro Ishii, Todd J. Schwedt, Meesha Trivedi, Gina Dumkrieger, Melissa M. Cortez, K. C. Brennan, Kathleen Digre and David W. Dodick

    Citation: The Journal of Headache and Pain 2021 22:80

    Content type: Research article

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  29. Migraine is the most common neurological disease, with high social-economical burden. Although there is growing evidence of brain structural and functional abnormalities in patients with migraine, few studies ...

    Authors: Alessia Guarnera, Francesca Bottino, Antonio Napolitano, Giorgia Sforza, Marco Cappa, Laura Chioma, Luca Pasquini, Maria Camilla Rossi-Espagnet, Giulia Lucignani, Lorenzo Figà-Talamanca, Chiara Carducci, Claudia Ruscitto, Massimiliano Valeriani, Daniela Longo and Laura Papetti

    Citation: The Journal of Headache and Pain 2021 22:79

    Content type: Research article

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  30. In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more effi...

    Authors: Timothy J. Steiner, Rigmor Jensen, Zaza Katsarava, Lars Jacob Stovner, Derya Uluduz, Latifa Adarmouch, Mohammed Al Jumah, Ali M. Al Khathaami, Messoud Ashina, Mark Braschinsky, Susan Broner, Jon H. Eliasson, Raquel Gil-Gouveia, Juan B. Gómez-Galván, Larus S. Gudmundsson, Akbar A. Herekar…

    Citation: The Journal of Headache and Pain 2021 22:78

    Content type: Consensus article

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  31. Sensory hypersensitivities such as photophobia, phonophobia, and osmophobia are common in patients with migraine. We investigated the burden of these multiple sensory hypersensitivities in migraine.

    Authors: Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Madoka Okamura, Yasuo Haruyama, Muneto Tatsumoto and Koichi Hirata

    Citation: The Journal of Headache and Pain 2021 22:77

    Content type: Research article

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  32. The paroxysmal nature of migraine is a hallmark of the disease. Some patients report increased attack frequency at certain seasons or towards the end of the week, while others experience diurnal variations of ...

    Authors: Amanda Holmen Poulsen, Samaira Younis, Janu Thuraiaiyah and Messoud Ashina

    Citation: The Journal of Headache and Pain 2021 22:76

    Content type: Review article

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  33. To describe interictal brain structural and metabolic differences between patients with episodic migraine (EM), chronic migraine (CM) and healthy controls (HC).

    Authors: Marta Torres-Ferrus, Deborah Pareto, Victor J Gallardo, Gemma Cuberas-Borrós, Alicia Alpuente, Edoardo Caronna, Adrià Vila-Balló, Carles Lorenzo-Bosquet, Joan Castell-Conesa, Alex Rovira and Patricia Pozo-Rosich

    Citation: The Journal of Headache and Pain 2021 22:75

    Content type: Research article

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  34. Erenumab was approved in Europe for migraine prevention in patients with ≥ 4 monthly migraine days (MMDs). In Spain, Novartis started a personalized managed access program, which allowed free access to erenuma...

    Authors: Robert Belvís, Pablo Irimia, Patricia Pozo-Rosich, Carmen González-Oria, Antonio Cano, Javier Viguera, Belén Sánchez, Francisco Molina, Isabel Beltrán, Agustín Oterino, Elisa Cuadrado, Angel Gómez-Camello, Miguel Alberte-Woodward, Carmen Jurado, Teresa Oms, David Ezpeleta…

    Citation: The Journal of Headache and Pain 2021 22:74

    Content type: Research article

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  35. Headache disorders are disabling and have a significant impact on productivity. The relationship between these two consequences is of considerable economic and political interest. We enquired into it through a...

    Authors: Simple Futarmal Kothari, Rigmor Hølland Jensen and Timothy J Steiner

    Citation: The Journal of Headache and Pain 2021 22:73

    Content type: Research article

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  36. Migraine constitutes a global health burden, and its pathophysiology is not well-understood; research evaluating cerebral perfusion and altered blood flow between brain areas using non-invasive imaging techniq...

    Authors: Di Zhang, Xiaobin Huang, Cunnan Mao, Yuchen Chen, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xinying Wu and Xindao Yin

    Citation: The Journal of Headache and Pain 2021 22:72

    Content type: Research article

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  37. Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of hea...

    Authors: Valeria Caponnetto, Manuela Deodato, Micaela Robotti, Maria Koutsokera, Valeria Pozzilli, Cristina Galati, Giovanna Nocera, Eleonora De Matteis, Gioacchino De Vanna, Emanuela Fellini, Gleni Halili, Daniele Martinelli, Gabriele Nalli, Serena Serratore, Irene Tramacere, Paolo Martelletti…

    Citation: The Journal of Headache and Pain 2021 22:71

    Content type: Review article

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  38. Migraine is a complex neurological disorder that is characterized by throbbing head pain, increased sensitivity to light, sound, and touch, as well as nausea and fatigue. It is one of the most common and most ...

    Authors: Amanda Avona, Theodore J Price and Gregory Dussor

    Citation: The Journal of Headache and Pain 2021 22:70

    Content type: Research article

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  39. Pressure pain thresholds (PPTs) are commonly assessed to quantify mechanical sensitivity in various conditions, including migraine. Digital and analogue algometers are used, but the concurrent validity between...

    Authors: René F. Castien, Michel W. Coppieters, Tom S. C. Durge and Gwendolyne G. M. Scholten-Peeters

    Citation: The Journal of Headache and Pain 2021 22:69

    Content type: Research article

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  40. Fremanezumab, a fully humanized monoclonal antibody (IgG2Δa) selectively targets the calcitonin gene-related peptide and has proven efficacy for the preventive treatment of migraine. In this study, we evaluate...

    Authors: Messoud Ashina, Joshua M. Cohen, Maja Galic, Verena Ramirez Campos, Steve Barash, Xiaoping Ning, Yoel Kessler, Lindsay Janka and Hans-Christoph Diener

    Citation: The Journal of Headache and Pain 2021 22:68

    Content type: Research article

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  41. Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without evidence of a tumor or any other underlying cause. Headache and visual disturbances are frequent complaint...

    Authors: Max Witry, Christine Kindler, Johannes Weller, Andreas Linder and Ullrich Wüllner

    Citation: The Journal of Headache and Pain 2021 22:67

    Content type: Research article

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  42. Migraine is a complex neurological disorder that is considered the most common disabling brain disorder affecting 14 % of people worldwide. The present study sought to infer potential causal relationships betw...

    Authors: Luis M. García-Marín, Adrián I. Campos, Nicholas G. Martin, Gabriel Cuéllar-Partida and Miguel E. Rentería

    Citation: The Journal of Headache and Pain 2021 22:66

    Content type: Research article

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  43. Migraine affects roughly 10% of youth aged 5–15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains...

    Authors: Tiffany Bell, Akashroop Khaira, Mehak Stokoe, Megan Webb, Melanie Noel, Farnaz Amoozegar and Ashley D. Harris

    Citation: The Journal of Headache and Pain 2021 22:65

    Content type: Research article

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  44. Authors: Tatiane Teru Takahashi, Raffaele Ornello, Giuseppe Quatrosi, Angelo Torrente, Maria Albanese, Simone Vigneri, Martina Guglielmetti, Cristiano Maria De Marco, Camille Dutordoir, Enrico Colangeli, Matteo Fuccaro, Davide Di Lenola, Valerio Spuntarelli, Laura Pilati, Salvatore Di Marco, Annelies Van Dycke…

    Citation: The Journal of Headache and Pain 2021 22:64

    Content type: Correction

    Published on:

    The original article was published in The Journal of Headache and Pain 2021 22:32

  45. The first manuscript in this series delineated a model of structured headache services, potentially cost-effective but requiring formal cost-effectiveness analysis (CEA). We envisaged a need for a new outcome ...

    Authors: Timothy J Steiner, Mattias Linde and Petra Schnell-Inderst

    Citation: The Journal of Headache and Pain 2021 22:63

    Content type: Research article

    Published on: