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  1. As the relay centre for processing sensory information, the thalamus may involve in the abnormal sensory procedure caused by cortical spreading depression (CSD). However, few studies have focused on the transi...

    Authors: Xiaoxi Fu, Ming Chen, Jinling Lu and Pengcheng Li

    Citation: The Journal of Headache and Pain 2022 23:15

    Content type: Research article

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  2. Few prospective population-based studies have evaluated the bidirectional relationship between headache and affective disorder. The aim of this large-scale population-based follow-up study was to investigate w...

    Authors: Samita Giri, Erling Andreas Tronvik and Knut Hagen

    Citation: The Journal of Headache and Pain 2022 23:14

    Content type: Research article

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  3. After the initiation of the COVID-19 vaccination program in Thailand, thousands of patients have experienced unusual focal neurological symptoms. We report 8 patients with focal neurological symptoms after rec...

    Authors: Nijasri C. Suwanwela, Naruchorn Kijpaisalratana, Supatporn Tepmongkol, Wanakorn Rattanawong, Pongpat Vorasayan, Chutibhorn Charnnarong, Jarturon Tantivattana, Sirigunya Roongruang, Tatchaporn Ongphichetmetha, Poonnakarn Panjasriprakarn, Aurauma Chutinet, Wasan Akarathanawat and Jeffrey L. Saver

    Citation: The Journal of Headache and Pain 2022 23:13

    Content type: Case report

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  4. Noninvasive vagus nerve stimulation (nVNS) has recently emerged as a promising therapy for migraine. We previously demonstrated that vagus nerve stimulation inhibits cortical spreading depression (CSD), the el...

    Authors: Tzu-Ting Liu, Andreia Morais, Tsubasa Takizawa, Inge Mulder, Bruce J. Simon, Shih-Pin Chen, Shuu-Jiun Wang, Cenk Ayata and Jiin-Cherng Yen

    Citation: The Journal of Headache and Pain 2022 23:12

    Content type: Research article

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  5. Defining the relationship between a headache and stroke is essential. The current diagnostic criteria of the ICHD-3 for acute headache attributed to ischemic stroke are based primarily on the opinion of expert...

    Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev and Jes Olesen

    Citation: The Journal of Headache and Pain 2022 23:11

    Content type: Research article

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  6. The objective of this study was to describe patterns in monthly migraine days (MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures in patients treated as needed (PRN) w...

    Authors: Karissa Johnston, Linda Harris, Lauren Powell, Evan Popoff, Vladimir Coric, Gilbert L’Italien and Curtis P. Schreiber

    Citation: The Journal of Headache and Pain 2022 23:10

    Content type: Research article

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  7. The precise underlying mechanisms of migraine remain unknown. Although we have previously shown acute orofacial pain evoked changes within the brainstem of individuals with migraine, we do not know if these br...

    Authors: Tiffani J. Mungoven, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey, Luke A. Henderson and Noemi Meylakh

    Citation: The Journal of Headache and Pain 2022 23:9

    Content type: Research article

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  8. Astrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, the temporal characteristics of the astrocytic activation in the trigeminal nucleus caudalis ...

    Authors: Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu and Ruozhuo Liu

    Citation: The Journal of Headache and Pain 2022 23:8

    Content type: Research article

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  9. Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanil...

    Authors: Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha, Gábor Jancsó and Mária Dux

    Citation: The Journal of Headache and Pain 2022 23:7

    Content type: Research article

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  10. Migraine is a common and disabling primary headache, which is associated with a wide range of psychiatric comorbidities. However, the mechanisms of emotion processing in migraine are not fully understood yet. ...

    Authors: Jing Ren, Qun Yao, Minjie Tian, Feng Li, Yueqiu Chen, Qiqi Chen, Jing Xiang and Jingping Shi

    Citation: The Journal of Headache and Pain 2022 23:6

    Content type: Research article

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  11. Migraine is a neurological disorder characterized by intense, debilitating headaches, often coupled with nausea, vomiting and sensitivity to light and sound. Whilst changes in sensory processes during a migrai...

    Authors: Noemi Meylakh and Luke A. Henderson

    Citation: The Journal of Headache and Pain 2022 23:5

    Content type: Research article

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  12. Migraine is a common brain disorder that predominantly affects women. Migraine pain seems mediated by the activation of mechanosensitive channels in meningeal afferents. Given the role of transient receptor po...

    Authors: G. Krivoshein, E. A. Tolner, van den Maagdenberg AMJM and R. A. Giniatullin

    Citation: The Journal of Headache and Pain 2022 23:4

    Content type: Research article

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  13. Several inflammatory and vascular molecules, and neurotrophins have been suggested to have a possible role in the development of migraine. However, pathophysiological events leading to migraine onset and trans...

    Authors: Mohammad Mozafarihashjin, Mansoureh Togha, Zeinab Ghorbani, Abolfazl Farbod, Pegah Rafiee and Fahimeh Martami

    Citation: The Journal of Headache and Pain 2022 23:3

    Content type: Research article

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  14. Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another.

    Authors: Pedro Augusto Sampaio Rocha-Filho, Pedro Mota Albuquerque, Larissa Clementino Leite Sá Carvalho, Mylana Dandara Pereira Gama and João Eudes Magalhães

    Citation: The Journal of Headache and Pain 2022 23:2

    Content type: Research article

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  15. Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP levels and ac...

    Authors: Hao Chen, Xueqian Tang, Jin Li, Bangyan Hu, Wenqin Yang, Meng Zhan, Tengyun Ma and Shijun Xu

    Citation: The Journal of Headache and Pain 2022 23:1

    Content type: Research article

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  16. Migraine preventive treatment with CGRP(−receptor) monoclonal antibodies (mAbs) has a positive effect on patients’ health-related quality of life (HRQoL). The German treatment guidelines recommend discontinuin...

    Authors: Maria Terhart, Jasper Mecklenburg, Lars Neeb, Lucas Hendrik Overeem, Anke Siebert, Maureen Steinicke, Bianca Raffaelli and Uwe Reuter

    Citation: The Journal of Headache and Pain 2021 22:158

    Content type: Research article

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  17. Fremanezumab, a fully humanized monoclonal antibody (IgG2Δa) that selectively targets calcitonin gene-related peptide (CGRP), is approved for migraine prevention in adults. Real-world data on the effectiveness...

    Authors: Peter McAllister, Lois Lamerato, Lynda J. Krasenbaum, Joshua M. Cohen, Krishna Tangirala, Stephen Thompson, Maurice Driessen, Julian Casciano, Zenobia Dotiwala and Alexander Mauskop

    Citation: The Journal of Headache and Pain 2021 22:156

    Content type: Research article

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  18. The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine.

    Authors: Anker Stubberud, Dawn C. Buse, Espen Saxhaug Kristoffersen, Mattias Linde and Erling Tronvik

    Citation: The Journal of Headache and Pain 2021 22:155

    Content type: Review article

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  19. Monoclonal antibodies anti-calcitonin gene-related peptide (mAbs anti-CGRP) pathway are effective and safe on migraine prevention. However, some drug agencies limited these treatments to one year due to their ...

    Authors: Fabrizio Vernieri, Nicoletta Brunelli, Roberta Messina, Carmelina Maria Costa, Bruno Colombo, Paola Torelli, Simone Quintana, Sabina Cevoli, Valentina Favoni, Florindo d’Onofrio, Gabriella Egeo, Renata Rao, Massimo Filippi, Piero Barbanti and Claudia Altamura

    Citation: The Journal of Headache and Pain 2021 22:154

    Content type: Research article

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  20. Headache disorders are disabling, with major consequences for productivity, yet the literature is silent on the relationship between headache-attributed disability and lost productivity, often erroneously rega...

    Authors: Hallie Thomas, Simple Futarmal Kothari, Andreas Husøy, Rigmor Højland Jensen, Zaza Katsarava, Michela Tinelli and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2021 22:153

    Content type: Research article

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  21. Migraine prevalence is age and sex dependent, predominating in women in early and middle adulthood; however, migraine also represents a substantial burden for men and adults of all ages. Thus, understanding th...

    Authors: Antoinette MaassenVanDenBrink, Gisela M. Terwindt, Joshua M. Cohen, Steve Barash, Verena Ramirez Campos, Maja Galic, Xiaoping Ning and Mikko Kärppä

    Citation: The Journal of Headache and Pain 2021 22:152

    Content type: Research article

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  22. Patient-Reported Outcomes (PROs) have been developed to numerically quantify disability, impact and quality of life. They have been widely used in migraine clinical trials. However, we still do not know which ...

    Authors: Alicia Alpuente, Victor J Gallardo, Edoardo Caronna, Marta Torres-Ferrus and Patricia Pozo-Rosich

    Citation: The Journal of Headache and Pain 2021 22:151

    Content type: Research article

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  23. An imbalance between inhibitory and excitatory neurometabolites has been implicated in chronic pain. Prior work identified elevated levels of Gamma-aminobutyric acid + macromolecules (“GABA+”) using magnetic r...

    Authors: Aimie L. Peek, Andrew M. Leaver, Sheryl Foster, Nicolaas A. Puts, Georg Oeltzschner, Luke Henderson, Graham Galloway, Karl Ng, Kathryn Refshauge and Trudy Rebbeck

    Citation: The Journal of Headache and Pain 2021 22:150

    Content type: Research article

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  24. Calcitonin gene-related peptide ligand/receptor (CGRP) antibodies effectively reduce headache frequency in migraine. It is understood that they act peripherally, which raises the question whether treatment mer...

    Authors: Anne Thiele, Lara Klehr, Sebastian Strauß, Anselm Angermaier, Ulf Schminke, Martin Kronenbuerger, Steffen Naegel and Robert Fleischmann

    Citation: The Journal of Headache and Pain 2021 22:149

    Content type: Research article

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  25. Patients with visual snow syndrome (VSS) suffer from a debilitating continuous (“TV noise-like”) visual disturbance. They report problems with vision at night and palinopsia despite normal visual acuity. The u...

    Authors: Ozan E. Eren, Andreas Straube, Florian Schöberl, Ruth Ruscheweyh, Thomas Eggert and Christoph J. Schankin

    Citation: The Journal of Headache and Pain 2021 22:148

    Content type: Research article

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  26. Accumulating studies have indicated a wide range of brain alterations with respect to the structure and function of classic trigeminal neuralgia (CTN). Given the dynamic nature of pain experience, the explorat...

    Authors: Pengfei Zhang, Yanli Jiang, Guangyao Liu, Jiao Han, Jun Wang, Laiyang Ma, Wanjun Hu and Jing Zhang

    Citation: The Journal of Headache and Pain 2021 22:147

    Content type: Research article

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  27. Purinergic P2X7 receptor plays an important role in migraine pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine remains unclear. This study explores the hypothesis that P2X...

    Authors: Lingdi Nie, Dongqing Ma, John P. Quinn and Minyan Wang

    Citation: The Journal of Headache and Pain 2021 22:146

    Content type: Research article

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  28. Migraine represents one of the most prevalent neurological conditions worldwide. It is a disabling condition with high impact on the working situation of migraineurs. Interestingly, gender-related differences ...

    Authors: Oreste Affatato, Maud Miguet, Helgi B. Schiöth and Jessica Mwinyi

    Citation: The Journal of Headache and Pain 2021 22:145

    Content type: Research article

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  29. Transcranial direct current stimulation (tDCS) could counteract the pathophysiological triggers of migraine attacks by modulating cortical excitability. Several pilot randomized controlled trials (RCTs) assess...

    Authors: Raffaele Ornello, Valeria Caponnetto, Susanna Ratti, Giulia D’Aurizio, Chiara Rosignoli, Francesca Pistoia, Michele Ferrara, Simona Sacco and Aurora D’Atri

    Citation: The Journal of Headache and Pain 2021 22:144

    Content type: Review article

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  30. Patients with migraine have an increased relative risk of cardio- and cerebrovascular events, and some migraine treatments may exacerbate this risk. The primary objective of this analysis was to determine whet...

    Authors: Timothy R. Smith, Egilius L. H. Spierings, Roger Cady, Joe Hirman, Anders Ettrup and Vivienne Shen

    Citation: The Journal of Headache and Pain 2021 22:143

    Content type: Research article

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  31. Migraine is a common brain disorder but reliable diagnostic biomarkers in blood are still lacking. Our aim was to identify, using proton nuclear magnetic resonance (1H-NMR) spectroscopy, metabolites in serum that...

    Authors: Aster V. E. Harder, Lisanne S. Vijfhuizen, Peter Henneman, Ko Willems van Dijk, Cornelia M. van Duijn, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg

    Citation: The Journal of Headache and Pain 2021 22:142

    Content type: Research article

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  32. Although migraine is less common in older people, preventive treatment of migraine in these individuals may be more challenging due to the presence of multiple comorbidities and polypharmacy. Additionally, evi...

    Authors: Stephanie J. Nahas, Steffen Naegel, Joshua M. Cohen, Xiaoping Ning, Lindsay Janka, Verena Ramirez Campos, Lynda J. Krasenbaum, Dagny Holle-Lee, David Kudrow and Christian Lampl

    Citation: The Journal of Headache and Pain 2021 22:141

    Content type: Research article

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  33. Health care costs of migraine constitute a major issue in health economics. Several publications analyzed health care costs for adult migraine patients, based on questionnaires or secondary (health insurance) ...

    Authors: Viola Obermeier, Monika Murawski, Florian Heinen, Mirjam N. Landgraf, Andreas Straube, Rüdiger von Kries and Ruth Ruscheweyh

    Citation: The Journal of Headache and Pain 2021 22:140

    Content type: Research article

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  34. Occipital transcranial direct current stimulation (tDCS) is an effective and safe treatment for migraine attack prevention. Structural brain alterations have been found in migraineurs in regions related to pai...

    Authors: Simon Schading, Heiko Pohl, Andreas Gantenbein, Roger Luechinger, Peter Sandor, Franz Riederer, Patrick Freund and Lars Michels

    Citation: The Journal of Headache and Pain 2021 22:139

    Content type: Research article

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  35. Pain is generally concomitant with an inflammatory reaction at the site where the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal inflammatory signaling cascade may play a rol...

    Authors: Şefik Evren Erdener, Zeynep Kaya and Turgay Dalkara

    Citation: The Journal of Headache and Pain 2021 22:138

    Content type: Review article

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  36. Post-traumatic headache (PTH) is a very common symptom following mild traumatic brain injury (mTBI), yet much remains unknown about the underlying pathophysiological mechanisms of PTH. Neuroimaging studies sug...

    Authors: Fengfang Li, Liyan Lu, Song’an Shang, Huiyou Chen, Peng Wang, Vijaya Prakash Muthaiah, Xindao Yin and Yu-Chen Chen

    Citation: The Journal of Headache and Pain 2021 22:137

    Content type: Research article

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  37. General practitioners (GPs) diagnose and manage a majority of headache patients seeking health care. With the aim to understand the potential for clinical improvement and educational needs, we performed a stud...

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Jakob Møller Hansen, Erling Andreas Tronvik, Jan C. Frich, Christofer Lundqvist and Bendik Slagsvold Winsvold

    Citation: The Journal of Headache and Pain 2021 22:136

    Content type: Research article

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  38. Headache affects 90–99% of the population. Based on the question “Do you think that you never ever in your whole life have had a headache?” 4% of the population say that they have never experienced a headache....

    Authors: Isa Amalie Olofsson, Jeppe Hvedstrup, Katrine Falkenberg, Mona Ameri Chalmer, Henrik Winther Schytz, Miguel Benjamin Pedersen, Henrik Ullum, Ole Birger Pedersen, Jes Olesen and Thomas Folkmann Hansen

    Citation: The Journal of Headache and Pain 2021 22:134

    Content type: Research article

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  39. Erenumab, the first-in-class fully human monoclonal antibody targeting the calcitonin gene-related peptide receptor, was shown to be efficacious and safe for the prophylactic treatment of migraine in adults in...

    Authors: Andreas Straube, Philipp Stude, Charly Gaul, Katrin Schuh and Mirja Koch

    Citation: The Journal of Headache and Pain 2021 22:133

    Content type: Research article

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  40. Lasmiditan (LTN) is a selective 5-HT1F receptor agonist for the acute treatment of migraine in adults. We present detailed safety findings from the placebo-controlled, double-blind Phase 3 study, of LTN treatment...

    Authors: C Tassorelli, S Bragg, JH Krege, EG Doty, PA Ardayfio, D Ruff, SA Dowsett and T Schwedt

    Citation: The Journal of Headache and Pain 2021 22:132

    Content type: Research article

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  41. Authors: Sara Bottiroli, Roberto De Icco, Gloria Vaghi, Stefania Pazzi, Elena Guaschino, Marta Allena, Natascia Ghiotto, Daniele Martinelli, Cristina Tassorelli and Grazia Sances

    Citation: The Journal of Headache and Pain 2021 22:131

    Content type: Correction

    Published on:

    The original article was published in The Journal of Headache and Pain 2021 22:114

  42. In this study, we aimed to investigate the spontaneous neural activity in the conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz, and slow-5: 0.01–0.027 Hz) in tensi...

    Authors: Shuxian Zhang, Huayun Li, Qinyan Xu, Chao Wang, Xue Li, Jiawei Sun, Yaqi Wang, Tong Sun, Qianqian Wang, Chengcheng Zhang, Jili Wang, Xize Jia and Xihe Sun

    Citation: The Journal of Headache and Pain 2021 22:129

    Content type: Research article

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  43. Several drugs are available for the preventive treatment of both episodic and chronic migraine. The choice of which therapy to initiate first, second, or third is not straightforward and is based on multiple f...

    Authors: Fenne Vandervorst, Laura Van Deun, Annelies Van Dycke, Koen Paemeleire, Uwe Reuter, Jean Schoenen and Jan Versijpt

    Citation: The Journal of Headache and Pain 2021 22:128

    Content type: Research article

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  44. Migraine sufferers face difficulties getting appropriate care and treatment. Migraine is associated with reduced gray matter volume (GMV) in several brain regions, which could be related to various clinical ch...

    Authors: Shana A.B. Burrowes, Olga Goloubeva, Michael L Keaser, Jennifer A. Haythornthwaite and David A. Seminowicz

    Citation: The Journal of Headache and Pain 2021 22:127

    Content type: Research article

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  45. The MIDAS is the most used questionnaire to evaluate migraine-related disability, but its utility to assess treatment response remains unclear. Our aim was to estimate the MIDAS’ minimal important change (MIC)...

    Authors: Gabriela F. Carvalho, Kerstin Luedtke and Tobias Braun

    Citation: The Journal of Headache and Pain 2021 22:126

    Content type: Short report

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  46. To compare symptoms of clinical androgen deficiency between men with migraine, men with cluster headache and non-headache male controls.

    Authors: Iris E. Verhagen, Roemer B. Brandt, Carlijn M. A. Kruitbosch, Antoinette MaassenVanDenBrink, Rolf Fronczek and Gisela M. Terwindt

    Citation: The Journal of Headache and Pain 2021 22:125

    Content type: Research article

    Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:135

  47. Migraine has been associated with cardiovascular disease (CVD) events among middle-aged adults. The objective of this study was to determine the risk for ischemic stroke and coronary heart disease (CHD) events...

    Authors: Emily C. McKinley, Christine L. Lay, Robert S. Rosenson, Ligong Chen, Victoria Chia, Lisandro D. Colantonio, Paul Muntner, Robert Urman and Michael E. Farkouh

    Citation: The Journal of Headache and Pain 2021 22:124

    Content type: Research article

    Published on: