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  1. Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related ...

    Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen

    Citation: The Journal of Headache and Pain 2020 21:87

    Content type: Short report

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  2. Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarizati...

    Authors: Andrea Negro, Jessica L. Seidel, Thijs Houben, Esther S. Yu, Ike Rosen, Andrea J. Arreguin, Nilufer Yalcin, Lea Shorser-Gentile, Lea Pearlman, Homa Sadhegian, Ramalingam Vetrivelan, Nancy L. Chamberlin, Cenk Ayata, Paolo Martelletti, Michael A. Moskowitz and Katharina Eikermann-Haerter

    Citation: The Journal of Headache and Pain 2020 21:86

    Content type: Research article

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  3. Migraine is a frequent headache disorder with high disease burden. The aims of this study were to determine the administrative prevalence and incidence of migraine in Germany; and to elucidate disease characte...

    Authors: Tatjana Roessler, Juergen Zschocke, Anne Roehrig, Michael Friedrichs, Heiko Friedel and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2020 21:85

    Content type: Research article

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  4. Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding ef...

    Authors: Armin Scheffler, Olga Messel, Sebastian Wurthmann, Michael Nsaka, Christoph Kleinschnitz, Martin Glas, Steffen Naegel and Dagny Holle

    Citation: The Journal of Headache and Pain 2020 21:84

    Content type: Research article

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  5. Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA recepto...

    Authors: Diego Currò, Pierluigi Navarra, Irene Samengo and Maria Martire

    Citation: The Journal of Headache and Pain 2020 21:83

    Content type: Research article

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  6. Trigeminal neuralgia (TN) is a severe, disabling form of painful cranial neuropathy. Even though TN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. In order to inv...

    Authors: F. Antonaci, S. Arceri, M. Rakusa, D. D. Mitsikostas, I. Milanov, V. Todorov, M. Cotta Ramusino and A. Costa

    Citation: The Journal of Headache and Pain 2020 21:82

    Content type: Research article

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  7. Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researc...

    Authors: Gabriele S. Merki-Feld, Nina Caveng, Gina Speiermann and E. Anne MacGregor

    Citation: The Journal of Headache and Pain 2020 21:81

    Content type: Research article

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  8. Primary headache disorders have being increasingly reported in younger populations. They can have significant effects on their quality of life and academic achievement and may cause significant distress to the...

    Authors: Jasem Y. Al-Hashel, R. Alroughani, S. Shauibi, A. AlAshqar, F. AlHamdan, H. AlThufairi, S. Owayed and Samar F. Ahmed

    Citation: The Journal of Headache and Pain 2020 21:80

    Content type: Research article

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  9. Migraine clinical profile may change with age, making it necessary to verify that migraine treatments are equally safe and effective in older patients. These analyses evaluated the effects of patient age on th...

    Authors: Virginia L. Stauffer, Ira Turner, Phebe Kemmer, William Kielbasa, Kathleen Day, Martha Port, Tonya Quinlan and Angelo Camporeale

    Citation: The Journal of Headache and Pain 2020 21:79

    Content type: Research article

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  10. Chronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophys...

    Authors: Yuanyuan Yin, Shushu He, Jingchen Xu, Wanfang You, Qian Li, Jingyi Long, Lekai Luo, Graham J. Kemp, John A. Sweeney, Fei Li, Song Chen and Qiyong Gong

    Citation: The Journal of Headache and Pain 2020 21:78

    Content type: Review article

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  11. Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments. It is the aim of the present document to provi...

    Authors: Simona Sacco, Mark Braschinsky, Anne Ducros, Christian Lampl, Patrick Little, Antoinette Maassen van den Brink, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Zaza Katsarava and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2020 21:76

    Content type: Consensus article

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  12. This study evaluates the accuracy of an automated classification tool of single attacks of the two major primary headache disorders migraine and tension-type headache used in an electronic headache diary.

    Authors: Aaron Roesch, Markus A Dahlem, Lars Neeb and Tobias Kurth

    Citation: The Journal of Headache and Pain 2020 21:75

    Content type: Research article

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  13. Headache is one of the most prevalent diseases. The Global Burden of Disease Study ranks it as the seventh most common disease overall and the second largest neurological cause of disability in the world. The ...

    Authors: Patricia Pozo-Rosich, Almudena Layos-Romero, Jimmy Martin-Delgado, Julio Pascual, Cristina Bailón, Ana Tentor, Alejandro Santiago, Emilio Ignacio, Antonio Torrés and José Joaquín Mira

    Citation: The Journal of Headache and Pain 2020 21:74

    Content type: Research article

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  14. While the Global Burden of Disease (GBD) study reports headache disorders as the second-highest cause of disability worldwide, the headache data in GBD come very largely from adults. This national study in Lit...

    Authors: Diana Genc, Nerija Vaičienė-Magistris, Apolinaras Zaborskis, Tayyar Şaşmaz, Aylin Yeniocak Tunç, Derya Uluduz and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:73

    Content type: Research article

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  15. Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to migraine had not been well elucidated. Thus, the present study investi...

    Authors: Yun Zhang, Yixin Zhang, Ke Tian, Yunfeng Wang, Xiaoping Fan, Qi Pan, Guangcheng Qin, Dunke Zhang, Lixue Chen and Jiying Zhou

    Citation: The Journal of Headache and Pain 2020 21:72

    Content type: Research article

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  16. Migraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this neurological disease led to the discovery that calcitonin gene-rela...

    Authors: David B. Clemow, Kirk W. Johnson, Helen M. Hochstetler, Michael H. Ossipov, Ann M. Hake and Andrew M. Blumenfeld

    Citation: The Journal of Headache and Pain 2020 21:71

    Content type: Review article

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  17. There are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors a...

    Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev and Jes Olesen

    Citation: The Journal of Headache and Pain 2020 21:70

    Content type: Research article

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  18. erenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report the clinical experience from an Italian real-world setting using ere...

    Authors: Antonio Russo, Marcello Silvestro, Fabrizio Scotto di Clemente, Francesca Trojsi, Alvino Bisecco, Simona Bonavita, Alessandro Tessitore and Gioacchino Tedeschi

    Citation: The Journal of Headache and Pain 2020 21:69

    Content type: Research article

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  19. Productivity and monetary loss due to migraine in the workplace may be substantial. This study aimed to determine the impact of migraine on productivity and monetary lost among employees in the banking sectors...

    Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U Bahkt Sultan Shah

    Citation: The Journal of Headache and Pain 2020 21:68

    Content type: Research article

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  20. Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investig...

    Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

    Citation: The Journal of Headache and Pain 2020 21:67

    Content type: Research article

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  21. Migraine has been recognized as one of common diseases in the world whose current treatment options are not ideal. Lasmiditan, an oral 5-hydroxytryptamine (HT)1F receptor agonist, appears more promising for the a...

    Authors: Min Hou, Haiyan Xing, Chen Li, Xianfeng Wang, Dongmei Deng, Juan Li, Pan Zhang and Jianhong Chen

    Citation: The Journal of Headache and Pain 2020 21:66

    Content type: Research article

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  22. The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and ...

    Authors: J. C. A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D’Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina…

    Citation: The Journal of Headache and Pain 2020 21:65

    Content type: Review article

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  23. Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Giv...

    Authors: Irene de Boer, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg

    Citation: The Journal of Headache and Pain 2020 21:64

    Content type: Review article

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  24. Calcitonin gene-related peptide (CGRP) has recently been implicated in the pathogenesis of post-traumatic headache (PTH), which raises the prospect for therapeutic use of monoclonal antibodies targeting CGRP o...

    Authors: Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Anna Kristina Eigenbrodt, Eigil Lindekilde Larsen, Amalie Middelboe Andersen, Kevin John Hansen, Karoline Bendix Bräuner, Thomas Mørch-Jessen, Basit Chaudhry, Sonja Antic, Casper Emil Christensen, Messoud Ashina, Faisal Mohammad Amin and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2020 21:62

    Content type: Research article

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  25. Clinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab i...

    Authors: Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova and Anna P. Andreou

    Citation: The Journal of Headache and Pain 2020 21:61

    Content type: Research article

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  26. There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribut...

    Authors: Tiffani J. Mungoven, Noemi Meylakh, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey and Luke A. Henderson

    Citation: The Journal of Headache and Pain 2020 21:59

    Content type: Research article

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  27. Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.

    Authors: Byung-Su Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Jeong Wook Park, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae-Moon Kim, Soo-Kyoung Kim, Yun-Ju Choi, Jae Myun Chung…

    Citation: The Journal of Headache and Pain 2020 21:58

    Content type: Research article

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  28. Neck pain in migraine patients is very prevalent between and during migraine attacks, but the underlying mechanism behind neck pain in migraine is unknown. The neck muscle rectus capitis posterior minor muscle...

    Authors: Jeppe Hvedstrup, Faisal Mohammad Amin, Anders Hougaard, Håkan Ashina, Casper Emil Christensen, Henrik Bo Wiberg Larsson, Messoud Ashina and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2020 21:57

    Content type: Research article

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  29. Vestibular symptoms and balance changes are common in patients with migraine, especially in the ones with aura and chronic migraine. However, it is not known if the balance changes are determined by the presen...

    Authors: Letícia Zorzin, Gabriela F. Carvalho, Jens Kreitewolf, Roberto Teggi, Carina F. Pinheiro, Jéssica R. Moreira, Fabíola Dach and Débora Bevilaqua-Grossi

    Citation: The Journal of Headache and Pain 2020 21:56

    Content type: Research article

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  30. Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops ...

    Authors: Alejandro Labastida-Ramírez, Silvia Benemei, Maria Albanese, Antonina D’Amico, Giovanni Grillo, Oxana Grosu, Devrimsel Harika Ertem, Jasper Mecklenburg, Elena Petrovna Fedorova, Pavel Řehulka, Francesca Schiano di Cola, Javier Trigo Lopez, Nina Vashchenko, Antoinette MaassenVanDenBrink and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2020 21:55

    Content type: Review article

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  31. Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among...

    Authors: Yen-Feng Wang, Yung-Tai Chen, Ching-Wen Tsai, Yu-Chun Yen, Yi-Chun Chen, Ben-Chang Shia and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2020 21:54

    Content type: Research article

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  32. Adult migraine remains underdiagnosed and undertreated, despite significant negative effects on physical and emotional functioning. Information on prescribing patterns and treatment costs of migraine in China ...

    Authors: Shengyuan Yu, Yanlei Zhang, Yuan Yao and Haijun Cao

    Citation: The Journal of Headache and Pain 2020 21:53

    Content type: Research article

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  33. Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people. The aims of this study are to evaluate the temporal varia...

    Authors: Davide Guido, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Ilona Koupil, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…

    Citation: The Journal of Headache and Pain 2020 21:52

    Content type: Research article

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  34. Estrogen influences susceptibility to migraine attacks and it has been suggested to affect jealousy in romantic relationships in women. Therefore, we hypothesized that migraine women may be more jealous.

    Authors: Daphne S. van Casteren, Florine A. C. van Willigenburg, Antoinette MaassenVanDenBrink and Gisela M. Terwindt

    Citation: The Journal of Headache and Pain 2020 21:51

    Content type: Research article

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  35. This quality improvement project was implemented in order to highlight the association between headache, mTBI and depression on lost productivity and resource utilization.

    Authors: Virginia B. Baker, Christopher B. Sowers and Nawaz K. Hack

    Citation: The Journal of Headache and Pain 2020 21:50

    Content type: Research article

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  36. Headache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study...

    Authors: Britta Müller, Thomas Dresler, Charly Gaul, Tim Jürgens, Peter Kropp, Anna Rehfeld, Olaf Reis, Ruth Ruscheweyh, Andreas Straube and Stefanie Förderreuther

    Citation: The Journal of Headache and Pain 2020 21:49

    Content type: Research article

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  37. To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine.

    Authors: Jacob Genizi, Ayelet Halevy, Mitchell Schertz, Khaled Osman, Nurit Assaf, Idan Segal, Isaac Srugo, Aharon Kessel and Batya Engel-Yeger

    Citation: The Journal of Headache and Pain 2020 21:48

    Content type: Research article

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  38. Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information process...

    Authors: Zhaoxia Qin, Jingjing Su, Xin-Wei He, Shiyu Ban, Qian Zhu, Yangyang Cui, Jilei Zhang, Yue Hu, Yi-Sheng Liu, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu and Xiaoxia Du

    Citation: The Journal of Headache and Pain 2020 21:47

    Content type: Research article

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  39. Tinnitus due to hyperactivity across neuronal ensembles along the auditory pathway is reported. We hypothesized that trigeminal neuralgia patients may subsequently suffer from tinnitus. Using nationwide, popul...

    Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin

    Citation: The Journal of Headache and Pain 2020 21:46

    Content type: Research article

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  40. Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people, and with increasing trends in general populations. Differ...

    Authors: Alberto Raggi, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Muhammad Z. Hossin, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…

    Citation: The Journal of Headache and Pain 2020 21:45

    Content type: Research article

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  41. Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy ...

    Authors: Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti and Francesco Saverio Mennini

    Citation: The Journal of Headache and Pain 2020 21:44

    Content type: Research article

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  42. Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic...

    Authors: M. Torres-Ferrús, F. Ursitti, A. Alpuente, F. Brunello, D. Chiappino, T. de Vries, S. Di Marco, S. Ferlisi, L. Guerritore, N. Gonzalez-Garcia, A. Gonzalez-Martinez, D. Khutorov, M. Kritsilis, A. Kyrou, T. Makeeva, A. Minguez-Olaondo…

    Citation: The Journal of Headache and Pain 2020 21:42

    Content type: Review article

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  43. Migraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, ar...

    Authors: Louise Lombard, Mallory Farrar, Wenyu Ye, Yongin Kim, Sarah Cotton, Andrew S. Buchanan, James Jackson and Shivang Joshi

    Citation: The Journal of Headache and Pain 2020 21:41

    Content type: Research article

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  44. Treatment with onabotulinumtoxin A (BT-A) is safe and effective for chronic migraine (CM). Several studies assessed possible predictors of response to treatment with BT-A, but there is little knowledge on the ...

    Authors: Raffaele Ornello, Simona Guerzoni, Carlo Baraldi, Luana Evangelista, Ilaria Frattale, Carmine Marini, Cindy Tiseo, Francesca Pistoia and Simona Sacco

    Citation: The Journal of Headache and Pain 2020 21:40

    Content type: Research article

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  45. Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.

    Authors: Lilla Bonanno, Viviana Lo Buono, Simona De Salvo, Claudio Ruvolo, Viviana Torre, Placido Bramanti, Silvia Marino and Francesco Corallo

    Citation: The Journal of Headache and Pain 2020 21:39

    Content type: Research article

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  46. The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and providing the best possible care to infected patients, a...

    Authors: Antoinette MaassenVanDenBrink, Tessa de Vries and A. H. Jan Danser

    Citation: The Journal of Headache and Pain 2020 21:38

    Content type: Commentary

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