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  1. Migraine is a disabling neurological disorder whose diagnosis is based on clinical criteria. A shortcoming of these criteria is that they do not fully capture the underlying neurobiological factors and sex-spe...

    Authors: F. C. van Welie, L. A. Kreft, J. M. A. Huisman and G. M. Terwindt
    Citation: The Journal of Headache and Pain 2023 24:64
    Content type: Review Published on:

  2. Authors: Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2023 24:67
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:48

  3. Chronic migraine (CM) is a common neurological disorder with complex pathogenesis. Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces migraine-like attacks and may be potenti...

    Authors: Lily Zhang, Yanjie Zhou, Liu Yang, Yue Wang and Zheman Xiao
    Citation: The Journal of Headache and Pain 2023 24:66
    Content type: Research Published on:

  4. Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller ...

    Authors: Zhengming Shan, Yajuan Wang, Tao Qiu, Yanjie Zhou, Yu Zhang, Luyu Hu, Lili Zhang, Jingjing Liang, Man Ding, Shanghua Fan and Zheman Xiao
    Citation: The Journal of Headache and Pain 2023 24:65
    Content type: Research Published on:

  5. Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age res...

    Authors: Albert Muñoz-Vendrell, Sergio Campoy, Edoardo Caronna, Alicia Alpuente, Marta Torres-Ferrus, Candela Nieves Castellanos, Marina Olivier, Jaume Campdelacreu, Joan Prat, Javier Camiña Muñiz, Francisco José Molina Martínez, Ane Mínguez-Olaondo, Marta Ruibal Salgado, Sonia Santos Lasaosa, María Pilar Navarro Pérez, Noemí Morollón…
    Citation: The Journal of Headache and Pain 2023 24:63
    Content type: Research Published on:

  6. Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a h...

    Authors: Chiho Kudo, Andrea M. Harriott, Michael A. Moskowitz, Christian Waeber and Cenk Ayata
    Citation: The Journal of Headache and Pain 2023 24:62
    Content type: Research Published on:

  7. Migraine is a highly disabling health burden with multiple symptoms; however, it remains undertreated because of an inadequate understanding of its neural mechanisms. Neuropeptide Y (NPY) has been demonstrated...

    Authors: Chunxiao Yang, Zihua Gong, Xiaochen Zhang, Shuai Miao, Bozhi Li, Wei Xie, Tao Wang, Xun Han, Liang Wang, Zhao Dong and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:61
    Content type: Research Published on:

  8. Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate...

    Authors: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:60
    Content type: Research Published on:

  9. Neuroimaging studies have made an important contribution to our understanding of headache pathophysiology. This systematic review aims to provide a comprehensive overview and critical appraisal of mechanisms o...

    Authors: R. Messina, R. H. Christensen, I. Cetta, M. Ashina and M. Filippi
    Citation: The Journal of Headache and Pain 2023 24:58
    Content type: Review Published on:

  10. Monoclonal antibodies targeting the CGRP pathway are effective and safe for prophylactic treatment of episodic (EM) and chronic migraine (CM). In case of treatment failure of a CGRP pathway targeting mAb, phys...

    Authors: Andreas Straube, Gregor Broessner, Charly Gaul, Xenia Hamann, Joachim Hipp, Torsten Kraya and Lars Neeb
    Citation: The Journal of Headache and Pain 2023 24:59
    Content type: Research Published on:

  11. Although headache disorders are common, the current diagnostic approach is unsatisfactory. Previously, we designed a guideline-based clinical decision support system (CDSS 1.0) for diagnosing headache disorder...

    Authors: Xun Han, Dongjun Wan, Shuhua Zhang, Ziming Yin, Siyang Huang, Fengbo Xie, Junhong Guo, Hongli Qu, Yuanrong Yao, Huifang Xu, Dongfang Li, Sufen Chen, Faming Wang, Hebo Wang, Chunfu Chen, Qiu He…
    Citation: The Journal of Headache and Pain 2023 24:57
    Content type: Research Published on:

  12. While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We c...

    Authors: Christian Lampl, Antoinette MaassenVanDenBrink, Christina I. Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Margarita Sanchez-del-Rio, Uwe Reuter, Derya Uluduz, Jan Versijpt, Dena Zeraatkar and Simona Sacco
    Citation: The Journal of Headache and Pain 2023 24:56
    Content type: Research Published on:

  13. Accumulating data emphasizes the importance of olfaction in migraine pathophysiology. However, there are only a few studies evaluating how the migraine brain processes olfactory stimulation, and virtually no s...

    Authors: Coralie Mignot, Vanda Faria, Thomas Hummel, Marie Frost, Christoph M. Michel, Gudrun Gossrau and Antje Haehner
    Citation: The Journal of Headache and Pain 2023 24:55
    Content type: Research Published on:

  14. The aberrance of gray matter morphology in migraineurs has been widely investigated. However, it remains largely unknown whether there are illness duration-related hierarchical changes in the gray matter struc...

    Authors: Tao Yin, Lei Lan, Zilei Tian, Zhengjie Li, Mailan Liu, Yujie Gao, Fanrong Liang and Fang Zeng
    Citation: The Journal of Headache and Pain 2023 24:53
    Content type: Research Published on:

  15. Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatmen...

    Authors: Stewart J. Tepper, Jessica Cirillo, Edward Kim, Gil L’Italien, Julie M. Tweedie, Kunal Lodaya, Dushon Riley, Farah Pathan, Nicholas Antaki, Brian H. Nathanson and Peter McAllister
    Citation: The Journal of Headache and Pain 2023 24:54
    Content type: Research Published on:

  16. Although studies have identified a high prevalence of migraine among employees in the banking sector, the symptoms of migraine, related disability and occupational risk factors are not well understood.

    Authors: Du Wei, Tharani Loganathan and Li Ping Wong
    Citation: The Journal of Headache and Pain 2023 24:52
    Content type: Research Published on:

  17. This study compares the outcome of patients suffering from medically refractory classical trigeminal neuralgia (TN) after treatment with radiosurgery using two different shot sizes (5- and 6-mm).

    Authors: Cécile Ortholan, Philippe Colin, Benjamin Serrano, Thibault Bouet, Nicolas Garnier, Maud le Guyader, Regis Amblard, Rémy Villeneuve, Stéphane Chanalet, Haiel Alchaar, Eric Bozzolo, Michel Lanteri-Minet and Denys Fontaine
    Citation: The Journal of Headache and Pain 2023 24:51
    Content type: Research Published on:

  18. Dental treatment associated with unadaptable occlusal alteration can cause chronic primary myofascial orofacial pain. The serotonin (5-HT) pathway from the rostral ventromedial medulla (RVM) exerts descending ...

    Authors: Si-Yi Mo, Yang Xue, Yuan Li, Yao-Jun Zhang, Xiao-Xiang Xu, Kai-Yuan Fu, Barry J. Sessle, Qiu-Fei Xie and Ye Cao
    Citation: The Journal of Headache and Pain 2023 24:50
    Content type: Research Published on:

  19. Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.

    Authors: Yuan Zhang, Hua Wang, Yufang Sun, Zitong Huang, Yu Tao, Yiru Wang, Xinghong Jiang and Jin Tao
    Citation: The Journal of Headache and Pain 2023 24:49
    Content type: Research Published on:

  20. Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an analgesic effect in several pain models, does not have side effects and has low toxicity. The data about CBD mechanisms of...

    Authors: Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2023 24:48
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:67

  21. Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO...

    Authors: Sara Bottiroli, Alessia Rosi, Grazia Sances, Marta Allena, Roberto De Icco, Serena Lecce, Tomaso Vecchi, Cristina Tassorelli and Elena Cavallini
    Citation: The Journal of Headache and Pain 2023 24:47
    Content type: Research Published on:

  22. The pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional connectivity (FC) in patients with NDPH using resting-state functional magnetic resonance ima...

    Authors: Wei Wang, Ziyu Yuan, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Dong Qiu, Yingkui Zhang, Peng Zhang, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:46
    Content type: Research Published on:

  23. New daily persistent headache (NDPH) is a rare but debilitating primary headache disorder that poses a significant burden on individuals and society. Despite its clinical importance, the underlying pathophysio...

    Authors: Dong Qiu, Wei Wang, Yanliang Mei, Hefei Tang, Ziyu Yuan, Peng Zhang, Yaqing Zhang, Xueying Yu, Chunqing Yang, Qun Wang and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:45
    Content type: Research Published on:

  24. Central sensitization has been widely accepted as an underlying pathophysiological mechanism of chronic migraine (CM), activation of cannabinoid type-1 receptor (CB1R) exerts antinociceptive effects by relievi...

    Authors: Xiaoxu Zeng, Jia Mai, Hongjian Xie, Ling Yang and Xiaojuan Liu
    Citation: The Journal of Headache and Pain 2023 24:44
    Content type: Research Published on:

  25. Neuroanatomical alterations have been associated with cognitive deficits in mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal gray matter volume in widespread brain regions...

    Authors: Hui Xu, Cheng Xu, Pengpeng Gu, Yike Hu, Yunyu Guo and Guanghui Bai
    Citation: The Journal of Headache and Pain 2023 24:43
    Content type: Research Published on:

  26. Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache response...

    Authors: Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price and Greg Dussor
    Citation: The Journal of Headache and Pain 2023 24:42
    Content type: Research Published on:

  27. Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the ech...

    Authors: Dolores Vilas, Sara Rubio, Mireia Gea, Jose Rios, Lourdes Ispierto, María Hernández-Pérez, Martí Paré, Mònica Millán and Laura Dorado
    Citation: The Journal of Headache and Pain 2023 24:41
    Content type: Research Published on:

  28. The Migraine in Poland study is the first large scale nationwide cross-sectional online survey of symptoms, approaches to management, treatment patterns, quality of life, and sociodemographic characteristics o...

    Authors: Marta Waliszewska-Prosół, Marcin Straburzyński, Ewa K. Czapińska-Ciepiela, Magdalena Nowaczewska, Anna Gryglas-Dworak and Sławomir Budrewicz
    Citation: The Journal of Headache and Pain 2023 24:40
    Content type: Research Published on:

  29. The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.

    Authors: Christian Lampl, Jan Versijpt, Faisal Mohammad Amin, Christina I. Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Antoinette MaassenVanDenBrink, Raffaele Ornello, Jakob Paungarttner, Margarita Sanchez-del-Rio, Uwe Reuter, Derya Uluduz, Tessa de Vries, Dena Zeraatkar and Simona Sacco
    Citation: The Journal of Headache and Pain 2023 24:39
    Content type: Research Published on:

  30. Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide...

    Authors: Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha Savinainen and Rashid Giniatullin
    Citation: The Journal of Headache and Pain 2023 24:38
    Content type: Research Published on:

  31. The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement n...

    Authors: Bernadett Tuka, Tamás Körtési, Nikolett Nánási, Ferenc Tömösi, Tamás Janáky, Dániel Veréb, Délia Szok, János Tajti and László Vécsei
    Citation: The Journal of Headache and Pain 2023 24:35
    Content type: Research Published on:

  32. Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socio...

    Authors: Britta Müller, Charly Gaul, Olaf Reis, Tim P. Jürgens, Peter Kropp, Ruth Ruscheweyh, Andreas Straube, Elmar Brähler, Stefanie Förderreuther, Jennifer Schroth and Thomas Dresler
    Citation: The Journal of Headache and Pain 2023 24:37
    Content type: Research Published on:

  33. The role of inflammation and cytokines in the pathophysiology of primary headache disorders is uncertain. We performed a systematic review and meta-analysis to synthesise the results of studies comparing perip...

    Authors: Abdu Kisekka Musubire, Sanjay Cheema, Jason C. Ray, Elspeth J. Hutton and Manjit Matharu
    Citation: The Journal of Headache and Pain 2023 24:36
    Content type: Research Published on:

  35. In the study by Johnston et al., gepants were meant to be taken to treat emergent migraine. It is tempting to speculate what the effect would be if patients were instructed to take a gepant as needed (PRN) or ...

    Authors: Andreas R. Gantenbein and Andreas Kleinschmidt
    Citation: The Journal of Headache and Pain 2023 24:33
    Content type: Comment Published on:

  37. Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuat...

    Authors: Anna K. Szewczyk, Samiye Ulutas, Tülin Aktürk, Linda Al-Hassany, Corinna Börner, Federica Cernigliaro, Michalis Kodounis, Salvatore Lo Cascio, David Mikolajek, Dilara Onan, Chiara Ragaglini, Susanna Ratti, Eduardo Rivera-Mancilla, Sofia Tsanoula, Rafael Villino, Karl Messlinger…
    Citation: The Journal of Headache and Pain 2023 24:31
    Content type: Review Published on:

  38. To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic migraine (CM: ≥ 15 days/month)...

    Authors: Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Paola Torelli, Cinzia Finocchi, Florindo d’Onofrio, Luigi d’Onofrio, Renata Rao, Stefano Messina, Laura Di Clemente, Angelo Ranieri, Massimo Autunno, Giuliano Sette, Bruno Colombo, Antonio Carnevale, Marco Aguggia…
    Citation: The Journal of Headache and Pain 2023 24:30
    Content type: Research Published on:

  39. Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 2...

    Authors: Jiahui He, Mengting Zhou, Fanglin Zhao, Hongrong Cheng, Hao Huang, Xiaopei Xu, Jian Han, Wenwu Hong, Faming Wang, Yujin Xiao, Jinjin Xia and Kaiming Liu
    Citation: The Journal of Headache and Pain 2023 24:28
    Content type: Research Published on:

  40. The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of...

    Authors: Zhijian Cao, Wenjing Yu, Luping Zhang, Jiajia Yang, Jiafei Lou, Maosheng Xu and Zhengxiang Zhang
    Citation: The Journal of Headache and Pain 2023 24:27
    Content type: Research Published on:

  41. Current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intrac...

    Authors: Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji and Ran Meng
    Citation: The Journal of Headache and Pain 2023 24:29
    Content type: Research Published on:

  42. The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, an...

    Authors: Sait Ashina, Agustin Melo-Carrillo, Ajayi Toluwanimi, Nicolas Bolo, Edina Szabo, David Borsook and Rami Burstein
    Citation: The Journal of Headache and Pain 2023 24:26
    Content type: Research Published on:

  43. Appropriate and timely diagnosis is one of the most important milestones in effective migraine care and is affected by public awareness, access to medical care, health care systems, and physicians’ knowledge. ...

    Authors: Ido Peles, Mohnnad Asla, Mariya Abayev, Michal Gordon, Ali Alhoashle, Victor Novack, Rinat Ribalov, Tamar Lengil, Ron Maor, Mayera Elizur and Gal Ifergane
    Citation: The Journal of Headache and Pain 2023 24:25
    Content type: Research Published on:

  44. Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essentia...

    Authors: H. Genc, B. Baykan, H. Bolay, D. Uluduz, I. Unal-Cevik, N. Kissani, O. Luvsannorov, M. Togha, A. A. Ozdemir and A. Ozge
    Citation: The Journal of Headache and Pain 2023 24:24
    Content type: Research Published on:

  45. Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are a favourable option for patients with migraine who experience distressful headache disability and fail to respond to traditional preven...

    Authors: Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Naoki Miyazaki, Kei Ishizuchi, Satoko Hori, Ryo Takemura, Jin Nakahara and Tsubasa Takizawa
    Citation: The Journal of Headache and Pain 2023 24:23
    Content type: Research Published on:

  46. Authors: Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra M. Raghava, Frauke Wolfram, Henrik B. W. Larsson and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:22
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2021 22:98

  47. In order to pursue its purpose of reducing the global burden of headache, the Global Campaign against Headache has gathered data on headache-attributed burden from countries worldwide. These data, from the ind...

    Authors: Timothy J. Steiner, Andreas Husøy, Hallie Thomas and Lars Jacob Stovner
    Citation: The Journal of Headache and Pain 2023 24:21
    Content type: Comment Published on:

  48. To explore the possibility of further dividing migraine without aura (MWA), 1444 female patients fulfilled the criterion were recruited, and grouped basing on the association of MWA onset with menarche and chi...

    Authors: Xiaolin Wang, Weinan Na, Ying Yang, Wenwen Zhang, Junxia Zhao, Tingting Zhang, Yuanji Zhou, Hua Liu, Dong Zhao and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:20
    Content type: Research Published on:

  49. Headache during hemodialysis (HDH) is prevalent but not negligible. Despite the high prevalence of dialysis headaches, they have rarely been studied. Therefore, this study aimed to evaluate the prevalence, ris...

    Authors: Ying Yang, Fanchao Meng, Hanyu Zhu, Lei Zhang, Guangshuang Lu, Shaobo Xiao, Jiaji He, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2023 24:19
    Content type: Research Published on:

  50. Clinical trials and real-world studies revealed a spectrum of response to CGRP(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at all to total migraine freedom. In this ...

    Authors: Bianca Raffaelli, Mira Fitzek, Lucas H. Overeem, Elisabeth Storch, Maria Terhart and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:16
    Content type: Research Published on:
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