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  1. We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

    Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

    Citation: The Journal of Headache and Pain 2020 21:32

    Content type: Research article

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  2. The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...

    Authors: Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares and Raquel Gil-Gouveia

    Citation: The Journal of Headache and Pain 2020 21:31

    Content type: Research article

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  3. The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, ...

    Authors: Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2020 21:29

    Content type: Research article

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  4. Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms o...

    Authors: S. P. Mollan, K. Paemeleire, J. Versijpt, R. Luqmani and A. J. Sinclair

    Citation: The Journal of Headache and Pain 2020 21:28

    Content type: Consensus article

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  5. Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased ...

    Authors: Jessica L. Rohmann, Pamela M. Rist, Julie E. Buring and Tobias Kurth

    Citation: The Journal of Headache and Pain 2020 21:27

    Content type: Research article

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  6. Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency faci...

    Authors: Andrea Negro, Valerio Spuntarelli, Paolo Sciattella and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2020 21:25

    Content type: Research article

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  7. The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal ass...

    Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

    Citation: The Journal of Headache and Pain 2020 21:24

    Content type: Research article

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  8. Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) freq...

    Authors: Dawn C. Buse, Michael L. Reed, Kristina M. Fanning, Ryan Bostic, David W. Dodick, Todd J. Schwedt, Sagar Munjal, Preeti Singh and Richard B. Lipton

    Citation: The Journal of Headache and Pain 2020 21:23

    Content type: Research article

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  9. Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migrai...

    Authors: Zeinab Ghorbani, Pegah Rafiee, Akbar Fotouhi, Samane Haghighi, Reyhaneh Rasekh Magham, Zeynab Sadat Ahmadi, Mahmoud Djalali, Mahnaz Zareei, Soodeh Razeghi Jahromi, Sahar Shahemi, Maryam Mahmoudi and Mansoureh Togha

    Citation: The Journal of Headache and Pain 2020 21:22

    Content type: Research article

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  10. Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of...

    Authors: Richard B. Lipton, Louise Lombard, Dustin D. Ruff, John H. Krege, Li Shen Loo, Andrew Buchanan, Thomas E. Melby and Dawn C. Buse

    Citation: The Journal of Headache and Pain 2020 21:20

    Content type: Research article

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  11. Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache pr...

    Authors: Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Matias Metcalf-Clausen, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

    Citation: The Journal of Headache and Pain 2020 21:19

    Content type: Research article

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  12. To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

    Authors: Di Zhang, Xiaobin Huang, Wen Su, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu

    Citation: The Journal of Headache and Pain 2020 21:17

    Content type: Research article

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  13. People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity thr...

    Authors: Gwendolyne G. M. Scholten-Peeters, Michel W. Coppieters, Tom S. C. Durge and René F. Castien

    Citation: The Journal of Headache and Pain 2020 21:16

    Content type: Research article

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  14. The terminology “gut-brain axis “points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some...

    Authors: Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco and Mansoureh Togha

    Citation: The Journal of Headache and Pain 2020 21:15

    Content type: Review article

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  15. Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomiz...

    Authors: Yanbo Yang, Zilan Wang, Bixi Gao, He Xuan, Yun Zhu, Zhouqing Chen and Zhong Wang

    Citation: The Journal of Headache and Pain 2020 21:14

    Content type: Research article

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  16. Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthines...

    Authors: Yating Zhao, Ruixia Zhu, Tongling Xiao and Xu Liu

    Citation: The Journal of Headache and Pain 2020 21:13

    Content type: Research article

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  17. The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include most of Eastern Mediterranean Region (EMR). Following a nationwide population-based study in Pakistan, we...

    Authors: Mohammed Al Jumah, Ali M. Al Khathaami, Suleman Kojan, Mohamed Hussain, Hallie Thomas and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:11

    Content type: Research article

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  18. To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarker...

    Authors: Ane Mínguez-Olaondo, Iván Martínez-Valbuena, Sonia Romero, Gema Frühbeck, María Rosario Luquin, Eduardo Martínez-Vila and Pablo Irimia

    Citation: The Journal of Headache and Pain 2020 21:9

    Content type: Research article

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  19. Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age u...

    Authors: Minna A. Korolainen, Samuli Tuominen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Timo Purmonen, Jaana Santaholma and Markku Nissilä

    Citation: The Journal of Headache and Pain 2020 21:8

    Content type: Research article

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  20. Dural arteriovenous fistulas are intracranial vascular malformations, fed by dural arteries and draining venous sinuses or meningeal veins. Clinical course varies widely and ranges from benign with spontaneous...

    Authors: Ilenia Corbelli, Francesca De Maria, Paolo Eusebi, Michele Romoli, Gabriela Cardaioli, Mohammed Hamam, Piero Floridi, Letizia Maria Cupini, Paola Sarchielli and Paolo Calabresi

    Citation: The Journal of Headache and Pain 2020 21:6

    Content type: Research article

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  21. A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey wa...

    Authors: Wei Xie, Ruibing Li, Mianwang He, Fang Cui, Tingting Sun, Jianmei Xiong, Dengfa Zhao, Weinan Na, Ruozhuo Liu and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2020 21:5

    Content type: Research article

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  22. According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk betwe...

    Authors: Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen and Jiying Zhou

    Citation: The Journal of Headache and Pain 2020 21:4

    Content type: Research article

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  23. Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and ...

    Authors: Bereket Duko, Mohammed Ayalew and Alemayehu Toma

    Citation: The Journal of Headache and Pain 2020 21:3

    Content type: Research article

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  24. In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account ...

    Authors: Carl H. Göbel, Sarah C. Karstedt, Thomas F. Münte, Hartmut Göbel, Sebastian Wolfrum, Elena R. Lebedeva, Jes Olesen and Georg Royl

    Citation: The Journal of Headache and Pain 2020 21:2

    Content type: Research article

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  25. White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is l...

    Authors: Álvaro Planchuelo-Gómez, David García-Azorín, Ángel L. Guerrero, Santiago Aja-Fernández, Margarita Rodríguez and Rodrigo de Luis-García

    Citation: The Journal of Headache and Pain 2020 21:1

    Content type: Research article

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  26. Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated with a...

    Authors: Andrea Negro, Paolo Sciattella, Daniele Rossi, Martina Guglielmetti, Paolo Martelletti and Francesco Saverio Mennini

    Citation: The Journal of Headache and Pain 2019 20:120

    Content type: Research article

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  27. To evaluate the crossover design in migraine preventive treatment trials by assessing dropout rate, and potential period and carryover effect in four placebo-controlled randomized controlled trials (RCTs).

    Authors: Astrid Bjørke Jenssen, Lars Jacob Stovner, Erling Tronvik, Trond Sand, Grethe Helde, Gøril Bruvik Gravdahl and Knut Hagen

    Citation: The Journal of Headache and Pain 2019 20:119

    Content type: Research article

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  28. After publication of our article [1] we were notified that the data presented in the upper row of Fig. 7 was inadvertently the least square mean change from baseline (standard error) at Month 6 rather than the...

    Authors: Stephen D. Silberstein, Virginia L. Stauffer, Katie A. Day, Sarah Lipsius and Maria-Carmen Wilson

    Citation: The Journal of Headache and Pain 2019 20:118

    Content type: Correction

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    The original article was published in The Journal of Headache and Pain 2019 20:75

  29. Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has bee...

    Authors: Anna P. Andreou and Lars Edvinsson

    Citation: The Journal of Headache and Pain 2019 20:117

    Content type: Review article

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  30. Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions,...

    Authors: Heng-Le Wei, Xin Zhou, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Li-Jie Qu, Xindao Yin, Junrong Li and Hong Zhang

    Citation: The Journal of Headache and Pain 2019 20:116

    Content type: Research article

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  31. Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We a...

    Authors: Yu-Hsiang Ling, Shih-Pin Chen, Cathy Shen-Jang Fann, Shuu-Jiun Wang and Yen-Feng Wang

    Citation: The Journal of Headache and Pain 2019 20:115

    Content type: Research article

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  32. In the ongoing Global Campaign endeavour to improve knowledge and awareness of headache prevalence worldwide, Mongolia is a country of interest. It sits between Russia and China, in which prevalence is, respec...

    Authors: Otgonbayar Luvsannorov, Byambasuren Tsenddorj, Dorjkhand Baldorj, Selenge Enkhtuya, Delgermaa Purev, Hallie Thomas and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2019 20:114

    Content type: Research article

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  33. More than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-expert...

    Authors: Evangelos Kouremenos, Chrysa Arvaniti, Theodoros S. Constantinidis, Ermioni Giannouli, Nikolaos Fakas, Themistoklis Kalamatas, Evangelia Kararizou, Dimitrios Naoumis and Dimos D. Mitsikostas

    Citation: The Journal of Headache and Pain 2019 20:113

    Content type: Consensus article

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  34. The objective of this review was to determine the unmet needs for migraine in East Asian adults and children.

    Authors: Takao Takeshima, Qi Wan, Yanlei Zhang, Mika Komori, Serina Stretton, Narayan Rajan, Tamas Treuer and Kaname Ueda

    Citation: The Journal of Headache and Pain 2019 20:111

    Content type: Review article

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  35. The aim of this cross-sectional study was to investigate the cortical metabolite concentrations in patients suffering from migraine with aura (MWA). We hypothesized that occipital γ-aminobutyric acid (GABA) le...

    Authors: Tobias G. Stærmose, Marie K. Knudsen, Helge Kasch and Jakob U. Blicher

    Citation: The Journal of Headache and Pain 2019 20:110

    Content type: Research article

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  36. Resting-state functional connectivity (FC) MRI has widely been used to understand migraine pathophysiology and to identify an imaging marker of the disorder. Here, we review what we have learned from FC studies.

    Authors: Kirill Skorobogatykh, Willem Sebastiaan van Hoogstraten, Diana Degan, Anastasia Prischepa, Anastasya Savitskaya, Biondo Michela Ileen, Enrico Bentivegna, Iaroslav Skiba, Laura D’Acunto, Livia Ferri, Simona Sacco, Jakob Møller Hansen and Faisal Mohammad Amin

    Citation: The Journal of Headache and Pain 2019 20:108

    Content type: Review article

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  37. Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transpor...

    Authors: R. Barbieri, S. Bertelli, M. Pusch and P. Gavazzo

    Citation: The Journal of Headache and Pain 2019 20:107

    Content type: Research article

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  38. The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in...

    Authors: Soodeh Razeghi Jahromi, Zeinab Ghorbani, Paolo Martelletti, Christian Lampl and Mansoureh Togha

    Citation: The Journal of Headache and Pain 2019 20:106

    Content type: Review article

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  39. Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brai...

    Authors: Jacob C. A. Edvinsson, Karin Warfvinge, Diana N. Krause, Frank W. Blixt, Majid Sheykhzade, Lars Edvinsson and Kristian A. Haanes

    Citation: The Journal of Headache and Pain 2019 20:105

    Content type: Research article

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  40. Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substa...

    Authors: Xiaobin Huang, Di Zhang, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xinying Wu and Xindao Yin

    Citation: The Journal of Headache and Pain 2019 20:104

    Content type: Research article

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  41. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive f...

    Authors: Jingjing Su, Shiyu Ban, Mengxing Wang, Fengchun Hua, Liang Wang, Xin Cheng, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du and Jianren Liu

    Citation: The Journal of Headache and Pain 2019 20:103

    Content type: Research article

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  42. Headache has emerged as a global public health concern. However, little is known about the burden from headache disorders in China. The aim of this work was to quantify the spatial patterns and temporal trends...

    Authors: Chengye Yao, Yu Wang, Lijun Wang, Yunning Liu, Jiangmei Liu, Jinlei Qi, Yun Lin, Peng Yin and Maigeng Zhou

    Citation: The Journal of Headache and Pain 2019 20:102

    Content type: Research article

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  43. Headache disorders are highly prevalent worldwide, but not so well investigated in children and adolescents as in adults: few studies have included representative nationwide samples. No data exist for Austria ...

    Authors: Julia Philipp, Michael Zeiler, Christian Wöber, Gudrun Wagner, Andreas F. K. Karwautz, Timothy J. Steiner and Çiçek Wöber-Bingöl

    Citation: The Journal of Headache and Pain 2019 20:101

    Content type: Research article

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