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  1. Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transpor...

    Authors: R. Barbieri, S. Bertelli, M. Pusch and P. Gavazzo

    Citation: The Journal of Headache and Pain 2019 20:107

    Content type: Research article

    Published on:

  2. The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in...

    Authors: Soodeh Razeghi Jahromi, Zeinab Ghorbani, Paolo Martelletti, Christian Lampl and Mansoureh Togha

    Citation: The Journal of Headache and Pain 2019 20:106

    Content type: Review article

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  3. Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brai...

    Authors: Jacob C. A. Edvinsson, Karin Warfvinge, Diana N. Krause, Frank W. Blixt, Majid Sheykhzade, Lars Edvinsson and Kristian A. Haanes

    Citation: The Journal of Headache and Pain 2019 20:105

    Content type: Research article

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  4. Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substa...

    Authors: Xiaobin Huang, Di Zhang, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xinying Wu and Xindao Yin

    Citation: The Journal of Headache and Pain 2019 20:104

    Content type: Research article

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  5. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive f...

    Authors: Jingjing Su, Shiyu Ban, Mengxing Wang, Fengchun Hua, Liang Wang, Xin Cheng, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du and Jianren Liu

    Citation: The Journal of Headache and Pain 2019 20:103

    Content type: Research article

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  6. Headache has emerged as a global public health concern. However, little is known about the burden from headache disorders in China. The aim of this work was to quantify the spatial patterns and temporal trends...

    Authors: Chengye Yao, Yu Wang, Lijun Wang, Yunning Liu, Jiangmei Liu, Jinlei Qi, Yun Lin, Peng Yin and Maigeng Zhou

    Citation: The Journal of Headache and Pain 2019 20:102

    Content type: Research article

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  7. Headache disorders are highly prevalent worldwide, but not so well investigated in children and adolescents as in adults: few studies have included representative nationwide samples. No data exist for Austria ...

    Authors: Julia Philipp, Michael Zeiler, Christian Wöber, Gudrun Wagner, Andreas F. K. Karwautz, Timothy J. Steiner and Çiçek Wöber-Bingöl

    Citation: The Journal of Headache and Pain 2019 20:101

    Content type: Research article

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  8. Headache is very often the cause for seeking an emergency department (ED). However, less is known about the different diagnosis of headache disorders in the ED, their management and treatment. The aim of this ...

    Authors: Alberto Doretti, Irina Shestaritc, Daniela Ungaro, John-Ih Lee, Loukas Lymperopoulos, Lili Kokoti, Martina Guglielmetti, Dimos Dimitrios Mitsikostas and Christian Lampl

    Citation: The Journal of Headache and Pain 2019 20:100

    Content type: Research article

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  9. Erenumab, a fully human monoclonal antibody directed against the calcitonin gene-related peptide receptor, was approved for the prevention of episodic (EM) or chronic migraine (CM) at the monthly dose of 70 mg...

    Authors: Raffaele Ornello, Cindy Tiseo, Ilaria Frattale, Giulia Perrotta, Carmine Marini, Francesca Pistoia and Simona Sacco

    Citation: The Journal of Headache and Pain 2019 20:99

    Content type: Review article

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  10. Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH trea...

    Authors: Eigil Lindekilde Larsen, Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Kristoffer Seem, Messoud Ashina, Sait Ashina and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2019 20:98

    Content type: Review article

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  11. Migraine is a major public health problem afflicting approximately 10% of the general population and is a leading cause of disability worldwide, yet our understanding of the basis mechanisms of migraine remain...

    Authors: Jakob Møller Hansen and Andrew Charles

    Citation: The Journal of Headache and Pain 2019 20:96

    Content type: Review article

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  12. Migraine is a complex brain disorder and initiating events for acute attacks still remain unclear. It seems difficult to explain the development of migraine headache with one mechanism and/or a single anatomic...

    Authors: Hayrunnisa Bolay, Doga Vuralli and Peter J. Goadsby

    Citation: The Journal of Headache and Pain 2019 20:94

    Content type: Review article

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  13. Increasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, the descending pain system of the brainstem is the major site of trigeminal pain processing and modulati...

    Authors: Zhaoxia Qin, Xin-Wei He, Jilei Zhang, Shuai Xu, Ge-Fei Li, Jingjing Su, Yan-Hui Shi, Shiyu Ban, Yue Hu, Yi-Sheng Liu, Mei-Ting Zhuang, Rong Zhao, Xiao-Lei Shen, Jianqi Li, Jian-Ren Liu and Xiaoxia Du

    Citation: The Journal of Headache and Pain 2019 20:93

    Content type: Research article

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  14. Chronic migraine is a disabling condition that is currently underdiagnosed and undertreated. In this narrative review, we discuss the future of chronic migraine management in relation to recent progress in evi...

    Authors: Elio Clemente Agostoni, Piero Barbanti, Paolo Calabresi, Bruno Colombo, Pietro Cortelli, Fabio Frediani, Pietrangelo Geppetti, Licia Grazzi, Massimo Leone, Paolo Martelletti, Luigi Alberto Pini, Maria Pia Prudenzano, Paola Sarchielli, Gioacchino Tedeschi and Antonio Russo

    Citation: The Journal of Headache and Pain 2019 20:92

    Content type: Review article

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  15. Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of...

    Authors: Andrea M. Harriott, Lauren C. Strother, Marta Vila-Pueyo and Philip R. Holland

    Citation: The Journal of Headache and Pain 2019 20:91

    Content type: Review article

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  16. In addition to the increased risk for cardiovascular (CV) disease and CV events associated with migraine, patients with migraine can also present with a number of CV risk factors (CVRFs). Existing treatment op...

    Authors: Robert E. Shapiro, Helen M. Hochstetler, Ellen B. Dennehy, Rashna Khanna, Erin Gautier Doty, Paul H. Berg and Amaal J. Starling

    Citation: The Journal of Headache and Pain 2019 20:90

    Content type: Research article

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  17. Migraine diagnosis is based on clinical aspects and is dependent on the experience of the attending physician. This study aimed to describe the patients journey profile until they start their experience in a t...

    Authors: Mario Fernando Prieto Peres, Diego Belandrino Swerts, Arão Belitardo de Oliveira and Raimundo Pereira Silva-Neto

    Citation: The Journal of Headache and Pain 2019 20:88

    Content type: Research article

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  18. Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear.

    Authors: Junping Cao, Yuan Zhang, Lei Wu, Lidong Shan, Yufang Sun, Xinghong Jiang and Jin Tao

    Citation: The Journal of Headache and Pain 2019 20:87

    Content type: Research article

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  19. Migraine is a common and severely disabling neurological disorder affecting millions of patients in Europe. Despite the availability of evidence-based national and international guidelines, the management of m...

    Authors: Christian Ziegeler, Greta Brauns, Tim P. Jürgens and Arne May

    Citation: The Journal of Headache and Pain 2019 20:86

    Content type: Research article

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  20. Even though migraine and other primary headache disorders are common and debilitating, major health surveys in Brazil have not included them. We repair this omission by combining data on non-communicable disea...

    Authors: Mario Fernando Prieto Peres, Luiz Paulo Queiroz, Pedro Sampaio Rocha-Filho, Elder Machado Sarmento, Zaza Katsarava and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2019 20:85

    Content type: Research article

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  21. To study the efficacy and safety of lasmiditan for acute treatment of migraine in patients using migraine preventive medications.

    Authors: Li Shen Loo, Jessica Ailani, Jack Schim, Simin Baygani, Hans-Peter Hundemer, Martha Port and John H. Krege

    Citation: The Journal of Headache and Pain 2019 20:84

    Content type: Research article

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  22. There is a significant unmet need for new, effective and well tolerated acute migraine treatments. A recent study has demonstrated that a novel remote electrical neuromodulation (REN) treatment provides superi...

    Authors: Alan M. Rapoport, Jo H. Bonner, Tamar Lin, Dagan Harris, Yaron Gruper, Alon Ironi and Robert P. Cowan

    Citation: The Journal of Headache and Pain 2019 20:83

    Content type: Research article

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  23. OnabotulinumtoxinA (BOTOX®, Allergan plc, Dublin, Ireland) is approved for the preventive treatment of headaches in adult patients with chronic migraine (CM) in Australia by the country’s reimbursement mechani...

    Authors: Catherine Stark, Richard Stark, Nicole Limberg, Julian Rodrigues, Dennis Cordato, Raymond Schwartz and Robert Jukic

    Citation: The Journal of Headache and Pain 2019 20:81

    Content type: Research article

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  24. Mouse models of rare monogenic forms of migraine provide a unique experimental system to study the cellular and circuit mechanisms of the primary brain dysfunctions causing a migraine disorder. Here, we discus...

    Authors: Daniela Pietrobon and K. C. Brennan

    Citation: The Journal of Headache and Pain 2019 20:79

    Content type: Review article

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  25. Several studies have investigated white matter with diffusion tensor imaging (DTI) in those suffering from headache, but so far only in clinic based samples and with conflicting results.

    Authors: Andreas Kattem Husøy, Live Eikenes, Asta K. Håberg, Knut Hagen and Lars Jacob Stovner

    Citation: The Journal of Headache and Pain 2019 20:78

    Content type: Research article

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  26. The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other wel...

    Authors: Martin Syvertsen Mykland, Marte Helene Bjørk, Marit Stjern, Petter Moe Omland, Martin Uglem and Trond Sand

    Citation: The Journal of Headache and Pain 2019 20:77

    Content type: Research article

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  27. Patients with high-frequency episodic migraine (HFEM) have a greater disease burden than those with low-frequency episodic migraine (LFEM). Acute treatment overuse increases the risk of migraine chronification...

    Authors: Stephen D. Silberstein, Virginia L. Stauffer, Katie A. Day, Sarah Lipsius and Maria-Carmen Wilson

    Citation: The Journal of Headache and Pain 2019 20:75

    Content type: Research article

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  28. Although migraine is a disabling neurological condition that causes important disability, it remains an area of underdiagnosis and undertreatment worldwide. The aim of this study was to depict the burden of th...

    Authors: Carlo Piccinni, Sabina Cevoli, Giulia Ronconi, Letizia Dondi, Silvia Calabria, Antonella Pedrini, Immacolata Esposito, Valentina Favoni, Giulia Pierangeli, Pietro Cortelli and Nello Martini

    Citation: The Journal of Headache and Pain 2019 20:74

    Content type: Research article

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  29. To assess the quality of the therapeutic approach in Specialized Headache Units in Spain.

    Authors: Patricia Pozo-Rosich, Alba Martínez-García, Julio Pascual, Emilio Ignacio, Ángel L. Guerrero-Peral, José Balseiro-Gómez, Jesús Porta-Etessam, Germán Latorre-González, Almudena Layos-Romero, César Lucas and José J. Mira

    Citation: The Journal of Headache and Pain 2019 20:73

    Content type: Research article

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  30. Migraine is a complex neurovascular disorder with a strong genetic component. There are rare monogenic forms of migraine, as well as more common polygenic forms; research into the genes involved in both types ...

    Authors: Heidi G. Sutherland, Cassie L. Albury and Lyn R. Griffiths

    Citation: The Journal of Headache and Pain 2019 20:72

    Content type: Review article

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  31. Questionnaire-based headache diagnoses should be validated against diagnoses made by the gold standard, which is personal interview by a headache expert. The diagnostic algorithm with the best diagnostic accur...

    Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner and Trond Sand

    Citation: The Journal of Headache and Pain 2019 20:70

    Content type: Research article

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  32. In Japan, detailed information on the characteristics, disease burden, and treatment patterns of people living with migraine is limited. The aim of this study was to compare clinical characteristics, disease b...

    Authors: Kaname Ueda, Wenyu Ye, Louise Lombard, Atsushi Kuga, Yongin Kim, Sarah Cotton, James Jackson and Tamas Treuer

    Citation: The Journal of Headache and Pain 2019 20:68

    Content type: Research article

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  33. Monoclonal antibodies (mAbs) targeting the CGRP pathway are safe and efficacious therapies for the prevention of migraine. In this study we assessed the effects of discontinuation of preventive erenumab and ga...

    Authors: Bianca Raffaelli, Valeria Mussetto, Heike Israel, Lars Neeb and Uwe Reuter

    Citation: The Journal of Headache and Pain 2019 20:66

    Content type: Research article

    Published on:

  34. Migraine is a disabling, chronic neurological disease leading to severe headache episodes affecting 13.2% of the Swedish population. Migraine leads to an extensive socio-economic burden in terms of healthcare ...

    Authors: Frida Hjalte, Sara Olofsson, Ulf Persson and Mattias Linde

    Citation: The Journal of Headache and Pain 2019 20:65

    Content type: Research article

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  35. Migraine aura (MA) is a common and disabling neurological condition, characterized by transient visual, and less frequently sensory and dysphasic aura disturbances.

    Authors: Michele Viana, Erling Andreas Tronvik, Thien Phu Do, Chiara Zecca and Anders Hougaard

    Citation: The Journal of Headache and Pain 2019 20:64

    Content type: Review article

    Published on:

  36. After publication of the original article [1], the authors have notified us that an updated version of Figures 1, 2 and 3 should have been published. The incorrect and revised figures can be found below.

    Authors: Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

    Citation: The Journal of Headache and Pain 2019 20:62

    Content type: Correction

    Published on:

    The original article was published in The Journal of Headache and Pain 2019 20:48

  37. Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migr...

    Authors: Angela Koverech, Claudia Cicione, Luana Lionetto, Marta Maestri, Francesco Passariello, Elisabetta Sabbatini, Matilde Capi, Cristiano Maria De Marco, Martina Guglielmetti, Andrea Negro, Luisa Di Menna, Maurizio Simmaco, Ferdinando Nicoletti and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2019 20:61

    Content type: Research article

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  38. Elevation of intracranial pressure in idiopathic intracranial hypertension induces an edema of the prelaminar section of the optic nerve (papilledema). Beside the commonly observed optic nerve sheath distentio...

    Authors: Jan Hoffmann, Katharina Maria Kreutz, Christoph Csapó-Schmidt, Nils Becker, Hagen Kunte, Lucius Samo Fekonja, Anas Jadan and Edzard Wiener

    Citation: The Journal of Headache and Pain 2019 20:59

    Content type: Research article

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  39. Abstract

    Authors: Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2019 20:58

    Content type: Correction

    Published on:

    The original article was published in The Journal of Headache and Pain 2019 20:6

    The Letter to the Editor to this article has been published in The Journal of Headache and Pain 2019 20:67

    The Letter to the Editor to this article has been published in The Journal of Headache and Pain 2019 20:22

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