Skip to main content

Celebrating 25 years of The Journal of Headache and Pain

This year marks the 25th anniversary of The Journal of Headache and Pain

After receiving its first Impact Factor in 2008, it has developed into one of the leading fully open-access journals in its field.

To kick off our celebrations, please enjoy this blog and video from the Editor-in-Chief, Paolo Martelletti, reflecting on the journal's inception and the contributions of scientists from around the world that have made the journal into what it is today.

New Content Item

Call for papers

Endogenous Treatments for Migraine Pain

Edited by: Adriana Della Pietra and Andrew Russo

This collection aims to provide a better understanding of the basic molecular mechanisms of endogenous pain management. This may lead to better and/or alternative migraine pain treatments based on an enhancement of endogenous analgesic systems. 

Headache Burden in Children and Adolescents

Edited by: Marco Antônio Arruda and Timothy J. Steiner

This series will embrace estimates from worldwide of headache-attributed burden, studies characterising the headache disorders of childhood and their evolution throughout adolescence (especially longitudinal cohort studies), those providing insights into the diagnostic uncertainties of child and adolescent headache, and those proposing or evaluating systems of care for child and adolescent headache.

Spreading Depolarization in Headache Disorders

Edited by: Shih Pin Chen and Cenk Ayata

This new collection in The Journal of Headache and Pain invites researchers, clinicians, and academicians to discuss spreading depolarization, exploring its mechanisms, relevance, and implications in both primary and secondary neurological disorders.

Vascular Triggers of Headache Disorders

Edited by: Shih Pin Chen and Cenk Ayata

The Journal of Headache and Pain invites submissions on the interplay between vascular mechanisms and headache, particularly migraine, to our new Collection: Vascular Triggers of Headache.

Gender-Specific Aspects of Headache

Edited by: Antoinette Maassen van den Brink and Bianca Raffaelli

The Journal of Headache and Pain is calling for submissions to our Collection on Gender-Specific Aspects of Headache. This collection aims to explore the multifaceted relationship between gender (as well as biological sex) and headache, encompassing both biological and socio-cultural dimensions.

Neuroimmune Interplay in Headache

Edited by Gregory Dussor and Kristian Agmund Haanes

The Journal of Headache and Pain invites participating authors to submit their manuscripts to our Collection on Neuroimmune Interplay in Headache. This collection will explore the latest research on the molecular and cellular mechanisms of migraine-associated neuroimmune interplay, as well as the clinical implications of these findings.

One Health for Headache

Edited by Dr. Matilde Leonardi and Dr. Paolo Martelletti
The Journal of Headache and Pain is calling for submissions to our Collection on One Health for Headache. This Collection aims to create a cross-disciplinary space for those working within and across clinical, social, and public health paradigms to address and reduce the burden of headache globally and reduce disability from this major non-communicable disease.

Chronic Headaches and Medication Overuse

Edited by Dr. Gianluca Coppola
The Journal of Headache and Pain invites participating authors to submit to our Collection on Chronic Headaches and Medication Overuse. This thematic series intends to approach chronic headache and symptom overuse from a broad and multidisciplinary perspective centred on these and other unanswered concerns. 

Article collections

Click here to see the article collections and thematic series that the journal has published in recent years.

Behind the Paper

The story behind a simple idea: rethinking headache care as a way to improve population health globally

New Content Item (5)

In this blog, author Alberto Raggi discusses the process of compiling a recently published review in The Journal of Headache and Pain. The review asks, in an era of a changing landscape in global population health, if improving the overall health of people suffering from headache disorders will be a feasible way to improve global population health.

Aims and scope

The Journal of Headache and Pain is a peer-reviewed open access journal specifically dedicated to researchers involved in all aspects of headache and related pain syndromes, including epidemiology, public health, basic science, translational medicine, clinical trials and real-world data. With a multidisciplinary perspective, The Journal of Headache and Pain covers headache medicine and related pain syndromes in all medical disciplines and particularly encourages clinical, translational and basic science submissions in the areas of pain management, genetics, neurology and internal medicine. Read more


  1. Authors: Claudio Tana, Enrico Bentivegna, Soo-Jin Cho, Andrea M. Harriott, David García-Azorín, Alejandro Labastida-Ramirez, Raffaele Ornello, Bianca Raffaelli, Eloísa Rubio Beltrán, Ruth Ruscheweyh and Paolo Martelletti

Top cited articles 2021-2022

Review article | 12 April 2022
The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates December 2020
Lars Jacob Stovner, Knut Hagen, Mattias Linde & Timothy J. Steiner

Consensus article | 11 June 2022
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention-2022 update
Simona Sacco, Faisal Mohammad Amin, Messoud Ashina, Lars Bendtsen, Christina I. Deligianni, Raquel Gil-Gouveia, Zaza Katsarava, Antoinette MaassenVanDenBrink, Paolo Martelletti, Dimos-Dimitrios Mitsikostas, Raffaele Ornello, Uwe Reuter, Margarita Sanchez-del-Rio, Alexandra J. Sinclair, Gisela Terwindt, Derya Uluduz, Jan Versijpt & Christian Lampl 

Review article | 10 June 2021
Migraine and neuroinflammation: the inflammasome perspective
Oguzhan Kursun, Muge Yemisci, Arn M. J. M. van den Maagdenberg & Hulya Karatas 

Research article | 3 May 2021
Galcanezumab for the prevention of high frequency episodic and chronic migraine in real life in Italy: a multicenter prospective cohort study (the GARLIT study)
Fabrizio Vernieri, Claudia Altamura, Nicoletta Brunelli, Carmelina Maria Costa, Cinzia Aurilia, Gabriella Egeo, Luisa Fofi, Valentina Favoni, Giulia Pierangeli, Carlo Lovati, Marco Aguggia, Florindo d’Onofrio, Alberto Doretti, Paola Di Fiore, Cinzia Finocchi, Renata Rao, Francesco Bono, Angelo Ranieri, Maria Albanese, Sabina Cevoli & Piero Barbanti for the GARLIT Study Group

Review article | 14 July 2021
Comorbidities of primary headache disorders: a literature review with meta-analysis
Valeria Caponnetto, Manuela Deodato, Micaela Robotti, Maria Koutsokera, Valeria Pozzilli, Cristina Galati, Giovanna Nocera, Eleonora De Matteis, Gioacchino De Vanna, Emanuela Fellini, Gleni Halili, Daniele Martinelli, Gabriele Nalli, Serena Serratore, Irene Tramacere, Paolo Martelletti & Alberto Raggi On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)

Research article | 25 October 2021
CGRP monoclonal antibodies in migraine: an efficacy and tolerability comparison with standard prophylactic drugs
Fenne Vandervorst, Laura Van Deun, Annelies Van Dycke, Koen Paemeleire, Uwe Reuter, Jean Schoenen & Jan Versijpt 

Review article | 1 August 2022
Long COVID headache
Claudio Tana, Enrico Bentivegna, Soo-Jin Cho, Andrea M. Harriott, David García-Azorín, Alejandro Labastida-Ramirez, Raffaele Ornello, Bianca Raffaelli, Eloísa Rubio Beltrán, Ruth Ruscheweyh & Paolo Martelletti 

Research article | 21 April 2021
Disability, quality of life, productivity impairment and employer costs of migraine in the workplace
Toshihiko Shimizu, Fumihiko Sakai, Hitoshi Miyake, Tomofumi Sone, Mitsuhiro Sato, Satoshi Tanabe, Yasuhiro Azuma & David W. Dodick 

Short Report | 7 October 2021
Anti-CGRP monoclonal antibodies in chronic migraine with medication overuse: real-life effectiveness and predictors of response at 6 months
Edoardo Caronna, Victor José Gallardo, Alicia Alpuente, Marta Torres-Ferrus & Patricia Pozo-Rosich 

Research article | 3 January 2022
IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine
Hao Chen, Xueqian Tang, Jin Li, Bangyan Hu, Wenqin Yang, Meng Zhan, Tengyun Ma & Shijun Xu 

Publication years: 2021-2022
Source: Web of Science, data collected: January 2024

Trending articles

Click here to view which articles were talked about the most last month!

Editorial Board spotlight

Adriana Della Pietra, PhD, is a Postdoctoral researcher at University of Iowa, in the Carver College of Medicine, Iowa City, USA.

She completed her PhD in 2023 in the University of Eastern Finland, A.I. Virtanen Institute, Kuopio. Her research focused on unraveling the intricate migraine pain mechanisms via electrophysiological and chemoproteomic techniques. In particular, she examined the pro-nociceptive role of mechanosensitive Piezo1 channels within the trigeminovascular system implicated in migraine pain. Additionally, she explored the therapeutic anti-nociceptive potential of the endocannabinoid system to reduce migraine pain, promoting endogenous analgesia.

More recently, her work with Prof. Andrew Russo investigates the connection between mild traumatic brain injury, post-traumatic headache (PTH), and sleep disruption, proposing that impaired glymphatic system function contributes to PTH symptoms.

She is serving as a Guest Editor of the recently launched collection Endogenous Treatments for Migraine Pain.

New Content Item

From the Junior Editorial Board

Read the reviews on Health equity, care access and quality in headache- Part 1 and Part 2 here!

New Content Item

Visual Abstracts

The Journal of Headache and Pain encourages authors to submit a visual abstract as a supplementary file along with their manuscripts. 

As an author submitting at The Journal of Headache and Pain you are entitled to a 20% discount on professionally produced visual abstracts. Click here to find out more about the service, and your discount will be automatically applied when using this link.

Read More

Exploring SDG3: Good Health and Wellbeing

Collaborative evidence-based approaches to public policy and healthcare policy and practice are essential, not only in addressing inequalities but also in building trusted sustainable ways forward in which to ensure good health and wellbeing for all. The Journal of Headache and Pain supports submissions that address the SDG3 targets and indicators.

Read More

Training Course in HEADACHES

New Content Item (5)

UnitelmaSapienza announces a new online Training Course for graduate healthcare professionals interested in headaches. 

- Public Health Priorities
- Biopsychosocial Burden
- Economic Problems and Barriers to Treatment
- WHOiGAP Global Action Plan on Neurological Disorders
- Sustainable Development Goal SDG3 as a Pillar of Education

40 free scholarships are available on a first-come first-served basis for registrants from Low or Medium Income Countries (according to World Bank parameters). 

For more information, or to register for the course, click here.    

European Headache Federation School of Advanced Studies

The European HeadacheFederation School of Advanced Studies (EHF-SAS) aims to support headache science and offers young EU scientists high quality educational activities to enhance their critical spirit and skills to face headache medicine from a multidisciplinary perspective.

The EHF-SAS covers the richness and diversity of headache medicine fields, including basic science, clinical science, and diagnostic science, and places an emphasis on collaborative projects. The European Headache Federation will support its fellows’ activities allowing them to independently build their own plan sided by the EHF-SAS Scientific Committee.