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Aims and Scope - now also encouraging basic science submissions

The Journal of Headache and Pain is a peer-reviewed open access journal published under the brand BMC, part of Springer Nature. It is specifically dedicated to researchers involved in all aspects of headache and related pain syndromes, including epidemiology, public health, basic science, translational medicine, clinical trials and real-world data.

With a multidisciplinary perspective, The Journal of Headache and Pain covers headache medicine and related pain syndromes in all medical disciplines and particularly encourages clinical, translational and basic science submissions in the areas of pain management, genetics, neurology and internal medicine. The Journal publishes research articles, reviews, letters to the Editor as well as consensus articles and guidelines, which promote best practice in the management of patients with  headaches and related pain.


  1. Authors: Soodeh Razeghi Jahromi, Zeinab Ghorbani, Paolo Martelletti, Christian Lampl and Mansoureh Togha

    Content type: Review article

  1. Authors: Giorgio Lambru, Sarah Miller and Manjit S Matharu

    Content type: Review article

Most mentioned in 2018

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort
Baron EP., Lucas P. and Hogue O. 

Migraine is first cause of disability in under 50s: will health politicians now take notice?
Steiner TJ., Stovner LJ., Vos T., Jensen R. and Katsarava Z.

Factors associated with acute medication overuse in people with migraine: results from the 2017 migraine in America symptoms and treatment (MAST) study
Schwedt TJ, Alam A., Reed ML., Fanning KM., Munjal S. et al.

Medication-overuse headache: a widely recognized entity amidst ongoing debate
Vandenbussche N., Laterza D., Lisicki M., Lloyd J., Lupi C. et al.

The association between migraine and physical exercise
Amin FM., Aristeidou S., Baraldi C., Czapinska-Ciepiela EK., Ariadni DD. et al.

PACAP38 and PAC1 receptor blockade: a new target for headache?
Rubio-Beltrán E., Correnti E., Deen M., Kaam K., Kelderman T. et al.

Pituitary adenylate-cyclase-activating polypeptide (PACAP): another novel target for treatment of primary headaches?
Ashina M., and Martelletti P.

Altered muscle activity during rest and during mental or physical activity is not a trait symptom of migraine - a neck muscle EMG study
Leudtke K., Mehnert J. and May A.

My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed
Martelletti P., Schwedt TJ., Lanteri-Minet M., Quintana R., Carboni V. et al.

Migraine and cluster headache – the common link
Vollesen AL., Benemei S., Cortese F., Labastida-Ramírez A., Marchese F. et al.

(Publication year 2018. Data collected February 2019. Source: Altmetric)

Top cited 2016-2017

Interictal burden attributable to episodic headache: findings from the Eurolight project
Lampl C., Thomas H., Stovner LJ., Tassorelli C., Katsarava Z. et al. 

GBD 2015: migraine is the third cause of disability in under 50s
Steiner TJ., Stovner LJ. And Vos T.

Impact of migraine on fibromyalgia symptoms
Giamberardino MA., Affaitati G., Martelletti P., Tana C., Negro, A. et al.

Release of PACAP-38 in episodic cluster headache patients - an exploratory study
Tuka B., Szabó N., Tóth E., Kincses ZT., Párdutz Á. et al.

Calcitonin gene-related peptide and pain: a systematic review
Schou WS., Ashina S., Amin FM., Goadsby PJ. and Ashina M.

Altered kynurenine pathway metabolites in serum of chronic migraine patients
Curto M., Lionetto L., Negro A., Capi M., Fazio F. et al.

The burden of headache disorders in Nepal: estimates from a population-based survey
Manandhar K., Risal A., Linde M. and Steiner TJ.

Headache, depression and anxiety: associations in the Eurolight project
Lampl C., Thomas H., Tassorelli C., Katsarava Z., Miguel Laínez J. et al.

Therapeutic efficacy and safety of Botulinum Toxin A Therapy in Trigeminal Neuralgia: a systematic review and meta-analysis of randomized controlled trials
Morra ME., Elgebaly A., Elmaraezy A., Khalil, AM., Altibi AMA. et al.

Blocking CGRP in migraine patients - a review of pros and cons
Deen M., Correnti E., Kamm K., Kelderman T., Papetti L. et al.

Oxidative stress and DNA damage in patients with migraine
Geyik S., Altunisik E., Neyal AM. and Taysi S.

Altered serum levels of kynurenine metabolites in patients affected by cluster headache
Curto M., Lionetto L., Negro A., Capi M., Perugino F. et al.

European headache federation consensus on technical investigation for primary headache disorders
Mitsikostas DD., Ashina M., Craven A., Diener HC., Goadsby PJ. et al.

Cost-effectiveness analysis of non-invasive vagus nerve stimulation for the treatment of chronic cluster headache
Morris J., Straube A., Diener H-C., Ahmed F., Silver N. et al.

Clinically relevant behavioral endpoints in a recurrent nitroglycerin migraine model in rats
Sufka K., Staszko SM., Johnson AP., Davis ME., Davis RE. et al.

Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up
Grazzi L., Sansone E., Raggi A., D'Amico D., De Giorgio A. et al.

The efficiency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache
Pihut M., Ferendiuk E., Szewczyk M., Kasprzyk K. and Wieckiewicz M.

Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study
Grazzi L., Egeo G., Calhoun AH., McClure CK., Liebler E. et al.

Altered effective connectivity of posterior thalamus in migraine with cutaneous allodynia: a resting-state fMRI study with granger causality analysis
Wang T., Chen N., Zhan W., Liu J., Zhang J. et al.

The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis
Hou M., Xing H., Cai Y., Li B., Wang X. et al.

(Publication years 2016-2017). Data collected February 2019. Source: Web of Science)

European Headache Federation School of Advanced Studies

The European Headache Federation School of Advanced Studies (EHF-SAS) aims to support headache science and offers young EU scientists high quality educational activities to enhance their critical spirit and skills to face headache medicine from a multidisciplinary perspective.

The EHF-SAS covers the richness and diversity of headache medicine fields, including basic science, clinical science, and diagnostic science, and places an emphasis on collaborative projects. The European Headache Federation will support its fellows’ activities allowing them to independently build their own plan sided by the EHF-SAS Scientific Committee.

Editorial Office

Editor in Chief (Founding) 
Paolo Martelletti, MD, 
Department of Clinical and Molecular Medicine
Sapienza University of Rome 
Via di Grottarossa 1035 
I-00189 Rome, Italy 
Tel.: +39-06-33775111 
Fax: +39-06-33775110 

Assistant to the Editor: Valerio De Angelis 

Thematic Series

Animal models in headache research

​​​​​​​Edited by Dr Cenk Ayata and Dr Andrea M. Harriott

Open to submissions

The changing face of migraine

Edited by Prof Messoud Ashina, Prof Lars Edvinsson and Prof Paolo Martelletti

Migraine Aura - Current understanding and future perspectives

Edited by Dr Anders Hougaard, Prof Paolo Martelletti and Dr Michele Viana

Open to submissions

Hot topics in headache and pain from the EHF-SAS

Edited by Prof Paolo Martelletti 

Editorial Board Spotlight

Prof Dawn C. Buse PhD is a Clinical Professor of Neurology at Albert Einstein College of Medicine in New York City, an Assistant Professor in the Clinical Health Psychology Doctoral Program of Ferkauf Graduate School of Psychology, a licensed psychologist and is a member of the American Headache Society (AHS) Board of Directors.

Dr. Buse conducts research on migraine, pain and stress among other chronic conditions and is a co-investigator on the American Migraine Prevalence and Prevention (AMPP) Study, the Chronic Migraine Epidemiology and Outcomes (CAMEO) Study, the International Burden of Migraine (IBMS) Study, Migraine Signature Study (MSS) and the Migraine, Symptoms and Treatment in America (MAST) Study. Her research has won six national and international research awards and she has received professional awards from the American Headache Society and National Headache Foundation.

Academic education in headache

The demand for a broad, complete and independent education in Headache Disorders has increased over time. The following international Masters courses guarantee a full coverage of this area of clinical medicine.

For more information:

Master in Headache Medicine - 17th Edition
Academic Year 2019-2020

Master of Headache Disorders - 2nd Edition
Academic Years 2018-2020


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