The Journal of Headache and Pain

Featured Articles: December, 2022

December 2022 Featured Article Left Image

CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine

Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex

Call for papers

Real-world evidence of emerging therapies in headache

New Content Item Edited by: Shuu-Jiun Wang and Michel Lanteri-Minet

The aim of this thematic series is to collect high quality real-world data within the headache field. Read more about the scope of the series and contribute with your own research and review articles.

Molecular interactions in migraine

Edit New Content Item ed by Rashid Giniatullin

The aim of this thematic series is to highlight the complexity of molecular mechanisms underlying different types of migraine.

Article collections

Click here to see the article collections and thematic series that the journal has published in recent years.

Visual Abstracts

The Journal of Headache and Pain encourages authors to submit a visual abstract along with their manuscripts.

As an author submitting at The Journal of Headache and Pain you are entitled to a 20% discount on professionally produced visual abstracts. Click here to find out more about the service, and your discount will be automatically applied when using this link.

Medium-term real-world data for erenumab in 177 treatment resistant or difficult to treat chronic migraine patients: persistence and patient reported outcome measures after 17–30 months

Authors: Emma Troy, Arif A. Shrukalla, Alina Buture, Katie Conaty, Esther Macken, Roisin Lonergan, Jane Melling, Niamh Long, Eamonn Shaikh, Kieran Birrane, Esther M. Tomkins, Peter J. Goadsby and Martin H. Ruttledge

Content type: Research 16 January 2023
MARS1 mutations linked to familial trigeminal neuralgia via the integrated stress response

Authors: Anni Wang, Zimu Song, Xu Zhang, LiFei Xiao, Yan Feng, Chong Qi, Guohuan Zhang, Jinbo Bai, Yang Liu, Tao Sun, Fangang Meng and Feng Wang

Content type: Research 14 January 2023
Migraine attacks are of peripheral origin: the debate goes on

Authors: Thien Phu Do, Anders Hougaard, Greg Dussor, K. C. Brennan and Faisal Mohammad Amin

Content type: Review 10 January 2023
Sphenopalatine ganglion volumetry in episodic cluster headache: from symptom laterality to cranial autonomic symptoms

Authors: Jr-Wei Wu, Shu-Ting Chen, Yen-Feng Wang, Kuan-Lin Lai, Ting-Yi Chen, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang

Content type: Research 3 January 2023
Role of ATP in migraine mechanisms: focus on P2X3 receptors

Authors: R. Giniatullin and A. Nistri

Content type: Review 3 January 2023

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Headache in transient ischemic attacks

Authors: Elena R. Lebedeva, Natalia M. Gurary and Jes Olesen

Content type: Research article 27 July 2018
Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis

Authors: David García-Azorín, Thien Phu Do, Andreas R. Gantenbein, Jakob Møller Hansen, Marcio Nattan P. Souza, Mark Obermann, Heiko Pohl, Christoph J. Schankin, Henrik Winther Schytz, Alexandra Sinclair, Guus G. Schoonman and Espen Saxhaug Kristoffersen

Content type: Short report 17 September 2021
Headache characteristics in COVID-19 pandemic-a survey study

Authors: Özge Uygun, Mustafa Ertaş, Esme Ekizoğlu, Hayrunnisa Bolay, Aynur Özge, Elif Kocasoy Orhan, Arif Atahan Çağatay and Betül Baykan

Content type: Research article 13 October 2020
Long COVID headache

Authors: Claudio Tana, Enrico Bentivegna, Soo-Jin Cho, Andrea M. Harriott, David García-Azorín, Alejandro Labastida-Ramirez, Raffaele Ornello, Bianca Raffaelli, Eloísa Rubio Beltrán, Ruth Ruscheweyh and Paolo Martelletti

Content type: Review 1 August 2022
Headache medication and the COVID-19 pandemic

Authors: Antoinette MaassenVanDenBrink, Tessa de Vries and A. H. Jan Danser

Content type: Commentary 25 April 2020

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_{Consensus article | 16 January 2019}
European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention
_{Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti}

^{Consensus article | 21 May 2019}
Aids to management of headache disorders in primary care (2nd edition)
_{on behalf of the European Headache Federation and Lifting The Burden: the Global Campaign against Headache
T. J. Steiner, R. Jensen, Z. Katsarava, M. Linde, E. A. MacGregor, V. Osipova, K. Paemeleire, J. Olesen, M. Peters & P. Martelletti}

_{Review article | 25 April 2019}
A narrative review on the burden of migraine: when the burden is the impact on people’s life
_{Matilde Leonardi & Alberto Raggi}

_{Research article | 07 April 2020}
Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy
_{Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia & Simona Sacco}

_{Review article | 09 May 2019}
Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications
_{Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello & Gianluca Serafini on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)}

_{Review article | 13 February 2020}
Gut-brain Axis and migraine headache: a comprehensive review
_{Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco & Mansoureh Togha On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)}

_{Review article | 30 August 2019}
Current and emerging evidence-based treatment options in chronic migraine: a narrative review
_{Elio Clemente Agostoni, Piero Barbanti, Paolo Calabresi, Bruno Colombo, Pietro Cortelli, Fabio Frediani, Pietrangelo Geppetti, Licia Grazzi, Massimo Leone, Paolo Martelletti, Luigi Alberto Pini, Maria Pia Prudenzano, Paola Sarchielli, Gioacchino Tedeschi, Antonio Russo & The Italian chronic migraine group}

_{Editorial | 02 December 2020}
Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019
_{T. J. Steiner, L. J. Stovner, R. Jensen, D. Uluduz & Z. Katsarava on behalf of Lifting The Burden: the Global Campaign against Headache}

_{Review article | 17 April 2019}
Therapeutic novelties in migraine: new drugs, new hope?
_{Thien Phu Do, Song Guo & Messoud Ashina}

_{Research article | 29 July 2020}
Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study
_{Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente, Juan Francisco Arenillas & Ángel L. Guerrero}

_{Research article | 01 June 2020}
A prospective real-world analysis of erenumab in refractory chronic migraine
_{Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova & Anna P. Andreou}

_{Publication years: 2019-2020
Source: Web of Science, data collected: February 2022}

Recent blogs

Headache after vaccination against COVID-19

01 April 2022
A questionnaire to measure the impact of cluster headaches

17 March 2022
Migraine food triggers and the vicious cycle of painkillers

14 March 2022

New collection: Debates on Migraine

Debates Editors: Messoud Ashina and Paolo Martelletti

Migraine pathophysiology is complex and many unanswered questions remain regarding the pathogenesis of migraine. Debates on complex scientific questions are important because they stimulate critical thinking and future directions. In a series of Oxford Union-style debates (for or against the motion), three topics were discussed at the 1st International Conference on Advances in Migraine Sciences (ICAMS 2022) held in Copenhagen, Denmark. In this Series, we present key data for or against these motions, summarise lessons learned and provide future direction. For each individual review article, there is a video recording of the debate itself and a visual abstract.

First Springer Nature AI-generated book in medicine now available!

The book Migraine in Medicine edited by Paolo Martelletti is now available. This is the first Springer Nature AI-generated book in medicine. Read more…

European Headache Federation School of Advanced Studies

The European HeadacheFederation School of Advanced Studies (EHF-SAS) aims to support headache science and offers young EU scientists high quality educational activities to enhance their critical spirit and skills to face headache medicine from a multidisciplinary perspective.

The EHF-SAS covers the richness and diversity of headache medicine fields, including basic science, clinical science, and diagnostic science, and places an emphasis on collaborative projects. The European Headache Federation will support its fellows’ activities allowing them to independently build their own plan sided by the EHF-SAS Scientific Committee.

Aims and scope

The Journal of Headache and Pain is a peer-reviewed open access journal specifically dedicated to researchers involved in all aspects of headache and related pain syndromes, including epidemiology, public health, basic science, translational medicine, clinical trials and real-world data. With a multidisciplinary perspective, The Journal of Headache and Pain covers headache medicine and related pain syndromes in all medical disciplines and particularly encourages clinical, translational and basic science submissions in the areas of pain management, genetics, neurology and internal medicine. Read more.

Editorial Board Spotlight

New Content Item Dr. Pravin Thomas is a headache neurologist and leads the headache and facial pain program at Narayana Health, India. He is also a teaching fellow at Queen Square Institute of Neurology, University College London. His special interests include classifications in headache medicine, development and deployment of headache medicine distance learning modules.