Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

CACNA1A gene mutations in familial hemiplegic migraine


Familial hemiplegic migraine (FHM) is an autosomal dominant subtpye of migraine with aura. A few years ago, the gene linked to FHM was identified. CACNA1A encodes a voltage-activated, pore-forming α1A subunit of the P/Q-type calcium channel. At present, an increasing number of mutations have been identified in this gene in patients with FHM. Genotype-phenotype comparisons have become feasible only recently. The in vitro functional consequences on channel function of the first mutations have been deciphered. This is the moment to evaluate these recent discoveries and see how they can help us understant the pathophysiology of FHM and the common forms of migraine.

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

van den Maagdenberg, A., Striessnig, J., Ferrari, M. et al. CACNA1A gene mutations in familial hemiplegic migraine. J Headache Pain 1, S121–S128 (2000).

Download citation

  • Key words FHM
  • Migraine
  • Calcium channel
  • CACNA1A gene


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.