Skip to content

Advertisement

  • Open Access

CACNA1A gene mutations in familial hemiplegic migraine

  • ,
  • ,
  • and
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S121.10194

https://doi.org/10.1007/s101940070005

Abstract

Familial hemiplegic migraine (FHM) is an autosomal dominant subtpye of migraine with aura. A few years ago, the gene linked to FHM was identified. CACNA1A encodes a voltage-activated, pore-forming α1A subunit of the P/Q-type calcium channel. At present, an increasing number of mutations have been identified in this gene in patients with FHM. Genotype-phenotype comparisons have become feasible only recently. The in vitro functional consequences on channel function of the first mutations have been deciphered. This is the moment to evaluate these recent discoveries and see how they can help us understant the pathophysiology of FHM and the common forms of migraine.

  • Key words FHM
  • Migraine
  • Calcium channel
  • CACNA1A gene

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.

Advertisement