- Open Access
The circadian clock in mammals
© Springer-Verlag Italia 2005
The original article was published in The Journal of Headache and Pain 2000 1:103
The basic physiological and anatomical basis for circadian rhythms in mammalian behaviour and physiology is introduced. The pathways involved in photic entrainment of the circadian clock are discussed in relation of new findings that identify the molecules that are involved in signalling between the environment and the clock. The molecular basis of endogenous cycles is described in the mouse, and compared to the mechanism that is present in the fly. Finally we speculate on the relationship between circadian physiology and pain.