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  • Open Access

Migraine comorbidity: from genotype to phenotype

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The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S115.10194

https://doi.org/10.1007/s101940070004

Abstract

In this paper, we review the “current” and “ancient” concepts of comorbidity in migraine attack and disease. We emphasize the role of migraine as a complex disease and stress the appropriate consideration that genetic determinants require in modern taxonomy of migraine headaches. Novel attempts to revise migraine nosography should consider the complexity of genotype-phenotype-environment interactions in order to identify more rational approaches to treatment.

  • Key words Channelopathy
  • Comorbidity
  • Genotype
  • Heterogeneity
  • Migraine
  • Phenotype

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