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Migraine comorbidity: from genotype to phenotype
The Journal of Headache and Pain volume 1, pagesS115–S120(2000)
In this paper, we review the “current” and “ancient” concepts of comorbidity in migraine attack and disease. We emphasize the role of migraine as a complex disease and stress the appropriate consideration that genetic determinants require in modern taxonomy of migraine headaches. Novel attempts to revise migraine nosography should consider the complexity of genotype-phenotype-environment interactions in order to identify more rational approaches to treatment.
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Nappi, G., Costa, A., Fortini, D. et al. Migraine comorbidity: from genotype to phenotype. J Headache Pain 1, S115–S120 (2000). https://doi.org/10.1007/s101940070004
- Key words Channelopathy