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Migraine comorbidity: from genotype to phenotype


In this paper, we review the “current” and “ancient” concepts of comorbidity in migraine attack and disease. We emphasize the role of migraine as a complex disease and stress the appropriate consideration that genetic determinants require in modern taxonomy of migraine headaches. Novel attempts to revise migraine nosography should consider the complexity of genotype-phenotype-environment interactions in order to identify more rational approaches to treatment.

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Nappi, G., Costa, A., Fortini, D. et al. Migraine comorbidity: from genotype to phenotype. J Headache Pain 1 (Suppl 2), S115–S120 (2000).

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