Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Migraine comorbidity: from genotype to phenotype


In this paper, we review the “current” and “ancient” concepts of comorbidity in migraine attack and disease. We emphasize the role of migraine as a complex disease and stress the appropriate consideration that genetic determinants require in modern taxonomy of migraine headaches. Novel attempts to revise migraine nosography should consider the complexity of genotype-phenotype-environment interactions in order to identify more rational approaches to treatment.

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nappi, G., Costa, A., Fortini, D. et al. Migraine comorbidity: from genotype to phenotype. J Headache Pain 1, S115–S120 (2000).

Download citation

  • Key words Channelopathy
  • Comorbidity
  • Genotype
  • Heterogeneity
  • Migraine
  • Phenotype


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.