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Prothrombotic genetic risk factors in chronic daily headache


The aetiology of chronic daily or near-daily headache (CDH) is unknown. We evaluated prothrombotic genetic risk factors (factor V G1691A, factor II 20210 G/A, methylenetetrahydrofolate reductase mutations and plasminogen activator inhibitor-1 4G/5G polymorphism) in 100 patients with CDH, and in 73 healthy controls. Patients did not differ from controls for the studied prothrombotic polymorphisms. These findings suggest that prothrombotic genetic risk factors do not play a role in the development of CDH.

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Bono, F., De Marco, E., Lucisano, A. et al. Prothrombotic genetic risk factors in chronic daily headache. J Headache Pain 1, S183–S185 (2000).

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  • Key words Chronic daily headache
  • Hemostasis
  • Genetic risk factors


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