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  1. Post-traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI). Patients at risk to develop acute PTH (aPTH) and further persistent PTH (pPTH) need to be recognized.

    Authors: Yvonn Kraemer, Kaisa Mäki, Ivan Marinkovic, Taina Nybo, Harri Isokuortti, Antti Huovinen, Antti Korvenoja, Susanna Melkas and Hanna Harno
    Citation: The Journal of Headache and Pain 2022 23:27
    Content type: Research article Published on:

  2. 5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migrain...

    Authors: Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip V. Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson and Kristian A. Haanes
    Citation: The Journal of Headache and Pain 2022 23:26
    Content type: Research article Published on:

  3. Central sensitization is an important pathophysiological mechanism of chronic migraine (CM), and microglia activation in trigeminocervical complex (TCC) contributes to the development of central sensitization....

    Authors: Qi Pan, Yunfeng Wang, Ruimin Tian, Qianwen Wen, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang and Jiying Zhou
    Citation: The Journal of Headache and Pain 2022 23:25
    Content type: Research article Published on:

  4. Early onset of action has become recognized as an important efficacy feature of preventive migraine treatment, which can help overcome adherence issues commonly associated with older medications. Preventive tr...

    Authors: Takao Takeshima, Masami Nakai, Yoshiyuki Shibasaki, Miki Ishida, Byung-Kun Kim, Xiaoping Ning and Nobuyuki Koga
    Citation: The Journal of Headache and Pain 2022 23:24
    Content type: Research article Published on:

  5. PROMISE-1 and PROMISE-2 evaluated the preventive efficacy, tolerability, and safety of eptinezumab, a calcitonin gene-related peptide–targeted monoclonal antibody, in adults with episodic (EM) and chronic migr...

    Authors: Richard B. Lipton, Larry Charleston IV, Cristina Tassorelli, Thomas Brevig, Joe Hirman and Roger Cady
    Citation: The Journal of Headache and Pain 2022 23:23
    Content type: Research article Published on:

  6. Demonstrating therapeutic value from the patient perspective is important in patient-centered migraine management. The objective of this study was to investigate the impact of eptinezumab, a preventive migrain...

    Authors: Peter McAllister, Paul K. Winner, Jessica Ailani, Dawn C. Buse, Richard B. Lipton, George Chakhava, Mette Krog Josiassen, Annika Lindsten, Lahar Mehta, Anders Ettrup and Roger Cady
    Citation: The Journal of Headache and Pain 2022 23:22
    Content type: Research article Published on:

  7. Migraine has complex pathophysiological characteristics and episodic attacks. To decipher the cyclic neurophysiological features of migraine attacks, in this study, we compared neuronal excitability in the bra...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Li-Ling Hope Pan, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Gianluca Coppola and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2022 23:21
    Content type: Research article Published on:

  8. Angiography headache (AH) is common but not negligible, and the criteria for AH have been based on only a few studies. The purpose of this study was to investigate the incidence, risk factors and possible mech...

    Authors: Chenglong Lu, Leyi Zhang, Jun Wang, Xiangyu Cao, Xin Jia, Xiaohui Ma, Ran Zhang, Lin Wang, Ying Yang, Fanchao Meng, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2022 23:20
    Content type: Research article Published on:

  9. Migraine is a common neurovascular disorder that has a severe impact on the individual daily life. Atogepant (AGN-241689) is an orally ingested, small-molecule drugs belonging to calcitonin gene-related peptid...

    Authors: Xinyu Tao, Zeya Yan, Jiahao Meng, Wei Wang, Qiling Dai, Qiufeng Zhou, Zhifeng Wang and Zhong Wang
    Citation: The Journal of Headache and Pain 2022 23:19
    Content type: Research article Published on:

  10. Whilst cranial autonomic symptoms (CAS) are typically associated with trigeminal autonomic cephalalgias (TAC’s), they have also been reported in migraine. Identification and understanding of these symptoms in ...

    Authors: Nazia Karsan, Karthik Nagaraj and Peter J. Goadsby
    Citation: The Journal of Headache and Pain 2022 23:18
    Content type: Research article Published on:

  12. Migraine is a ubiquitous neurologic disease that afflicts people of all ages. Its molecular pathogenesis involves peptides that promote intracranial vasodilation and modulate nociceptive transmission upon rele...

    Authors: Astrid Wiggers, Håkan Ashina, Nouchine Hadjikhani, Abhay Sagare, Berislav V. Zlokovic, Martin Lauritzen and Messoud Ashina
    Citation: The Journal of Headache and Pain 2022 23:16
    Content type: Review article Published on:

  13. As the relay centre for processing sensory information, the thalamus may involve in the abnormal sensory procedure caused by cortical spreading depression (CSD). However, few studies have focused on the transi...

    Authors: Xiaoxi Fu, Ming Chen, Jinling Lu and Pengcheng Li
    Citation: The Journal of Headache and Pain 2022 23:15
    Content type: Research article Published on:

  14. Few prospective population-based studies have evaluated the bidirectional relationship between headache and affective disorder. The aim of this large-scale population-based follow-up study was to investigate w...

    Authors: Samita Giri, Erling Andreas Tronvik and Knut Hagen
    Citation: The Journal of Headache and Pain 2022 23:14
    Content type: Research article Published on:

  15. After the initiation of the COVID-19 vaccination program in Thailand, thousands of patients have experienced unusual focal neurological symptoms. We report 8 patients with focal neurological symptoms after rec...

    Authors: Nijasri C. Suwanwela, Naruchorn Kijpaisalratana, Supatporn Tepmongkol, Wanakorn Rattanawong, Pongpat Vorasayan, Chutibhorn Charnnarong, Jarturon Tantivattana, Sirigunya Roongruang, Tatchaporn Ongphichetmetha, Poonnakarn Panjasriprakarn, Aurauma Chutinet, Wasan Akarathanawat and Jeffrey L. Saver
    Citation: The Journal of Headache and Pain 2022 23:13
    Content type: Case report Published on:

  16. Noninvasive vagus nerve stimulation (nVNS) has recently emerged as a promising therapy for migraine. We previously demonstrated that vagus nerve stimulation inhibits cortical spreading depression (CSD), the el...

    Authors: Tzu-Ting Liu, Andreia Morais, Tsubasa Takizawa, Inge Mulder, Bruce J. Simon, Shih-Pin Chen, Shuu-Jiun Wang, Cenk Ayata and Jiin-Cherng Yen
    Citation: The Journal of Headache and Pain 2022 23:12
    Content type: Research article Published on:

  17. Defining the relationship between a headache and stroke is essential. The current diagnostic criteria of the ICHD-3 for acute headache attributed to ischemic stroke are based primarily on the opinion of expert...

    Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev and Jes Olesen
    Citation: The Journal of Headache and Pain 2022 23:11
    Content type: Research article Published on:

  18. The objective of this study was to describe patterns in monthly migraine days (MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures in patients treated as needed (PRN) w...

    Authors: Karissa Johnston, Linda Harris, Lauren Powell, Evan Popoff, Vladimir Coric, Gilbert L’Italien and Curtis P. Schreiber
    Citation: The Journal of Headache and Pain 2022 23:10
    Content type: Research article Published on:

  19. The precise underlying mechanisms of migraine remain unknown. Although we have previously shown acute orofacial pain evoked changes within the brainstem of individuals with migraine, we do not know if these br...

    Authors: Tiffani J. Mungoven, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey, Luke A. Henderson and Noemi Meylakh
    Citation: The Journal of Headache and Pain 2022 23:9
    Content type: Research article Published on:

  20. Astrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, the temporal characteristics of the astrocytic activation in the trigeminal nucleus caudalis ...

    Authors: Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2022 23:8
    Content type: Research article Published on:

  21. Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanil...

    Authors: Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha, Gábor Jancsó and Mária Dux
    Citation: The Journal of Headache and Pain 2022 23:7
    Content type: Research article Published on:

  22. Migraine is a common and disabling primary headache, which is associated with a wide range of psychiatric comorbidities. However, the mechanisms of emotion processing in migraine are not fully understood yet. ...

    Authors: Jing Ren, Qun Yao, Minjie Tian, Feng Li, Yueqiu Chen, Qiqi Chen, Jing Xiang and Jingping Shi
    Citation: The Journal of Headache and Pain 2022 23:6
    Content type: Research article Published on:

  23. Migraine is a neurological disorder characterized by intense, debilitating headaches, often coupled with nausea, vomiting and sensitivity to light and sound. Whilst changes in sensory processes during a migrai...

    Authors: Noemi Meylakh and Luke A. Henderson
    Citation: The Journal of Headache and Pain 2022 23:5
    Content type: Research article Published on:

  24. Migraine is a common brain disorder that predominantly affects women. Migraine pain seems mediated by the activation of mechanosensitive channels in meningeal afferents. Given the role of transient receptor po...

    Authors: G. Krivoshein, E. A. Tolner, AMJM van den Maagdenberg and R. A. Giniatullin
    Citation: The Journal of Headache and Pain 2022 23:4
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2022 23:17

  25. Several inflammatory and vascular molecules, and neurotrophins have been suggested to have a possible role in the development of migraine. However, pathophysiological events leading to migraine onset and trans...

    Authors: Mohammad Mozafarihashjin, Mansoureh Togha, Zeinab Ghorbani, Abolfazl Farbod, Pegah Rafiee and Fahimeh Martami
    Citation: The Journal of Headache and Pain 2022 23:3
    Content type: Research article Published on:

  26. Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another.

    Authors: Pedro Augusto Sampaio Rocha-Filho, Pedro Mota Albuquerque, Larissa Clementino Leite Sá Carvalho, Mylana Dandara Pereira Gama and João Eudes Magalhães
    Citation: The Journal of Headache and Pain 2022 23:2
    Content type: Research article Published on:

  27. Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP levels and ac...

    Authors: Hao Chen, Xueqian Tang, Jin Li, Bangyan Hu, Wenqin Yang, Meng Zhan, Tengyun Ma and Shijun Xu
    Citation: The Journal of Headache and Pain 2022 23:1
    Content type: Research article Published on:

  28. Migraine preventive treatment with CGRP(−receptor) monoclonal antibodies (mAbs) has a positive effect on patients’ health-related quality of life (HRQoL). The German treatment guidelines recommend discontinuin...

    Authors: Maria Terhart, Jasper Mecklenburg, Lars Neeb, Lucas Hendrik Overeem, Anke Siebert, Maureen Steinicke, Bianca Raffaelli and Uwe Reuter
    Citation: The Journal of Headache and Pain 2021 22:158
    Content type: Research article Published on:

  30. Fremanezumab, a fully humanized monoclonal antibody (IgG2Δa) that selectively targets calcitonin gene-related peptide (CGRP), is approved for migraine prevention in adults. Real-world data on the effectiveness...

    Authors: Peter McAllister, Lois Lamerato, Lynda J. Krasenbaum, Joshua M. Cohen, Krishna Tangirala, Stephen Thompson, Maurice Driessen, Julian Casciano, Zenobia Dotiwala and Alexander Mauskop
    Citation: The Journal of Headache and Pain 2021 22:156
    Content type: Research article Published on:

  31. The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine.

    Authors: Anker Stubberud, Dawn C. Buse, Espen Saxhaug Kristoffersen, Mattias Linde and Erling Tronvik
    Citation: The Journal of Headache and Pain 2021 22:155
    Content type: Review article Published on:

  32. Monoclonal antibodies anti-calcitonin gene-related peptide (mAbs anti-CGRP) pathway are effective and safe on migraine prevention. However, some drug agencies limited these treatments to one year due to their ...

    Authors: Fabrizio Vernieri, Nicoletta Brunelli, Roberta Messina, Carmelina Maria Costa, Bruno Colombo, Paola Torelli, Simone Quintana, Sabina Cevoli, Valentina Favoni, Florindo d’Onofrio, Gabriella Egeo, Renata Rao, Massimo Filippi, Piero Barbanti and Claudia Altamura
    Citation: The Journal of Headache and Pain 2021 22:154
    Content type: Research article Published on:

  33. Headache disorders are disabling, with major consequences for productivity, yet the literature is silent on the relationship between headache-attributed disability and lost productivity, often erroneously rega...

    Authors: Hallie Thomas, Simple Futarmal Kothari, Andreas Husøy, Rigmor Højland Jensen, Zaza Katsarava, Michela Tinelli and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2021 22:153
    Content type: Research article Published on:

  34. Migraine prevalence is age and sex dependent, predominating in women in early and middle adulthood; however, migraine also represents a substantial burden for men and adults of all ages. Thus, understanding th...

    Authors: Antoinette MaassenVanDenBrink, Gisela M. Terwindt, Joshua M. Cohen, Steve Barash, Verena Ramirez Campos, Maja Galic, Xiaoping Ning and Mikko Kärppä
    Citation: The Journal of Headache and Pain 2021 22:152
    Content type: Research article Published on:

  35. Patient-Reported Outcomes (PROs) have been developed to numerically quantify disability, impact and quality of life. They have been widely used in migraine clinical trials. However, we still do not know which ...

    Authors: Alicia Alpuente, Victor J Gallardo, Edoardo Caronna, Marta Torres-Ferrus and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2021 22:151
    Content type: Research article Published on:

  36. An imbalance between inhibitory and excitatory neurometabolites has been implicated in chronic pain. Prior work identified elevated levels of Gamma-aminobutyric acid + macromolecules (“GABA+”) using magnetic r...

    Authors: Aimie L. Peek, Andrew M. Leaver, Sheryl Foster, Nicolaas A. Puts, Georg Oeltzschner, Luke Henderson, Graham Galloway, Karl Ng, Kathryn Refshauge and Trudy Rebbeck
    Citation: The Journal of Headache and Pain 2021 22:150
    Content type: Research article Published on:

  37. Calcitonin gene-related peptide ligand/receptor (CGRP) antibodies effectively reduce headache frequency in migraine. It is understood that they act peripherally, which raises the question whether treatment mer...

    Authors: Anne Thiele, Lara Klehr, Sebastian Strauß, Anselm Angermaier, Ulf Schminke, Martin Kronenbuerger, Steffen Naegel and Robert Fleischmann
    Citation: The Journal of Headache and Pain 2021 22:149
    Content type: Research article Published on:

  38. Patients with visual snow syndrome (VSS) suffer from a debilitating continuous (“TV noise-like”) visual disturbance. They report problems with vision at night and palinopsia despite normal visual acuity. The u...

    Authors: Ozan E. Eren, Andreas Straube, Florian Schöberl, Ruth Ruscheweyh, Thomas Eggert and Christoph J. Schankin
    Citation: The Journal of Headache and Pain 2021 22:148
    Content type: Research article Published on:

  39. Accumulating studies have indicated a wide range of brain alterations with respect to the structure and function of classic trigeminal neuralgia (CTN). Given the dynamic nature of pain experience, the explorat...

    Authors: Pengfei Zhang, Yanli Jiang, Guangyao Liu, Jiao Han, Jun Wang, Laiyang Ma, Wanjun Hu and Jing Zhang
    Citation: The Journal of Headache and Pain 2021 22:147
    Content type: Research article Published on:

  40. Purinergic P2X7 receptor plays an important role in migraine pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine remains unclear. This study explores the hypothesis that P2X...

    Authors: Lingdi Nie, Dongqing Ma, John P. Quinn and Minyan Wang
    Citation: The Journal of Headache and Pain 2021 22:146
    Content type: Research article Published on:

  41. Migraine represents one of the most prevalent neurological conditions worldwide. It is a disabling condition with high impact on the working situation of migraineurs. Interestingly, gender-related differences ...

    Authors: Oreste Affatato, Maud Miguet, Helgi B. Schiöth and Jessica Mwinyi
    Citation: The Journal of Headache and Pain 2021 22:145
    Content type: Research article Published on:

  42. Transcranial direct current stimulation (tDCS) could counteract the pathophysiological triggers of migraine attacks by modulating cortical excitability. Several pilot randomized controlled trials (RCTs) assess...

    Authors: Raffaele Ornello, Valeria Caponnetto, Susanna Ratti, Giulia D’Aurizio, Chiara Rosignoli, Francesca Pistoia, Michele Ferrara, Simona Sacco and Aurora D’Atri
    Citation: The Journal of Headache and Pain 2021 22:144
    Content type: Review article Published on:

  43. Patients with migraine have an increased relative risk of cardio- and cerebrovascular events, and some migraine treatments may exacerbate this risk. The primary objective of this analysis was to determine whet...

    Authors: Timothy R. Smith, Egilius L. H. Spierings, Roger Cady, Joe Hirman, Anders Ettrup and Vivienne Shen
    Citation: The Journal of Headache and Pain 2021 22:143
    Content type: Research article Published on:

  44. Migraine is a common brain disorder but reliable diagnostic biomarkers in blood are still lacking. Our aim was to identify, using proton nuclear magnetic resonance (1H-NMR) spectroscopy, metabolites in serum that...

    Authors: Aster V. E. Harder, Lisanne S. Vijfhuizen, Peter Henneman, Ko Willems van Dijk, Cornelia M. van Duijn, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg
    Citation: The Journal of Headache and Pain 2021 22:142
    Content type: Research article Published on:

  45. Although migraine is less common in older people, preventive treatment of migraine in these individuals may be more challenging due to the presence of multiple comorbidities and polypharmacy. Additionally, evi...

    Authors: Stephanie J. Nahas, Steffen Naegel, Joshua M. Cohen, Xiaoping Ning, Lindsay Janka, Verena Ramirez Campos, Lynda J. Krasenbaum, Dagny Holle-Lee, David Kudrow and Christian Lampl
    Citation: The Journal of Headache and Pain 2021 22:141
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2022 23:57

  46. Health care costs of migraine constitute a major issue in health economics. Several publications analyzed health care costs for adult migraine patients, based on questionnaires or secondary (health insurance) ...

    Authors: Viola Obermeier, Monika Murawski, Florian Heinen, Mirjam N. Landgraf, Andreas Straube, Rüdiger von Kries and Ruth Ruscheweyh
    Citation: The Journal of Headache and Pain 2021 22:140
    Content type: Research article Published on:

  47. Occipital transcranial direct current stimulation (tDCS) is an effective and safe treatment for migraine attack prevention. Structural brain alterations have been found in migraineurs in regions related to pai...

    Authors: Simon Schading, Heiko Pohl, Andreas Gantenbein, Roger Luechinger, Peter Sandor, Franz Riederer, Patrick Freund and Lars Michels
    Citation: The Journal of Headache and Pain 2021 22:139
    Content type: Research article Published on:

  48. Pain is generally concomitant with an inflammatory reaction at the site where the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal inflammatory signaling cascade may play a rol...

    Authors: Şefik Evren Erdener, Zeynep Kaya and Turgay Dalkara
    Citation: The Journal of Headache and Pain 2021 22:138
    Content type: Review article Published on:

  50. Post-traumatic headache (PTH) is a very common symptom following mild traumatic brain injury (mTBI), yet much remains unknown about the underlying pathophysiological mechanisms of PTH. Neuroimaging studies sug...

    Authors: Fengfang Li, Liyan Lu, Song’an Shang, Huiyou Chen, Peng Wang, Vijaya Prakash Muthaiah, Xindao Yin and Yu-Chen Chen
    Citation: The Journal of Headache and Pain 2021 22:137
    Content type: Research article Published on:
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