Articles

Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality

Cognitive decline is a major concern in patients with migraine. Depression, anxiety, and/or poor sleep quality are well-known comorbidities of migraine, but available evidence on the subjective cognitive decli...

Authors: Sun Hwa Lee, Yeonwook Kang and Soo-Jin Cho

The comorbidity burden of patients with cluster headache: a population-based study

Evidence is limited regarding the comorbidity burden of patients with cluster headache (CH). We aimed to characterize comorbid conditions in a cohort of CH patients diagnosed by headache experts, using electro...

Authors: Shivang Joshi, Paul Rizzoli and Elizabeth Loder

OnabotulinumtoxinA injections in chronic migraine, targeted to sites of pericranial myofascial pain: an observational, open label, real-life cohort study

OnabotulinumtoxinA has proven its efficacy in reducing the number of headache days in chronic migraine (CM) patients. The usual paradigm includes 31 pericranial injection sites with low dose (5 U) per site. Th...

Authors: Danièle Ranoux, Gaelle Martiné, Gaëlle Espagne-Dubreuilh, Marlène Amilhaud-Bordier, François Caire and Laurent Magy

Assessment of gray and white matter structural alterations in migraineurs without aura

Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that so...

Authors: Jilei Zhang, Yi-Lan Wu, Jingjing Su, Qian Yao, Mengxing Wang, Ge-Fei Li, Rong Zhao, Yan-Hui Shi, Ying Zhao, Qiting Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Guo-Hong Cui, Jianqi Li, Jian-Ren Liu…

Perceived stress in patients with migraine: a case-control study

Perceived stress is the most common trigger for migraine. The objective of this study was to examine the clinical significance of perceived stress in migraine patients.

Authors: Hye-Jin Moon, Jong-Geun Seo and Sung-Pa Park

Functional connectivity and cognitive impairment in migraine with and without aura

Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of pre...

Authors: Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti and Silvia Marino

Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal

Hemicrania continua (HC), paroxysmal hemicrania (PH) and short lasting neuralgiform headache attacks (SUNCT and SUNA) are rare syndromes with a difficult therapeutic approach. The aim of this review is to summ...

Authors: Carlo Baraldi, Lanfranco Pellesi, Simona Guerzoni, Maria Michela Cainazzo and Luigi Alberto Pini

Anodal transcranial direct current stimulation over the left temporal pole restores normal visual evoked potential habituation in interictal migraineurs

Neuroimaging data has implicated the temporal pole (TP) in migraine pathophysiology; the density and functional activity of the TP were reported to fluctuate in accordance with the migraine cycle. Yet, the exa...

Authors: Francesca Cortese, Francesco Pierelli, Ilaria Bove, Cherubino Di Lorenzo, Maurizio Evangelista, Armando Perrotta, Mariano Serrao, Vincenzo Parisi and Gianluca Coppola

Is topiramate effective for migraine prevention in patients less than 18 years of age? A meta-analysis of randomized controlled trials

Mainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age...

Authors: Kai Le, Dafan Yu, Jiamin Wang, Abdoulaye Idriss Ali and Yijing Guo

Erratum to: De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report

Authors: Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Nappi Giuseppe, Marcella Neri and Cristina Cereda

Migraine and the risk of post-traumatic stress disorder among a cohort of pregnant women

Individually both migraine and post-traumatic stress disorder (PTSD) prevalence estimates are higher among women. However, there is limited data on the association of migraine and PTSD in women during pregnancy.

Authors: Lauren E. Friedman, Christina Aponte, Rigoberto Perez Hernandez, Juan Carlos Velez, Bizu Gelaye, Sixto E. Sánchez, Michelle A. Williams and B. Lee Peterlin

Onabotulinumtoxin A for the management of chronic migraine in current clinical practice: results of a survey of sixty-three Italian headache centers

Chronic migraine is a complex clinical condition often undertreated. Onabotulinumtoxin A (OBT-A) was approved in Italy in 2013 for symptom relief in patients with chronic migraine who have failed, or do not to...

Authors: Cristina Tassorelli, Marco Aguggia, Marina De Tommaso, Pierangelo Geppetti, Licia Grazzi, Luigi Alberto Pini, Paola Sarchielli, Gioacchino Tedeschi, Paolo Martelletti and Pietro Cortelli

The changing comet

Authors: Paolo Martelletti

Post-traumatic headache in patients with minimal traumatic intracranial hemorrhage after traumatic brain injury: a retrospective matched case-control study

No evidence is available on the risks of neurologically asymptomatic minimal traumatic intracranial hemorrhage (mTIH) in patients with traumatic brain injury (TBI) for post-traumatic headache (PTH). The purpos...

Authors: Chang-Ki Hong, Yu Shik Shim, Sook Young Sim, Jin-Yang Joo, Min A Kwon, Yong Bae Kim and Joonho Chung

De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report

Sporadic Hemiplegic Migraine is a rare form of migraine headache. Mutations in three different genes, two ion-channel genes and one encoding an ATP exchanger, CACNA1A, ATP1A2 and SCN1A are all responsible for the...

Authors: Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Giuseppe Nappi, Marcella Neri and Cristina Cereda

The role of attachment insecurity in the emergence of anxiety symptoms in children and adolescents with migraine: an empirical study

It is widely recognised that there are associations between headache, psychiatric comorbidity and attachment insecurity in both adults and children. The aims of this study were: 1) to compare perceived attachm...

Authors: Riccardo Williams, Luigi Leone, Noemi Faedda, Giulia Natalucci, Benedetta Bellini, Elisa Salvi, Paola Verdecchia, Rita Cerutti, Marco Arruda and Vincenzo Guidetti

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca²⁺ levels in the perfused and non-perfused isolated rat middle cerebral artery

Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of th...

Authors: André Erdling, Majid Sheykhzade and Lars Edvinsson

Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery

Given that post-traumatic headache is one of the most prevalent and long-lasting post-concussion sequelae, causes significant morbidity, and might be associated with slower neurocognitive recovery, we sought t...

Authors: Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Central sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This stud...

Authors: Marina de Tommaso, Vittorio Sciruicchio, Marianna Delussi, Eleonora Vecchio, Marvita Goffredo, Michele Simeone and Maria Grazia Foschino Barbaro

The burden of headache disorders in Ethiopia: national estimates from a population-based door-to-door survey

Headache disorders are the third-highest cause of disability worldwide, with migraine and medication-overuse headache (MOH) the major contributors. In Ethiopia we have shown these disorders to be highly preval...

Authors: Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas and Timothy J Steiner

Validation of the Social support and Pain Questionnaire (SPQ) in patients with painful temporomandibular disorders

The present study aimed to validate of Social support and Pain Questionnaire (SPQ) for use in Chinese patients with painful temporomandibular disorders (TMD).

Authors: Songlin He and Jinhua Wang

Treatment of withdrawal headache in patients with medication overuse headache: a pilot study

Drug withdrawal still remains the key element in the treatment of Medication Overuse Headache (MOH), but there is no consensus about the withdrawal procedure. Still debated is the role of the steroid therapy. ...

Authors: Sabina Cevoli, Giulia Giannini, Valentina Favoni, Rossana Terlizzi, Elisa Sancisi, Marianna Nicodemo, Stefano Zanigni, Maria Letizia Bacchi Reggiani, Giulia Pierangeli and Pietro Cortelli

Quality indicators in headache care: an implementation study in six Italian specialist-care centres

Headache disorders are highly prevalent, and have a substantial and negative impact on health worldwide. They are largely treatable, but differences in structure, objectives, organization and delivery affect t...

Authors: L. Pellesi, S. Benemei, V. Favoni, C. Lupi, E. Mampreso, A. Negro, M. Paolucci, T. J. Steiner, M. Ulivi, S. Cevoli and S. Guerzoni

Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials

The aim of this study was to evaluate the changes in the cognitive performance of migraine patients using a comprehensive series of cognitive/behavioral and electrophysiological tests.

Authors: Lifang Huang, Hong juan Dong, Xi Wang, Yan Wang and Zheman Xiao

Prevalence and burden of headache disorders in Lithuania and their public-health and policy implications: a population-based study within the Eurolight Project

The Eurolight project assessed the impact of headache disorders in ten EU countries, using the same structured questionnaire but varying sampling methods. In Lithuania, sample selection employed methods in lin...

Authors: Daiva Rastenytė, Dalia Mickevičienė, Lars Jacob Stovner, Hallie Thomas, Colette Andrée and Timothy J Steiner

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascul...

Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Oswaldo Hernández-Abreu, Bruce L. Daugherty, Antoinette MaassenVanDenBrink and Carlos M. Villalón

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

Hyperbaric oxygen (HBO) has the potential to relieve neuropathic pain. The purpose of this study was to determine whether the NO-cGMP-PKG signaling pathway is involved in the analgesic effects of early hyperba...

Authors: Yuanyuan Ding, Peng Yao, Tao Hong, Zhenkai Han, Baisong Zhao and Weimin Chen

Insufficient sleep is prevalent among migraineurs: a population-based study

Sleep disorder and sleep complaints are common in subjects with migraine. Although the association between sleep disorders and migraine has been reported, the association between perceived insufficient sleep a...

Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Tackling the perils of unawareness: the cluster headache case

Authors: Giorgio Lambru, Anna P. Andreou, Elena Ruiz de la Torre and Paolo Martelletti

The course of headache in patients with moderate-to-severe headache due to mild traumatic brain injury: a retrospective cross-sectional study

Little is known about the long-term course of headache in patients with moderate-to-severe headache due to traumatic brain injury (TBI). We evaluated the course of headache in patients with moderate-to-severe...

Authors: Chang-Ki Hong, Jin-Yang Joo, Yu Shik Shim, Sook Young Sim, Min A Kwon, Yong Bae Kim and Joonho Chung

Restless legs syndrome and tension-type headache: a population-based study

Recent studies have shown a significant association between restless legs syndrome (RLS) and primary headache disorders. Nevertheless, information regarding the association between tension-type headache (TTH) ...

Authors: Pil-Wook Chung, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Level of physical activity, well-being, stress and self-rated health in persons with migraine and co-existing tension-type headache and neck pain

The prevalence of migraine with co-existing tension-type headache and neck pain is high in the general population. However, there is very little literature on the characteristics of these combined conditions. ...

Authors: Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Maria Lurenda Westergaard, Trine Nielsen, Louise Bönsdorff Sloth, Rigmor Højland Jensen and Gunvor Gard

Treatment of menstrual migraine; multidisciplinary or mono-disciplinary approach

The aim of this study was to compare a multidisciplinary approach of menstrual (related) migraine, combining the neurological and gynaecological consultation, to a mono-disciplinary approach involving neurolog...

Authors: Hester Witteveen, Peter van den Berg and Guus Vermeulen

Clinical patterns of primary stabbing headache: a single clinic-based prospective study

The clinical features and disease courses of primary stabbing headache (PSH) are diverse. We aimed to identify distinct clinical patterns of PSH.

Authors: Dong Yeop Kim, Mi Ji Lee, Hyun Ah Choi, Hanna Choi and Chin-Sang Chung

Identification of subgroups of patients with tension type headache with higher widespread pressure pain hyperalgesia

Identification of subgroups of patients with different levels of sensitization and clinical features can help to identify groups at risk and the development of better therapeutic strategies. The aim of this st...

Authors: César Fernández-de-las-Peñas, Elena Benito-González, María Palacios-Ceña, Kelun Wang, Matteo Castaldo and Lars Arendt-Nielsen

The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis

Migraine has been recognized as one of the leading causes of disability in the 2013 Global Burden of Disease Study and seriously affects the quality of patients’ life, current treatment options are not ideal. ...

Authors: Min Hou, Haiyan Xing, Yongqing Cai, Bin Li, Xianfeng Wang, Pan Li, Xiaolin Hu and Jianhong Chen

Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity

Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to supp...

Authors: Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlović, Julie Roth, Lucille Rathier and Dale S. Bond

Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbidities, treatment and outcome

Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly. There is no s...

Authors: Dimos D. Mitsikostas, Srdjan Ljubisavljevic and Christina I. Deligianni

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...

Authors: M. Lukács, K. Warfvinge, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

Authors: Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin

Anxiety and depression symptoms and migraine: a symptom-based approach research

Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

Authors: Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered func...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

Association of excessive daytime sleepiness with migraine and headache frequency in the general population

Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

Authors: Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell

Calcitonin gene-related peptide and pain: a systematic review

Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

Authors: Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina

Erratum to: Psychiatric comorbidities and photophobia in patients with migraine

Authors: Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

Family studies to find rare high risk variants in migraine

Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

Authors: Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen

A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

Authors: Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport

Increased levels of intramuscular cytokines in patients with jaw muscle pain

The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

Authors: S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg

Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study

The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS).

Authors: Hyun Ah Choi, Mi Ji Lee and Chin-Sang Chung

Primary headache disorders in the adult general population of Pakistan – a cross sectional nationwide prevalence survey

The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

Authors: A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner