Articles

Anxiety and depression symptoms and migraine: a symptom-based approach research

Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

Authors: Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

Authors: Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered func...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

Association of excessive daytime sleepiness with migraine and headache frequency in the general population

Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

Authors: Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell

Calcitonin gene-related peptide and pain: a systematic review

Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

Authors: Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina

Erratum to: Psychiatric comorbidities and photophobia in patients with migraine

Authors: Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

Family studies to find rare high risk variants in migraine

Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

Authors: Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen

A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

Authors: Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport

Increased levels of intramuscular cytokines in patients with jaw muscle pain

The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

Authors: S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg

Primary headache disorders in the adult general population of Pakistan – a cross sectional nationwide prevalence survey

The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

Authors: A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner

Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study

The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS).

Authors: Hyun Ah Choi, Mi Ji Lee and Chin-Sang Chung

Depression and anxiety behaviour in a rat model of chronic migraine

Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

Authors: Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong and Shengyuan Yu

Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis

A large number patients struggle with migraine which is classified as a chronic disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine play a key role in managing thi...

Authors: Aijie He, Dehua Song, Lei Zhang and Chen Li

Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu

Cardiac cephalalgia: one case with cortical hypoperfusion in headaches and literature review

Cardiac cephalalgia (CC) is a rare disease occurring during an episode of myocardial ischemia and relieved by nitroglycerine. Though more than 30 cases of CC have been reported since 1997, the mechanism is yet...

Authors: Miao Wang, Lu Wang, Changfu Liu, Xiangbing Bian, Zhao Dong and Shengyuan Yu

OnabotulinumtoxinA effectiveness on chronic migraine, negative emotional states and sleep quality: a single-center prospective cohort study

OnabotulinumtoxinA (OnabotA) is considered effective in in patients with chronic migraine (CM) who failed on traditional therapies. This study was designed to evaluate the effect of OnabotA injection series on...

Authors: Elif Ilgaz Aydinlar, Pinar Yalinay Dikmen, Seda Kosak and Ayse Sagduyu Kocaman

Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study

In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus stan...

Authors: Charly Gaul, Delphine Magis, Eric Liebler and Andreas Straube

Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out.

Authors: Claudine Angela Blum, Bettina Winzeler, Nicole Nigro, Philipp Schuetz, Silke Biethahn, Timo Kahles, Cornelia Mueller, Katharina Timper, Katharina Haaf, Janina Tepperberg, Margareth Amort, Andreas Huber, Roland Bingisser, Peter Stephan Sándor, Krassen Nedeltchev, Beat Müller…

Genetic and biochemical changes of the serotonergic system in migraine pathobiology

Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the...

Authors: Claudia Francesca Gasparini, Robert Anthony Smith and Lyn Robyn Griffiths

The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

A better understanding of potential relationship between mood disorders, sleep quality, pain, and headache frequency may assist clinicians in determining optimal therapeutic programs. The aim of the current st...

Authors: María Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

Psychiatric comorbidities and photophobia in patients with migraine

Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia.

Authors: Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system

Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms.

Authors: Ashley L. Tyburski, Lan Cheng, Soroush Assari, Kurosh Darvish and Melanie B. Elliott

Randomized, double-blind, crossover study comparing DFN-11 injection (3 mg subcutaneous sumatriptan) with 6 mg subcutaneous sumatriptan for the treatment of rapidly-escalating attacks of episodic migraine

A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

Authors: Roger K. Cady, Sagar Munjal, Ryan J. Cady, Heather R. Manley and Elimor Brand-Schieber

Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up

Chronic Migraine (CM) is a disabling condition, worsened when associated with Medication Overuse (MO). Mindfulness is an emerging technique, effective in different pain conditions, but it has yet to be explore...

Authors: Licia Grazzi, Emanuela Sansone, Alberto Raggi, Domenico D’Amico, Andrea De Giorgio, Matilde Leonardi, Laura De Torres, Francisco Salgado-García and Frank Andrasik

Texture features of periaqueductal gray in the patients with medication-overuse headache

Periaqueductal gray (PAG) is the descending pain modulatory center, and PAG dysfunction had been recognized in migraine. Here we propose to investigate altered PAG texture features (quantitative approach for e...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis

Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migrain...

Authors: Xiaoying Cai, Xiaolei Shi, Ximeng Zhang, Aiwu Zhang, Minying Zheng and Yannan Fang

Volume gain of periaqueductal gray in medication-overuse headache

Periaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headach...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

Erratum to: 1st Joint ANIRCEF-SISC Congress (meeting abstracts)

Authors: Paolo Martelletti

Simulated airplane headache: a proxy towards identification of underlying mechanisms

Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrence of this...

Authors: Sebastian Bao Dinh Bui, Torben Petersen, Jeppe Nørgaard Poulsen and Parisa Gazerani

Endovascular thrombectomy and post-procedural headache

We investigated the prevalence of post-procedural headache in patients who have undergone thrombectomy for ischemic stroke, and correlated history of migraine with risk of peri-procedural complications. A tota...

Authors: Sabrina Khan, Faisal Mohammad Amin, Markus Holtmannspötter, Klaus Hansen, Anna Maria Florescu, Zainab Fakhril-Din, Julie Falkenberg Petersen, Hashmat Ghanizada, Cenk Ayata, David Gaist and Messoud Ashina

Interictal brain activity differs in migraine with and without aura: resting state fMRI study

Migraine is one of the most severe primary headache disorders. The nature of the headache and the associated symptoms during the attack suggest underlying functional alterations in the brain. In this study, we...

Authors: Péter Faragó, Bernadett Tuka, Eszter Tóth, Nikoletta Szabó, András Király, Gergő Csete, Délia Szok, János Tajti, Árpád Párdutz, László Vécsei and Zsigmond Tamás Kincses

Altered functional connectivity of amygdala underlying the neuromechanism of migraine pathogenesis

The amygdala is a large grey matter complex in the limbic system, and it may contribute in the neurolimbic pain network in migraine. However, the detailed neuromechanism remained to be elucidated. The objectiv...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu

The status of diagnosis and treatment to intracranial hypotension, including SIH

Intracranial hypotension, especially spontaneous intracranial hypotension (SIH), is a well—recognized entity associated with cerebrospinal fluid (CSF) leaks, and has being recognized better in resent years, wh...

Authors: Jin-ping Lin, Shu-dong Zhang, Fei-fang He, Min-jun Liu and Xiao-xu Ma

Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats

The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can b...

Authors: Ram Kandasamy, Andrea T. Lee and Michael M. Morgan

Headache and anxiety/mood disorders: are we trapped in a cul-de-sac?

Authors: Federica Galli

The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study

There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine pati...

Authors: Akio Iwasaki, Keisuke Suzuki, Hidehiro Takekawa, Ryotaro Takashima, Ayano Suzuki, Shiho Suzuki and Koichi Hirata

Excitability of the motor cortex in patients with migraine changes with the time elapsed from the last attack

Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability. Previously, MEP thresholds were found t...

Authors: Francesca Cortese, Gianluca Coppola, Davide Di Lenola, Mariano Serrao, Cherubino Di Lorenzo, Vincenzo Parisi and Francesco Pierelli

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

Hyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during as...

Authors: Baisong Zhao, Yongying Pan, Haiping Xu and Xingrong Song

A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants

Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been...

Authors: Elena Bacchelli, Maria Michela Cainazzo, Cinzia Cameli, Simona Guerzoni, Angela Martinelli, Michele Zoli, Elena Maestrini and Luigi Alberto Pini

Network meta-analysis of migraine disorder treatment by NSAIDs and triptans

Migraine is a neurological disorder resulting in large socioeconomic burden. This network meta-analysis (NMA) is designed to compare the relative efficacy and tolerability of non-steroidal anti-inflammatory ag...

Authors: Haiyang Xu, Wei Han, Jinghua Wang and Mingxian Li

Real-life data in 115 chronic migraine patients treated with Onabotulinumtoxin A during more than one year

OnabotulinumtoxinA (OnabotA) is effective in Chronic Migraine (CM) during first year of treatment and longer. In real clinical setting, CM patients with acute Medication Overuse (MO) or concurrently receiving ...

Authors: I. Aicua-Rapun, E. Martínez-Velasco, A. Rojo, A. Hernando, M. Ruiz, A. Carreres, E. Porqueres, S. Herrero, F. Iglesias and A. L. Guerrero

Headache service quality: evaluation of quality indicators in 14 specialist-care centres

The study was a collaboration between Lifting The Burden (LTB) and the European Headache Federation (EHF). Its aim was to evaluate the implementation of quality indicators for headache care Europe-wide in special...

Authors: Sara Schramm, Derya Uluduz, Raquel Gil Gouveia, Rigmor Jensen, Aksel Siva, Ugur Uygunoglu, Giorgadze Gvantsa, Maka Mania, Mark Braschinsky, Elena Filatova, Nina Latysheva, Vera Osipova, Kirill Skorobogatykh, Julia Azimova, Andreas Straube, Ozan Emre Eren…

The prevalence of primary headache disorders in Ethiopia

Knowledge of the epidemiology of primary headache disorders in sub-Saharan Africa (SSA) remains very limited. We performed a population-based survey in rural and urban areas of Ethiopia, using methods similar ...

Authors: Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K. Worku, Hallie Thomas and Timothy J. Steiner

Validation of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD) in patients with painful TMD

The aim of the study was to validation of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD) for use in patients with painful TMD.

Authors: Songlin He, Jinhua Wang and Ping Ji

The potential impact of primary headache disorders on stroke risk

Headache such as migraine is associated with stroke. Studies focused on primary headache disorders (PHDs) as a risk factor for stroke are limited. The purpose of this population-based cohort study was to explo...

Authors: Chia-Lin Tsai, Chung-Hsing Chou, Pei-Jung Lee, Jiu-Haw Yin, Shao-Yuan Chen, Chun-Chieh Lin, Yueh-Feng Sung, Fu-Chi Yang, Chi-Hsiang Chung, Wu-Chien Chien, Chia-Kuang Tsai and Jiunn-Tay Lee

Risk of medication overuse headache across classes of treatments for acute migraine

The most commonly prescribed medications used to treat migraine acutely are single analgesics, ergots, opioids, and triptans. Due to varying mechanisms of action across drug classes, there is reason to believe...

Authors: Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward J. Mills, Michel Lanteri-Minet and Stewart Tepper

Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series

Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions. We present a ...

Authors: Clinton Lauritsen, Santiago Mazuera, Richard B. Lipton and Sait Ashina

GBD 2015: migraine is the third cause of disability in under 50s

Authors: Timothy J. Steiner, Lars J. Stovner and Theo Vos

Cortical plasticity between the pain and pain-free phases in patients with episodic tension-type headache

State-related brain structural alterations in patients with episodic tension-type headache (ETTH) are unclear. We aimed to conduct a longitudinal study to explore dynamic gray matter (GM) changes between the p...

Authors: Bing Chen, Yuan He, Lei Xia, Li-Li Guo and Jin-Long Zheng

Chronic Temporomandibular Disorders: disability, pain intensity and fear of movement

The objective was to compare and correlate disability, pain intensity, the impact of headache on daily life and the fear of movement between subgroups of patients with chronic temporomandibular disorder (TMD).

Authors: Alfonso Gil-Martínez, Mónica Grande-Alonso, Ibai López-de-Uralde-Villanueva, Almudena López-López, Josué Fernández-Carnero and Roy La Touche