Articles

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca²⁺ levels in the perfused and non-perfused isolated rat middle cerebral artery

Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of th...

Authors: André Erdling, Majid Sheykhzade and Lars Edvinsson

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Central sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This stud...

Authors: Marina de Tommaso, Vittorio Sciruicchio, Marianna Delussi, Eleonora Vecchio, Marvita Goffredo, Michele Simeone and Maria Grazia Foschino Barbaro

The burden of headache disorders in Ethiopia: national estimates from a population-based door-to-door survey

Headache disorders are the third-highest cause of disability worldwide, with migraine and medication-overuse headache (MOH) the major contributors. In Ethiopia we have shown these disorders to be highly preval...

Authors: Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas and Timothy J Steiner

Validation of the Social support and Pain Questionnaire (SPQ) in patients with painful temporomandibular disorders

The present study aimed to validate of Social support and Pain Questionnaire (SPQ) for use in Chinese patients with painful temporomandibular disorders (TMD).

Authors: Songlin He and Jinhua Wang

Treatment of withdrawal headache in patients with medication overuse headache: a pilot study

Drug withdrawal still remains the key element in the treatment of Medication Overuse Headache (MOH), but there is no consensus about the withdrawal procedure. Still debated is the role of the steroid therapy. ...

Authors: Sabina Cevoli, Giulia Giannini, Valentina Favoni, Rossana Terlizzi, Elisa Sancisi, Marianna Nicodemo, Stefano Zanigni, Maria Letizia Bacchi Reggiani, Giulia Pierangeli and Pietro Cortelli

Quality indicators in headache care: an implementation study in six Italian specialist-care centres

Headache disorders are highly prevalent, and have a substantial and negative impact on health worldwide. They are largely treatable, but differences in structure, objectives, organization and delivery affect t...

Authors: L. Pellesi, S. Benemei, V. Favoni, C. Lupi, E. Mampreso, A. Negro, M. Paolucci, T. J. Steiner, M. Ulivi, S. Cevoli and S. Guerzoni

Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials

The aim of this study was to evaluate the changes in the cognitive performance of migraine patients using a comprehensive series of cognitive/behavioral and electrophysiological tests.

Authors: Lifang Huang, Hong juan Dong, Xi Wang, Yan Wang and Zheman Xiao

Prevalence and burden of headache disorders in Lithuania and their public-health and policy implications: a population-based study within the Eurolight Project

The Eurolight project assessed the impact of headache disorders in ten EU countries, using the same structured questionnaire but varying sampling methods. In Lithuania, sample selection employed methods in lin...

Authors: Daiva Rastenytė, Dalia Mickevičienė, Lars Jacob Stovner, Hallie Thomas, Colette Andrée and Timothy J Steiner

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascul...

Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Oswaldo Hernández-Abreu, Bruce L. Daugherty, Antoinette MaassenVanDenBrink and Carlos M. Villalón

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

Hyperbaric oxygen (HBO) has the potential to relieve neuropathic pain. The purpose of this study was to determine whether the NO-cGMP-PKG signaling pathway is involved in the analgesic effects of early hyperba...

Authors: Yuanyuan Ding, Peng Yao, Tao Hong, Zhenkai Han, Baisong Zhao and Weimin Chen

Insufficient sleep is prevalent among migraineurs: a population-based study

Sleep disorder and sleep complaints are common in subjects with migraine. Although the association between sleep disorders and migraine has been reported, the association between perceived insufficient sleep a...

Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Tackling the perils of unawareness: the cluster headache case

Authors: Giorgio Lambru, Anna P. Andreou, Elena Ruiz de la Torre and Paolo Martelletti

The course of headache in patients with moderate-to-severe headache due to mild traumatic brain injury: a retrospective cross-sectional study

Little is known about the long-term course of headache in patients with moderate-to-severe headache due to traumatic brain injury (TBI). We evaluated the course of headache in patients with moderate-to-severe...

Authors: Chang-Ki Hong, Jin-Yang Joo, Yu Shik Shim, Sook Young Sim, Min A Kwon, Yong Bae Kim and Joonho Chung

Restless legs syndrome and tension-type headache: a population-based study

Recent studies have shown a significant association between restless legs syndrome (RLS) and primary headache disorders. Nevertheless, information regarding the association between tension-type headache (TTH) ...

Authors: Pil-Wook Chung, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Level of physical activity, well-being, stress and self-rated health in persons with migraine and co-existing tension-type headache and neck pain

The prevalence of migraine with co-existing tension-type headache and neck pain is high in the general population. However, there is very little literature on the characteristics of these combined conditions. ...

Authors: Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Maria Lurenda Westergaard, Trine Nielsen, Louise Bönsdorff Sloth, Rigmor Højland Jensen and Gunvor Gard

Treatment of menstrual migraine; multidisciplinary or mono-disciplinary approach

The aim of this study was to compare a multidisciplinary approach of menstrual (related) migraine, combining the neurological and gynaecological consultation, to a mono-disciplinary approach involving neurolog...

Authors: Hester Witteveen, Peter van den Berg and Guus Vermeulen

Clinical patterns of primary stabbing headache: a single clinic-based prospective study

The clinical features and disease courses of primary stabbing headache (PSH) are diverse. We aimed to identify distinct clinical patterns of PSH.

Authors: Dong Yeop Kim, Mi Ji Lee, Hyun Ah Choi, Hanna Choi and Chin-Sang Chung

Identification of subgroups of patients with tension type headache with higher widespread pressure pain hyperalgesia

Identification of subgroups of patients with different levels of sensitization and clinical features can help to identify groups at risk and the development of better therapeutic strategies. The aim of this st...

Authors: César Fernández-de-las-Peñas, Elena Benito-González, María Palacios-Ceña, Kelun Wang, Matteo Castaldo and Lars Arendt-Nielsen

The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis

Migraine has been recognized as one of the leading causes of disability in the 2013 Global Burden of Disease Study and seriously affects the quality of patients’ life, current treatment options are not ideal. ...

Authors: Min Hou, Haiyan Xing, Yongqing Cai, Bin Li, Xianfeng Wang, Pan Li, Xiaolin Hu and Jianhong Chen

Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity

Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to supp...

Authors: Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlović, Julie Roth, Lucille Rathier and Dale S. Bond

Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbidities, treatment and outcome

Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly. There is no s...

Authors: Dimos D. Mitsikostas, Srdjan Ljubisavljevic and Christina I. Deligianni

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...

Authors: M. Lukács, K. Warfvinge, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

Authors: Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin

Anxiety and depression symptoms and migraine: a symptom-based approach research

Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

Authors: Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered func...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

Association of excessive daytime sleepiness with migraine and headache frequency in the general population

Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

Authors: Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell

Calcitonin gene-related peptide and pain: a systematic review

Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

Authors: Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina

Erratum to: Psychiatric comorbidities and photophobia in patients with migraine

Authors: Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

Family studies to find rare high risk variants in migraine

Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

Authors: Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen

A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

Authors: Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport

Increased levels of intramuscular cytokines in patients with jaw muscle pain

The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

Authors: S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg

Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study

The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS).

Authors: Hyun Ah Choi, Mi Ji Lee and Chin-Sang Chung

Primary headache disorders in the adult general population of Pakistan – a cross sectional nationwide prevalence survey

The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

Authors: A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner

Depression and anxiety behaviour in a rat model of chronic migraine

Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

Authors: Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong and Shengyuan Yu

Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis

A large number patients struggle with migraine which is classified as a chronic disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine play a key role in managing thi...

Authors: Aijie He, Dehua Song, Lei Zhang and Chen Li

Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu

Cardiac cephalalgia: one case with cortical hypoperfusion in headaches and literature review

Cardiac cephalalgia (CC) is a rare disease occurring during an episode of myocardial ischemia and relieved by nitroglycerine. Though more than 30 cases of CC have been reported since 1997, the mechanism is yet...

Authors: Miao Wang, Lu Wang, Changfu Liu, Xiangbing Bian, Zhao Dong and Shengyuan Yu

OnabotulinumtoxinA effectiveness on chronic migraine, negative emotional states and sleep quality: a single-center prospective cohort study

OnabotulinumtoxinA (OnabotA) is considered effective in in patients with chronic migraine (CM) who failed on traditional therapies. This study was designed to evaluate the effect of OnabotA injection series on...

Authors: Elif Ilgaz Aydinlar, Pinar Yalinay Dikmen, Seda Kosak and Ayse Sagduyu Kocaman

Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study

In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus stan...

Authors: Charly Gaul, Delphine Magis, Eric Liebler and Andreas Straube

Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out.

Authors: Claudine Angela Blum, Bettina Winzeler, Nicole Nigro, Philipp Schuetz, Silke Biethahn, Timo Kahles, Cornelia Mueller, Katharina Timper, Katharina Haaf, Janina Tepperberg, Margareth Amort, Andreas Huber, Roland Bingisser, Peter Stephan Sándor, Krassen Nedeltchev, Beat Müller…

Genetic and biochemical changes of the serotonergic system in migraine pathobiology

Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the...

Authors: Claudia Francesca Gasparini, Robert Anthony Smith and Lyn Robyn Griffiths

The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

A better understanding of potential relationship between mood disorders, sleep quality, pain, and headache frequency may assist clinicians in determining optimal therapeutic programs. The aim of the current st...

Authors: María Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

Psychiatric comorbidities and photophobia in patients with migraine

Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia.

Authors: Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

Randomized, double-blind, crossover study comparing DFN-11 injection (3 mg subcutaneous sumatriptan) with 6 mg subcutaneous sumatriptan for the treatment of rapidly-escalating attacks of episodic migraine

A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

Authors: Roger K. Cady, Sagar Munjal, Ryan J. Cady, Heather R. Manley and Elimor Brand-Schieber

Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system

Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms.

Authors: Ashley L. Tyburski, Lan Cheng, Soroush Assari, Kurosh Darvish and Melanie B. Elliott

Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up

Chronic Migraine (CM) is a disabling condition, worsened when associated with Medication Overuse (MO). Mindfulness is an emerging technique, effective in different pain conditions, but it has yet to be explore...

Authors: Licia Grazzi, Emanuela Sansone, Alberto Raggi, Domenico D’Amico, Andrea De Giorgio, Matilde Leonardi, Laura De Torres, Francisco Salgado-García and Frank Andrasik

Texture features of periaqueductal gray in the patients with medication-overuse headache

Periaqueductal gray (PAG) is the descending pain modulatory center, and PAG dysfunction had been recognized in migraine. Here we propose to investigate altered PAG texture features (quantitative approach for e...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis

Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migrain...

Authors: Xiaoying Cai, Xiaolei Shi, Ximeng Zhang, Aiwu Zhang, Minying Zheng and Yannan Fang

Volume gain of periaqueductal gray in medication-overuse headache

Periaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headach...

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

Erratum to: 1st Joint ANIRCEF-SISC Congress (meeting abstracts)

Authors: Paolo Martelletti