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  1. Chronic headache is particularly prevalent in migraineurs and it can progress to a condition known as medication overuse headache (MOH). MOH is a secondary headache caused by overuse of analgesics or other med...

    Authors: Tatiane Teru Takahashi, Raffaele Ornello, Giuseppe Quatrosi, Angelo Torrente, Maria Albanese, Simone Vigneri, Martina Guglielmetti, Cristiano Maria De Marco, Camille Dutordoir, Enrico Colangeli, Matteo Fuccaro, Davide Di Lenola, Valerio Spuntarelli, Laura Pilati, Salvatore Di Marco, Annelies Van Dycke…
    Citation: The Journal of Headache and Pain 2021 22:32
    Content type: Review article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:64

  2. Trigeminal neuralgia is a characteristic disease that manifests as orofacial phasic or continuous severe pain triggered by innocuous orofacial stimulation; its mechanisms are not fully understood. In this stud...

    Authors: Momoko Koizumi, Sayaka Asano, Akihiko Furukawa, Yoshinori Hayashi, Suzuro Hitomi, Ikuko Shibuta, Katsuhiko Hayashi, Fusao Kato, Koichi Iwata and Masamichi Shinoda
    Citation: The Journal of Headache and Pain 2021 22:31
    Content type: Research article Published on:

  3. Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia...

    Authors: Mickael Aubignat, Melissa Tir, Pierre Krystkowiak and Daniela Andriuta
    Citation: The Journal of Headache and Pain 2021 22:30
    Content type: Case report Published on:

  4. Migraine is the leading cause of days lost due to disability in the world among people less than 50 years of age. There is a paucity of evidence on the impact of migraine and other headache disorders and the c...

    Authors: Toshihiko Shimizu, Fumihiko Sakai, Hitoshi Miyake, Tomofumi Sone, Mitsuhiro Sato, Satoshi Tanabe, Yasuhiro Azuma and David W. Dodick
    Citation: The Journal of Headache and Pain 2021 22:29
    Content type: Research article Published on:

  5. To determine the frequency of suicidal ideation and assess suicide risk in cluster headache (CH) patients compared to matched controls without CH in this observational case-control study.

    Authors: Brian B. Koo, Ahmed Bayoumi, Abdalla Albanna, Mohammed Abusuliman, Laura Burrone, Jason J. Sico and Emmanuelle A. D. Schindler
    Citation: The Journal of Headache and Pain 2021 22:28
    Content type: Research article Published on:

  6. Migraine is one of the leading causes of disability worldwide. Erenumab is a fully human monoclonal antibody that targets the calcitonin gene-related peptide (CGRP) receptor. This study aimed to evaluate real-...

    Authors: Stewart J. Tepper, Juanzhi Fang, Pamela Vo, Ying Shen, Lujia Zhou, Ahmad Abdrabboh, Mrudula Glassberg and Matias Ferraris
    Citation: The Journal of Headache and Pain 2021 22:27
    Content type: Research article Published on:

  7. The FOCUS study evaluated the efficacy of migraine preventive medications across different countries within the same patient population, particularly for patients with difficult-to-treat migraine. These prespe...

    Authors: Egilius L. H. Spierings, Mikko Kärppä, Xiaoping Ning, Joshua M. Cohen, Verena Ramirez Campos, Ronghua Yang and Uwe Reuter
    Citation: The Journal of Headache and Pain 2021 22:26
    Content type: Research article Published on:

  8. Granger causality analysis (GCA) has been used to investigate the pathophysiology of migraine. Amygdala plays a key role in pain modulation of migraine attack. However, the detailed neuromechanism remained to ...

    Authors: Xiaobin Huang, Di Zhang, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu
    Citation: The Journal of Headache and Pain 2021 22:25
    Content type: Research article Published on:

  9. We recently showed headache to be common in children (aged 7–11 years) and adolescents (aged 12–17) in Lithuania. Here we provide evidence from the same study of the headache-attributable burden.

    Authors: Diana Genc, Nerija Vaičienė-Magistris, Apolinaras Zaborskis, Tayyar Şaşmaz, Aylin Yeniocak Tunç, Derya Uluduz, Christian Wöber, Çiçek Wöber-Bingöl and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2021 22:24
    Content type: Research article Published on:

  10. Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. Calcitonin gene-...

    Authors: Johanna Kleeberg-Hartmann, Birgit Vogler and Karl Messlinger
    Citation: The Journal of Headache and Pain 2021 22:23
    Content type: Research article Published on:

  11. Headache and facial pain are among the most common, disabling and costly diseases in Europe, which demands for high quality health care on all levels within the health system. The role of the Danish Headache S...

    Authors: Henrik W. Schytz, Faisal M. Amin, Rigmor H. Jensen, Louise Carlsen, Stine Maarbjerg, Nunu Lund, Karen Aegidius, Lise L. Thomsen, Flemming W. Bach, Dagmar Beier, Hanne Johansen, Jakob M. Hansen, Helge Kasch, Signe B. Munksgaard, Lars Poulsen, Per Schmidt Sørensen…
    Citation: The Journal of Headache and Pain 2021 22:22
    Content type: Consensus article Published on:

  12. This study aimed to assess the efficacy of concurrent magnesium-sodium valproate therapy and compare it with either magnesium or sodium valproate alone in migraine prophylaxis.

    Authors: Samira Khani, Seyed Amir Hejazi, Mehdi Yaghoubi and Ehsan Sharifipour
    Citation: The Journal of Headache and Pain 2021 22:21
    Content type: Research article Published on:

  14. With headache experienced by up to 75% of adults worldwide in the last year, primary headache disorders constitute a major public health problem, yet they remain under-diagnosed and under-treated.

    Authors: Peter J. Goadsby, Michel Lantéri-Minet, Martin C. Michel, Mario Peres, Mamoru Shibata, Andreas Straube, Tissa Wijeratne, Caty Ebel-Bitoun, Luminita Constantin and Simon Hitier
    Citation: The Journal of Headache and Pain 2021 22:19
    Content type: Commentary Published on:

  15. Existent animal models of migraine are not without drawbacks and limitations. The aim of our study was to evaluate imaging photoplethysmography (PPG) as a method of assessing intracranial blood flow in rats an...

    Authors: Alexey Y. Sokolov, Maxim A. Volynsky, Valery V. Zaytsev, Anastasiia V. Osipchuk and Alexei A. Kamshilin
    Citation: The Journal of Headache and Pain 2021 22:18
    Content type: Research article Published on:

  16. The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs. Calcitonin gene-related peptide...

    Authors: Eleonóra Spekker, Klaudia Flóra Laborc, Zsuzsanna Bohár, Gábor Nagy-Grócz, Annamária Fejes-Szabó, Mónika Szűcs, László Vécsei and Árpád Párdutz
    Citation: The Journal of Headache and Pain 2021 22:17
    Content type: Research article Published on:

  17. The humanized anti-CGRP monoclonal antibody eptinezumab has been evaluated in five large-scale clinical trials conducted in patients with migraine. This integrated analysis was conducted to evaluate the compre...

    Authors: Timothy R. Smith, Egilius L. H. Spierings, Roger Cady, Joe Hirman, Barbara Schaeffler, Vivienne Shen, Bjørn Sperling, Thomas Brevig, Mette Krog Josiassen, Elizabeth Brunner, Loan Honeywell and Lahar Mehta
    Citation: The Journal of Headache and Pain 2021 22:16
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:46

  18. Galcanezumab is a monoclonal antibody (mAb) that binds calcitonin gene-related peptide (CGRP) and is indicated for the preventive treatment of migraine. Galcanezumab demonstrated early onset of effect in patie...

    Authors: Todd J. Schwedt, Dulanji K. Kuruppu, Yan Dong, Katherine Standley, Laura Yunes-Medina and Eric Pearlman
    Citation: The Journal of Headache and Pain 2021 22:15
    Content type: Research article Published on:

  19. Chronic headache may persist after the remission of reversible cerebral vasoconstriction syndrome (RCVS) in some patients. We aimed to investigate the prevalence, characteristics, risk factors, and the impact ...

    Authors: Yu-Hsiang Ling, Yen-Feng Wang, Jiing-Feng Lirng, Jong-Ling Fuh, Shuu-Jiun Wang and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2021 22:14
    Content type: Research article Published on:

  20. Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol in women ...

    Authors: Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi and Anna Ferrari
    Citation: The Journal of Headache and Pain 2021 22:13
    Content type: Short report Published on:

  21. The mechanisms of genotype-phenotype interaction in Familiar Hemiplegic migraine type 2 (FHM2) are still far from clear. Different ATP1A2 mutations have been described, with a spectrum of phenotypes ranging from ...

    Authors: Fabio Antonaci, Sabrina Ravaglia, Gaetano S. Grieco, Stella Gagliardi, Cristina Cereda and Alfredo Costa
    Citation: The Journal of Headache and Pain 2021 22:12
    Content type: Case report Published on:

  23. Migraine is one of the most common neurological diseases around the world and calcitonin gene-related peptide (CGRP) plays an important role in its pathophysiology. Therefore, in the present study, we evaluate...

    Authors: Zeya Yan, Tao Xue, Shujun Chen, Xin Wu, Xingyu Yang, Guangjie Liu, Shan Gao, Zhouqing Chen and Zhong Wang
    Citation: The Journal of Headache and Pain 2021 22:10
    Content type: Research article Published on:

  24. Idiopatic trigeminal neuralgia purely paroxysmal (ITNp) distributed in the supraorbital and suprathrochlear dermatomes (SSd), refractory to conventional treatments have been linked to the hyperactivity of the ...

    Authors: Alessandro Gualdi, Janos Cambiaso-Daniel, Jonatann Gatti, Ziv M. Peled, Robert Hagan, Dario Bertossi, Paul Wurzer, Lars-Peter Kamolz, Saja Scherer and Giorgio Pietramaggiori
    Citation: The Journal of Headache and Pain 2021 22:9
    Content type: Research article Published on:

  25. Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an ...

    Authors: Lars Michels, Nabin Koirala, Sergiu Groppa, Roger Luechinger, Andreas R. Gantenbein, Peter S. Sandor, Spyros Kollias, Franz Riederer and Muthuraman Muthuraman
    Citation: The Journal of Headache and Pain 2021 22:8
    Content type: Research article Published on:

  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jasem Y. Al-Hashel, R. Alroughani, S. Shuaibi, A. AlAshqar, F. AlHamdan, H. AlThufairi, S. Owayed and Samar F. Ahmed
    Citation: The Journal of Headache and Pain 2021 22:7
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2020 21:80

  27. Galcanezumab, a humanized monoclonal antibody that binds calcitonin gene-related peptide, has demonstrated a significant reduction in monthly migraine headache days compared with placebo. Here, we analyze data...

    Authors: Michael Ament, Kathleen Day, Virginia L Stauffer, Vladimir Skljarevski, Mallikarjuna Rettiganti, Eric Pearlman and Sheena K. Aurora
    Citation: The Journal of Headache and Pain 2021 22:6
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:100

  28. The CGRP antagonists offer a novel therapeutic approach in migraine. Their utility in patients with severe forms of chronic migraine is a subject of particular interest. We present outcomes of 9 months of eren...

    Authors: J. Talbot, R. Stuckey, L. Crawford, S. Weatherby and S. Mullin
    Citation: The Journal of Headache and Pain 2021 22:5
    Content type: Research article Published on:

  29. The moment-to-moment variability of resting-state brain activity has been suggested to play an active role in chronic pain. Here, we investigated the regional blood-oxygen-level-dependent signal variability (BOLD

    Authors: Manyoel Lim, Hassan Jassar, Dajung J. Kim, Thiago D. Nascimento and Alexandre F. DaSilva
    Citation: The Journal of Headache and Pain 2021 22:4
    Content type: Research article Published on:

  30. Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been shown to be effective in migraine prevention. Eptinezumab, erenumab, fremanezumab, and galcanezumb have shown...

    Authors: Joshua M. Cohen, Xiaoping Ning, Yoel Kessler, Michele Rasamoelisolo, Verena Ramirez Campos, Michael J. Seminerio, Lynda J. Krasenbaum, Honglue Shen and Jennifer Stratton
    Citation: The Journal of Headache and Pain 2021 22:3
    Content type: Review article Published on:

  31. Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway, including the fully humanized monoclonal antibody (IgG2Δa) fremanezumab, have demonstrated safety and efficacy for migraine p...

    Authors: Stephen D. Silberstein, Joshua M. Cohen, Ronghua Yang, Sanjay K. Gandhi, Evelyn Du, Adelene E. Jann and Michael J. Marmura
    Citation: The Journal of Headache and Pain 2021 22:2
    Content type: Research article Published on:

  32. Triptans and erenumab are both migraine-specific agents acting on the calcitonin gene-related peptide pathway. Therefore, response to triptans might be associated with response to erenumab.

    Authors: Ilaria Frattale, Valeria Caponnetto, Alfonsina Casalena, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Giannapia Affaitati, Maria Adele Giamberardino, Stefano Viola, Amleto Gabriele, Francesca Pistoia, Davide Cerone, Carmine Marini, Simona Sacco and Raffaele Ornello
    Citation: The Journal of Headache and Pain 2021 22:1
    Content type: Short report Published on:

  33. Several neuromodulation methods exists for migraine treatment. The aim of the present study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) focusing on migraine trea...

    Authors: Xavier Moisset, Bruno Pereira, Daniel Ciampi de Andrade, Denys Fontaine, Michel Lantéri-Minet and Jérôme Mawet
    Citation: The Journal of Headache and Pain 2020 21:142
    Content type: Review article Published on:

  34. To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS).

    Authors: Zhengjie Li, Jun Zhou, Lei Lan, Shirui Cheng, Ruirui Sun, Qiyong Gong, Max Wintermark, Fang Zeng and Fanrong Liang
    Citation: The Journal of Headache and Pain 2020 21:141
    Content type: Research article Published on:

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen
    Citation: The Journal of Headache and Pain 2020 21:140
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2020 21:87

  36. The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization. Metabotropic glutamate re...

    Authors: Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou and Lixue Chen
    Citation: The Journal of Headache and Pain 2020 21:139
    Content type: Research article Published on:

  37. Post-traumatic headache (PTH) is one of the most common and long-lasting symptoms following mild traumatic brain injury (TBI). However, the pathological mechanisms underlying the development of persistent PTH ...

    Authors: Kelly M. Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman and Fletcher A. White
    Citation: The Journal of Headache and Pain 2020 21:138
    Content type: Research article Published on:

  39. Previous researches have reported gray and white matter microalterations in primary trigeminal neuralgia (TN) with neurovascular compression (NVC). The central mechanism underlying TN without NVC are unknown b...

    Authors: Min Wu, Xiaofeng Jiang, Jun Qiu, Xianming Fu and Chaoshi Niu
    Citation: The Journal of Headache and Pain 2020 21:136
    Content type: Research article Published on:

  40. Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for...

    Authors: Xuan Niu, Lijun Bai, Yingxiang Sun, Yuan Wang, Guanghui Bai, Bo Yin, Shan Wang, Shuoqiu Gan, Xiaoyan Jia and Hongjuan Liu
    Citation: The Journal of Headache and Pain 2020 21:135
    Content type: Research article Published on:

  41. Persistent post-traumatic headache (PTH) is a common sequela of mild traumatic brain injury (TBI) and retrospective assessments have found a migraine-like phenotype to be very frequent. This has raised a discu...

    Authors: Håkan Ashina, Afrim Iljazi, Faisal M. Amin, Messoud Ashina, Richard B. Lipton and Henrik W. Schytz
    Citation: The Journal of Headache and Pain 2020 21:134
    Content type: Research article Published on:

  42. Pain sensitivity may determine the risk, severity, prognosis, and efficacy of treatment of clinical pain. Magnetic resonance imaging studies have linked thermal pain sensitivity to changes in brain structure. ...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Li-Ling Hope Pan and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2020 21:133
    Content type: Research article Published on:

  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen
    Citation: The Journal of Headache and Pain 2020 21:132
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2020 21:128

  44. Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding ...

    Authors: Karin Warfvinge, Diana N. Krause, Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson and Kristian A. Haanes
    Citation: The Journal of Headache and Pain 2020 21:131
    Content type: Research article Published on:

  45. Trigeminal neuralgia (TN) causes severe episodic, unilateral facial pain and is initially treated with antiepileptic medications. For patients not responding or intolerant to medications, surgery is an option.

    Authors: Lasair O’Callaghan, Lysbeth Floden, Lisa Vinikoor-Imler, Tara Symonds, Kathryn Giblin, Chris Hartford and Joanna M. Zakrzewska
    Citation: The Journal of Headache and Pain 2020 21:130
    Content type: Research article Published on:

  47. The Covid-19 pandemic is causing changes in delivery of medical care worldwide. It is not known how the management of headache patients was affected by the lockdown during the pandemic. The aim of the present ...

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen
    Citation: The Journal of Headache and Pain 2020 21:128
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:132

  48. Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aur...

    Authors: Kazutaka Sugimoto, Andreia Morais, Homa Sadeghian, Tao Qin, David Y. Chung, Messoud Ashina, Anders Hougaard and Cenk Ayata
    Citation: The Journal of Headache and Pain 2020 21:127
    Content type: Research article Published on:

  49. Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.

    Authors: Cindy Tiseo, Alessandro Vacca, Anton Felbush, Tamara Filimonova, Annalisa Gai, Tatyana Glazyrina, Irina Anna Hubalek, Yelena Marchenko, Lucas Hendrik Overeem, Serena Piroso, Alexander Tkachev, Paolo Martelletti and Simona Sacco
    Citation: The Journal of Headache and Pain 2020 21:126
    Content type: Review article Published on:

  50. Migraine imposes a substantial personal and economic burden to many working age individuals. This study aimed to evaluate the burden and impact of migraine on work productivity in selected workplaces in the Ph...

    Authors: Nel Jason Haw, Ian Theodore Cabaluna, Germaine Erika Kaw, Joanna Feliz Cortez, Maria Pamela Chua and Kristel Guce
    Citation: The Journal of Headache and Pain 2020 21:125
    Content type: Research article Published on:
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