Articles

Answer to the comment on Castien et al. (2018) pressure pain thresholds over the cranio-cervical region in headache - a systematic review and meta-analysis

Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

Comment on Castien et al. (2018) pressure pain thresholds over the cranio-cervical region in headache - a systematic review and meta-analysis

Authors: Kerstin Luedtke, Tibor Szikszay, Wacław Adamczyk and Arne May

Polygenic risk score: use in migraine research

The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10^− 8) due to multiple testing. T...

Authors: Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen and Thomas Folkmann Hansen

Discovery of PACAP and its receptors in the brain

Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study

Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.

Authors: Beáta Éva Petrovski, Kjersti G. Vetvik, Christofer Lundqvist and Malin Eberhard-Gran

Altered muscle activity during rest and during mental or physical activity is not a trait symptom of migraine - a neck muscle EMG study

Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...

Authors: Kerstin Luedtke, Jan Mehnert and Arne May

The epidemiology of headache disorders: a face-to-face interview of participants in HUNT4

The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.

Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl and Trond Sand

Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures

The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

Authors: Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma

The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system

Calcitonin gene-related peptide (CGRP) has long been a focus of migraine research, since it turned out that inhibition of CGRP or CGRP receptors by antagonists or monoclonal IgG antibodies was therapeutic in f...

Authors: Karl Messlinger

PACAP and its role in primary headaches

Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache

The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannu...

Authors: Philip R. Holland, Mads Barloese and Jan Fahrenkrug

Protective effects of PACAP in ischemia

Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey

Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

Authors: Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

Migraine is first cause of disability in under 50s: will health politicians now take notice?

Authors: Timothy J. Steiner, Lars J. Stovner, Theo Vos, R. Jensen and Z. Katsarava

PACAP and its receptors in cranial arteries and mast cells

In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility

Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

Authors: T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

Measurement and implications of the distance between the sphenopalatine ganglion and nasal mucosa: a neuroimaging study

Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

Authors: Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

Long-term study of the efficacy and safety of OnabotulinumtoxinA for the prevention of chronic migraine: COMPEL study

OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

Authors: Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

The Headache-Attributed Lost Time (HALT) Indices: measures of burden for clinical management and population-based research

The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...

Authors: T. J. Steiner and R. B. Lipton

Cilostazol induced migraine does not respond to sumatriptan in a double blind trial

Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

Authors: Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

Poor medical care for people with migraine in Europe – evidence from the Eurolight study

Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...

Authors: Zaza Katsarava, Maka Mania, Christian Lampl, Johanna Herberhold and Timothy J. Steiner

Pressure pain thresholds over the cranio-cervical region in headache: a systematic review and meta-analysis

Sensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. ...

Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

Headache following head injury: a population-based longitudinal cohort study (HUNT)

Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether sub...

Authors: Lena Hoem Nordhaug, Knut Hagen, Anne Vik, Lars Jacob Stovner, Turid Follestad, Torunn Pedersen, Gøril Bruvik Gravdahl and Mattias Linde

PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunit...

Authors: Binbin Wang, Siyuan Liu, Bingbing Fan, Xingguo Xu, Yonglin Chen, Rongxiang Lu, Zhongling Xu and Xiaojuan Liu

Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry

Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcom...

Authors: Mads Barloese, Anja Petersen, Philipp Stude, Tim Jürgens, Rigmor Højland Jensen and Arne May

Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation

Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with ...

Authors: Francesca Puledda, Peter J. Goadsby and Prab Prabhakar

Comparison of gray matter volume between migraine and “strict-criteria” tension-type headache

Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both t...

Authors: Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M. Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin and Shuu-Jiun Wang

Effect of a calcitonin gene-related peptide-binding L-RNA aptamer on neuronal activity in the rat spinal trigeminal nucleus

Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues inc...

Authors: Michael J. M. Fischer, Jakob Schmidt, Stanislav Koulchitsky, Sven Klussmann, Axel Vater and Karl Messlinger

The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine

Migraine remains one of the biggest clinical case to be solved among the non-communicable diseases, second to low back pain for disability caused as reported by the Global Burden of Disease Study 2016. Despite...

Authors: Paolo Martelletti

Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study

Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirme...

Authors: Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao and Shengyuan Yu

The burden of headache is associated to pain interference, depression and headache duration in chronic tension type headache: a 1-year longitudinal study

To investigate variables associated at one year (longitudinal design) with the physical or emotional component of burden in chronic tension type headache (CTTH).

Authors: Stella Fuensalida-Novo, Maria Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Antonella Catena, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

Sphenopalatine ganglion: block, radiofrequency ablation and neurostimulation - a systematic review

Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its e...

Authors: Kwo Wei David Ho, Rene Przkora and Sanjeev Kumar

Characterization of migraineurs presenting interictal widespread pressure hyperalgesia identified using a tender point count: a cross-sectional study

Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressu...

Authors: Toshihide Toriyama, Tetsuyoshi Horiuchi and Kazuhiro Hongo

The enigma of site of action of migraine preventives: no effect of metoprolol on trigeminal pain processing in patients and healthy controls

Beta-blockers are a first choice migraine preventive medication. So far it is unknown how they exert their therapeutic effect in migraine. To this end we examined the neural effect of metoprolol on trigeminal ...

Authors: Julia M. Hebestreit and Arne May

Cerebral gray matter volume in patients with chronic migraine: correlations with clinical features

To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morph...

Authors: Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

Characteristics and diagnoses of acute headache in pregnant women – a retrospective cross-sectional study

Acute headache is one of the most frequent neurological symptoms in pregnant women. The early diagnosis of underlying secondary conditions has a major influence on patient outcome, especially in emergency sett...

Authors: Bianca Raffaelli, Eberhard Siebert, Jeannette Körner, Thomas Liman, Uwe Reuter and Lars Neeb

11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Authors:

Experts’ opinion about the pediatric secondary headaches diagnostic criteria of the ICHD-3 beta

The 2013 International Classification of Headache Disorders-3 was published in a beta version to allow clinicians to confirm the validity of the criteria or suggest improvements based on field studies. The aim...

Authors: Aynur Özge, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Noemi Faedda, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis

Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR...

Authors: Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma and Shengyuan Yu

PACAP38 in human models of primary headaches

To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.

Authors: Håkan Ashina, Song Guo, Anne L. H. Vollesen and Messoud Ashina

Experts’ opinion about the primary headache diagnostic criteria of the ICHD-3rd edition beta in children and adolescents

The 2013 International Classification of Headache Disorders-3 (ICHD-3) was published in a beta version to allow the clinicians to confirm the validity of the criteria or to suggest improvements based on field ...

Authors: Aynur Özge, Noemi Faedda, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)

Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migra...

Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

Caffeine in the management of patients with headache

Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmac...

Authors: Richard B. Lipton, Hans-Christoph Diener, Matthew S. Robbins, Sandy Yacoub Garas and Ketu Patel

Headache and pregnancy: a systematic review

This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

Authors: A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

Burden of migraine in a Kuwaiti population: a door-to-door survey

Migraine prevalence and disability imprints on Kuwaiti population are underreported. We aimed to measure the prevalence of migraine and to assess its burden in Kuwait.

Authors: Jasem Yousef Al-Hashel, Samar Farouk Ahmed and Raed Alroughani

The role of α₁- and α₂-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D₂-like receptors, serotonin 5-HT_1/2 receptors and α₁/α₂-adrenoceptors. Since activation of vascular α₁/α₂-adrenoceptors ...

Authors: Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink and Carlos M. Villalón

Triptans and CGRP blockade – impact on the cranial vasculature

The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

Authors: Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

Patients’ preferences for headache acute and preventive treatment

We aimed to explore patients’ preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo.

Authors: Dimos D. Mitsikostas, Ioanna Belesioti, Chryssa Arvaniti, Euthymia Mitropoulou, Christina Deligianni, Elina Kasioti, Theodoros Constantinidis, Manolis Dermitzakis and Michail Vikelis

Fluctuations in episodic and chronic migraine status over the course of 1 year: implications for diagnosis, treatment and clinical trial design

Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

Authors: Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse