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  1. The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing. T...

    Authors: Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen and Thomas Folkmann Hansen

    Citation: The Journal of Headache and Pain 2018 19:29

    Content type: Review article

    Published on:

  2. Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

    Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

    Citation: The Journal of Headache and Pain 2018 19:28

    Content type: Review article

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  3. Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.

    Authors: Beáta Éva Petrovski, Kjersti G. Vetvik, Christofer Lundqvist and Malin Eberhard-Gran

    Citation: The Journal of Headache and Pain 2018 19:27

    Content type: Research article

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  4. Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...

    Authors: Kerstin Luedtke, Jan Mehnert and Arne May

    Citation: The Journal of Headache and Pain 2018 19:26

    Content type: Research article

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  5. The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.

    Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl and Trond Sand

    Citation: The Journal of Headache and Pain 2018 19:25

    Content type: Research article

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  6. The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

    Authors: Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

    Citation: The Journal of Headache and Pain 2018 19:24

    Content type: Research article

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  7. The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

    Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

    Citation: The Journal of Headache and Pain 2018 19:23

    Content type: Review article

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  8. Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

    Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

    Citation: The Journal of Headache and Pain 2018 19:21

    Content type: Review article

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  9. Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:19

    Content type: Review article

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  10. Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

    Authors: Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:18

    Content type: Research article

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  11. In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

    Citation: The Journal of Headache and Pain 2018 19:16

    Content type: Review article

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  12. Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

    Authors: T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

    Citation: The Journal of Headache and Pain 2018 19:15

    Content type: Methodology

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  13. Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

    Authors: Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

    Citation: The Journal of Headache and Pain 2018 19:14

    Content type: Research article

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  14. OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

    Authors: Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

    Citation: The Journal of Headache and Pain 2018 19:13

    Content type: Research article

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  15. The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...

    Authors: T. J. Steiner and R. B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:12

    Content type: Methodology

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  16. Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

    Authors: Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

    Citation: The Journal of Headache and Pain 2018 19:11

    Content type: Research article

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  17. Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...

    Authors: Zaza Katsarava, Maka Mania, Christian Lampl, Johanna Herberhold and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:10

    Content type: Research article

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  18. Sensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. ...

    Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

    Citation: The Journal of Headache and Pain 2018 19:9

    Content type: Review article

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  19. Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether sub...

    Authors: Lena Hoem Nordhaug, Knut Hagen, Anne Vik, Lars Jacob Stovner, Turid Follestad, Torunn Pedersen, Gøril Bruvik Gravdahl and Mattias Linde

    Citation: The Journal of Headache and Pain 2018 19:8

    Content type: Research article

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  20. Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunit...

    Authors: Binbin Wang, Siyuan Liu, Bingbing Fan, Xingguo Xu, Yonglin Chen, Rongxiang Lu, Zhongling Xu and Xiaojuan Liu

    Citation: The Journal of Headache and Pain 2018 19:7

    Content type: Research article

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  21. Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcom...

    Authors: Mads Barloese, Anja Petersen, Philipp Stude, Tim Jürgens, Rigmor Højland Jensen and Arne May

    Citation: The Journal of Headache and Pain 2018 19:6

    Content type: Research article

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  22. Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with ...

    Authors: Francesca Puledda, Peter J. Goadsby and Prab Prabhakar

    Citation: The Journal of Headache and Pain 2018 19:5

    Content type: Research article

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  23. Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both t...

    Authors: Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M. Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2018 19:4

    Content type: Research article

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  24. Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues inc...

    Authors: Michael J. M. Fischer, Jakob Schmidt, Stanislav Koulchitsky, Sven Klussmann, Axel Vater and Karl Messlinger

    Citation: The Journal of Headache and Pain 2018 19:3

    Content type: Research article

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  25. Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirme...

    Authors: Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2018 19:1

    Content type: Research article

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  26. To investigate variables associated at one year (longitudinal design) with the physical or emotional component of burden in chronic tension type headache (CTTH).

    Authors: Stella Fuensalida-Novo, Maria Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Antonella Catena, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

    Citation: The Journal of Headache and Pain 2017 18:119

    Content type: Research article

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  27. Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its e...

    Authors: Kwo Wei David Ho, Rene Przkora and Sanjeev Kumar

    Citation: The Journal of Headache and Pain 2017 18:118

    Content type: Review article

    Published on:

  28. Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressu...

    Authors: Toshihide Toriyama, Tetsuyoshi Horiuchi and Kazuhiro Hongo

    Citation: The Journal of Headache and Pain 2017 18:117

    Content type: Research article

    Published on:

  29. Beta-blockers are a first choice migraine preventive medication. So far it is unknown how they exert their therapeutic effect in migraine. To this end we examined the neural effect of metoprolol on trigeminal ...

    Authors: Julia M. Hebestreit and Arne May

    Citation: The Journal of Headache and Pain 2017 18:116

    Content type: Research article

    Published on:

  30. To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morph...

    Authors: Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

    Citation: The Journal of Headache and Pain 2017 18:115

    Content type: Research article

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  31. Acute headache is one of the most frequent neurological symptoms in pregnant women. The early diagnosis of underlying secondary conditions has a major influence on patient outcome, especially in emergency sett...

    Authors: Bianca Raffaelli, Eberhard Siebert, Jeannette Körner, Thomas Liman, Uwe Reuter and Lars Neeb

    Citation: The Journal of Headache and Pain 2017 18:114

    Content type: Research article

    Published on:

  32. The 2013 International Classification of Headache Disorders-3 was published in a beta version to allow clinicians to confirm the validity of the criteria or suggest improvements based on field studies. The aim...

    Authors: Aynur Özge, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Noemi Faedda, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:113

    Content type: Research article

    Published on:

  33. Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR...

    Authors: Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2017 18:112

    Content type: Research article

    Published on:

  34. To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.

    Authors: Håkan Ashina, Song Guo, Anne L. H. Vollesen and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:110

    Content type: Review article

    Published on:

  35. The 2013 International Classification of Headache Disorders-3 (ICHD-3) was published in a beta version to allow the clinicians to confirm the validity of the criteria or to suggest improvements based on field ...

    Authors: Aynur Özge, Noemi Faedda, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:109

    Content type: Review article

    Published on:

  36. Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migra...

    Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2017 18:108

    Content type: Consensus article

    Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2018 19:81

  37. Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmac...

    Authors: Richard B. Lipton, Hans-Christoph Diener, Matthew S. Robbins, Sandy Yacoub Garas and Ketu Patel

    Citation: The Journal of Headache and Pain 2017 18:107

    Content type: Review article

    Published on:

  38. This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

    Authors: A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

    Citation: The Journal of Headache and Pain 2017 18:106

    Content type: Review article

    Published on:

  39. Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α12-adrenoceptors. Since activation of vascular α12-adrenoceptors ...

    Authors: Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    Citation: The Journal of Headache and Pain 2017 18:104

    Content type: Research article

    Published on:

  40. The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

    Authors: Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:103

    Content type: Review article

    Published on:

  41. We aimed to explore patients’ preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo.

    Authors: Dimos D. Mitsikostas, Ioanna Belesioti, Chryssa Arvaniti, Euthymia Mitropoulou, Christina Deligianni, Elina Kasioti, Theodoros Constantinidis, Manolis Dermitzakis and Michail Vikelis

    Citation: The Journal of Headache and Pain 2017 18:102

    Content type: Research article

    Published on:

  42. Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

    Authors: Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse

    Citation: The Journal of Headache and Pain 2017 18:101

    Content type: Research article

    Published on:

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