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  1. Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD a...

    Authors: Andreas Dawson, Niclas Stensson, Bijar Ghafouri, Björn Gerdle, Thomas List, Peter Svensson and Malin Ernberg
    Citation: The Journal of Headache and Pain 2016 17:65
    Content type: Research article Published on:

  2. Neurogenic inflammation has for decades been considered an important part of migraine pathophysiology. In the present study, we asked the question if administration of a novel kynurenic acid analogue (SZR72), ...

    Authors: M. Lukács, K. Warfvinge, L. S. Kruse, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson
    Citation: The Journal of Headache and Pain 2016 17:64
    Content type: Short report Published on:

  3. Several different interventions have been examined to alleviate pain and reduce frequency of trigeminal neuralgia (TN) paroxysms. However, some patients continue to have persistent or recurrent painful attacks...

    Authors: Mostafa Ebraheem Morra, Ahmed Elgebaly, Ahmed Elmaraezy, Adham M. Khalil, Ahmed M. A. Altibi, Tran Le-Huy Vu, Mostafa Reda Mostafa, Nguyen Tien Huy and Kenji Hirayama
    Citation: The Journal of Headache and Pain 2016 17:63
    Content type: Review article Published on:

  4. Previous studies have shown that migraine and sleep disturbances are closely associated. Excessive daytime sleepiness (EDS) is a common symptom of various types of sleep disturbance. Findings from clinic-based...

    Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2016 17:62
    Content type: Research article Published on:

  5. Clinical differentiation between pain mechanisms of temporomandibular joint (TMJ) arthralgia and osteoarthritis (OA) is challenging. The aims were to compare somatosensory function at the TMJs and conditioned ...

    Authors: Simple Futarmal Kothari, Lene Baad-Hansen, Lars Bolvig Hansen, Niels Bang, Leif Hovgaard Sørensen, Helle Wulf Eskildsen and Peter Svensson
    Citation: The Journal of Headache and Pain 2016 17:61
    Content type: Research article Published on:

  6. Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurr...

    Authors: Saras Menon, Bushra Nasir, Nesli Avgan, Sussan Ghassabian, Christopher Oliver, Rodney Lea, Maree Smith and Lyn Griffiths
    Citation: The Journal of Headache and Pain 2016 17:60
    Content type: Research article Published on:

  7. Headache disorders and psychiatric disorders are both common, while evidence, mostly pertaining to migraine, suggests they are comorbid more often than might be expected by chance. There are good reasons for e...

    Authors: Christian Lampl, Hallie Thomas, Cristina Tassorelli, Zaza Katsarava, Jose Miguel Laínez, Michel Lantéri-Minet, Daiva Rastenyte, Elena Ruiz de la Torre, Lars Jacob Stovner, Colette Andrée and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2016 17:59
    Content type: Research article Published on:

  8. Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine.

    Authors: Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Vincenzo Parisi and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2016 17:58
    Content type: Research article Published on:

  9. No study has compared the associations of headache, anxiety, and depression at baseline with muscle soreness or pain (MS/P) at baseline and at the two-year follow-up point among outpatients with major depressi...

    Authors: Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2016 17:57
    Content type: Research article Published on:

  10. The headache disorders, namely, migraine and tension type headache and the associated analgesic consumption is badly underestimated and thus makes a major current public health problem. The objective of this s...

    Authors: Eshetie Melese Birru, Zenahebezu Abay, Mohammedbrhan Abdelwuhab, Abebe Basazn, Betelhem Sirak and Fitsum Sebsibe Teni
    Citation: The Journal of Headache and Pain 2016 17:56
    Content type: Research article Published on:

  11. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder caused by mutations in the NOTCH3 gene. Although CADASIL ...

    Authors: Dan He, Daiqi Chen, Xuefei Li, Zheng Hu, Zhiyuan Yu, Wei Wang and Xiang luo
    Citation: The Journal of Headache and Pain 2016 17:55
    Content type: Research article Published on:

  13. In the dura mater encephali a significant population of trigeminal afferents coexpress the nociceptive ion channel transient receptor potential vanilloid type 1 (TRPV1) receptor and calcitonin gene-related pep...

    Authors: Mária Dux, Éva Deák, Noémi Tassi, Péter Sántha and Gábor Jancsó
    Citation: The Journal of Headache and Pain 2016 17:53
    Content type: Research article Published on:

  14. The autonomous cardiovascular control can contribute to progression of migraine. However, current data on cardiovascular reactivity in migraine, especially severe forms, are essentially contradictory. The main...

    Authors: Oleg V. Mamontov, Laura Babayan, Alexander V. Amelin, Rashid Giniatullin and Alexei A. Kamshilin
    Citation: The Journal of Headache and Pain 2016 17:52
    Content type: Research article Published on:

  15. There is increasing interest in using electronic behavioral interventions as well as mobile technologies such as smartphones for improving the care of chronic disabling diseases such as migraines. However, les...

    Authors: Mia Tova Minen, John Torous, Jenelle Raynowska, Allison Piazza, Corita Grudzen, Scott Powers, Richard Lipton and Mary Ann Sevick
    Citation: The Journal of Headache and Pain 2016 17:51
    Content type: Review article Published on:

  17. As a complex nervous system disease, migraine causes severe healthy and social issues worldwide. Valproate (VPA) is a widely used treatment agent against seizures and bipolar disorder, and its function to alle...

    Authors: Yuanchao Li, Qin Zhang, Dandan Qi, Li Zhang, Lian Yi, Qianqian Li and Zhongling Zhang
    Citation: The Journal of Headache and Pain 2016 17:49
    Content type: Research article Published on:

  18. Chronic migraine is one of the most common diseases in the world and it is often associated with medication overuse that can worsen the headache itself. Thus, it is important to adopt effective therapies to re...

    Authors: Simona Guerzoni, Lanfranco Pellesi, Carlo Baraldi and Luigi Alberto Pini
    Citation: The Journal of Headache and Pain 2016 17:48
    Content type: Research article Published on:

  19. Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such a...

    Authors: Martina Curto, Luana Lionetto, Andrea Negro, Matilde Capi, Francesco Fazio, Maria Adele Giamberardino, Maurizio Simmaco, Ferdinando Nicoletti and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2016 17:47
    Content type: Research article Published on:

  20. Reports have suggested that abnormal cortical excitability may be associated with acute migraines. The present study quantitatively assesses the degree of cortical excitability in chronic migraine as compared ...

    Authors: Kimberly A. Leiken, Jing Xiang, Emily Curry, Hisako Fujiwara, Douglas F. Rose, Janelle R. Allen, Joanne E. Kacperski, Hope L. O’Brien, Marielle A. Kabbouche, Scott W. Powers and Andrew D. Hershey
    Citation: The Journal of Headache and Pain 2016 17:46
    Content type: Research article Published on:

  21. Headache disorders, anxiety and depression – the major disorders of the brain – are highly comorbid in the western world. Whether this is so in South Asia has not been investigated, but the question is of publ...

    Authors: Ajay Risal, Kedar Manandhar, Are Holen, Timothy J. Steiner and Mattias Linde
    Citation: The Journal of Headache and Pain 2016 17:45
    Content type: Research article Published on:

  22. In the largest case series of cluster headache (CH) published in the literature, age of onset varies between 29.6 and 31.6 years. Differences in onset age based on gender and subtype diagnosis are reported, wh...

    Authors: Gian Camillo Manzoni, Arens Taga, Marco Russo and Paola Torelli
    Citation: The Journal of Headache and Pain 2016 17:44
    Content type: Research article Published on:

  23. Cluster headache (CH) is a debilitating condition that is generally associated with substantial health care costs. Few therapies are approved for abortive or prophylactic treatment. Results from the prospectiv...

    Authors: James Morris, Andreas Straube, Hans-Christoph Diener, Fayyaz Ahmed, Nicholas Silver, Simon Walker, Eric Liebler and Charly Gaul
    Citation: The Journal of Headache and Pain 2016 17:43
    Content type: Research article Published on:

  24. Headache is a common complaint among children. The most common primary headache syndromes in childhood are migraine and TTH. However many times they seem to overlap. The purpose of our study was to assess the ...

    Authors: Jacob Genizi, Amal Khourieh Matar, Mitchell Schertz, Nathanel Zelnik and Isaac Srugo
    Citation: The Journal of Headache and Pain 2016 17:42
    Content type: Research article Published on:

  25. Studies have indicated that the prevalence of symptoms and signs of temporomandibular disorders (TMD) are rare early in childhood, but become more prevalent in adolescents and adulthood. To our knowledge, no s...

    Authors: Amal Al-Khotani, Aron Naimi-Akbar, Emad Albadawi, Malin Ernberg, Britt Hedenberg-Magnusson and Nikolaos Christidis
    Citation: The Journal of Headache and Pain 2016 17:41
    Content type: Research article Published on:

  26. This research sought to further validate the rat nitroglycerin (NTG) migraine model by comparing the effects of single versus recurrent NTG episodes on behavioral endpoints that mirror ICHD-3 diagnostic criter...

    Authors: Kenneth J. Sufka, Stephanie M. Staszko, Ainslee P. Johnson, Morgan E. Davis, Rachel E. Davis and Todd A. Smitherman
    Citation: The Journal of Headache and Pain 2016 17:40
    Content type: Research article Published on:

  27. Headache is a common disorder affecting a growing number of children and adolescents. In recent years, there has been an increase in scientific interest in exploring the relationship between migraine and emoti...

    Authors: Rita Cerutti, Carmela Valastro, Samuela Tarantino, Massimiliano Valeriani, Noemi Faedda, Valentina Spensieri and Vincenzo Guidetti
    Citation: The Journal of Headache and Pain 2016 17:39
    Content type: Research article Published on:

  28. Although alterations in resting-state neural network have been previously reported in migraine using functional MRI, whether this atypical neural network is frequency dependent remains unknown. The aim of this...

    Authors: Di Wu, Yuchen Zhou, Jing Xiang, Lu Tang, Hongxing Liu, Shuyang Huang, Ting Wu, Qiqi Chen and Xiaoshan Wang
    Citation: The Journal of Headache and Pain 2016 17:38
    Content type: Research article Published on:

  29. Central information processing, visible in evoked potentials like the contingent negative variation (CNV) is altered in migraine patients who exhibit higher CNV amplitudes and a reduced habituation. Both chara...

    Authors: Bianca Meyer, Armin Keller, Hans-Georg Wöhlbier, Claudia Helene Overath, Britta Müller and Peter Kropp
    Citation: The Journal of Headache and Pain 2016 17:37
    Content type: Research article Published on:

  30. Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms an...

    Authors: Sırma Geyik, Sercan Ergun, Samiye Kuzudişli, Figen Şensoy, Ebru Temiz, Erman Altunışık, Murat Korkmaz, Hasan Dağlı, Seval Kul, Aylin Akçalı and Ayşe Münife Neyal
    Citation: The Journal of Headache and Pain 2016 17:36
    Content type: Research article Published on:

  31. The trigeminal nociceptive system plays a pivotal role in the pathophysiology of migraines. The present study investigated whether there are differences between patients with episodic migraine (EM) and patient...

    Authors: Jong-Hee Sohn, Chul-Ho Kim and Hui-Chul Choi
    Citation: The Journal of Headache and Pain 2016 17:35
    Content type: Research article Published on:

  32. Most patients with migraine report photophobia associated with headache; a subset report interictal photophobia. These patients are light sensitive even during headache-free periods. The objective of this case...

    Authors: Stephanie M. Llop, Jonathan E. Frandsen, Kathleen B. Digre, Bradley J. Katz, Alison V. Crum, Chong Zhang and Judith E. A. Warner
    Citation: The Journal of Headache and Pain 2016 17:34
    Content type: Research article Published on:

  33. Airplane headache (AH) is a headache that occurs during take-off and landing. The pain is described as severe, unilateral, and located in the fronto-orbital region. This study aimed at investigating the incide...

    Authors: Sebastian Bao Dinh Bui, Torben Petersen, Jeppe Nørgaard Poulsen and Parisa Gazerani
    Citation: The Journal of Headache and Pain 2016 17:33
    Content type: Research article Published on:

    The Erratum to this article has been published in The Journal of Headache and Pain 2016 17:50

  34. Headache is the most common pain disorder in children and adolescents and is associated with diverse dysfunctions and psychological symptoms. Several studies evidenced sex-specific differences in headache freq...

    Authors: Corinna Isensee, Carolin Fernandez Castelao and Birgit Kröner-Herwig
    Citation: The Journal of Headache and Pain 2016 17:32
    Content type: Research article Published on:

  36. Temporomandibular disorders (TMD) in children and adolescents is prevalent with pain as a common component, and has a comorbidity with psychosocial problems such as stress, depression, anxiety as well as somat...

    Authors: Amal Al-Khotani, Aron Naimi-Akbar, Mattias Gjelset, Emad Albadawi, Lanre Bello, Britt Hedenberg-Magnusson and Nikolaos Christidis
    Citation: The Journal of Headache and Pain 2016 17:30
    Content type: Research article Published on:

  37. Temporomandibular joint dysfunction are often accompanied by symptoms of headache such as tension-type headache which is the most frequent spontaneous primary headache. Masseter muscle pain is commonly reporte...

    Authors: Malgorzata Pihut, Ewa Ferendiuk, Michal Szewczyk, Katarzyna Kasprzyk and Mieszko Wieckiewicz
    Citation: The Journal of Headache and Pain 2016 17:29
    Content type: Research article Published on:

  38. Fibromyalgia (FMS) and high frequency episodic/chronic migraine (M) very frequently co-occur, suggesting common pathophysiological mechanisms; both conditions display generalized somatic hyperalgesia. In FMS-M...

    Authors: Maria Adele Giamberardino, Giannapia Affaitati, Paolo Martelletti, Claudio Tana, Andrea Negro, Domenico Lapenna, Martina Curto, Cosima Schiavone, Luisa Stellin, Francesco Cipollone and Raffaele Costantini
    Citation: The Journal of Headache and Pain 2016 17:28
    Content type: Research article Published on:

  39. The reported efficacy of memantine in the treatment of patients with cluster headache (CH) suggests that NMDA receptors are involved in mechanisms of nociceptive sensitization within the trigeminal system asso...

    Authors: Martina Curto, Luana Lionetto, Andrea Negro, Matilde Capi, Francesca Perugino, Francesco Fazio, Maria Adele Giamberardino, Maurizio Simmaco, Ferdinando Nicoletti and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2016 17:27
    Content type: Research article Published on:

  40. Chronic migraine is a disabling, under-recognized, and undertreated disorder that increases health burdens. The aim of this study was to evaluate phenotypic features and the relevance of accompanying symptoms ...

    Authors: Osman Özgür Yalın, Derya Uluduz, Aynur Özge, Mehmet Ali Sungur, Macit Selekler and Aksel Siva
    Citation: The Journal of Headache and Pain 2016 17:26
    Content type: Research article Published on:

  41. Cluster headache (CH) has been associated with certain personality traits and lifestyle features, but there are few studies assessing personality profiles in CH. We aimed to analyze personality traits in patie...

    Authors: I. Muñoz, M. S. Hernández, S. Santos, C. Jurado, L. Ruiz, E. Toribio, E. M. Sotelo, A. L. Guerrero, V. Molina, F. Uribe and M. L. Cuadrado
    Citation: The Journal of Headache and Pain 2016 17:25
    Content type: Research article Published on:

  42. Headache disorders are under-recognized and under-diagnosed. A principal factor in their suboptimal management is lack of headache-related training among health-care providers, especially in primary care. In E...

    Authors: Mark Braschinsky, Sulev Haldre, Mart Kals, Anna Iofik, Ave Kivisild, Jaanus Korjas, Silvia Koljal, Zaza Katsarava and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2016 17:24
    Content type: Research article Published on:

  43. Cluster headache is classified as a primary headache by definition not caused by an underlying pathology. However, symptomatic cases of otherwise typical cluster headache have been reported.

    Authors: Annelien De Pue, Bart Lutin and Koen Paemeleire
    Citation: The Journal of Headache and Pain 2016 17:23
    Content type: Case report Published on:

  44. Authors: Marian Gomez-Beldarrain, Isabel Oroz, Begoña Garcia Zapirain, Begoña Fernandez Ruanova, Yolanda Garcia-Chimeno, Alberto Cabrera, Ane Anton-Ladislao, Urko Aguirre-Larracoechea and Juan Carlos Garcıa-Monco
    Citation: The Journal of Headache and Pain 2016 17:22
    Content type: Erratum Published on:

    The original article was published in The Journal of Headache and Pain 2016 17:4

  45. The diagnostic criteria for primary stabbing headache (PSH) in the 3rd beta edition of International Classification of Headache Disorders (ICDH-3 beta) were recently revised. In the ICDH-3 beta, PSH is defined...

    Authors: Minwoo Lee, Min Kyung Chu, Juyoung Lee, Jinhyuk Yoo and Hong Ki Song
    Citation: The Journal of Headache and Pain 2016 17:21
    Content type: Research article Published on:

  46. Medication overuse headache (MOH) is a very disabling and costly disorder due to indirect costs, medication and healthcare utilization. The aim of the study was to describe general demographic and clinical cha...

    Authors: Ninett Louise Find, Rossana Terlizzi, Signe Bruun Munksgaard, Lars Bendtsen, Cristina Tassorelli, Giuseppe Nappi, Zaza Katsarava, Miguel Lainez, Maria Teresa Goicochea, Beatriz Shand, Ricardo Fadic, Santiago Spadafora, Marco Pagani and Rigmor Jensen
    Citation: The Journal of Headache and Pain 2016 17:20
    Content type: Research article Published on:

  47. Methylprednisolone (MPD) is a rapid acting highly effective cluster headache preventive and also suppresses the recurrence of migraine attacks. Previously, we could demonstrate that elevated CGRP plasma levels...

    Authors: Lars Neeb, Peter Hellen, Jan Hoffmann, Ulrich Dirnagl and Uwe Reuter
    Citation: The Journal of Headache and Pain 2016 17:19
    Content type: Research article Published on:

  49. Migraine headache has a high prevalence and a severe impact on personal, social and work life, forming a significant burden on patients, service providers and society. There is some evidence of the effectivene...

    Authors: Myfanwy Morgan, Sian Cousins, Laura Middleton, Genevieve Warriner-Gallyer and Leone Ridsdale
    Citation: The Journal of Headache and Pain 2016 17:16
    Content type: Research article Published on:

  50. Recurrent and especially chronic headaches are associated with psychiatric comorbidities such as depression and anxiety. Only few studies examined the impact of depression and anxiety on episodic (EH) and chro...

    Authors: Karin Zebenholzer, Anita Lechner, Gregor Broessner, Christian Lampl, Gernot Luthringshausen, Albert Wuschitz, Sonja-Maria Obmann, Klaus Berek and Christian Wöber
    Citation: The Journal of Headache and Pain 2016 17:15
    Content type: Research article Published on:
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