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  1. The degree to which work-related difficulties are recognized in headache research is poor and often carried out with inadequate information such as “reduced ability to work as usual”, which do not capture at a...

    Authors: Alberto Raggi, Venusia Covelli, Erika Guastafierro, Matilde Leonardi, Chiara Scaratti, Licia Grazzi, Marco Bartolini, Giovanna Viticchi, Sabina Cevoli, Giulia Pierangeli, Gioacchino Tedeschi, Antonio Russo, Piero Barbanti, Cinzia Aurilia, Carlo Lovati, Luca Giani…
    Citation: The Journal of Headache and Pain 2018 19:85
    Content type: Research article Published on:

  2. A myofascial trigger point is defined as a hyperirritable spot in skeletal muscle that is associated with a hypersensitive palpable nodule in a taut band. It has been suggested that myofascial trigger points t...

    Authors: Thien Phu Do, Gerda Ferja Heldarskard, Lærke Tørring Kolding, Jeppe Hvedstrup and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2018 19:84
    Content type: Review article Published on:

  3. Migraine is a distinct neurological disease that imposes a significant burden on patients, society, and the healthcare system. This study aimed to characterize the incremental burden of migraine in individuals...

    Authors: Pamela Vo, Juanzhi Fang, Aikaterini Bilitou, Annik K. Laflamme and Shaloo Gupta
    Citation: The Journal of Headache and Pain 2018 19:82
    Content type: Research article Published on:

  5. Cluster headaches (CH) are recurrent severe headaches, which impose a major burden on the life of patients. We investigated the impact of CH on employment status and job burden.

    Authors: Yun-Ju Choi, Byung-Kun Kim, Pil-Wook Chung, Mi Ji Lee, Jung-Wook Park, Min Kyung Chu, Jin-Young Ahn, Byung-Su Kim, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Kwang-Soo Lee, Soo-Kyoung Kim, Kwang-Yeol Park, Jae Myun Chung, Heui-Soo Moon…
    Citation: The Journal of Headache and Pain 2018 19:78
    Content type: Research article Published on:

  6. There is limited literature on prolonged aura (PA - defined as an aura including at least one symptom for > 1 h and < 7d), and there are no prospective studies.

    Authors: Michele Viana, Grazia Sances, Mattias Linde, Giuseppe Nappi, Farihah Khaliq, Peter J. Goadsby and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2018 19:77
    Content type: Short report Published on:

  7. We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was unde...

    Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Andreas R. Gantenbein, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Koen Paemeleire, Per Morten Sandset…
    Citation: The Journal of Headache and Pain 2018 19:76
    Content type: Consensus article Published on:

  8. Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected. Here have been desc...

    Authors: G. S. Grieco, S. Gagliardi, I. Ricca, O. Pansarasa, M. Neri, F. Gualandi, G. Nappi, A. Ferlini and C. Cereda
    Citation: The Journal of Headache and Pain 2018 19:75
    Content type: Research article Published on:

  9. Limited histopathology studies have suggested that reversible cerebral vasoconstriction syndromes (RCVS) does not present with vascular wall inflammation. Previous vascular imaging studies have had inconsisten...

    Authors: Chun-Yu Chen, Shih-Pin Chen, Jong-Ling Fuh, Jiing-Feng Lirng, Feng-Chi Chang, Yen-Feng Wang and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2018 19:74
    Content type: Research article Published on:

  10. Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating with clinical efficacy is available to ...

    Authors: Alessandro Viganò, Maria Claudia Torrieri, Massimiliano Toscano, Francesca Puledda, Barbara Petolicchio, Tullia Sasso D’Elia, Angela Verzina, Sonia Ruggiero, Marta Altieri, Edoardo Vicenzini, Jean Schoenen and Vittorio Di Piero
    Citation: The Journal of Headache and Pain 2018 19:73
    Content type: Research article Published on:

  11. Percutaneous occipital nerve stimulation (ONS) is effective in refractory chronic cluster headache (rCCH) patients. Responders to ONS differ from non-responders by greater glucose metabolism in subgenual anter...

    Authors: Delphine Magis, Kevin D’Ostilio, Marco Lisicki, Chany Lee and Jean Schoenen
    Citation: The Journal of Headache and Pain 2018 19:72
    Content type: Research article Published on:

  13. DFN-11, a 3 mg sumatriptan subcutaneous (SC) autoinjector for acute treatment of migraine, has not been assessed previously in multiple attacks. The objective of this study was to evaluate the efficacy, tolera...

    Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport
    Citation: The Journal of Headache and Pain 2018 19:70
    Content type: Research article Published on:

  14. In a previous randomized, double-blind, proof-of-concept study in rapidly escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated with fewer and shorter triptan sensations than a 6...

    Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport
    Citation: The Journal of Headache and Pain 2018 19:69
    Content type: Research article Published on:

  15. Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is al...

    Authors: Efstratia Vatzaki, Sabine Straus, Jean-Michel Dogne, Juan Garcia Burgos, Thomas Girard and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2018 19:68
    Content type: Consensus article Published on:

  17. Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. ...

    Authors: Lena Ohlsson, Erik Kronvall, Jennifer Stratton and Lars Edvinsson
    Citation: The Journal of Headache and Pain 2018 19:66
    Content type: Research article Published on:

  18. Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evo...

    Authors: Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M. Capitano, Brigida Fierro and Filippo Brighina
    Citation: The Journal of Headache and Pain 2018 19:65
    Content type: Research article Published on:

  19. Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent i...

    Authors: Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink and Lars Edvinsson
    Citation: The Journal of Headache and Pain 2018 19:64
    Content type: Review article Published on:

  21. Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with secondary chron...

    Authors: Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist and Michael Bjørn Russell
    Citation: The Journal of Headache and Pain 2018 19:62
    Content type: Research article Published on:

  22. Migraine is a common and disabling disorder. Fibromyalgia has been shown to be commonly comorbid in patients with migraine and can intensify disability. The aim of this study was to determine if patients with ...

    Authors: Mark Whealy, Sanjeev Nanda, Ann Vincent, Jay Mandrekar and F. Michael Cutrer
    Citation: The Journal of Headache and Pain 2018 19:61
    Content type: Short report Published on:

  23. Headache is a common feature in acute cerebrovascular disease but no studies have evaluated the prevalence of specific headache types in patients with transient ischemic attacks (TIA). The purpose of the prese...

    Authors: Elena R. Lebedeva, Natalia M. Gurary and Jes Olesen
    Citation: The Journal of Headache and Pain 2018 19:60
    Content type: Research article Published on:

  24. High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, he...

    Authors: Kun Wang, Menghan Zhang, Yi Li, Weilin Pu, Yanyun Ma, Yi Wang, Xiaoyu Liu, Longli Kang, Xiaofeng Wang, Jiucun Wang, Bin Qiao and Li Jin
    Citation: The Journal of Headache and Pain 2018 19:59
    Content type: Research article Published on:

  25. Probable migraine (PM) is a subtype of migraine that is prevalent in the general population. Previous studies have shown that poor sleep quality is common among migraineurs and is associated with an exacerbati...

    Authors: Tae-Jin Song, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2018 19:58
    Content type: Research article Published on:

  27. No study has investigated the associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD). This study aimed to investigate this issue.

    Authors: Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2018 19:56
    Content type: Research article Published on:

  28. Increased cortical excitability has been hypothesized to play a critical role in various neurological disorders, such as restless legs syndrome, epilepsy and migraine. Particularly for migraine, local hyperexc...

    Authors: Adina Bathel, Lauren Schweizer, Philipp Stude, Benjamin Glaubitz, Niklas Wulms, Sibel Delice and Tobias Schmidt-Wilcke
    Citation: The Journal of Headache and Pain 2018 19:55
    Content type: Research article Published on:

  29. Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D leve...

    Authors: Jong-Hee Sohn, Min-Kyung Chu, Kwang-Yeol Park, Hong-Yup Ahn and Soo-Jin Cho
    Citation: The Journal of Headache and Pain 2018 19:54
    Content type: Research article Published on:

  30. Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chro...

    Authors: Mi Ji Lee, Sook-Yeon Lee, Soohyun Cho, Eun-Suk Kang and Chin-Sang Chung
    Citation: The Journal of Headache and Pain 2018 19:53
    Content type: Research article Published on:

  32. Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CG...

    Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2018 19:51
    Content type: Research article Published on:

  33. Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to h...

    Authors: Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire and Zaza Katsarava
    Citation: The Journal of Headache and Pain 2018 19:50
    Content type: Review article Published on:

  34. Migraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abn...

    Authors: Marco Lisicki, Kevin D’Ostilio, Gianluca Coppola, Felix Scholtes, Alain Maertens de Noordhout, Vincenzo Parisi, Jean Schoenen and Delphine Magis
    Citation: The Journal of Headache and Pain 2018 19:49
    Content type: Research article Published on:

  35. Major depressive disorder is a common comorbidity in migraineurs. Depression may affect the progression and prognosis of migraine. Few studies have examined the brain function in migraineurs that may cause thi...

    Authors: Mengmeng Ma, Junran Zhang, Ning Chen, Jian Guo, Yang Zhang and Li He
    Citation: The Journal of Headache and Pain 2018 19:48
    Content type: Research article Published on:

  36. Chronic pain including migraine is associated with structural and functional changes in the somatosensory cortex. Previous reports proposed two-point discrimination (TPD) as a measurement for cortical alterati...

    Authors: Kerstin Luedtke, Waclaw Adamczyk, Katrin Mehrtens, Inken Moeller, Louisa Rosenbaum, Axel Schaefer, Janine Schroeder, Tibor Szikszay, Christian Zimmer and Bettina Wollesen
    Citation: The Journal of Headache and Pain 2018 19:47
    Content type: Research article Published on:

  37. Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (N...

    Authors: Junpeng Liu, Jiajia Zhu, Fei Yuan, Xuejun Zhang and Quan Zhang
    Citation: The Journal of Headache and Pain 2018 19:46
    Content type: Research article Published on:

  39. Studies involving human pharmacological migraine models have predominantly focused on the vasoactive effects of headache-inducing drugs, including sildenafil and calcitonin gene-related peptide (CGRP). However...

    Authors: Samaira Younis, Anders Hougaard, Casper Emil Christensen, Mark Bitsch Vestergaard, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson and Messoud Ashina
    Citation: The Journal of Headache and Pain 2018 19:44
    Content type: Research article Published on:

  40. The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors ...

    Authors: Alexei A. Kamshilin, Maxim A. Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V. Amelin, Oleg V. Mamontov and Rashid Giniatullin
    Citation: The Journal of Headache and Pain 2018 19:43
    Content type: Research article Published on:

  41. Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulat...

    Authors: Huimin Tao, Teng Wang, Xin Dong, Qi Guo, Huan Xu and Qi Wan
    Citation: The Journal of Headache and Pain 2018 19:42
    Content type: Research article Published on:

  42. Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodil...

    Authors: Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2018 19:41
    Content type: Research article Published on:

  43. Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the recept...

    Authors: Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink and Carlos M. Villalón
    Citation: The Journal of Headache and Pain 2018 19:40
    Content type: Research article Published on:

  44. Factors associated with development of medication-overuse headache (MOH) in migraine patients are not fully understood, but with respect to prevention, the ability to predict the onset of MOH is clinically imp...

    Authors: Louise S. Mose, Susanne S. Pedersen, Birgit Debrabant, Rigmor H. Jensen and Bibi Gram
    Citation: The Journal of Headache and Pain 2018 19:39
    Content type: Research Published on:

  45. The MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO wi...

    Authors: Todd J. Schwedt, Aftab Alam, Michael L. Reed, Kristina M. Fanning, Sagar Munjal, Dawn C. Buse, David W. Dodick and Richard B. Lipton
    Citation: The Journal of Headache and Pain 2018 19:38
    Content type: Research article Published on:

  46. Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthriti...

    Authors: Eric P. Baron, Philippe Lucas, Joshua Eades and Olivia Hogue
    Citation: The Journal of Headache and Pain 2018 19:37
    Content type: Research article Published on:

  47. Although previous studies have demonstrated that structural and functional abnormalities in episodic migraine (EM), less is known about altered brain perfusion in the EM. The aim of this study is to investigat...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengyu Liu, Mengqi Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2018 19:36
    Content type: Research article Published on:

  48. Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) i...

    Authors: Faisal Mohammad Amin and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2018 19:35
    Content type: Review article Published on:
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