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A patient with trigeminal neuralgia may need different forms of treatment during his or her lifetime. Physicians should be aware of the different available surgical treatments, and know their effectiveness, s...
Circumstantial evidence points to the possible role of magnesium (Mg+2) deficiency in the pathogenesis of migraine and has raised questions about the clinical utility of magnesium as a therapeutic regimen in mig...
To estimate the cost of the migraine patient in Italy, we undertook an observational, multicenter study. The study was carried out by 902 Italian general practitioners (GPs). GPs asked patients over 14 years ...
In our previous study we found a high prevalence of disordered sleep breathing in migraine children vs. controls. Since no quantitative studies about sleep respiratory disorders have been carried out in migra...
The localization of dopamine D1-D5 receptor protein was investigated in different sized dog pial arteries. This was done to further understand the pathophysiology of cerebrovascular dopaminergic system in mig...
Pain is a common situation and it is one of the most frequent presenting symptoms of different pathologies. Treating pain could be a precise request to the doctor, from the patient and his caregiver. Manageme...
Nitric oxide (NO) has been proposed to be a key molecule in migraine. Experimental evidence suggests its intervention in vasodilatation and activation of the trigeminovascular system as well as its involvemen...
Migraine and epilepsy are common neurological conditions that often co-exist. There are some common symptoms and in some patients there may be a diagnostic problem. The purpose of this study was to review the...
We describe an 8-year-old, with a 1-year history of migraine without aura who experienced an episode of unusual visual aura, characterised by a fourfold view of her mother's image. These images were clearly v...
A 38-year-old man presented with ptosis, miosis, facial pain and hypoesthesia in the ipsilateral ophthalmic division of the trigeminal nerve. Brain magnetic resonance imaging and magnetic resonance antiograph...
Migraine without aura (MWOA) and migraine with aura (MWA) are disorders in which multiple factors, including environmental and genetic factors, are involved. In a previous study we hypothesized a protective r...
How does the preceding experience of pain by the mother affect the child's response to the painful event? This work intends to be a preliminary answer to this problem. A questionnaire with 10 items was admini...
Objective. To evaluate the blink reflex (BR) in chronic cluster headache (CH) patients. Design. The elecrophysiological data were collected in during the headache-free phase. Setting. Headache patients were r...
Patients with migraine, without aura (MO), either during or between attacks, present elevated histamine levels in platelet-poor plasma but normal whole blood histamine levels, compared with controls. This fin...
The trigeminovascular system is considered to play a role in the mechanism of migraine headache. Novel in vitro animal models that investigate the release of neuropeptides may be of help to understand the pat...
Cortical hyperexcitability in migraine has been suggested to play a pivotal role in triggering migraine attacks, possibly via generation of spreading depression. Low levels of plasma, intracellular and brain ...
Using BOLD-fMRI we have previously documented activation of the red nucleus (RN) and substantia nigra (SN) during spontaneously and visually activated migraine headache. These observations prompted us to stud...
The basic physiological and anatomical basis for circadian rhythms in mammalian behaviour and physiology is introduced. The pathways involved in photic entrainment of the circadian clock are discussed in rela...
This article is part of a Supplement: Volume 1 Supplement 2
The Erratum to this article has been published in The Journal of Headache and Pain 2005 6:Art1
Although chronic daily headache (CDH) represents one of the most relevant complaints of patients in headache centers, the mechanisms underlying the chronicization of head pain are poorly understood. Experimen...
This article is part of a Supplement: Volume 1 Supplement 1
Pathophysiological studies have dominated migraine research for several years. However, these studies are difficult to interpret because it is difficult to decide whether the observed phenomena are primary or...
This article is part of a Supplement: Volume 1 Supplement 2
Migraine carries a significant hereditary determination. Familial hemiplegic migraine (FHM) has been recently linked to mutations in the CACNA1A gene on chromosome 19. CACNA1A codes for a subunit of a neural ...
This article is part of a Supplement: Volume 1 Supplement 2
Familial hemiplegic migraine (FHM) is an autosomal dominant subtpye of migraine with aura. A few years ago, the gene linked to FHM was identified. CACNA1A encodes a voltage-activated, pore-forming α1A subunit...
This article is part of a Supplement: Volume 1 Supplement 2
The major histocompatibility complex (MHC) is a genetic system of over 70 known genes on the short arm of chromosome 6 and spans about 4 million base pairs of DNA. The high resolution typing of class I and cl...
This article is part of a Supplement: Volume 1 Supplement 2
This article is part of a Supplement: Volume 1 Supplement 1
The pathophysiology of chronic daily headache is unclear. Clinical research aiming to elucidate causative mechanisms is often confounded by the variability of factors involved. Furthermore, there is a recent ...
This article is part of a Supplement: Volume 1 Supplement 1
The aim of this study was to describe the distinctive personality traits and their interest to the development of a chronic form of headache, by means of the Rorschach test, a projective approach, in an autom...
This article is part of a Supplement: Volume 1 Supplement 1
Unresolved questions in headache research are the roles of drug abuse and psychopathology in headache disorder, especially in chronic daily headache. We investigated the utility of the revised version of the ...
This article is part of a Supplement: Volume 1 Supplement 1
The aims of this study were to assess how stress affects chronic headaches, and in particular to determine whether events play a role in the transformation of an episodic headache into a chronic form. A popul...
This article is part of a Supplement: Volume 1 Supplement 1
Memory loss is a common complaint in headache sufferers. 71 patients, 50 women and 21 men, affected by chronic daily headache with different diagnoses at onset and at study entry underwent a test battery in o...
This article is part of a Supplement: Volume 1 Supplement 1
With an ad hoc, previously validated clinical record, we analysed the headache characteristics in 245 patients (F, 78.4%, M, 21,6%; mean age, 43.1±12.9 years) affected by chronic daily headache (CDH) attendin...
This article is part of a Supplement: Volume 1 Supplement 1
In 1988 the problems concerning chronic daily headache (CDH) were neglected by the classification of the International Headache Society (IHS). More than ten years later, this issue is still debated, also in l...
This article is part of a Supplement: Volume 1 Supplement 1
Although an association between primary headache and psychiatric disorders, has been recognised for over 100 years, this association has been investigated systematically only recently. The nature of this asso...
This article is part of a Supplement: Volume 1 Supplement 1
The aetiology of chronic daily or near-daily headache (CDH) is unknown. We evaluated prothrombotic genetic risk factors (factor V G1691A, factor II 20210 G/A, methylenetetrahydrofolate reductase mutations and...
This article is part of a Supplement: Volume 1 Supplement 2
The linkage between HLA antigens and disease susceptibility has been investigated in several diseases. Two different mechanisms are known to act in the relation between the HLA system and headache: linkage an...
This article is part of a Supplement: Volume 1 Supplement 2
A Danish genetic study showed increased risk of cluster headache (CH) among relatives of CH patients. We studied the families of 191 CH patients (118 males, 73 females; mean age 45.9 years) attending the Mila...
This article is part of a Supplement: Volume 1 Supplement 2
Human leukocyte Antigens (HLA) are encoded by genes located on chromosome 6p21. Genes important in migraine are being recognized in two basic ways: association studies and linkage analysis. One of the stronge...
This article is part of a Supplement: Volume 1 Supplement 2
Migraine is a common chronic disorder with an etiology still mostly unknown. Several neurotransmitters such as dopamine and serotonin are considered to be involved in the pathogenesis of the disease and the s...
This article is part of a Supplement: Volume 1 Supplement 2
Familial hemiplegic migraine is an autosomal dominant form of migraine with aura, characterized by the occurrence of a motor deficit during the aura. In 20% of families, permanent cerebellar signs (ataxia or ...
This article is part of a Supplement: Volume 1 Supplement 2
In this paper, we review the “current” and “ancient” concepts of comorbidity in migraine attack and disease. We emphasize the role of migraine as a complex disease and stress the appropriate consideration tha...
This article is part of a Supplement: Volume 1 Supplement 2
Chronic daily headache (CDH) in children and adolescents presents features not sufficiently recognized by the current classification system. The aim of our study was to analyze the applicability of adult CDH c...
This article is part of a Supplement: Volume 1 Supplement 1
Chronic pathologies, above all those in which is present pain, can induce a considerable impairment in quality of life. The concept of illness behaviour is closely related to that of quality of life. It can b...
This article is part of a Supplement: Volume 1 Supplement 1
The psychopathological approach is fundamental in the study of chronic headache because it integrates the diagnosis of a pathology in which the symptom (headache) is the disease itself hiding in itself the de...
This article is part of a Supplement: Volume 1 Supplement 1
A multicenter study was carried out to investigate the prevalence of psychosocial stressors and psychiatric comorbidity in patients suffering from migraine without aura (MWO) according to the International He...
Recent years have seen exciting advances in the understanding of the mechanisms that underlie circadian rhythms in a variety of organisms, including mammals. Several key genes have been identified, whose prod...
The Journal of Headache and Pain is the official journal of the European Headache Federation and Lifting The Burden.
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