Skip to main content

Molecular variation within the dopamine receptor DRD2 gene in migraine


Molecular genetics offers a novel approach to the understanding and management of migraine since the disorder is known to have a strong genetic component. In recent studies, polymorphisms in the genes for dopamine receptors have been evaluated. Both positive and negative association studies have been reported. In particular, these data suggest that activation of the DRD2 receptor plays a modifying role in the pathophysiology of migraine. As a result, existing data provide a molecular rationale for the documented efficacy of dopamine D2 receptor antagonists in the treatment of migraine. Therefore, at the present time, molecular genetic data provide support for the hypothesis that susceptibility to migraine may be modified, in part, by variations in dopamine DRD2 receptor function.

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Peroutka, S. Molecular variation within the dopamine receptor DRD2 gene in migraine. J Headache Pain 1 (Suppl 2), S147–S151 (2000).

Download citation

  • Issue Date:

  • DOI: