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  1. Content type: Review article

    To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.

    Authors: Håkan Ashina, Song Guo, Anne L. H. Vollesen and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:110

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  2. Content type: Review article

    The 2013 International Classification of Headache Disorders-3 (ICHD-3) was published in a beta version to allow the clinicians to confirm the validity of the criteria or to suggest improvements based on field ...

    Authors: Aynur Özge, Noemi Faedda, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:109

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  3. Content type: Consensus article

    Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migra...

    Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2017 18:108

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    The Correction to this article has been published in The Journal of Headache and Pain 2018 19:81

  4. Content type: Review article

    Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmac...

    Authors: Richard B. Lipton, Hans-Christoph Diener, Matthew S. Robbins, Sandy Yacoub Garas and Ketu Patel

    Citation: The Journal of Headache and Pain 2017 18:107

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  5. Content type: Review article

    This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

    Authors: A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

    Citation: The Journal of Headache and Pain 2017 18:106

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  6. Content type: Research article

    Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α12-adrenoceptors. Since activation of vascular α12-adrenoceptors ...

    Authors: Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    Citation: The Journal of Headache and Pain 2017 18:104

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  7. Content type: Review article

    The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

    Authors: Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:103

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  8. Content type: Research article

    We aimed to explore patients’ preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo.

    Authors: Dimos D. Mitsikostas, Ioanna Belesioti, Chryssa Arvaniti, Euthymia Mitropoulou, Christina Deligianni, Elina Kasioti, Theodoros Constantinidis, Manolis Dermitzakis and Michail Vikelis

    Citation: The Journal of Headache and Pain 2017 18:102

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  9. Content type: Research article

    Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

    Authors: Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse

    Citation: The Journal of Headache and Pain 2017 18:101

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  10. Content type: Research article

    Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targe...

    Authors: Martin Uglem, Petter Moe Omland, Marit Stjern, Gøril Bruvik Gravdahl and Trond Sand

    Citation: The Journal of Headache and Pain 2017 18:100

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  11. Content type: Research article

    Pain is a very common condition in patient undergoing rehabilitation for neurological disease; however the presence of primary headaches and other cranio-facial pains, particularly when they are actually or ap...

    Authors: Cristina Tassorelli, Marco Tramontano, Mariangela Berlangieri, Vittorio Schweiger, Mariagrazia D’Ippolito, Valerio Palmerini, Sara Bonazza, Riccardo Rosa, Rosanna Cerbo and Maria Gabriella Buzzi

    Citation: The Journal of Headache and Pain 2017 18:99

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  12. Content type: Research article

    To apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG and under visual stimulation by checkerboard gratings with 0.5 and 2.0 cpd as spatial fre...

    Authors: Marina de Tommaso, Gabriele Trotta, Eleonora Vecchio, Katia Ricci, R. Siugzdaite and Sebastiano Stramaglia

    Citation: The Journal of Headache and Pain 2017 18:98

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  13. Content type: Review article

    Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than mi...

    Authors: Marie Deen, Edvige Correnti, Katharina Kamm, Tim Kelderman, Laura Papetti, Eloisa Rubio-Beltrán, Simone Vigneri, Lars Edvinsson and Antoinette Maassen Van Den Brink

    Citation: The Journal of Headache and Pain 2017 18:96

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  14. Content type: Research article

    Tension-type headache (TTH) represents the most common type of headache among the general population. Although such headaches are usually mild in severity, some individuals with TTH experience severe symptoms ...

    Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    Citation: The Journal of Headache and Pain 2017 18:95

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  15. Content type: Research article

    Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate t...

    Authors: Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi and Rosaria Greco

    Citation: The Journal of Headache and Pain 2017 18:94

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  16. Content type: Research article

    Migraine is a debilitating neurological disorder that affects 14.1% of the US and 14.7% of the European populations. Chronic migraine (CM) is broadly defined as headache occurring on ≥15 days per month for ≥3 ...

    Authors: Brendan Davies, Charly Gaul, Paolo Martelletti, Juan Carlos García-Moncó and Stephanie Brown

    Citation: The Journal of Headache and Pain 2017 18:93

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  17. Content type: Letter to the Editor

    This article consists of a Letter to the Editor regarding Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery, recently published in The Jo...

    Authors: Salman Khazaei, Shiva Mansouri Hanis, Kamyar Mansori, Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen

    Citation: The Journal of Headache and Pain 2017 18:92

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  18. Content type: Research article

    Menstrually related migraine (MRM) in the hormone-free interval (HFI) of combined hormonal contraceptives (CHC) are according to the ICHD definition also estrogen withdrawal migraines (EWH). MRMs are less resp...

    Authors: Gabriele S. Merki-Feld, Gina Epple, Nina Caveng, Bruno Imthurn, Burkhardt Seifert, Peter Sandor and Andreas R. Gantenbein

    Citation: The Journal of Headache and Pain 2017 18:91

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  19. Content type: Review article

    To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.

    Authors: Mohammad Al-Mahdi Al-Karagholi, Jakob Møller Hansen, Johanne Severinsen, Inger Jansen-Olesen and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:90

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  20. Content type: Research article

    Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology. Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and the def...

    Authors: Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang and Wei-Ta Chen

    Citation: The Journal of Headache and Pain 2017 18:89

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  21. Content type: Research article

    We have genotyped a Swedish cluster headache case-control population for three genetic variants representing the most significant markers identified in a recently published genome wide association study on clu...

    Authors: Caroline Ran, Carmen Fourier, Julia M. Michalska, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind and Andrea Carmine Belin

    Citation: The Journal of Headache and Pain 2017 18:88

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  22. Content type: Research article

    The majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumat...

    Authors: Todd J. Schwedt, Catherine D. Chong, Jacob Peplinski, Katherine Ross and Visar Berisha

    Citation: The Journal of Headache and Pain 2017 18:87

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  23. Content type: Research article

    As a non-invasive therapy, whether transcranial magnetic stimulation (TMS) is effective on migraine. This article was aimed to assess the efficacy of TMS on migraine based on randomized controlled trails (RCTs).

    Authors: Lihuan Lan, Xiaoni Zhang, Xiangpen Li, Xiaoming Rong and Ying Peng

    Citation: The Journal of Headache and Pain 2017 18:86

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  24. Content type: Short report

    Excessive daytime sleepiness (EDS, defined as Epworth sleepiness scale score > 10) is a common symptom, with a prevalence of 10–20% in the general population. It is associated with headache and other chronic p...

    Authors: Espen Saxhaug Kristoffersen, Knut Stavem, Christofer Lundqvist and Michael Bjørn Russell

    Citation: The Journal of Headache and Pain 2017 18:85

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  25. Content type: Review article

    Headache attributed to airplane travel, also named "airplane headache" (AH) is a headache that occurs during take-off and landing. Today, there are still uncertainties about the pathophysiology and treatment o...

    Authors: Sebastian Bao Dinh Bui and Parisa Gazerani

    Citation: The Journal of Headache and Pain 2017 18:84

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  26. Content type: Research article

    The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the nonspecific PAG lesions were also observed in episodic migraine (EM) recently. However, the PAG volume change was not totally detec...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2017 18:83

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  27. Content type: Research

    The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse heada...

    Authors: Zhiye Chen, Zhihua Jia, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2017 18:82

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  28. Content type: Research article

    Several RCT studies including ours, seem to prove the role of Botulinum toxin type A (BTX-A) in the treatment of trigeminal neuralgia (TN), but no standardized dosing regimen has been established. In our study...

    Authors: Haifeng Zhang, Yajun Lian, Nanchang Xie, Chen Chen and Yake Zheng

    Citation: The Journal of Headache and Pain 2017 18:81

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  29. Content type: Research article

    The available data on gender differences in clinical migraine parameters among pediatric patients are based on relatively few studies, which did not use the current version of the International Classification ...

    Authors: Tal Eidlitz-Markus and Avraham Zeharia

    Citation: The Journal of Headache and Pain 2017 18:80

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  30. Content type: Research article

    OnabotulinumtoxinA has been shown to reduce headache-days among patients with chronic migraine (CM). The objective of this analysis was to determine whether onabotulinumtoxinA has an impact on headache-day sev...

    Authors: Manjit Matharu, Rashmi Halker, Patricia Pozo-Rosich, Ronald DeGryse, Aubrey Manack Adams and Sheena K. Aurora

    Citation: The Journal of Headache and Pain 2017 18:78

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  31. Content type: Research article

    Cognitive decline is a major concern in patients with migraine. Depression, anxiety, and/or poor sleep quality are well-known comorbidities of migraine, but available evidence on the subjective cognitive decli...

    Authors: Sun Hwa Lee, Yeonwook Kang and Soo-Jin Cho

    Citation: The Journal of Headache and Pain 2017 18:77

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  32. Content type: Research article

    OnabotulinumtoxinA has proven its efficacy in reducing the number of headache days in chronic migraine (CM) patients. The usual paradigm includes 31 pericranial injection sites with low dose (5 U) per site. Th...

    Authors: Danièle Ranoux, Gaelle Martiné, Gaëlle Espagne-Dubreuilh, Marlène Amilhaud-Bordier, François Caire and Laurent Magy

    Citation: The Journal of Headache and Pain 2017 18:75

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  33. Content type: Research article

    Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that so...

    Authors: Jilei Zhang, Yi-Lan Wu, Jingjing Su, Qian Yao, Mengxing Wang, Ge-Fei Li, Rong Zhao, Yan-Hui Shi, Ying Zhao, Qiting Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Guo-Hong Cui, Jianqi Li, Jian-Ren Liu…

    Citation: The Journal of Headache and Pain 2017 18:74

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  34. Content type: Research article

    Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of pre...

    Authors: Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti and Silvia Marino

    Citation: The Journal of Headache and Pain 2017 18:72

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  35. Content type: Research article

    Hemicrania continua (HC), paroxysmal hemicrania (PH) and short lasting neuralgiform headache attacks (SUNCT and SUNA) are rare syndromes with a difficult therapeutic approach. The aim of this review is to summ...

    Authors: Carlo Baraldi, Lanfranco Pellesi, Simona Guerzoni, Maria Michela Cainazzo and Luigi Alberto Pini

    Citation: The Journal of Headache and Pain 2017 18:71

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  36. Content type: Research article

    Neuroimaging data has implicated the temporal pole (TP) in migraine pathophysiology; the density and functional activity of the TP were reported to fluctuate in accordance with the migraine cycle. Yet, the exa...

    Authors: Francesca Cortese, Francesco Pierelli, Ilaria Bove, Cherubino Di Lorenzo, Maurizio Evangelista, Armando Perrotta, Mariano Serrao, Vincenzo Parisi and Gianluca Coppola

    Citation: The Journal of Headache and Pain 2017 18:70

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  37. Content type: Research article

    Mainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age...

    Authors: Kai Le, Dafan Yu, Jiamin Wang, Abdoulaye Idriss Ali and Yijing Guo

    Citation: The Journal of Headache and Pain 2017 18:69

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  38. Content type: Erratum

    Authors: Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Nappi Giuseppe, Marcella Neri and Cristina Cereda

    Citation: The Journal of Headache and Pain 2017 18:68

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    The original article was published in The Journal of Headache and Pain 2017 18:63

  39. Content type: Research article

    Individually both migraine and post-traumatic stress disorder (PTSD) prevalence estimates are higher among women. However, there is limited data on the association of migraine and PTSD in women during pregnancy.

    Authors: Lauren E. Friedman, Christina Aponte, Rigoberto Perez Hernandez, Juan Carlos Velez, Bizu Gelaye, Sixto E. Sánchez, Michelle A. Williams and B. Lee Peterlin

    Citation: The Journal of Headache and Pain 2017 18:67

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  40. Content type: Research article

    Chronic migraine is a complex clinical condition often undertreated. Onabotulinumtoxin A (OBT-A) was approved in Italy in 2013 for symptom relief in patients with chronic migraine who have failed, or do not to...

    Authors: Cristina Tassorelli, Marco Aguggia, Marina De Tommaso, Pierangelo Geppetti, Licia Grazzi, Luigi Alberto Pini, Paola Sarchielli, Gioacchino Tedeschi, Paolo Martelletti and Pietro Cortelli

    Citation: The Journal of Headache and Pain 2017 18:66

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  41. Content type: Research article

    No evidence is available on the risks of neurologically asymptomatic minimal traumatic intracranial hemorrhage (mTIH) in patients with traumatic brain injury (TBI) for post-traumatic headache (PTH). The purpos...

    Authors: Chang-Ki Hong, Yu Shik Shim, Sook Young Sim, Jin-Yang Joo, Min A Kwon, Yong Bae Kim and Joonho Chung

    Citation: The Journal of Headache and Pain 2017 18:64

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  42. Content type: Case report

    Sporadic Hemiplegic Migraine is a rare form of migraine headache. Mutations in three different genes, two ion-channel genes and one encoding an ATP exchanger, CACNA1A, ATP1A2 and SCN1A are all responsible for the...

    Authors: Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Giuseppe Nappi, Marcella Neri and Cristina Cereda

    Citation: The Journal of Headache and Pain 2017 18:63

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    The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:68

  43. Content type: Research article

    It is widely recognised that there are associations between headache, psychiatric comorbidity and attachment insecurity in both adults and children. The aims of this study were: 1) to compare perceived attachm...

    Authors: Riccardo Williams, Luigi Leone, Noemi Faedda, Giulia Natalucci, Benedetta Bellini, Elisa Salvi, Paola Verdecchia, Rita Cerutti, Marco Arruda and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:62

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  44. Content type: Research article

    Given that post-traumatic headache is one of the most prevalent and long-lasting post-concussion sequelae, causes significant morbidity, and might be associated with slower neurocognitive recovery, we sought t...

    Authors: Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen

    Citation: The Journal of Headache and Pain 2017 18:60

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