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  1. Content type: Review article

    Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:19

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  2. Content type: Research article

    Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

    Authors: Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:18

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  3. Content type: Review article

    In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

    Citation: The Journal of Headache and Pain 2018 19:16

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  4. Content type: Methodology

    Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

    Authors: T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

    Citation: The Journal of Headache and Pain 2018 19:15

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  5. Content type: Research article

    Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

    Authors: Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

    Citation: The Journal of Headache and Pain 2018 19:14

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  6. Content type: Research article

    OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

    Authors: Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

    Citation: The Journal of Headache and Pain 2018 19:13

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  7. Content type: Research article

    Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

    Authors: Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

    Citation: The Journal of Headache and Pain 2018 19:11

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  8. Content type: Methodology

    The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...

    Authors: T. J. Steiner and R. B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:12

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  9. Content type: Research article

    Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...

    Authors: Zaza Katsarava, Maka Mania, Christian Lampl, Johanna Herberhold and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:10

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  10. Content type: Review article

    Sensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. ...

    Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

    Citation: The Journal of Headache and Pain 2018 19:9

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  11. Content type: Research article

    Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether sub...

    Authors: Lena Hoem Nordhaug, Knut Hagen, Anne Vik, Lars Jacob Stovner, Turid Follestad, Torunn Pedersen, Gøril Bruvik Gravdahl and Mattias Linde

    Citation: The Journal of Headache and Pain 2018 19:8

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  12. Content type: Research article

    Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunit...

    Authors: Binbin Wang, Siyuan Liu, Bingbing Fan, Xingguo Xu, Yonglin Chen, Rongxiang Lu, Zhongling Xu and Xiaojuan Liu

    Citation: The Journal of Headache and Pain 2018 19:7

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  13. Content type: Research article

    Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcom...

    Authors: Mads Barloese, Anja Petersen, Philipp Stude, Tim Jürgens, Rigmor Højland Jensen and Arne May

    Citation: The Journal of Headache and Pain 2018 19:6

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  14. Content type: Research article

    Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with ...

    Authors: Francesca Puledda, Peter J. Goadsby and Prab Prabhakar

    Citation: The Journal of Headache and Pain 2018 19:5

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  15. Content type: Research article

    Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both t...

    Authors: Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M. Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2018 19:4

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  16. Content type: Research article

    Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues inc...

    Authors: Michael J. M. Fischer, Jakob Schmidt, Stanislav Koulchitsky, Sven Klussmann, Axel Vater and Karl Messlinger

    Citation: The Journal of Headache and Pain 2018 19:3

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  17. Content type: Research article

    Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirme...

    Authors: Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2018 19:1

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  18. Content type: Research article

    Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressu...

    Authors: Toshihide Toriyama, Tetsuyoshi Horiuchi and Kazuhiro Hongo

    Citation: The Journal of Headache and Pain 2017 18:117

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  19. Content type: Review article

    Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its e...

    Authors: Kwo Wei David Ho, Rene Przkora and Sanjeev Kumar

    Citation: The Journal of Headache and Pain 2017 18:118

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  20. Content type: Research article

    To investigate variables associated at one year (longitudinal design) with the physical or emotional component of burden in chronic tension type headache (CTTH).

    Authors: Stella Fuensalida-Novo, Maria Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Antonella Catena, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

    Citation: The Journal of Headache and Pain 2017 18:119

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  21. Content type: Research article

    Beta-blockers are a first choice migraine preventive medication. So far it is unknown how they exert their therapeutic effect in migraine. To this end we examined the neural effect of metoprolol on trigeminal ...

    Authors: Julia M. Hebestreit and Arne May

    Citation: The Journal of Headache and Pain 2017 18:116

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  22. Content type: Research article

    To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morph...

    Authors: Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

    Citation: The Journal of Headache and Pain 2017 18:115

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  23. Content type: Research article

    Acute headache is one of the most frequent neurological symptoms in pregnant women. The early diagnosis of underlying secondary conditions has a major influence on patient outcome, especially in emergency sett...

    Authors: Bianca Raffaelli, Eberhard Siebert, Jeannette Körner, Thomas Liman, Uwe Reuter and Lars Neeb

    Citation: The Journal of Headache and Pain 2017 18:114

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  24. Content type: Research article

    The 2013 International Classification of Headache Disorders-3 was published in a beta version to allow clinicians to confirm the validity of the criteria or suggest improvements based on field studies. The aim...

    Authors: Aynur Özge, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Noemi Faedda, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:113

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  25. Content type: Research article

    Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR...

    Authors: Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2017 18:112

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  26. Content type: Review article

    The 2013 International Classification of Headache Disorders-3 (ICHD-3) was published in a beta version to allow the clinicians to confirm the validity of the criteria or to suggest improvements based on field ...

    Authors: Aynur Özge, Noemi Faedda, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:109

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  27. Content type: Review article

    To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.

    Authors: Håkan Ashina, Song Guo, Anne L. H. Vollesen and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:110

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  28. Content type: Consensus article

    Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migra...

    Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2017 18:108

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    The Correction to this article has been published in The Journal of Headache and Pain 2018 19:81

  29. Content type: Review article

    Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmac...

    Authors: Richard B. Lipton, Hans-Christoph Diener, Matthew S. Robbins, Sandy Yacoub Garas and Ketu Patel

    Citation: The Journal of Headache and Pain 2017 18:107

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  30. Content type: Review article

    This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

    Authors: A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

    Citation: The Journal of Headache and Pain 2017 18:106

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  31. Content type: Research article

    Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α12-adrenoceptors. Since activation of vascular α12-adrenoceptors ...

    Authors: Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    Citation: The Journal of Headache and Pain 2017 18:104

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  32. Content type: Review article

    The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

    Authors: Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:103

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  33. Content type: Research article

    We aimed to explore patients’ preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo.

    Authors: Dimos D. Mitsikostas, Ioanna Belesioti, Chryssa Arvaniti, Euthymia Mitropoulou, Christina Deligianni, Elina Kasioti, Theodoros Constantinidis, Manolis Dermitzakis and Michail Vikelis

    Citation: The Journal of Headache and Pain 2017 18:102

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  34. Content type: Research article

    Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

    Authors: Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse

    Citation: The Journal of Headache and Pain 2017 18:101

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  35. Content type: Research article

    Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targe...

    Authors: Martin Uglem, Petter Moe Omland, Marit Stjern, Gøril Bruvik Gravdahl and Trond Sand

    Citation: The Journal of Headache and Pain 2017 18:100

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  36. Content type: Research article

    Pain is a very common condition in patient undergoing rehabilitation for neurological disease; however the presence of primary headaches and other cranio-facial pains, particularly when they are actually or ap...

    Authors: Cristina Tassorelli, Marco Tramontano, Mariangela Berlangieri, Vittorio Schweiger, Mariagrazia D’Ippolito, Valerio Palmerini, Sara Bonazza, Riccardo Rosa, Rosanna Cerbo and Maria Gabriella Buzzi

    Citation: The Journal of Headache and Pain 2017 18:99

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  37. Content type: Research article

    To apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG and under visual stimulation by checkerboard gratings with 0.5 and 2.0 cpd as spatial fre...

    Authors: Marina de Tommaso, Gabriele Trotta, Eleonora Vecchio, Katia Ricci, R. Siugzdaite and Sebastiano Stramaglia

    Citation: The Journal of Headache and Pain 2017 18:98

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  38. Content type: Review article

    Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than mi...

    Authors: Marie Deen, Edvige Correnti, Katharina Kamm, Tim Kelderman, Laura Papetti, Eloisa Rubio-Beltrán, Simone Vigneri, Lars Edvinsson and Antoinette Maassen Van Den Brink

    Citation: The Journal of Headache and Pain 2017 18:96

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  39. Content type: Research article

    Tension-type headache (TTH) represents the most common type of headache among the general population. Although such headaches are usually mild in severity, some individuals with TTH experience severe symptoms ...

    Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    Citation: The Journal of Headache and Pain 2017 18:95

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  40. Content type: Research article

    Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate t...

    Authors: Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi and Rosaria Greco

    Citation: The Journal of Headache and Pain 2017 18:94

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  41. Content type: Research article

    Migraine is a debilitating neurological disorder that affects 14.1% of the US and 14.7% of the European populations. Chronic migraine (CM) is broadly defined as headache occurring on ≥15 days per month for ≥3 ...

    Authors: Brendan Davies, Charly Gaul, Paolo Martelletti, Juan Carlos García-Moncó and Stephanie Brown

    Citation: The Journal of Headache and Pain 2017 18:93

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  42. Content type: Letter to the Editor

    This article consists of a Letter to the Editor regarding Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery, recently published in The Jo...

    Authors: Salman Khazaei, Shiva Mansouri Hanis, Kamyar Mansori, Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen

    Citation: The Journal of Headache and Pain 2017 18:92

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  43. Content type: Research article

    Menstrually related migraine (MRM) in the hormone-free interval (HFI) of combined hormonal contraceptives (CHC) are according to the ICHD definition also estrogen withdrawal migraines (EWH). MRMs are less resp...

    Authors: Gabriele S. Merki-Feld, Gina Epple, Nina Caveng, Bruno Imthurn, Burkhardt Seifert, Peter Sandor and Andreas R. Gantenbein

    Citation: The Journal of Headache and Pain 2017 18:91

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  44. Content type: Research article

    Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology. Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and the def...

    Authors: Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang and Wei-Ta Chen

    Citation: The Journal of Headache and Pain 2017 18:89

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  45. Content type: Review article

    To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.

    Authors: Mohammad Al-Mahdi Al-Karagholi, Jakob Møller Hansen, Johanne Severinsen, Inger Jansen-Olesen and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:90

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