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  1. Migraine stands as a prevalent primary headache disorder, with prior research highlighting the significant involvement of oxidative stress and inflammatory pathways in its pathogenesis and chronicity. Existing...

    Authors: Yingyuan Liu, Zihua Gong, Deqi Zhai, Chunxiao Yang, Guangshuang Lu, Shuqing Wang, Shaobo Xiao, Chenhao Li, Ludan Chen, Xiaoxue Lin, Shuhua Zhang, Shengyuan Yu and Zhao Dong
    Citation: The Journal of Headache and Pain 2024 25:50
    Content type: Research Published on:

  2. We previously reported high prevalences of headache disorders among children (6–11 years) and adolescents (12–17 years) in Ethiopia. Here we provide data on headache-attributed burden collected contemporaneous...

    Authors: Yared Zenebe Zewde, Mehila Zebenigus, Hanna Demissie, Redda Tekle-Haimanot, Derya Uluduz, Tayyar Şaşmaz, Fatma Bozdag and Timothy J Steiner
    Citation: The Journal of Headache and Pain 2024 25:47
    Content type: Research Published on:

  3. To date, migraine is diagnosed exclusively based on clinical criteria, but fluid biomarkers are desirable to gain insight into pathophysiological processes and inform clinical management. We investigated the s...

    Authors: Marie Süße, Christine Kloetzer, Sebastian Strauß, Johanna Ruhnau, Lucas Hendrik Overeem, Merle Bendig, Juliane Schulze, Uwe Reuter, Antje Vogelgesang and Robert Fleischmann
    Citation: The Journal of Headache and Pain 2024 25:46
    Content type: Research Published on:

  4. As new migraine therapies emerge, it is crucial for measures to capture the complexities of health-related quality of life (HRQoL) improvement beyond improvements in monthly migraine day (MMD) reduction. Inves...

    Authors: Linus Jönsson, Susanne F. Awad, Stephane A. Regnier, Brian Talon, Steven Kymes, Xin Ying Lee and Peter J. Goadsby
    Citation: The Journal of Headache and Pain 2024 25:45
    Content type: Research Published on:

  5. Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors aft...

    Authors: Emilie Isager Howe, Nada Andelic, Cathrine Brunborg, Marina Zeldovich, Eirik Helseth, Toril Skandsen, Alexander Olsen, Silje C. R. Fure, Alice Theadom, Katrin Rauen, Benedikte Å. Madsen, Bram Jacobs, Joukje van der Naalt, Maria Carmela Tartaglia, Cathrine Elisabeth Einarsen, Gøril Storvig…
    Citation: The Journal of Headache and Pain 2024 25:44
    Content type: Research Published on:

  6. The objective of this analysis was to gain new insights into the patient characteristics and other factors associated with lasmiditan usage and clinical outcomes under conditions resembling the real-world sett...

    Authors: Mika Komori, Akichika Ozeki, Yuka Tanji, Eriko Kamiki, John H. Krege, Lily Qian Li, Shiho Suzuki, Mamoru Shibata and Takao Takeshima
    Citation: The Journal of Headache and Pain 2024 25:43
    Content type: Research Published on:

  7. Knowledge of headache prevalence, and the burdens attributable to headache disorders, remains incomplete in sub-Saharan Africa (SSA): reliable studies have been conducted only in Zambia (southern SSA) and Ethi...

    Authors: Callixte Kuate Tegueu, Anastase Dzudie Tamdja, Franklin Kom, Blaise Forgwa Barche, Peter Ebasone, Mélanie Magnerou, Paul Mbonda, Jacques Doumbe, Andreas Husøy, Hallie Thomas and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:42
    Content type: Research Published on:

  8. Knowledge of the prevalence and attributable burden of headache disorders in India is sparse, with only two recent population-based studies from South and East India. These produced conflicting results. A stud...

    Authors: Ashish Duggal, Debashish Chowdhury, Anand Krishnan, Ritvik Amarchand and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:41
    Content type: Methodology Published on:

  9. The reimbursement of erenumab in Spain and other European countries is currently restricted because of the cost of this novel therapy to patients with migraine who have experienced previous failures to traditi...

    Authors: Patricia Pozo-Rosich, José Luis Poveda, Carlos Crespo, María Martínez, José Manuel Rodríguez and Pablo Irimia
    Citation: The Journal of Headache and Pain 2024 25:40
    Content type: Research Published on:

  10. Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) have greatly changed migraine treatment options. In Japan, although CGRPmAb guidelines (≥ 4 monthly migraine days (MMDs) and ≥ 1 previous p...

    Authors: Tsubasa Takizawa, Keiko Ihara, Narumi Watanabe, Ryo Takemura, Nobuyuki Takahashi, Naoki Miyazaki, Mamoru Shibata, Keisuke Suzuki, Noboru Imai, Norihiro Suzuki, Koichi Hirata, Takao Takeshima and Jin Nakahara
    Citation: The Journal of Headache and Pain 2024 25:39
    Content type: Research Published on:

  11. The burden of migraine goes beyond the pain and associated symptoms. We aimed to describe the impact of migraine in healthcare resource utilization (HCRU), work productivity, and mood disorders, as well as its...

    Authors: David García-Azorín, Carlota Moya-Alarcón, Beatriz Armada and Margarita Sánchez del Río
    Citation: The Journal of Headache and Pain 2024 25:38
    Content type: Research Published on:

  12. The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients’ disability has recently been questioned. This prompts consideration that clinical features beyond pain ...

    Authors: Tatiana Castro Zamparella, Mariela Carpinella, Mario Peres, Florencia Patricia Cuello, Pilar Maza, Melanie Van Gansen, Marcelo Filipchuk, Verónica Balaszczuk, Carolina Maldonado, Pablo Scarnato, Diego Conci Magris and Marco Lisicki
    Citation: The Journal of Headache and Pain 2024 25:37
    Content type: Research Published on:

  13. The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain. Calcitonin receptor (CTR)-based ...

    Authors: Tayla A. Rees, Zoe Tasma, Michael L. Garelja, Simon J. O’Carroll, Christopher S. Walker and Debbie L. Hay
    Citation: The Journal of Headache and Pain 2024 25:36
    Content type: Research Published on:

  14. Conventional, non-specific preventive migraine treatments often demonstrate low rates of treatment persistence due to poor efficacy or tolerability. Effective, well-tolerated preventive treatments are needed t...

    Authors: Paul Rizzoli, Michael J. Marmura, Jennifer Robblee, Jennifer McVige, Sara Sacco, Stephanie J. Nahas, Jessica Ailani, Rosa De Abreu Ferreira, Julia Ma, Jonathan H. Smith, Brett Dabruzzo and Messoud Ashina
    Citation: The Journal of Headache and Pain 2024 25:35
    Content type: Research Published on:

  15. Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial f...

    Authors: Maria Grazia Vittorini, Aysenur Sahin, Antonin Trojan, Sevil Yusifli, Tamta Alashvili, Gonçalo V. Bonifácio, Ketevan Paposhvili, Viktoria Tischler, Christian Lampl and Simona Sacco
    Citation: The Journal of Headache and Pain 2024 25:34
    Content type: Review Published on:

  17. Energy metabolism disorders and neurogenic inflammation play important roles in the central sensitization to chronic migraine (CM). AMP-activated protein kinase (AMPK) is an intracellular energy sensor, and it...

    Authors: Guangshuang Lu, Shaobo Xiao, Fanchao Meng, Leyi Zhang, Yan Chang, Jinjing Zhao, Nan Gao, Wenjie Su, Xinghao Guo, Yingyuan Liu, Chenhao Li, Wenjing Tang, Liping Zou, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2024 25:29
    Content type: Research Published on:

  20. Both epidemiological and clinical studies have indicated that headache and sleep disturbances share a complex relationship. Although headache and sleep share common neurophysiological and anatomical foundation...

    Authors: Bozhi Li, Ya Cao, Huijuan Yuan, Zhe Yu, Shuai Miao, Chunxiao Yang, Zihua Gong, Wei Xie, Chenhao Li, Wenhao Bai, Wenjing Tang, Dengfa Zhao and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2024 25:31
    Content type: Research Published on:

  21. Trigeminal nerve injury is one of the most serious complications in oral clinics, and the subsequent chronic orofacial pain is a consumptive disease. Increasing evidence demonstrates long non-coding RNAs (lncR...

    Authors: YaJing Liu, Fei Liu, YiKe Li, YueLing Li, YuHeng Feng, JiaShuo Zhao, Cheng Zhou, ChunJie Li, JieFei Shen and YanYan Zhang
    Citation: The Journal of Headache and Pain 2024 25:28
    Content type: Research Published on:

  22. The burden and disability associated with headaches are conceptualized and measured differently at patients’ and populations’ levels. At the patients’ level, through patient-reported outcome measures (PROMs); ...

    Authors: Marta Waliszewska-Prosół, Danilo Antonio Montisano, Mariola Antolak, Federico Bighiani, Francescantonio Cammarota, Ilaria Cetta, Michele Corrado, Keiko Ihara, Regina Kartamysheva, Igor Petrušić, Maria Magdalena Pocora, Tsubasa Takizawa, Gloria Vaghi, Paolo Martelletti, Barbara Corso and Alberto Raggi
    Citation: The Journal of Headache and Pain 2024 25:27
    Content type: Review Published on:

  23. Migraine is a disabling neurologic disease that can fluctuate over time in severity, frequency, and acute medication use. Harris Poll Migraine Report Card was a US population-based survey to ascertain quantifi...

    Authors: Amaal J. Starling, Roger Cady, Dawn C. Buse, Meghan Buzby, Charlie Spinale, Kathy Steinberg, Kevin Lenaburg and Steven Kymes
    Citation: The Journal of Headache and Pain 2024 25:26
    Content type: Research Published on:

  24. Migraine is a multiphasic neurovascular disorder, where headache can be succeeded by postdromal symptoms. However, there are limited research on postdromal symptoms. This study aimed to investigate the proport...

    Authors: Janu Thuraiaiyah, Håkan Ashina, Rune Häckert Christensen, Haidar M. Al-Khazali and Messoud Ashina
    Citation: The Journal of Headache and Pain 2024 25:25
    Content type: Research Published on:

  25. Prior research has shown that individual lifestyles were associated with migraine. Yet, few studies focused on combined lifestyles, particularly in Chinese populations. This cross-sectional study aimed to inve...

    Authors: Yunyang Deng, Harry Haoxiang Wang, Fei Wan Ngai, Dexing Zhang, Jing Qin, Xiangyan Chen and Yao Jie Xie
    Citation: The Journal of Headache and Pain 2024 25:24
    Content type: Research Published on:

  26. Medication overuse headache (MOH) was recently shown to be associated with leaky gut in rodents. We aimed to investigate whether chronic migraine (CM) patients with MOH have elevated lipopolysaccharide levels ...

    Authors: Doga Vuralli, Merve Ceren Akgor, Hale Gok Dagidir, Ozlem Gulbahar, Meltem Yalinay and Hayrunnisa Bolay
    Citation: The Journal of Headache and Pain 2024 25:23
    Content type: Research Published on:

  27. About one-third of persons with migraine experience transient neurologic symptoms, referred to as aura. Despite its widespread prevalence, comprehensive clinical descriptions of migraine with aura remain spars...

    Authors: Andreas Vinther Thomsen, Håkan Ashina, Haidar M. Al-Khazali, Kathrine Rose, Rune Häckert Christensen, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2024 25:22
    Content type: Research Published on:

  28. Migraine is a disabling neurovascular disorder among people of all ages, with the highest prevalence in the fertile years, and in women. Migraine impacts the quality of life of affected individuals tremendousl...

    Authors: Noor Bruijn, Romy van Lohuizen, Malgorzata Boron, Mira Fitzek, Francesca Gabriele, Giada Giuliani, Laura Melgarejo, Pavel Řehulka, Gabriele Sebastianelli, Paul Triller, Simone Vigneri, Behiye Özcan and Antoinette Maassen van den Brink
    Citation: The Journal of Headache and Pain 2024 25:20
    Content type: Review Published on:

  29. Migraine is one of the main causes of disability worldwide. Anti-CGRP monoclonal antibodies (MAbs) have proven to be safe and efficacious as preventive migraine treatments. However, their use is restricted in ...

    Authors: Carlos Lazaro-Hernandez, Edoardo Caronna, Joana Rosell-Mirmi, Victor J Gallardo, Alicia Alpuente, Marta Torres-Ferrus and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2024 25:21
    Content type: Research Published on:

  30. Clinical characteristics and treatment practice of patients with migraine in Japan in real-world setting have not been fully investigated. We conducted a retrospective cohort study using claims database to un...

    Authors: Tsubasa Takizawa, Takahiro Kitano, Masahiro Iijima, Kanae Togo and Naohiro Yonemoto
    Citation: The Journal of Headache and Pain 2024 25:19
    Content type: Research Published on:

  31. Headache is a common symptom of influenza infection; however, its causes and consequences remain uncertain. In this manuscript, we analyzed which demographic and clinical factors were associated with the prese...

    Authors: David García-Azorín, Laura Santana-López, José Eugenio Lozano-Alonso, Ana Ordax-Díez, Tomas Vega-Alonso, Diego Macias Saint-Gerons, Yésica González-Osorio, Silvia Rojo-Rello, José M. Eiros, Javier Sánchez-Martínez, Álvaro Sierra-Mencía, Andrea Recio-García, Alejandro Martín-Toribio, Ivan Sanz-Muñoz and Ángel Luis Guerrero-Peral
    Citation: The Journal of Headache and Pain 2024 25:18
    Content type: Research Published on:

  32. The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and the role of glymphatics in RCVS pathophysiology has not been evaluated. We aimed to investigate RCVS glymph...

    Authors: Chia-Hung Wu, Yu Kuo, Yu-Hsiang Ling, Yen-Feng Wang, Jong-Ling Fuh, Jiing-Feng Lirng, Hsiu-Mei Wu, Shuu-Jiun Wang and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2024 25:17
    Content type: Research Published on:

  33. To compare the outcomes associated with the use of lasmiditan, rimegepant, ubrogepant, and zavegepant for the acute management of migraine headaches.

    Authors: Xinxin Deng, Liying Zhou, Cui Liang, Xue Shang, Xu Hui, Wendi Liu, Shanshan Liang, Yongsheng Wang, Meng Xu, Kangle Guo, Kehu Yang and Xiuxia Li
    Citation: The Journal of Headache and Pain 2024 25:16
    Content type: Review Published on:

  34. Pediatric Migraine Disability Assessment (PedMIDAS) is one of the most frequently used questionnaires to assess disability from migraine in pediatric patients. This work aimed to evaluate the validity and test...

    Authors: Rehab Magdy, Amr Hassan, Zeinab Mohammed, Mohamed A. Abdeltwab, Nawal F. Abdel Ghaffar and Mona Hussein
    Citation: The Journal of Headache and Pain 2024 25:15
    Content type: Research Published on:

  35. Several risk factors are associated with the chronic evolution of migraine. Clinical and preclinical studies have provided data about the role of hypertension (HT) as one of the potential modifiable risk facto...

    Authors: Federico Mazzacane, Gloria Vaghi, Matteo Cotta Ramusino, Giulia Perini and Alfredo Costa
    Citation: The Journal of Headache and Pain 2024 25:13
    Content type: Review Published on:

  36. Chronic migraine (CM) is a disabling condition with high prevalence in the general population. Until the recent approval of monoclonal antibodies targeting the calcitonin gene-related peptide (Anti-CGRP mAbs),...

    Authors: Licia Grazzi, Riccardo Giossi, Danilo Antonio Montisano, Mattia Canella, Marilena Marcosano, Claudia Altamura and Fabrizio Vernieri
    Citation: The Journal of Headache and Pain 2024 25:14
    Content type: Research Published on:

  37. Current definitions of migraine that are based mainly on clinical characteristics do not account for other patient’s features such as those related to an impaired quality of life, due to loss of social life an...

    Authors: Claudio Tana, Bianca Raffaelli, Marcio Nattan Portes Souza, Elena Ruiz de la Torre, Daniel Gams Massi, Najib Kisani, David García-Azorín and Marta Waliszewska-Prosół
    Citation: The Journal of Headache and Pain 2024 25:12
    Content type: Review Published on:

    The Review to this article has been published in The Journal of Headache and Pain 2023 24:167

  38. Migraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disor...

    Authors: Jakob Paungarttner, Martina Quartana, Lucrezia Patti, Barbora Sklenárová, Fatemeh Farham, Inés Hernando Jiménez, M. Gokcen Soylu, Irina Maria Vlad, Semih Tasdelen, Teresa Mateu, Oreste Marsico, Federica Reina, Viktoria Tischler and Christian Lampl
    Citation: The Journal of Headache and Pain 2024 25:11
    Content type: Review Published on:

  39. Current evidence on the safety of calcitonin gene–related peptide antagonists (CGRP-A) in pregnancy for the treatment of both episodic and chronic migraine is scarce and does not yet provide definitive informa...

    Authors: Roberta Noseda, Francesca Bedussi, Claudio Gobbi, Alessandro Ceschi and Chiara Zecca
    Citation: The Journal of Headache and Pain 2024 25:10
    Content type: Brief Report Published on:

  40. Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the prevention of chronic and frequent episodic migraine. Since the antibodies do not cross the b...

    Authors: Nadine Friedrich, Krisztina Németh, Martin Tanner, Judit Rosta, Ildikó Dobos, Orsolya Oszlács, Gábor Jancsó, Karl Messlinger and Mária Dux
    Citation: The Journal of Headache and Pain 2024 25:9
    Content type: Research Published on:

  41. Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to elicit transient local silencing cortical activity. Sweeping across the cortex, the el...

    Authors: Tatiana M. Medvedeva, Maria P. Smirnova, Irina V. Pavlova and Lyudmila V. Vinogradova
    Citation: The Journal of Headache and Pain 2024 25:8
    Content type: Research Published on:

  42. Migraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensitive receptors of different families, which specifically respond to various mechanical s...

    Authors: Adriana Della Pietra, Laura Gómez Dabó, Petr Mikulenka, Christian Espinoza-Vinces, Doga Vuralli, Isil Baytekin, Paolo Martelletti and Rashid Giniatullin
    Citation: The Journal of Headache and Pain 2024 25:6
    Content type: Review Published on:

  43. Despite hypothalamus has long being considered to be involved in the pathophysiology of cluster headache, the inconsistencies of previous neuroimaging studies and a limited understanding of the hypothalamic ar...

    Authors: Stefania Ferraro, Anna Nigri, Maria Grazia Bruzzone, Jean Paul Medina Carrion, Davide Fedeli, Greta Demichelis, Luisa Chiapparini, Giuseppe Ciullo, Ariosky Areces Gonzalez, Alberto Proietti Cecchini, Luca Giani, Benjamin Becker and Massimo Leone
    Citation: The Journal of Headache and Pain 2024 25:7
    Content type: Research Published on:

  44. Given the findings of central effects of erenumab in the literature, we aimed to conduct a rigorous placebo-controlled, double-blind, randomized study to elucidate whether the observed changes are directly att...

    Authors: Hauke Basedau, Kuan-Po Peng, Marlene Schellong and Arne May
    Citation: The Journal of Headache and Pain 2024 25:5
    Content type: Research Published on:

  45. Neuroinflammation, mediated by the activation of microglia, contributes to central sensitization, which is associated with the development of chronic migraine (CM). TREM1 receptors amplify the inflammatory res...

    Authors: Songtang Sun, Zhenzhen Fan, Xuejiao Liu, Longde Wang and Zhaoming Ge
    Citation: The Journal of Headache and Pain 2024 25:3
    Content type: Research Published on:

  46. The pathogenesis of pediatric migraine remains unclear and presents challenges in diagnosis. Recently, growing evidence has indicated that the gut microbiota can exert modulatory functions at the gut-brain axi...

    Authors: Junhui Liu, Kaiyan Xi, Linlin Zhang, Mugu Han, Qingran Wang and Xinjie Liu
    Citation: The Journal of Headache and Pain 2024 25:2
    Content type: Research Published on:

  47. Prior MRI studies on vestibular migraine (VM) have revealed abnormalities in static regional intrinsic brain activity (iBA) and dynamic functional connectivity between brain regions or networks. However, the t...

    Authors: Xing Xiong, Lingling Dai, Wen Chen, Jiajie Lu, Chunhong Hu, Hongru Zhao and Jun Ke
    Citation: The Journal of Headache and Pain 2024 25:1
    Content type: Research Published on:

  48. The World Health Organization (WHO) Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders was developed by WHO to address the worldwide challenges and gaps in provision of care and serv...

    Authors: Matilde Leonardi, Paolo Martelletti, Rami Burstein, Arianna Fornari, Licia Grazzi, Alla Guekht, Richard B. Lipton, Dimos Dimitrios Mitsikostas, Jes Olesen, Mayowa Ojo Owolabi, Elena Ruiz De la Torre, Simona Sacco, Timothy J. Steiner, Nirmal Surya, Takao Takeshima, Cristina Tassorelli…
    Citation: The Journal of Headache and Pain 2024 25:4
    Content type: Review Published on:

  50. Half of the sufferers of reversible cerebral vasoconstriction syndrome (RCVS) exhibit imaging-proven blood-brain barrier disruption. The pathogenesis of blood-brain barrier disruption in RCVS remains unclear a...

    Authors: Yu-Hsiang Ling, Nai-Fang Chi, Li-Ling Hope Pan, Yen-Feng Wang, Chia-Hung Wu, Jiing-Feng Lirng, Jong-Ling Fuh, Shuu-Jiun Wang and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2023 24:170
    Content type: Research Published on:
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