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  1. Content type: Research article

    Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodil...

    Authors: Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:41

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  2. Content type: Research article

    Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the recept...

    Authors: Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    Citation: The Journal of Headache and Pain 2018 19:40

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  3. Content type: Research

    Factors associated with development of medication-overuse headache (MOH) in migraine patients are not fully understood, but with respect to prevention, the ability to predict the onset of MOH is clinically imp...

    Authors: Louise S. Mose, Susanne S. Pedersen, Birgit Debrabant, Rigmor H. Jensen and Bibi Gram

    Citation: The Journal of Headache and Pain 2018 19:39

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  4. Content type: Research article

    The MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO wi...

    Authors: Todd J. Schwedt, Aftab Alam, Michael L. Reed, Kristina M. Fanning, Sagar Munjal, Dawn C. Buse, David W. Dodick and Richard B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:38

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  5. Content type: Research article

    Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthriti...

    Authors: Eric P. Baron, Philippe Lucas, Joshua Eades and Olivia Hogue

    Citation: The Journal of Headache and Pain 2018 19:37

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  6. Content type: Research article

    Although previous studies have demonstrated that structural and functional abnormalities in episodic migraine (EM), less is known about altered brain perfusion in the EM. The aim of this study is to investigat...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengyu Liu, Mengqi Liu, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2018 19:36

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  7. Content type: Review article

    Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) i...

    Authors: Faisal Mohammad Amin and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2018 19:35

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  8. Content type: Research article

    In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificit...

    Authors: Charmaine E. Pollock, Heidi G. Sutherland, Bridget H. Maher, Rodney A. Lea, Larisa M. Haupt, Alison Frith, E. Anne MacGregor and Lyn R. Griffiths

    Citation: The Journal of Headache and Pain 2018 19:31

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  9. Content type: Review article

    The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing. T...

    Authors: Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen and Thomas Folkmann Hansen

    Citation: The Journal of Headache and Pain 2018 19:29

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  10. Content type: Review article

    Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

    Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

    Citation: The Journal of Headache and Pain 2018 19:28

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  11. Content type: Research article

    Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.

    Authors: Beáta Éva Petrovski, Kjersti G. Vetvik, Christofer Lundqvist and Malin Eberhard-Gran

    Citation: The Journal of Headache and Pain 2018 19:27

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  12. Content type: Research article

    Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...

    Authors: Kerstin Luedtke, Jan Mehnert and Arne May

    Citation: The Journal of Headache and Pain 2018 19:26

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  13. Content type: Research article

    The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.

    Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl and Trond Sand

    Citation: The Journal of Headache and Pain 2018 19:25

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  14. Content type: Research article

    The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

    Authors: Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

    Citation: The Journal of Headache and Pain 2018 19:24

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  15. Content type: Review article

    The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

    Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

    Citation: The Journal of Headache and Pain 2018 19:23

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  16. Content type: Review article

    Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

    Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

    Citation: The Journal of Headache and Pain 2018 19:21

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  17. Content type: Review article

    Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:19

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  18. Content type: Research article

    Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

    Authors: Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:18

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  19. Content type: Review article

    In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

    Citation: The Journal of Headache and Pain 2018 19:16

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  20. Content type: Methodology

    Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

    Authors: T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

    Citation: The Journal of Headache and Pain 2018 19:15

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  21. Content type: Research article

    Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

    Authors: Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

    Citation: The Journal of Headache and Pain 2018 19:14

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  22. Content type: Research article

    OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

    Authors: Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

    Citation: The Journal of Headache and Pain 2018 19:13

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  23. Content type: Methodology

    The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...

    Authors: T. J. Steiner and R. B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:12

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  24. Content type: Research article

    Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

    Authors: Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

    Citation: The Journal of Headache and Pain 2018 19:11

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  25. Content type: Research article

    Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...

    Authors: Zaza Katsarava, Maka Mania, Christian Lampl, Johanna Herberhold and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:10

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  26. Content type: Review article

    Sensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. ...

    Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

    Citation: The Journal of Headache and Pain 2018 19:9

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  27. Content type: Research article

    Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether sub...

    Authors: Lena Hoem Nordhaug, Knut Hagen, Anne Vik, Lars Jacob Stovner, Turid Follestad, Torunn Pedersen, Gøril Bruvik Gravdahl and Mattias Linde

    Citation: The Journal of Headache and Pain 2018 19:8

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  28. Content type: Research article

    Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunit...

    Authors: Binbin Wang, Siyuan Liu, Bingbing Fan, Xingguo Xu, Yonglin Chen, Rongxiang Lu, Zhongling Xu and Xiaojuan Liu

    Citation: The Journal of Headache and Pain 2018 19:7

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  29. Content type: Research article

    Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcom...

    Authors: Mads Barloese, Anja Petersen, Philipp Stude, Tim Jürgens, Rigmor Højland Jensen and Arne May

    Citation: The Journal of Headache and Pain 2018 19:6

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  30. Content type: Research article

    Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with ...

    Authors: Francesca Puledda, Peter J. Goadsby and Prab Prabhakar

    Citation: The Journal of Headache and Pain 2018 19:5

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  31. Content type: Research article

    Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both t...

    Authors: Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M. Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2018 19:4

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  32. Content type: Research article

    Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues inc...

    Authors: Michael J. M. Fischer, Jakob Schmidt, Stanislav Koulchitsky, Sven Klussmann, Axel Vater and Karl Messlinger

    Citation: The Journal of Headache and Pain 2018 19:3

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  33. Content type: Research article

    Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirme...

    Authors: Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2018 19:1

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  34. Content type: Research article

    To investigate variables associated at one year (longitudinal design) with the physical or emotional component of burden in chronic tension type headache (CTTH).

    Authors: Stella Fuensalida-Novo, Maria Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Antonella Catena, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

    Citation: The Journal of Headache and Pain 2017 18:119

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  35. Content type: Review article

    Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its e...

    Authors: Kwo Wei David Ho, Rene Przkora and Sanjeev Kumar

    Citation: The Journal of Headache and Pain 2017 18:118

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  36. Content type: Research article

    Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressu...

    Authors: Toshihide Toriyama, Tetsuyoshi Horiuchi and Kazuhiro Hongo

    Citation: The Journal of Headache and Pain 2017 18:117

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  37. Content type: Research article

    Beta-blockers are a first choice migraine preventive medication. So far it is unknown how they exert their therapeutic effect in migraine. To this end we examined the neural effect of metoprolol on trigeminal ...

    Authors: Julia M. Hebestreit and Arne May

    Citation: The Journal of Headache and Pain 2017 18:116

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  38. Content type: Research article

    To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morph...

    Authors: Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

    Citation: The Journal of Headache and Pain 2017 18:115

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  39. Content type: Research article

    Acute headache is one of the most frequent neurological symptoms in pregnant women. The early diagnosis of underlying secondary conditions has a major influence on patient outcome, especially in emergency sett...

    Authors: Bianca Raffaelli, Eberhard Siebert, Jeannette Körner, Thomas Liman, Uwe Reuter and Lars Neeb

    Citation: The Journal of Headache and Pain 2017 18:114

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  40. Content type: Research article

    The 2013 International Classification of Headache Disorders-3 was published in a beta version to allow clinicians to confirm the validity of the criteria or suggest improvements based on field studies. The aim...

    Authors: Aynur Özge, Ishaq Abu-Arafeh, Amy A. Gelfand, Peter James Goadsby, Jean Christophe Cuvellier, Massimiliano Valeriani, Alexey Sergeev, Karen Barlow, Derya Uludüz, Osman Özgür Yalın, Noemi Faedda, Richard B. Lipton, Alan Rapoport and Vincenzo Guidetti

    Citation: The Journal of Headache and Pain 2017 18:113

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  41. Content type: Research article

    Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR...

    Authors: Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2017 18:112

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