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  1. Content type: Research article

    High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, he...

    Authors: Kun Wang, Menghan Zhang, Yi Li, Weilin Pu, Yanyun Ma, Yi Wang, Xiaoyu Liu, Longli Kang, Xiaofeng Wang, Jiucun Wang, Bin Qiao and Li Jin

    Citation: The Journal of Headache and Pain 2018 19:59

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  2. Content type: Research article

    Probable migraine (PM) is a subtype of migraine that is prevalent in the general population. Previous studies have shown that poor sleep quality is common among migraineurs and is associated with an exacerbati...

    Authors: Tae-Jin Song, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    Citation: The Journal of Headache and Pain 2018 19:58

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  3. Content type: Research article

    No study has investigated the associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD). This study aimed to investigate this issue.

    Authors: Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2018 19:56

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  4. Content type: Research article

    Increased cortical excitability has been hypothesized to play a critical role in various neurological disorders, such as restless legs syndrome, epilepsy and migraine. Particularly for migraine, local hyperexc...

    Authors: Adina Bathel, Lauren Schweizer, Philipp Stude, Benjamin Glaubitz, Niklas Wulms, Sibel Delice and Tobias Schmidt-Wilcke

    Citation: The Journal of Headache and Pain 2018 19:55

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  5. Content type: Research article

    Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D leve...

    Authors: Jong-Hee Sohn, Min-Kyung Chu, Kwang-Yeol Park, Hong-Yup Ahn and Soo-Jin Cho

    Citation: The Journal of Headache and Pain 2018 19:54

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  6. Content type: Research article

    Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chro...

    Authors: Mi Ji Lee, Sook-Yeon Lee, Soohyun Cho, Eun-Suk Kang and Chin-Sang Chung

    Citation: The Journal of Headache and Pain 2018 19:53

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  7. Content type: Research article

    Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CG...

    Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni and Cristina Tassorelli

    Citation: The Journal of Headache and Pain 2018 19:51

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  8. Content type: Review article

    Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to h...

    Authors: Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2018 19:50

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  9. Content type: Research article

    Migraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abn...

    Authors: Marco Lisicki, Kevin D’Ostilio, Gianluca Coppola, Felix Scholtes, Alain Maertens de Noordhout, Vincenzo Parisi, Jean Schoenen and Delphine Magis

    Citation: The Journal of Headache and Pain 2018 19:49

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  10. Content type: Research article

    Major depressive disorder is a common comorbidity in migraineurs. Depression may affect the progression and prognosis of migraine. Few studies have examined the brain function in migraineurs that may cause thi...

    Authors: Mengmeng Ma, Junran Zhang, Ning Chen, Jian Guo, Yang Zhang and Li He

    Citation: The Journal of Headache and Pain 2018 19:48

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  11. Content type: Research article

    Chronic pain including migraine is associated with structural and functional changes in the somatosensory cortex. Previous reports proposed two-point discrimination (TPD) as a measurement for cortical alterati...

    Authors: Kerstin Luedtke, Waclaw Adamczyk, Katrin Mehrtens, Inken Moeller, Louisa Rosenbaum, Axel Schaefer, Janine Schroeder, Tibor Szikszay, Christian Zimmer and Bettina Wollesen

    Citation: The Journal of Headache and Pain 2018 19:47

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  12. Content type: Research article

    Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (N...

    Authors: Junpeng Liu, Jiajia Zhu, Fei Yuan, Xuejun Zhang and Quan Zhang

    Citation: The Journal of Headache and Pain 2018 19:46

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  13. Content type: Research article

    Studies involving human pharmacological migraine models have predominantly focused on the vasoactive effects of headache-inducing drugs, including sildenafil and calcitonin gene-related peptide (CGRP). However...

    Authors: Samaira Younis, Anders Hougaard, Casper Emil Christensen, Mark Bitsch Vestergaard, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson and Messoud Ashina

    Citation: The Journal of Headache and Pain 2018 19:44

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  14. Content type: Research article

    The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors ...

    Authors: Alexei A. Kamshilin, Maxim A. Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V. Amelin, Oleg V. Mamontov and Rashid Giniatullin

    Citation: The Journal of Headache and Pain 2018 19:43

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  15. Content type: Research article

    Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulat...

    Authors: Huimin Tao, Teng Wang, Xin Dong, Qi Guo, Huan Xu and Qi Wan

    Citation: The Journal of Headache and Pain 2018 19:42

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  16. Content type: Research article

    Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodil...

    Authors: Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:41

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  17. Content type: Research article

    Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the recept...

    Authors: Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    Citation: The Journal of Headache and Pain 2018 19:40

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  18. Content type: Research

    Factors associated with development of medication-overuse headache (MOH) in migraine patients are not fully understood, but with respect to prevention, the ability to predict the onset of MOH is clinically imp...

    Authors: Louise S. Mose, Susanne S. Pedersen, Birgit Debrabant, Rigmor H. Jensen and Bibi Gram

    Citation: The Journal of Headache and Pain 2018 19:39

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  19. Content type: Research article

    The MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO wi...

    Authors: Todd J. Schwedt, Aftab Alam, Michael L. Reed, Kristina M. Fanning, Sagar Munjal, Dawn C. Buse, David W. Dodick and Richard B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:38

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  20. Content type: Research article

    Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthriti...

    Authors: Eric P. Baron, Philippe Lucas, Joshua Eades and Olivia Hogue

    Citation: The Journal of Headache and Pain 2018 19:37

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  21. Content type: Research article

    Although previous studies have demonstrated that structural and functional abnormalities in episodic migraine (EM), less is known about altered brain perfusion in the EM. The aim of this study is to investigat...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengyu Liu, Mengqi Liu, Lin Ma and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2018 19:36

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  22. Content type: Review article

    Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) i...

    Authors: Faisal Mohammad Amin and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2018 19:35

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  23. Content type: Research article

    In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificit...

    Authors: Charmaine E. Pollock, Heidi G. Sutherland, Bridget H. Maher, Rodney A. Lea, Larisa M. Haupt, Alison Frith, E. Anne MacGregor and Lyn R. Griffiths

    Citation: The Journal of Headache and Pain 2018 19:31

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  24. Content type: Review article

    The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing. T...

    Authors: Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen and Thomas Folkmann Hansen

    Citation: The Journal of Headache and Pain 2018 19:29

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  25. Content type: Review article

    Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

    Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

    Citation: The Journal of Headache and Pain 2018 19:28

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  26. Content type: Research article

    Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.

    Authors: Beáta Éva Petrovski, Kjersti G. Vetvik, Christofer Lundqvist and Malin Eberhard-Gran

    Citation: The Journal of Headache and Pain 2018 19:27

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  27. Content type: Research article

    Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...

    Authors: Kerstin Luedtke, Jan Mehnert and Arne May

    Citation: The Journal of Headache and Pain 2018 19:26

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  28. Content type: Research article

    The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.

    Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl and Trond Sand

    Citation: The Journal of Headache and Pain 2018 19:25

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  29. Content type: Research article

    The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

    Authors: Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

    Citation: The Journal of Headache and Pain 2018 19:24

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  30. Content type: Review article

    The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

    Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

    Citation: The Journal of Headache and Pain 2018 19:23

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  31. Content type: Review article

    Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

    Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

    Citation: The Journal of Headache and Pain 2018 19:21

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  32. Content type: Review article

    Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:19

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  33. Content type: Research article

    Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

    Authors: Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:18

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  34. Content type: Review article

    In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

    Citation: The Journal of Headache and Pain 2018 19:16

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  35. Content type: Methodology

    Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

    Authors: T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

    Citation: The Journal of Headache and Pain 2018 19:15

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  36. Content type: Research article

    Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

    Authors: Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

    Citation: The Journal of Headache and Pain 2018 19:14

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  37. Content type: Research article

    OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

    Authors: Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

    Citation: The Journal of Headache and Pain 2018 19:13

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  38. Content type: Methodology

    The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...

    Authors: T. J. Steiner and R. B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:12

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  39. Content type: Research article

    Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

    Authors: Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

    Citation: The Journal of Headache and Pain 2018 19:11

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  40. Content type: Research article

    Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...

    Authors: Zaza Katsarava, Maka Mania, Christian Lampl, Johanna Herberhold and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:10

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  41. Content type: Review article

    Sensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. ...

    Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

    Citation: The Journal of Headache and Pain 2018 19:9

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