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  1. Erenumab, the first-in-class fully human monoclonal antibody targeting the calcitonin gene-related peptide receptor, was shown to be efficacious and safe for the prophylactic treatment of migraine in adults in...

    Authors: Andreas Straube, Philipp Stude, Charly Gaul, Katrin Schuh and Mirja Koch
    Citation: The Journal of Headache and Pain 2021 22:133
  2. Lasmiditan (LTN) is a selective 5-HT1F receptor agonist for the acute treatment of migraine in adults. We present detailed safety findings from the placebo-controlled, double-blind Phase 3 study, of LTN treatment...

    Authors: C Tassorelli, S Bragg, JH Krege, EG Doty, PA Ardayfio, D Ruff, SA Dowsett and T Schwedt
    Citation: The Journal of Headache and Pain 2021 22:132
  3. Authors: Sara Bottiroli, Roberto De Icco, Gloria Vaghi, Stefania Pazzi, Elena Guaschino, Marta Allena, Natascia Ghiotto, Daniele Martinelli, Cristina Tassorelli and Grazia Sances
    Citation: The Journal of Headache and Pain 2021 22:131

    The original article was published in The Journal of Headache and Pain 2021 22:114

  4. In this study, we aimed to investigate the spontaneous neural activity in the conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz, and slow-5: 0.01–0.027 Hz) in tensi...

    Authors: Shuxian Zhang, Huayun Li, Qinyan Xu, Chao Wang, Xue Li, Jiawei Sun, Yaqi Wang, Tong Sun, Qianqian Wang, Chengcheng Zhang, Jili Wang, Xize Jia and Xihe Sun
    Citation: The Journal of Headache and Pain 2021 22:129
  5. Several drugs are available for the preventive treatment of both episodic and chronic migraine. The choice of which therapy to initiate first, second, or third is not straightforward and is based on multiple f...

    Authors: Fenne Vandervorst, Laura Van Deun, Annelies Van Dycke, Koen Paemeleire, Uwe Reuter, Jean Schoenen and Jan Versijpt
    Citation: The Journal of Headache and Pain 2021 22:128
  6. Migraine sufferers face difficulties getting appropriate care and treatment. Migraine is associated with reduced gray matter volume (GMV) in several brain regions, which could be related to various clinical ch...

    Authors: Shana A.B. Burrowes, Olga Goloubeva, Michael L Keaser, Jennifer A. Haythornthwaite and David A. Seminowicz
    Citation: The Journal of Headache and Pain 2021 22:127
  7. The MIDAS is the most used questionnaire to evaluate migraine-related disability, but its utility to assess treatment response remains unclear. Our aim was to estimate the MIDAS’ minimal important change (MIC)...

    Authors: Gabriela F. Carvalho, Kerstin Luedtke and Tobias Braun
    Citation: The Journal of Headache and Pain 2021 22:126
  8. To compare symptoms of clinical androgen deficiency between men with migraine, men with cluster headache and non-headache male controls.

    Authors: Iris E. Verhagen, Roemer B. Brandt, Carlijn M. A. Kruitbosch, Antoinette MaassenVanDenBrink, Rolf Fronczek and Gisela M. Terwindt
    Citation: The Journal of Headache and Pain 2021 22:125

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:135

  9. Migraine has been associated with cardiovascular disease (CVD) events among middle-aged adults. The objective of this study was to determine the risk for ischemic stroke and coronary heart disease (CHD) events...

    Authors: Emily C. McKinley, Christine L. Lay, Robert S. Rosenson, Ligong Chen, Victoria Chia, Lisandro D. Colantonio, Paul Muntner, Robert Urman and Michael E. Farkouh
    Citation: The Journal of Headache and Pain 2021 22:124
  10. Obesity confers adverse effects to every system in the body including the central nervous system. Obesity is associated with both migraine and idiopathic intracranial hypertension (IIH). The mechanisms underly...

    Authors: Connar Stanley James Westgate, Ida Marchen Egerod Israelsen, Rigmor Højland Jensen and Sajedeh Eftekhari
    Citation: The Journal of Headache and Pain 2021 22:123
  11. Brain arteriovenous malformations (AVMs) consist of abnormal connections between arteries and veins via an interposing nidus. While hemorrhage is the most common presentation, unruptured AVMs can present with ...

    Authors: Benjamin N Africk, Daniel M Heiferman, Amy W Wozniak, Faraz Behzadi, Matthew S Ballard, Joshua M Chazaro, Brandon M Zsigray, Rachyl M Shanker, Matthew R Reynolds, Douglas E Anderson and Joseph C Serrone
    Citation: The Journal of Headache and Pain 2021 22:122
  12. Calcitonin gene-related peptide (CGRP) is expressed throughout the body and is a known mediator of migraine, exerting this biological effect through activation of trigeminovascular, meningeal and associated ne...

    Authors: Jason C. Ray, Penelope Allen, Ann Bacsi, Julian J. Bosco, Luke Chen, Michael Eller, Hock Kua, Lyndell L. Lim, Manjit S. Matharu, Mastura Monif, Martin Ruttledge, Richard J. Stark and Elspeth J. Hutton
    Citation: The Journal of Headache and Pain 2021 22:121
  13. In daily practice, anti-CGRP monoclonal antibodies (MAbs) may be useful in chronic migraine (CM) with medication overuse (MO), but data is limited. We evaluated their effectiveness in a real-life clinical cohort.

    Authors: Edoardo Caronna, Victor José Gallardo, Alicia Alpuente, Marta Torres-Ferrus and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2021 22:120
  14. Migraine is a common neurological disease with extremely debilitating, but fully reversible symptoms. Women suffer from migraine more often than men. It was assumed that fluctuation of oestrogen level during m...

    Authors: Magdalena Kobus, Aneta Sitek, Bogusław Antoszewski, Jacek Rożniecki, Jacek Pełka and Elżbieta Żądzińska
    Citation: The Journal of Headache and Pain 2021 22:119
  15. Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate the association with intracranial pressure.

    Authors: S. P. Mollan, B. R. Wakerley, Z. Alimajstorovic, J. Mitchell, R. Ottridge, A. Yiangou, M. Thaller, A. Gupta, O. Grech, G. Lavery, K. Brock and A. J. Sinclair
    Citation: The Journal of Headache and Pain 2021 22:118
  16. Recent data suggest that gene expression profiles of peripheral white blood cells can reflect changes in the brain. We aimed to analyze the transcriptome of peripheral blood mononuclear cells (PBMC) and change...

    Authors: Timea Aczél, Tamás Körtési, József Kun, Péter Urbán, Witold Bauer, Róbert Herczeg, Róbert Farkas, Krisztián Kovács, Barna Vásárhelyi, Gellért B. Karvaly, Attila Gyenesei, Bernadett Tuka, János Tajti, László Vécsei, Kata Bölcskei and Zsuzsanna Helyes
    Citation: The Journal of Headache and Pain 2021 22:117
  17. Authors: Lotte Skytte Krøll, Henriette Edemann Callesen, Louise Ninett Carlsen, Kirsten Birkefoss, Dagmar Beier, Henrik Wulff Christensen, Mette Jensen, Hanna Tómasdóttir, Hanne Würtzen, Christel Vesth Høst and Jakob Møller Hansen
    Citation: The Journal of Headache and Pain 2021 22:116

    The original article was published in The Journal of Headache and Pain 2021 22:96

  18. Authors: Anne-Sophie Wattiez, Olivia J. Gaul, Adisa Kuburas, Erik Zorrilla, Jayme S. Waite, Bianca N. Mason, William C. Castonguay, Mengya Wang, Bennett R. Robertson and Andrew F. Russo
    Citation: The Journal of Headache and Pain 2021 22:115

    The original article was published in The Journal of Headache and Pain 2021 22:62

  19. Monoclonal antibodies (mABs) targeting the calcitonin gene-related peptide (CGRP) pathway represent the first disease-specific preventive migraine therapy. Growing evidence suggests that they are effective in ...

    Authors: Sara Bottiroli, Roberto De Icco, Gloria Vaghi, Stefania Pazzi, Elena Guaschino, Marta Allena, Natascia Ghiotto, Daniele Martinelli, Cristina Tassorelli and Grazia Sances
    Citation: The Journal of Headache and Pain 2021 22:114

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:131

  20. Chronic migraine (CM) and episodic migraine (EM) are associated with substantial headache-related disability, poor quality of life and global societal burden. In this subgroup analysis from the CONQUER study, ...

    Authors: Rose Okonkwo, Antje Tockhorn-Heidenreich, Chad Stroud, Marie-Ange Paget, Manjit S. Matharu and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2021 22:113
  21. Trigeminal Neuralgia (TN) is a chronic neurological disease that is strongly associated with neurovascular compression (NVC) of the trigeminal nerve near its root entry zone. The trigeminal nerve at the site o...

    Authors: Judy Alper, Alan C. Seifert, Gaurav Verma, Kuang-Han Huang, Yael Jacob, Ameen Al Qadi, John W. Rutland, Sheetal Patel, Joshua Bederson, Raj K. Shrivastava, Bradley N. Delman and Priti Balchandani
    Citation: The Journal of Headache and Pain 2021 22:112
  22. Calcitonin gene-related peptide (CGRP) (receptor) antibodies (erenumab, fremanezumab and galcanezumab) are increasingly used in prophylactic treatment of migraine. In the approval studies, severely affected pa...

    Authors: Armin Scheffler, Hannah Schenk, Sebastian Wurthmann, Michael Nsaka, Christoph Kleinschnitz, Martin Glas and Dagny Holle
    Citation: The Journal of Headache and Pain 2021 22:111
  23. These subgroup analyses of a Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of erenumab 70 mg in Japanese migraine patients with/without prior preventive treatmen...

    Authors: Koichi Hirata, Fumihiko Sakai, Takao Takeshima, Noboru Imai, Yasuhiko Matsumori, Ryuji Yoshida, Yotaro Numachi, Cheng Peng, Daniel D. Mikol and Sunfa Cheng
    Citation: The Journal of Headache and Pain 2021 22:110
  24. Headache is a frequent symptom following COVID-19 immunization with a typical onset within days post-vaccination. Cases of cerebral venous thrombosis (CVT) have been reported in adenovirus vector-based COVID-1...

    Authors: David García-Azorín, Thien Phu Do, Andreas R. Gantenbein, Jakob Møller Hansen, Marcio Nattan P. Souza, Mark Obermann, Heiko Pohl, Christoph J. Schankin, Henrik Winther Schytz, Alexandra Sinclair, Guus G. Schoonman and Espen Saxhaug Kristoffersen
    Citation: The Journal of Headache and Pain 2021 22:108
  25. Medication-overuse headache (MOH) is a relatively frequently occurring secondary headache caused by overuse of analgesics and/or acute migraine medications. It is believed that MOH is associated with dependenc...

    Authors: Wei Dai, Enchao Qiu, Yun Chen, Xinbo Xing, Wei Xi, Meichen Zhang, Ke Li, Lixia Tian, Zhao Dong and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2021 22:107
  26. Migraine is a primary headache disorder characterized by recurrent attacks that may have a significant impact on patients’ daily life. Treatment options must often be re-evaluated in light of efficacy, tolerab...

    Authors: M. Koch, Z. Katsarava, C. Baufeld, K. Schuh, A. Gendolla, A. Straube, W. von Pannwitz, W. E. Hofmann and S. Ortler
    Citation: The Journal of Headache and Pain 2021 22:106
  27. Calcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely accompanies severe headache attacks. Increased CGRP levels have been observed...

    Authors: Miriam Risch, Birgit Vogler, Mária Dux and Karl Messlinger
    Citation: The Journal of Headache and Pain 2021 22:105
  28. Neurovascular contact (NVC) is the main cause of primary trigeminal neuralgia (PTN); however, cases of PTN without NVC are still observed. In this study, the Meckel cave (MC) morphology in PTN were analyzed by...

    Authors: Jinzhi Lin, Yong Zhang, Wuming Li, Jianhao Yan and Yiquan Ke
    Citation: The Journal of Headache and Pain 2021 22:104
  29. In the past decades a plethora of studies has been conducted to explore resting-state functional connectivity (RS-FC) of the brain networks in migraine with conflicting results probably due to the variability ...

    Authors: Marcello Silvestro, Alessandro Tessitore, Giuseppina Caiazzo, Fabrizio Scotto di Clemente, Francesca Trojsi, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi and Antonio Russo
    Citation: The Journal of Headache and Pain 2021 22:102
  30. While pain freedom at 2 h is a key primary outcome for current trials for acute treatment of migraine, the relationship between the degree of head pain and other efficacy measures at 2 h has rarely been explor...

    Authors: Richard B. Lipton, Simin K. Baygani, Stewart J. Tepper, John H. Krege, Raghavendra Vasudeva, Eric M. Pearlman, Paula M. Hauck and Li Shen Loo
    Citation: The Journal of Headache and Pain 2021 22:101
  31. Health economic evaluations support health-care decision-making by providing information on the costs and consequences of health interventions. No universally accepted methodology exists for modelling effectiv...

    Authors: Michela Tinelli, Matilde Leonardi, Koen Paemeleire, Dimos Mitsikostas, Elena Ruiz de la Torre and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2021 22:99
  32. Structural imaging has revealed changes in cortical thickness in migraine patients compared to healthy controls is reported, but presence of dynamic cortical and subcortical changes during migraine attack vers...

    Authors: Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra Raghava, Frauke Wolfram, Henrik B. W. Larsson and Messoud Ashina
    Citation: The Journal of Headache and Pain 2021 22:98
  33. Coronavirus disease-19 is caused by the severe acute respiratory syndrome coronavirus 2 Headache is a common symptom during and after Coronavirus disease-19. We aimed to study headache character in relation to...

    Authors: Jasem Youssef Al-Hashel, Fathi Abokalawa, Maram Alenzi, Raed Alroughani and Samar Farouk Ahmed
    Citation: The Journal of Headache and Pain 2021 22:97
  34. Tension-type headache (TTH) has been ranked the second most prevalent health condition worldwide. Non-pharmacological treatments for TTH are widely used as a supplement or an alternative to medical treatment. ...

    Authors: Lotte Skytte Krøll, Henriette Edemann Callesen, Louise Ninett Carlsen, Kirsten Birkefoss, Dagmar Beier, Henrik Wulff Christensen, Mette Jensen, Hanna Tómasdóttir, Hanne Würtzen, Christel Vesth Høst and Jakob Møller Hansen
    Citation: The Journal of Headache and Pain 2021 22:96

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:116

  35. Pathogenesis of COVID-19 -related headache is unknown, though the induction of the trigeminal neurons through inflammation is proposed. We aimed to investigate key systemic circulating inflammatory molecules a...

    Authors: Hayrunnisa Bolay, Ömer Karadas, Bilgin Oztürk, Riza Sonkaya, Bahar Tasdelen, Tuba D. S. Bulut, Özlem Gülbahar, Aynur Özge and Betül Baykan
    Citation: The Journal of Headache and Pain 2021 22:94
  36. We report the first case of a patient who suffered transient focal neurological deficit mimicking stroke following CoronaVac vaccination. However, instead of an ischemic stroke, motor aura was suspected.

    Authors: Wanakorn Rattanawong, Wasan Akaratanawat, Supatporn Tepmongkol, Aurauma Chutinet, Jarturon Tantivatana and Nijasri Charnnarong Suwanwela
    Citation: The Journal of Headache and Pain 2021 22:93
  37. Mutations in ATP1A2, the gene encoding the α2 subunit of Na+/K+-ATPase, are the main cause of familial hemiplegic migraine type 2 (FHM2). The clinical presentation of FHM2 with mutations in the same gene varies f...

    Authors: Yingji Li, Wenjing Tang, Li Kang, Shanshan Kong, Zhao Dong, Dengfa Zhao, Ruozhuo Liu and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2021 22:92
  38. Cluster headache is an excruciating disorder with no cure. Greater occipital nerve blockades can transiently suppress attacks in approximately 50% of patients, however, its mechanism of action remains uncertai...

    Authors: Sonia Medina, Norazah Abu Bakar, Owen O’Daly, Sarah Miller, Elena Makovac, Tara Renton, Steve C. R. Williams, Manjit Matharu and Matthew A. Howard
    Citation: The Journal of Headache and Pain 2021 22:91
  39. There have been several calls for estimations of costs and consequences of headache interventions to inform European public-health policies. In a previous paper, in the absence of universally accepted methodol...

    Authors: Michela Tinelli, Matilde Leonardi, Koen Paemeleire, Alberto Raggi, Dimos Mitsikostas, Elena Ruiz de la Torre and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2021 22:90
  40. Considering the involvement of genetics in migraine pathogenesis in diverse ethnic populations, genome-wide association studies (GWAS) are being conducted to identify migraine-susceptibility genes. However, li...

    Authors: Chia-Kuang Tsai, Chih-Sung Liang, Guan-Yu Lin, Chia-Lin Tsai, Jiunn-Tay Lee, Yueh-Feng Sung, Yu-Kai Lin, Kuo-Sheng Hung, Wei-Liang Chen and Fu-Chi Yang
    Citation: The Journal of Headache and Pain 2021 22:89
  41. the interest of clinical reaseach in polymorphisms and epigenetics in migraine has been growing over the years. Due to the new era of preventative migraine treatment opened by monoclonal antibodies (mAbs) targ...

    Authors: Damiana Scuteri, Maria Tiziana Corasaniti, Paolo Tonin, Pierluigi Nicotera and Giacinto Bagetta
    Citation: The Journal of Headache and Pain 2021 22:87
  42. Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucag...

    Authors: Feng Jing, Qian Zou, Yangyang Wang, Zhiyou Cai and Yong Tang
    Citation: The Journal of Headache and Pain 2021 22:86
  43. Hemiplegic migraine (HM) is a rare form of migraine characterized by the presence of a motor and other types of aura. HM can be sporadic or familial. Familial hemiplegic migraine (FHM) is an autosomal dominant...

    Authors: Marina Romozzi, Guido Primiano, Eleonora Rollo, Lorena Travaglini, Paolo Calabresi, Serenella Servidei and Catello Vollono
    Citation: The Journal of Headache and Pain 2021 22:85
  44. Central sensitization is one of the characters of chronic migraine (CM). Aberrant synaptic plasticity can induce central sensitization. Oxytocin (OT), which is a hypothalamic hormone, plays an important antino...

    Authors: Yunfeng Wang, Qi Pan, Ruimin Tian, Qianwen Wen, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang and Jiying Zhou
    Citation: The Journal of Headache and Pain 2021 22:84
  45. To investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI).

    Authors: Håkan Ashina, Haidar Muhsen Al-Khazali, Afrim Iljazi, Sait Ashina, Faisal Mohammad Amin, Richard B. Lipton and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2021 22:83