Articles

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study

In a previous randomized, double-blind, proof-of-concept study in rapidly escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated with fewer and shorter triptan sensations than a 6...

Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport

Aggression and its association with suicidality in migraine patients: a case-control study

To identify aggression and its association with suicidality in migraine patients.

Authors: Sung-Pa Park and Jong-Geun Seo

Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation

Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is al...

Authors: Efstratia Vatzaki, Sabine Straus, Jean-Michel Dogne, Juan Garcia Burgos, Thomas Girard and Paolo Martelletti

Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. ...

Authors: Lena Ohlsson, Erik Kronvall, Jennifer Stratton and Lars Edvinsson

Intracortical facilitation within the migraine motor cortex depends on the stimulation intensity. A paired-pulse TMS study

Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evo...

Authors: Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M. Capitano, Brigida Fierro and Filippo Brighina

PACAP38 and PAC₁ receptor blockade: a new target for headache?

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent i...

Authors: Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink and Lars Edvinsson

Psychological distress, neuroticism and disability associated with secondary chronic headache in the general population – the Akershus study of chronic headache

Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with secondary chron...

Authors: Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist and Michael Bjørn Russell

The missclassification of obesity affects the course of migraine

Authors: Laura Di Renzo, Andrea Cammarano and Antonino De Lorenzo

Fibromyalgia in migraine: a retrospective cohort study

Migraine is a common and disabling disorder. Fibromyalgia has been shown to be commonly comorbid in patients with migraine and can intensify disability. The aim of this study was to determine if patients with ...

Authors: Mark Whealy, Sanjeev Nanda, Ann Vincent, Jay Mandrekar and F. Michael Cutrer

Headache in transient ischemic attacks

Headache is a common feature in acute cerebrovascular disease but no studies have evaluated the prevalence of specific headache types in patients with transient ischemic attacks (TIA). The purpose of the prese...

Authors: Elena R. Lebedeva, Natalia M. Gurary and Jes Olesen

Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m

High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, he...

Authors: Kun Wang, Menghan Zhang, Yi Li, Weilin Pu, Yanyun Ma, Yi Wang, Xiaoyu Liu, Longli Kang, Xiaofeng Wang, Jiucun Wang, Bin Qiao and Li Jin

Poor sleep quality in migraine and probable migraine: a population study

Probable migraine (PM) is a subtype of migraine that is prevalent in the general population. Previous studies have shown that poor sleep quality is common among migraineurs and is associated with an exacerbati...

Authors: Tae-Jin Song, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Survival outcome and mortality rate in patients with migraine: a population-based cohort study

Whether the patients with migraine have an elevated mortality risk in Taiwan is unclear.

Authors: Tomor Harnod, Cheng-Li Lin and Chia-Hung Kao

Migraine and greater pain symptoms at 10-year follow-up among patients with major depressive disorder

No study has investigated the associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD). This study aimed to investigate this issue.

Authors: Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang and Shuu-Jiun Wang

Vitamin D deficiency in patients with cluster headache: a preliminary study

Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D leve...

Authors: Jong-Hee Sohn, Min-Kyung Chu, Kwang-Yeol Park, Hong-Yup Ahn and Soo-Jin Cho

Increased thalamic glutamate/glutamine levels in migraineurs

Increased cortical excitability has been hypothesized to play a critical role in various neurological disorders, such as restless legs syndrome, epilepsy and migraine. Particularly for migraine, local hyperexc...

Authors: Adina Bathel, Lauren Schweizer, Philipp Stude, Benjamin Glaubitz, Niklas Wulms, Sibel Delice and Tobias Schmidt-Wilcke

Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing

Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CG...

Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni and Cristina Tassorelli

Medication-overuse headache: a widely recognized entity amidst ongoing debate

Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to h...

Authors: Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire and Zaza Katsarava

Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal

Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chro...

Authors: Mi Ji Lee, Sook-Yeon Lee, Soohyun Cho, Eun-Suk Kang and Chin-Sang Chung

Multigroup latent class model of musculoskeletal pain combinations in children/adolescents: identifying high-risk groups by gender and age

To investigate the combinations of Musculoskeletal pain (MSP) (neck, shoulder, upper and low back pain) among a sample of Iranian school children.

Authors: Iman Dianat, Arezou Alipour and Mohammad Asghari Jafarabadi

Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing ¹⁸FDG-PET and visual evoked potentials

Migraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abn...

Authors: Marco Lisicki, Kevin D’Ostilio, Gianluca Coppola, Felix Scholtes, Alain Maertens de Noordhout, Vincenzo Parisi, Jean Schoenen and Delphine Magis

Exploration of intrinsic brain activity in migraine with and without comorbid depression

Major depressive disorder is a common comorbidity in migraineurs. Depression may affect the progression and prognosis of migraine. Few studies have examined the brain function in migraineurs that may cause thi...

Authors: Mengmeng Ma, Junran Zhang, Ning Chen, Jian Guo, Yang Zhang and Li He

Upper cervical two-point discrimination thresholds in migraine patients and headache-free controls

Chronic pain including migraine is associated with structural and functional changes in the somatosensory cortex. Previous reports proposed two-point discrimination (TPD) as a measurement for cortical alterati...

Authors: Kerstin Luedtke, Waclaw Adamczyk, Katrin Mehrtens, Inken Moeller, Louisa Rosenbaum, Axel Schaefer, Janine Schroeder, Tibor Szikszay, Christian Zimmer and Bettina Wollesen

Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study

Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (N...

Authors: Junpeng Liu, Jiajia Zhu, Fei Yuan, Xuejun Zhang and Quan Zhang

OnabotulinumtoxinA in the treatment of refractory chronic cluster headache

Cluster headache (CH) is a clinically well-defined primary headache disorder, approximately 20% of cluster headache sufferers experience recurrent attacks without periods of significant remission. For the trea...

Authors: Christian Lampl, Mirjam Rudolph and Elisabeth Bräutigam

Novel capsaicin-induced parameters of microcirculation in migraine patients revealed by imaging photoplethysmography

The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors ...

Authors: Alexei A. Kamshilin, Maxim A. Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V. Amelin, Oleg V. Mamontov and Rashid Giniatullin

Effects of sildenafil and calcitonin gene-related peptide on brainstem glutamate levels: a pharmacological proton magnetic resonance spectroscopy study at 3.0 T

Studies involving human pharmacological migraine models have predominantly focused on the vasoactive effects of headache-inducing drugs, including sildenafil and calcitonin gene-related peptide (CGRP). However...

Authors: Samaira Younis, Anders Hougaard, Casper Emil Christensen, Mark Bitsch Vestergaard, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson and Messoud Ashina

Effectiveness of transcutaneous electrical nerve stimulation for the treatment of migraine: a meta-analysis of randomized controlled trials

Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulat...

Authors: Huimin Tao, Teng Wang, Xin Dong, Qi Guo, Huan Xu and Qi Wan

Characterization of the trigeminovascular actions of several adenosine A_2A receptor antagonists in an in vivo rat model of migraine

Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodil...

Authors: Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink

Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α₂-adrenoceptors and 5-HT₁ receptors

Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the recept...

Authors: Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink and Carlos M. Villalón

The role of personality, disability and physical activity in the development of medication-overuse headache: a prospective observational study

Factors associated with development of medication-overuse headache (MOH) in migraine patients are not fully understood, but with respect to prevention, the ability to predict the onset of MOH is clinically imp...

Authors: Louise S. Mose, Susanne S. Pedersen, Birgit Debrabant, Rigmor H. Jensen and Bibi Gram

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort

Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthriti...

Authors: Eric P. Baron, Philippe Lucas, Joshua Eades and Olivia Hogue

Factors associated with acute medication overuse in people with migraine: results from the 2017 migraine in America symptoms and treatment (MAST) study

The MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO wi...

Authors: Todd J. Schwedt, Aftab Alam, Michael L. Reed, Kristina M. Fanning, Sagar Munjal, Dawn C. Buse, David W. Dodick and Richard B. Lipton

Evaluation of gray matter perfusion in episodic migraine using voxel-wise comparison of 3D pseudo-continuous arterial spin labeling

Although previous studies have demonstrated that structural and functional abnormalities in episodic migraine (EM), less is known about altered brain perfusion in the EM. The aim of this study is to investigat...

Authors: Zhiye Chen, Xiaoyan Chen, Mengyu Liu, Mengqi Liu, Lin Ma and Shengyuan Yu

Transport of the pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier: implications for migraine

Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) i...

Authors: Faisal Mohammad Amin and Henrik Winther Schytz

Use and overuse of triptans in Austria – a survey based on nationwide healthcare claims data

To evaluate triptan use and overuse as well as prescription patterns in Austria based on a nationwide healthcare database because data on triptan use and overuse in Austria is missing.

Authors: Karin Zebenholzer, Walter Gall and Christian Wöber

Pituitary adenylate-cyclase-activating polypeptide (PACAP): another novel target for treatment of primary headaches?

Authors: Messoud Ashina and Paolo Martelletti

Answer to the comment on Castien et al. (2018) pressure pain thresholds over the cranio-cervical region in headache - a systematic review and meta-analysis

Authors: René F. Castien, Johannes C. van der Wouden and Willem De Hertogh

The NRP1 migraine risk variant shows evidence of association with menstrual migraine

In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificit...

Authors: Charmaine E. Pollock, Heidi G. Sutherland, Bridget H. Maher, Rodney A. Lea, Larisa M. Haupt, Alison Frith, E. Anne MacGregor and Lyn R. Griffiths

Comment on Castien et al. (2018) pressure pain thresholds over the cranio-cervical region in headache - a systematic review and meta-analysis

Authors: Kerstin Luedtke, Tibor Szikszay, Wacław Adamczyk and Arne May

Polygenic risk score: use in migraine research

The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10^− 8) due to multiple testing. T...

Authors: Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen and Thomas Folkmann Hansen

Discovery of PACAP and its receptors in the brain

Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study

Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.

Authors: Beáta Éva Petrovski, Kjersti G. Vetvik, Christofer Lundqvist and Malin Eberhard-Gran

The epidemiology of headache disorders: a face-to-face interview of participants in HUNT4

The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.

Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl and Trond Sand

Altered muscle activity during rest and during mental or physical activity is not a trait symptom of migraine - a neck muscle EMG study

Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...

Authors: Kerstin Luedtke, Jan Mehnert and Arne May

Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures

The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

Authors: Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma

The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system

Calcitonin gene-related peptide (CGRP) has long been a focus of migraine research, since it turned out that inhibition of CGRP or CGRP receptors by antagonists or monoclonal IgG antibodies was therapeutic in f...

Authors: Karl Messlinger

PACAP and its role in primary headaches

Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache

The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannu...

Authors: Philip R. Holland, Mads Barloese and Jan Fahrenkrug