Articles

The prevalence of headache disorders in children and adolescents in Lithuania: a schools-based study

While the Global Burden of Disease (GBD) study reports headache disorders as the second-highest cause of disability worldwide, the headache data in GBD come very largely from adults. This national study in Lit...

Authors: Diana Genc, Nerija Vaičienė-Magistris, Apolinaras Zaborskis, Tayyar Şaşmaz, Aylin Yeniocak Tunç, Derya Uluduz and Timothy J. Steiner

Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine

Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to migraine had not been well elucidated. Thus, the present study investi...

Authors: Yun Zhang, Yixin Zhang, Ke Tian, Yunfeng Wang, Xiaoping Fan, Qi Pan, Guangcheng Qin, Dunke Zhang, Lixue Chen and Jiying Zhou

Lasmiditan mechanism of action – review of a selective 5-HT_1F agonist

Migraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this neurological disease led to the discovery that calcitonin gene-rela...

Authors: David B. Clemow, Kirk W. Johnson, Helen M. Hochstetler, Michael H. Ossipov, Ann M. Hake and Andrew M. Blumenfeld

Sentinel headache as a warning symptom of ischemic stroke

There are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors a...

Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev and Jes Olesen

Multidimensional assessment of the effects of erenumab in chronic migraine patients with previous unsuccessful preventive treatments: a comprehensive real-world experience

erenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report the clinical experience from an Italian real-world setting using ere...

Authors: Antonio Russo, Marcello Silvestro, Fabrizio Scotto di Clemente, Francesca Trojsi, Alvino Bisecco, Simona Bonavita, Alessandro Tessitore and Gioacchino Tedeschi

Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia

Productivity and monetary loss due to migraine in the workplace may be substantial. This study aimed to determine the impact of migraine on productivity and monetary lost among employees in the banking sectors...

Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U Bahkt Sultan Shah

High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019

Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investig...

Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

Short-term efficacy and safety of lasmiditan, a novel 5-HT_1F receptor agonist, for the acute treatment of migraine: a systematic review and meta-analysis

Migraine has been recognized as one of common diseases in the world whose current treatment options are not ideal. Lasmiditan, an oral 5-hydroxytryptamine (HT)_1F receptor agonist, appears more promising for the a...

Authors: Min Hou, Haiyan Xing, Chen Li, Xianfeng Wang, Dongmei Deng, Juan Li, Pan Zhang and Jianhong Chen

The fifth cranial nerve in headaches

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and ...

Authors: J. C. A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D’Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina…

Genetics of migraine aura: an update

Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Giv...

Authors: Irene de Boer, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg

On the utility of the trail making test in migraine with and without aura: a meta-analysis

This meta-analytical review assesses the utility of the Trail Making Test (TMT), versions A and B, in detecting migraine-related cognitive deficits. A comprehensive literature search was performed in two elect...

Authors: Antonino Vallesi

Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study

Calcitonin gene-related peptide (CGRP) has recently been implicated in the pathogenesis of post-traumatic headache (PTH), which raises the prospect for therapeutic use of monoclonal antibodies targeting CGRP o...

Authors: Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Anna Kristina Eigenbrodt, Eigil Lindekilde Larsen, Amalie Middelboe Andersen, Kevin John Hansen, Karoline Bendix Bräuner, Thomas Mørch-Jessen, Basit Chaudhry, Sonja Antic, Casper Emil Christensen, Messoud Ashina, Faisal Mohammad Amin and Henrik Winther Schytz

A prospective real-world analysis of erenumab in refractory chronic migraine

Clinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab i...

Authors: Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova and Anna P. Andreou

The applicability of web-based solutions in headache epidemiology research

Epidemiological research of headache is vital but resource consuming prerequisite for evidence-based development in the field. Rapid evolution of information technology may provide new opportunities for popula...

Authors: Kati Toom, Aire Raidvee and Mark Braschinsky

Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging

There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribut...

Authors: Tiffani J. Mungoven, Noemi Meylakh, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey and Luke A. Henderson

The impact of remission and coexisting migraine on anxiety and depression in cluster headache

Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.

Authors: Byung-Su Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Jeong Wook Park, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae-Moon Kim, Soo-Kyoung Kim, Yun-Ju Choi, Jae Myun Chung…

Volume of the rectus capitis posterior minor muscle in migraine patients: a cross-sectional structural MRI study

Neck pain in migraine patients is very prevalent between and during migraine attacks, but the underlying mechanism behind neck pain in migraine is unknown. The neck muscle rectus capitis posterior minor muscle...

Authors: Jeppe Hvedstrup, Faisal Mohammad Amin, Anders Hougaard, Håkan Ashina, Casper Emil Christensen, Henrik Bo Wiberg Larsson, Messoud Ashina and Henrik Winther Schytz

Subdiagnosis, but not presence of vestibular symptoms, predicts balance impairment in migraine patients – a cross sectional study

Vestibular symptoms and balance changes are common in patients with migraine, especially in the ones with aura and chronic migraine. However, it is not known if the balance changes are determined by the presen...

Authors: Letícia Zorzin, Gabriela F. Carvalho, Jens Kreitewolf, Roberto Teggi, Carina F. Pinheiro, Jéssica R. Moreira, Fabíola Dach and Débora Bevilaqua-Grossi

Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence

Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops ...

Authors: Alejandro Labastida-Ramírez, Silvia Benemei, Maria Albanese, Antonina D’Amico, Giovanni Grillo, Oxana Grosu, Devrimsel Harika Ertem, Jasper Mecklenburg, Elena Petrovna Fedorova, Pavel Řehulka, Francesca Schiano di Cola, Javier Trigo Lopez, Nina Vashchenko, Antoinette MaassenVanDenBrink and Paolo Martelletti

Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study

Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among...

Authors: Yen-Feng Wang, Yung-Tai Chen, Ching-Wen Tsai, Yu-Chun Yen, Yi-Chun Chen, Ben-Chang Shia and Shuu-Jiun Wang

Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database

Adult migraine remains underdiagnosed and undertreated, despite significant negative effects on physical and emotional functioning. Information on prescribing patterns and treatment costs of migraine in China ...

Authors: Shengyuan Yu, Yanlei Zhang, Yuan Yao and Haijun Cao

Pain rates in general population for the period 1991–2015 and 10-years prediction: results from a multi-continent age-period-cohort analysis

Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people. The aims of this study are to evaluate the temporal varia...

Authors: Davide Guido, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Ilona Koupil, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…

13th European Headache Federation Congress 2019: Meeting Abstracts - part 2

Authors:

Jealousy in women with migraine: a cross-sectional case-control study

Estrogen influences susceptibility to migraine attacks and it has been suggested to affect jealousy in romantic relationships in women. Therefore, we hypothesized that migraine women may be more jealous.

Authors: Daphne S. van Casteren, Florine A. C. van Willigenburg, Antoinette MaassenVanDenBrink and Gisela M. Terwindt

Lost productivity associated with headache and depression: a quality improvement project identifying a patient population at risk

This quality improvement project was implemented in order to highlight the association between headache, mTBI and depression on lost productivity and resource utilization.

Authors: Virginia B. Baker, Christopher B. Sowers and Nawaz K. Hack

Use of outpatient medical care by headache patients in Germany: a population-based cross-sectional study

Headache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study...

Authors: Britta Müller, Thomas Dresler, Charly Gaul, Tim Jürgens, Peter Kropp, Anna Rehfeld, Olaf Reis, Ruth Ruscheweyh, Andreas Straube and Stefanie Förderreuther

Sensory processing patterns affect headache severity among adolescents with migraine

To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine.

Authors: Jacob Genizi, Ayelet Halevy, Mitchell Schertz, Khaled Osman, Nurit Assaf, Idan Segal, Isaac Srugo, Aharon Kessel and Batya Engel-Yeger

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information process...

Authors: Zhaoxia Qin, Jingjing Su, Xin-Wei He, Shiyu Ban, Qian Zhu, Yangyang Cui, Jilei Zhang, Yue Hu, Yi-Sheng Liu, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu and Xiaoxia Du

Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study

Tinnitus due to hyperactivity across neuronal ensembles along the auditory pathway is reported. We hypothesized that trigeminal neuralgia patients may subsequently suffer from tinnitus. Using nationwide, popul...

Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin

Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database

Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people, and with increasing trends in general populations. Differ...

Authors: Alberto Raggi, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Muhammad Z. Hossin, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…

Direct and indirect costs of cluster headache: a prospective analysis in a tertiary level headache centre

Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy ...

Authors: Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti and Francesco Saverio Mennini

From transformation to chronification of migraine: pathophysiological and clinical aspects

Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic...

Authors: M. Torres-Ferrús, F. Ursitti, A. Alpuente, F. Brunello, D. Chiappino, T. de Vries, S. Di Marco, S. Ferlisi, L. Guerritore, N. Gonzalez-Garcia, A. Gonzalez-Martinez, D. Khutorov, M. Kritsilis, A. Kyrou, T. Makeeva, A. Minguez-Olaondo…

A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication

Migraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, ar...

Authors: Louise Lombard, Mallory Farrar, Wenyu Ye, Yongin Kim, Sarah Cotton, Andrew S. Buchanan, James Jackson and Shivang Joshi

Sustained response to onabotulinumtoxin A in patients with chronic migraine: real-life data

Treatment with onabotulinumtoxin A (BT-A) is safe and effective for chronic migraine (CM). Several studies assessed possible predictors of response to treatment with BT-A, but there is little knowledge on the ...

Authors: Raffaele Ornello, Simona Guerzoni, Carlo Baraldi, Luana Evangelista, Ilaria Frattale, Carmine Marini, Cindy Tiseo, Francesca Pistoia and Simona Sacco

Brain morphologic abnormalities in migraine patients: an observational study

Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.

Authors: Lilla Bonanno, Viviana Lo Buono, Simona De Salvo, Claudio Ruvolo, Viviana Torre, Placido Bramanti, Silvia Marino and Francesco Corallo

Headache medication and the COVID-19 pandemic

The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and providing the best possible care to infected patients, a...

Authors: Antoinette MaassenVanDenBrink, Tessa de Vries and A. H. Jan Danser

Prevalence of familial cluster headache: a systematic review and meta-analysis

The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a s...

Authors: Emer O’Connor, Benjamin S. Simpson, Henry Houlden, Jana Vandrovcova and Manjit Matharu

An unexpected and suspended time

Authors: Paolo Martelletti

Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain

The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund’s adjuvant (C...

Authors: Edina K. Cseh, Gábor Veres, Tamás Körtési, Helga Polyák, Nikolett Nánási, János Tajti, Árpád Párdutz, Péter Klivényi, László Vécsei and Dénes Zádori

Short-latency afferent inhibition and somato-sensory evoked potentials during the migraine cycle: surrogate markers of a cycling cholinergic thalamo-cortical drive?

Short-latency afferent inhibition (SAI) consists of motor cortex inhibition induced by sensory afferents and depends on the excitatory effect of cholinergic thalamocortical projections on inhibitory GABAergic ...

Authors: Gianluca Coppola, Davide Di Lenola, Chiara Abagnale, Fabio Ferrandes, Gabriele Sebastianelli, Francesco Casillo, Cherubino Di Lorenzo, Mariano Serrao, Maurizio Evangelista, Jean Schoenen and Francesco Pierelli

Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine

Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients wi...

Authors: Soo-Kyoung Kim, Catherine D. Chong, Gina Dumkrieger, Katherine Ross, Visar Berisha and Todd J. Schwedt

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy

We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study

The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...

Authors: Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares and Raquel Gil-Gouveia

Phase dependent hypothalamic activation following trigeminal input in cluster headache

Task-free imaging approaches using PET have shown the posterior hypothalamus to be specifically activated during but not outside cluster headache attacks. Evidence from task related functional imaging approach...

Authors: Laura H. Schulte, Ame Abdu Haji and Arne May

The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine

The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, ...

Authors: Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang

European Headache Federation recommendations for neurologists managing giant cell arteritis

Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms o...

Authors: S. P. Mollan, K. Paemeleire, J. Versijpt, R. Luqmani and A. J. Sinclair

Migraine, headache, and mortality in women: a cohort study

Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased ...

Authors: Jessica L. Rohmann, Pamela M. Rist, Julie E. Buring and Tobias Kurth

Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies

Authors: Kristian Agmund Haanes, Lars Edvinsson and Anette Sams

Rapid referral for headache management from emergency department to headache centre: four years data

Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency faci...

Authors: Andrea Negro, Valerio Spuntarelli, Paolo Sciattella and Paolo Martelletti

Time trends of major headache diagnoses and predictive factors. Data from three Nord-Trøndelag health surveys

The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal ass...

Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart