Articles

Headache attributed to aeroplane travel: the first multicentric survey in a paediatric population affected by primary headaches

This multicentric survey investigates the prevalence and characteristics of Airplane Headache in children affected by primary headaches.

Authors: Debora De Carlo, Irene Toldo, Agnese Maria Tamborino, Barbara Bolzonella, Maria Giuseppina Ledda, Lucia Margari, Vincenzo Raieli, Margherita Santucci, Vittorio Sciruicchio, Angelo Vecchio, Sergio Zanini, Stefano Sartori, Michela Gatta, Alberto Verrotti and Pier Antonio Battistella

Perampanel inhibits calcitonin gene-related peptide release from rat brainstem in vitro

Perampanel is a novel antiepileptic drug acting via non-competitive antagonism on glutamatergic AMPA receptors, and the subsequent inhibition of ion calcium influx. Since it was recently postulated that the an...

Authors: Giuseppe Tringali, Diego Currò and Pierluigi Navarra

The validation of the Hungarian version of the ID-migraine questionnaire

Despite its high prevalence, migraine remains underdiagnosed and undertreated. ID-Migraine is a short, self-administrated questionnaire, originally developed in English by Lipton et al. and later validated in ...

Authors: Éva Csépány, Marianna Tóth, Tamás Gyüre, Máté Magyar, György Bozsik, Dániel Bereczki, Gabriella Juhász and Csaba Ertsey

Migraine induction with calcitonin gene-related peptide in patients from erenumab trials

Migraine prevention with erenumab and migraine induction by calcitonin gene-related peptide (CGRP) both carry notable individual variance. We wanted to explore a possible association between individual efficac...

Authors: Casper Emil Christensen, Samaira Younis, Marie Deen, Sabrina Khan, Hashmat Ghanizada and Messoud Ashina

Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis

In migraine patients with cervical myofascial trigger points whose target areas coincide with migraine sites (M + cTrPs), TrP anesthetic injection reduces migraine symptoms, but the procedure often causes disc...

Authors: Giannapia Affaitati, Raffaele Costantini, Claudio Tana, Domenico Lapenna, Cosima Schiavone, Francesco Cipollone and Maria Adele Giamberardino

Accuracy of the painDETECT screening questionnaire for detection of neuropathic components in hospital-based patients with orofacial pain: a prospective cohort study

Better tools are required for the earlier identification and management of orofacial pain with different aetiologies. The painDETECT questionnaire is a patient-completed screening tool with utility for identif...

Authors: Daniyal J Jafree, Joanna M Zakrzewska, Saumya Bhatia and Carolina Venda Nova

NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model

Although the mechanism of chronic migraine (CM) is unclear, it might be related to central sensitization and neuronal persistent hyperexcitability. The tyrosine phosphorylation of NR2B (NR2B-pTyr) reportedly c...

Authors: Xue-Ying Wang, Hui-Ru Zhou, Sha Wang, Chao-Yang Liu, Guang-Cheng Qin, Qing-Qing Fu, Ji-Ying Zhou and Li-Xue Chen

Consistent effects of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: additional findings from the randomized, sham-controlled, double-blind PRESTO trial

Non-invasive vagus nerve stimulation (nVNS) has been shown to be practical, safe, and well tolerated for treating primary headache disorders. The recent multicenter, randomized, double-blind, sham-controlled P...

Authors: Paolo Martelletti, Piero Barbanti, Licia Grazzi, Giulia Pierangeli, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Cristina Tassorelli, Eric Liebler and Marina de Tommaso

Implications for the migraine SNP rs1835740 in a Swedish cluster headache population

Cluster headache is a severe headache disorder with unknown aetiology. The pathophysiology and symptoms present certain common features with migraine. Specifically, activation of the trigeminal vascular system...

Authors: Caroline Ran, Carmen Fourier, Margret Zinnegger, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind and Andrea Carmine Belin

Polarity-specific modulation of pain processing by transcranial direct current stimulation – a blinded longitudinal fMRI study

To enrich the hitherto insufficient understanding regarding the mechanisms of action of transcranial direct current stimulation (tDCS) in pain disorders, we investigated its modulating effects on cerebral pain...

Authors: Steffen Naegel, Josephine Biermann, Nina Theysohn, Christoph Kleinschnitz, Hans-Christoph Diener, Zaza Katsarava, Mark Obermann and Dagny Holle

Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial

The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for ...

Authors: Licia Grazzi, Cristina Tassorelli, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler and Piero Barbanti

Symptoms of premenstrual syndrome in female migraineurs with and without menstrual migraine

Menstrual migraine (MM) and premenstrual syndrome (PMS) are two conditions linked to specific phases of the menstrual cycle. The exact pathophysiological mechanisms are not fully understood, but both condition...

Authors: Kjersti Grøtta Vetvik, E. Anne MacGregor, Christofer Lundqvist and Michael Bjørn Russell

Assessment of community pharmacy professionals’ knowledge and counseling skills achievement towards headache management: a cross-sectional and simulated-client based mixed study

Headache is one of the most common disabling medical condition affecting over 40% of adults globally. Many patients with headache prefer to alleviate their symptom with a range of over-the-counter analgesics t...

Authors: Adeladlew Kassie Netere, Daniel Asfaw Erku, Ashenafi Kibret Sendekie, Eyob Alemayehu Gebreyohannes, Niguse Yigzaw Muluneh and Sewunet Admasu Belachew

Headache disorder and the risk of dementia: a systematic review and meta-analysis of cohort studies

Until now, headache disorders have not been established as a risk factor for dementia. The aim of this study was to determine whether headache was associated with an increased risk of dementia.

Authors: Jing Wang, Weihao Xu, Shasha Sun, Shengyuan Yu and Li Fan

Oxygen treatment for cluster headache attacks at different flow rates: a double-blind, randomized, crossover study

Cluster headache attacks can, in many patients, be successfully treated with oxygen via a non-rebreather mask. In previous studies oxygen at flow rates of both 7 L/min and 12 L/min was shown to be effective. T...

Authors: Thijs H. T. Dirkx, Danielle Y. P. Haane and Peter J. Koehler

European Headache Federation guideline on idiopathic intracranial hypertension

Idiopathic Intracranial Hypertension (IIH) is characterized by an elevation of intracranial pressure (ICP no identifiable cause. The aetiology remains largely unknown, however observations made in a number of ...

Authors: Jan Hoffmann, Susan P Mollan, Koen Paemeleire, Christian Lampl, Rigmor H Jensen and Alexandra J Sinclair

Early onset of efficacy with erenumab in patients with episodic and chronic migraine

Subcutaneous erenumab reduced monthly migraine days and increased the likelihood of achieving a ≥ 50% reduction at all monthly assessment points tested in 2 pivotal trials in episodic migraine (EM) and chronic...

Authors: Todd Schwedt, Uwe Reuter, Stewart Tepper, Messoud Ashina, David Kudrow, Gregor Broessner, Guy P. Boudreau, Peter McAllister, Thuy Vu, Feng Zhang, Sunfa Cheng, Hernan Picard, Shihua Wen, Joseph Kahn, Jan Klatt and Daniel Mikol

Guideline on the use of onabotulinumtoxinA in chronic migraine: a consensus statement from the European Headache Federation

OnabotulinumtoxinA is being increasingly used in the management of chronic migraine (CM). Treatment with onabotulinumtoxinA poses challenges compared with traditional therapy with orally administered preventat...

Authors: Lars Bendtsen, Simona Sacco, Messoud Ashina, Dimos Mitsikostas, Fayyaz Ahmed, Patricia Pozo-Rosich and Paolo Martelletti

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

Primary headache are prevalent and debilitating disorders. Acute pain cessation is one of the key points in their treatment. Many drugs have been studied but the design of the trials is not usually homogeneous...

Authors: D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. Ferrili, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese

Migraine and cluster headache – the common link

Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related...

Authors: Anne Luise Vollesen, Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Messoud Ashina and Christian Lampl

Using the child behavior checklist to determine associations between psychosocial aspects and TMD-related pain in children and adolescents

Since children and adolescents are frequently experiencing emotional and behavioral consequences due to pain, their parents should be aware of this emotional and behavioral status. Therefore, the aim of this s...

Authors: Amal Al-Khotani, Mattias Gjelset, Aron Naimi-Akbar, Britt Hedenberg-Magnusson, Malin Ernberg and Nikolaos Christidis

12th European Headache Federation Congress jointly with 32nd National Congress of the Italian Society for the Study of Headaches

Authors:

Sustained onabotulinumtoxinA therapeutic benefits in patients with chronic migraine over 3 years of treatment

Evidence on whether the therapeutic effect and good safety profile of onabotulinumtoxinA (Botox®) in chronic migraine (CM) patients is maintained over long term treatment is still limited. We herein aimed at a...

Authors: Michail Vikelis, Andreas A. Argyriou, Emmanouil V. Dermitzakis, Konstantinos C. Spingos, Nikolaos Makris and Evangelia Kararizou

Impact of migraine on the clinical presentation of insomnia: a population-based study

Insomnia and migraine are closely related; insomnia aggravates migraine symptoms. This study was conducted to investigate the impact of migraine on the clinical presentation of insomnia symptoms.

Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Validation of a self-reported instrument to assess work-related difficulties in patients with migraine: the HEADWORK questionnaire

The degree to which work-related difficulties are recognized in headache research is poor and often carried out with inadequate information such as “reduced ability to work as usual”, which do not capture at a...

Authors: Alberto Raggi, Venusia Covelli, Erika Guastafierro, Matilde Leonardi, Chiara Scaratti, Licia Grazzi, Marco Bartolini, Giovanna Viticchi, Sabina Cevoli, Giulia Pierangeli, Gioacchino Tedeschi, Antonio Russo, Piero Barbanti, Cinzia Aurilia, Carlo Lovati, Luca Giani…

Myofascial trigger points in migraine and tension-type headache

A myofascial trigger point is defined as a hyperirritable spot in skeletal muscle that is associated with a hypersensitive palpable nodule in a taut band. It has been suggested that myofascial trigger points t...

Authors: Thien Phu Do, Gerda Ferja Heldarskard, Lærke Tørring Kolding, Jeppe Hvedstrup and Henrik Winther Schytz

The association between migraine and physical exercise

There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role ...

Authors: Faisal Mohammad Amin, Stavroula Aristeidou, Carlo Baraldi, Ewa K. Czapinska-Ciepiela, Daponte D. Ariadni, Davide Di Lenola, Cherilyn Fenech, Konstantinos Kampouris, Giorgos Karagiorgis, Mark Braschinsky and Mattias Linde

Patients’ perspective on the burden of migraine in Europe: a cross-sectional analysis of survey data in France, Germany, Italy, Spain, and the United Kingdom

Migraine is a distinct neurological disease that imposes a significant burden on patients, society, and the healthcare system. This study aimed to characterize the incremental burden of migraine in individuals...

Authors: Pamela Vo, Juanzhi Fang, Aikaterini Bilitou, Annik K. Laflamme and Shaloo Gupta

Correction to: Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)

Following the publication of this article [1], the authors noticed that they incorrectly reported the Absolute risk of ischemic stroke in women aged 20 to 44 years in relation to the use of hormonal contracept...

Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

Long-term follow-up of a community sample of adolescents with frequent headaches

Several outcome studies have reported on the short- and long-term effects of migraine in selected clinical samples of children and adolescents. However, current knowledge of the course, incidence, and outcome ...

Authors: Bo Larsson, Johannes Foss Sigurdson and Anne Mari Sund

Impact of cluster headache on employment status and job burden: a prospective cross-sectional multicenter study

Cluster headaches (CH) are recurrent severe headaches, which impose a major burden on the life of patients. We investigated the impact of CH on employment status and job burden.

Authors: Yun-Ju Choi, Byung-Kun Kim, Pil-Wook Chung, Mi Ji Lee, Jung-Wook Park, Min Kyung Chu, Jin-Young Ahn, Byung-Su Kim, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Kwang-Soo Lee, Soo-Kyoung Kim, Kwang-Yeol Park, Jae Myun Chung, Heui-Soo Moon…

Prolonged migraine aura: new insights from a prospective diary-aided study

There is limited literature on prolonged aura (PA - defined as an aura including at least one symptom for > 1 h and < 7d), and there are no prospective studies.

Authors: Michele Viana, Grazia Sances, Mattias Linde, Giuseppe Nappi, Farihah Khaliq, Peter J. Goadsby and Cristina Tassorelli

Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)

We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was unde...

Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Andreas R. Gantenbein, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Koen Paemeleire, Per Morten Sandset…

New CACNA1A deletions are associated to migraine phenotypes

Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected. Here have been desc...

Authors: G. S. Grieco, S. Gagliardi, I. Ricca, O. Pansarasa, M. Neri, F. Gualandi, G. Nappi, A. Ferlini and C. Cereda

Vascular wall imaging in reversible cerebral vasoconstriction syndrome – a 3-T contrast-enhanced MRI study

Limited histopathology studies have suggested that reversible cerebral vasoconstriction syndromes (RCVS) does not present with vascular wall inflammation. Previous vascular imaging studies have had inconsisten...

Authors: Chun-Yu Chen, Shih-Pin Chen, Jong-Ling Fuh, Jiing-Feng Lirng, Feng-Chi Chang, Yen-Feng Wang and Shuu-Jiun Wang

Neurophysiological correlates of clinical improvement after greater occipital nerve (GON) block in chronic migraine: relevance for chronic migraine pathophysiology

Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating with clinical efficacy is available to ...

Authors: Alessandro Viganò, Maria Claudia Torrieri, Massimiliano Toscano, Francesca Puledda, Barbara Petolicchio, Tullia Sasso D’Elia, Angela Verzina, Sonia Ruggiero, Marta Altieri, Edoardo Vicenzini, Jean Schoenen and Vittorio Di Piero

Anodal frontal tDCS for chronic cluster headache treatment: a proof-of-concept trial targeting the anterior cingulate cortex and searching for nociceptive correlates

Percutaneous occipital nerve stimulation (ONS) is effective in refractory chronic cluster headache (rCCH) patients. Responders to ONS differ from non-responders by greater glucose metabolism in subgenual anter...

Authors: Delphine Magis, Kevin D’Ostilio, Marco Lisicki, Chany Lee and Jean Schoenen

Pre-treatment with sumatriptan for cilostazol induced headache in healthy volunteers

Previous studies indicate that sumatriptan is not effective when second messenger levels are high as after cilostazol provocation. Therefore, we have conducted the present study, where sumatriptan is administr...

Authors: Katrine Falkenberg and Jes Olesen

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: an 8-week open-label extension study

DFN-11, a 3 mg sumatriptan subcutaneous (SC) autoinjector for acute treatment of migraine, has not been assessed previously in multiple attacks. The objective of this study was to evaluate the efficacy, tolera...

Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study

In a previous randomized, double-blind, proof-of-concept study in rapidly escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated with fewer and shorter triptan sensations than a 6...

Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport

Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation

Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is al...

Authors: Efstratia Vatzaki, Sabine Straus, Jean-Michel Dogne, Juan Garcia Burgos, Thomas Girard and Paolo Martelletti

Aggression and its association with suicidality in migraine patients: a case-control study

To identify aggression and its association with suicidality in migraine patients.

Authors: Sung-Pa Park and Jong-Geun Seo

Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. ...

Authors: Lena Ohlsson, Erik Kronvall, Jennifer Stratton and Lars Edvinsson

Intracortical facilitation within the migraine motor cortex depends on the stimulation intensity. A paired-pulse TMS study

Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evo...

Authors: Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M. Capitano, Brigida Fierro and Filippo Brighina

PACAP38 and PAC₁ receptor blockade: a new target for headache?

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent i...

Authors: Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink and Lars Edvinsson

The missclassification of obesity affects the course of migraine

Authors: Laura Di Renzo, Andrea Cammarano and Antonino De Lorenzo

Psychological distress, neuroticism and disability associated with secondary chronic headache in the general population – the Akershus study of chronic headache

Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with secondary chron...

Authors: Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist and Michael Bjørn Russell

Fibromyalgia in migraine: a retrospective cohort study

Migraine is a common and disabling disorder. Fibromyalgia has been shown to be commonly comorbid in patients with migraine and can intensify disability. The aim of this study was to determine if patients with ...

Authors: Mark Whealy, Sanjeev Nanda, Ann Vincent, Jay Mandrekar and F. Michael Cutrer

Headache in transient ischemic attacks

Headache is a common feature in acute cerebrovascular disease but no studies have evaluated the prevalence of specific headache types in patients with transient ischemic attacks (TIA). The purpose of the prese...

Authors: Elena R. Lebedeva, Natalia M. Gurary and Jes Olesen

Survival outcome and mortality rate in patients with migraine: a population-based cohort study

Whether the patients with migraine have an elevated mortality risk in Taiwan is unclear.

Authors: Tomor Harnod, Cheng-Li Lin and Chia-Hung Kao