Articles

Animal models of migraine and experimental techniques used to examine trigeminal sensory processing

Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of...

Authors: Andrea M. Harriott, Lauren C. Strother, Marta Vila-Pueyo and Philip R. Holland

Identifying and managing refractory migraine: barriers and opportunities?

The term refractory migraine has been used to describe persistent headache that is difficult to treat or fails to respond to standard and/or aggressive treatments. This subgroup of migraine patients are genera...

Authors: Linda D’Antona and Manjit Matharu

Migraine patients’ journey until a tertiary headache center: an observational study

Migraine diagnosis is based on clinical aspects and is dependent on the experience of the attending physician. This study aimed to describe the patients journey profile until they start their experience in a t...

Authors: Mario Fernando Prieto Peres, Diego Belandrino Swerts, Arão Belitardo de Oliveira and Raimundo Pereira Silva-Neto

Electrical stimulation of the superior sagittal sinus suppresses A-type K⁺ currents and increases P/Q- and T-type Ca²⁺ currents in rat trigeminal ganglion neurons

Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear.

Authors: Junping Cao, Yuan Zhang, Lei Wu, Lidong Shan, Yufang Sun, Xinghong Jiang and Jin Tao

Shortcomings and missed potentials in the management of migraine patients - experiences from a specialized tertiary care center

Migraine is a common and severely disabling neurological disorder affecting millions of patients in Europe. Despite the availability of evidence-based national and international guidelines, the management of m...

Authors: Christian Ziegeler, Greta Brauns, Tim P. Jürgens and Arne May

Migraine: a major debilitating chronic non-communicable disease in Brazil, evidence from two national surveys

Even though migraine and other primary headache disorders are common and debilitating, major health surveys in Brazil have not included them. We repair this omission by combining data on non-communicable disea...

Authors: Mario Fernando Prieto Peres, Luiz Paulo Queiroz, Pedro Sampaio Rocha-Filho, Elder Machado Sarmento, Zaza Katsarava and Timothy J. Steiner

Efficacy and safety of lasmiditan in patients using concomitant migraine preventive medications: findings from SAMURAI and SPARTAN, two randomized phase 3 trials

To study the efficacy and safety of lasmiditan for acute treatment of migraine in patients using migraine preventive medications.

Authors: Li Shen Loo, Jessica Ailani, Jack Schim, Simin Baygani, Hans-Peter Hundemer, Martha Port and John H. Krege

Remote electrical neuromodulation (REN) in the acute treatment of migraine: a comparison with usual care and acute migraine medications

There is a significant unmet need for new, effective and well tolerated acute migraine treatments. A recent study has demonstrated that a novel remote electrical neuromodulation (REN) treatment provides superi...

Authors: Alan M. Rapoport, Jo H. Bonner, Tamar Lin, Dagan Harris, Yaron Gruper, Alon Ironi and Robert P. Cowan

The association between headache and low back pain: a systematic review

To systematically review studies quantifying the association between primary chronic headaches and persistent low back pain (LBP).

Authors: Arani Vivekanantham, Claire Edwin, Tamar Pincus, Manjit Matharu, Helen Parsons and Martin Underwood

Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study

OnabotulinumtoxinA (BOTOX®, Allergan plc, Dublin, Ireland) is approved for the preventive treatment of headaches in adult patients with chronic migraine (CM) in Australia by the country’s reimbursement mechani...

Authors: Catherine Stark, Richard Stark, Nicole Limberg, Julian Rodrigues, Dennis Cordato, Raymond Schwartz and Robert Jukic

New daily persistent headache: a systematic review on an enigmatic disorder

New daily persistent headache (NDPH) presents with a sudden onset headache which continues without remission within 24 h. Although rare, NDPH is important because it is one of the most treatment refractory pri...

Authors: Nooshin Yamani and Jes Olesen

Genetic mouse models of migraine

Mouse models of rare monogenic forms of migraine provide a unique experimental system to study the cellular and circuit mechanisms of the primary brain dysfunctions causing a migraine disorder. Here, we discus...

Authors: Daniela Pietrobon and K. C. Brennan

Diffusion tensor imaging in middle-aged headache sufferers in the general population: a cross-sectional population-based imaging study in the Nord-Trøndelag health study (HUNT-MRI)

Several studies have investigated white matter with diffusion tensor imaging (DTI) in those suffering from headache, but so far only in clinic based samples and with conflicting results.

Authors: Andreas Kattem Husøy, Live Eikenes, Asta K. Håberg, Knut Hagen and Lars Jacob Stovner

Fluctuations of sensorimotor processing in migraine: a controlled longitudinal study of beta event related desynchronization

The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other wel...

Authors: Martin Syvertsen Mykland, Marte Helene Bjørk, Marit Stjern, Petter Moe Omland, Martin Uglem and Trond Sand

Emerging evidence of occipital nerve compression in unremitting head and neck pain

Unremitting head and neck pain (UHNP) is a commonly encountered phenomenon in Headache Medicine and may be seen in the setting of many well-defined headache types. The prevalence of UHNP is not clear, and esta...

Authors: Pamela Blake and Rami Burstein

Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2)

Patients with high-frequency episodic migraine (HFEM) have a greater disease burden than those with low-frequency episodic migraine (LFEM). Acute treatment overuse increases the risk of migraine chronification...

Authors: Stephen D. Silberstein, Virginia L. Stauffer, Katie A. Day, Sarah Lipsius and Maria-Carmen Wilson

A real-world study on unmet medical needs in triptan-treated migraine: prevalence, preventive therapies and triptan use modification from a large Italian population along two years

Although migraine is a disabling neurological condition that causes important disability, it remains an area of underdiagnosis and undertreatment worldwide. The aim of this study was to depict the burden of th...

Authors: Carlo Piccinni, Sabina Cevoli, Giulia Ronconi, Letizia Dondi, Silvia Calabria, Antonella Pedrini, Immacolata Esposito, Valentina Favoni, Giulia Pierangeli, Pietro Cortelli and Nello Martini

Quality assurance in specialized headache units in Spain: an observational prospective study

To assess the quality of the therapeutic approach in Specialized Headache Units in Spain.

Authors: Patricia Pozo-Rosich, Alba Martínez-García, Julio Pascual, Emilio Ignacio, Ángel L. Guerrero-Peral, José Balseiro-Gómez, Jesús Porta-Etessam, Germán Latorre-González, Almudena Layos-Romero, César Lucas and José J. Mira

Advances in genetics of migraine

Migraine is a complex neurovascular disorder with a strong genetic component. There are rare monogenic forms of migraine, as well as more common polygenic forms; research into the genes involved in both types ...

Authors: Heidi G. Sutherland, Cassie L. Albury and Lyn R. Griffiths

Correction to: Primary headaches during lifespan

Following publication of the original article [1], we have been notified that one of the author names was incompletely presented.

Authors: Andreas Straube and Anna P. Andreou

The HUNT4 study: the validity of questionnaire-based diagnoses

Questionnaire-based headache diagnoses should be validated against diagnoses made by the gold standard, which is personal interview by a headache expert. The diagnostic algorithm with the best diagnostic accur...

Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner and Trond Sand

Trigeminal autonomic cephalalgias presenting in a multidisciplinary tertiary orofacial pain clinic

Orofacial pain may have a variety of causes and offers a significant clinical challenge for its diagnosis and management.

Authors: D. Y. Wei, D. Moreno-Ajona, T. Renton and P. J. Goadsby

Real-world treatment patterns and patient-reported outcomes in episodic and chronic migraine in Japan: analysis of data from the Adelphi migraine disease specific programme

In Japan, detailed information on the characteristics, disease burden, and treatment patterns of people living with migraine is limited. The aim of this study was to compare clinical characteristics, disease b...

Authors: Kaname Ueda, Wenyu Ye, Louise Lombard, Atsushi Kuga, Yongin Kim, Sarah Cotton, James Jackson and Tamas Treuer

Letter to the editor: European headache federation guidelines on the use of monoclonal antibodies acting on the calcitonin gene-related peptide or its receptor for migraine prevention

Authors: Daniel D. Mikol and Josefin Snellman

Erenumab and galcanezumab in chronic migraine prevention: effects after treatment termination

Monoclonal antibodies (mAbs) targeting the CGRP pathway are safe and efficacious therapies for the prevention of migraine. In this study we assessed the effects of discontinuation of preventive erenumab and ga...

Authors: Bianca Raffaelli, Valeria Mussetto, Heike Israel, Lars Neeb and Uwe Reuter

Burden and costs of migraine in a Swedish defined patient population – a questionnaire-based study

Migraine is a disabling, chronic neurological disease leading to severe headache episodes affecting 13.2% of the Swedish population. Migraine leads to an extensive socio-economic burden in terms of healthcare ...

Authors: Frida Hjalte, Sara Olofsson, Ulf Persson and Mattias Linde

Clinical features of visual migraine aura: a systematic review

Migraine aura (MA) is a common and disabling neurological condition, characterized by transient visual, and less frequently sensory and dysphasic aura disturbances.

Authors: Michele Viana, Erling Andreas Tronvik, Thien Phu Do, Chiara Zecca and Anders Hougaard

Aura and Stroke: relationship and what we have learnt from preclinical models

Population-based studies have highlighted a close relationship between migraine and stroke. Migraine, especially with aura, is a risk factor for both ischemic and hemorrhagic stroke. Interestingly, stroke risk...

Authors: Muge Yemisci and Katharina Eikermann-Haerter

Correction to: Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

After publication of the original article [1], the authors have notified us that an updated version of Figures 1, 2 and 3 should have been published. The incorrect and revised figures can be found below.

Authors: Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

Migraine and cluster headache show impaired neurosteroids patterns

Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migr...

Authors: Angela Koverech, Claudia Cicione, Luana Lionetto, Marta Maestri, Francesco Passariello, Elisabetta Sabbatini, Matilde Capi, Cristiano Maria De Marco, Martina Guglielmetti, Andrea Negro, Luisa Di Menna, Maurizio Simmaco, Ferdinando Nicoletti and Paolo Martelletti

Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)

Authors: Paolo Martelletti, Lars Edvinsson and Messoud Ashina

The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension

Elevation of intracranial pressure in idiopathic intracranial hypertension induces an edema of the prelaminar section of the optic nerve (papilledema). Beside the commonly observed optic nerve sheath distentio...

Authors: Jan Hoffmann, Katharina Maria Kreutz, Christoph Csapó-Schmidt, Nils Becker, Hagen Kunte, Lucius Samo Fekonja, Anas Jadan and Edzard Wiener

Correction to: European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

Abstract

Authors: Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti

Aids to management of headache disorders in primary care (2nd edition)

The Aids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the ...

Authors: T. J. Steiner, R. Jensen, Z. Katsarava, M. Linde, E. A. MacGregor, V. Osipova, K. Paemeleire, J. Olesen, M. Peters and P. Martelletti

Optimising migraine treatment: from drug-drug interactions to personalized medicine

Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functio...

Authors: Leda Marina Pomes, Martina Guglielmetti, Enrico Bertamino, Maurizio Simmaco, Marina Borro and Paolo Martelletti

Correction to: Therapeutic novelties in migraine: new drugs, new hope?

After publication of the original article 1, the authors have notified us that the row corresponding to the “Alniditan” drug shouldn’t have been included in Table 1. Table 1 should therefore be presented as be...

Authors: Thien Phu Do, Song Guo and Messoud Ashina

The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse

The treatment of migraine is impeded by several difficulties, among which insufficient headache relief, side effects, and risk for developing medication overuse headache (MOH). Thus, new acutely acting antimig...

Authors: Willem Sebastiaan van Hoogstraten and Antoinette MaassenVanDenBrink

Hypoechogenicity of brainstem raphe correlates with depression in migraine patients

Brainstem raphe (BR) hypoechogenicity in transcranial sonography (TCS) has been depicted in patients with major depression (MD) and in depressed patients with different neurodegenerative diseases. But, up to d...

Authors: Wei-Wei Tao, Xin-Ting Cai, Jie Shen, Xue-Gong Shi and Yu Wang

The changing faces of migraine

Authors: Paolo Martelletti, Messoud Ashina and Lars Edvinsson

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migrain...

Authors: Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello and Gianluca Serafini

Physician and patient preferences for dosing options in migraine prevention

Adherence to a therapy, though a key factor for successful treatment, is low among patients with chronic conditions such as migraine. Dose frequency plays a major role in adherence. This study evaluated the im...

Authors: Robert Cowan, Joshua M. Cohen, Erik Rosenman and Ravi Iyer

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice

Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden. Preventive treatments are required to reduc...

Authors: Cindy Tiseo, Raffaele Ornello, Francesca Pistoia and Simona Sacco

Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field stre...

Authors: Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize th...

Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Kristian A. Haanes, René de Vries, Ruben Dammers, A. J. J. C. Bogers, Antoon van den Bogaerdt, Bruce L. Daugherty, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink

Advanced visual network and cerebellar hyperresponsiveness to trigeminal nociception in migraine with aura

Despite the growing body of advanced studies investigating the neuronal correlates of pain processing in patients with migraine without aura (MwoA), only few similar studies have been conducted in patients wit...

Authors: Antonio Russo, Alessandro Tessitore, Marcello Silvestro, Federica Di Nardo, Francesca Trojsi, Teresa Del Santo, Rosa De Micco, Fabrizio Esposito and Gioacchino Tedeschi

Spreading depression as a preclinical model of migraine

Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine au...

Authors: Andrea M. Harriott, Tsubasa Takizawa, David Y. Chung and Shih-Pin Chen

Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor bloc...

Authors: Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan and Cen Xu

The effect of orofacial complete Freund’s adjuvant treatment on the expression of migraine-related molecules

Migraine is a neurovascular primary headache disorder, which causes significant socioeconomic problems worldwide. The pathomechanism of disease is enigmatic, but activation of the trigeminovascular system (TS)...

Authors: Tamás Körtési, Bernadett Tuka, Aliz Nyári, László Vécsei and János Tajti

Clinical neurophysiology of migraine with aura

The purpose of this review is to provide a comprehensive overview of the findings of clinical electrophysiology studies aimed to investigate changes in information processing of migraine with aura patients.

Authors: Gianluca Coppola, Cherubino Di Lorenzo, Vincenzo Parisi, Marco Lisicki, Mariano Serrao and Francesco Pierelli

The burden of headache disorders in the Eastern Mediterranean Region, 1990-2016: findings from the Global Burden of Disease study 2016

Using the findings of the Global Burden of Disease Study (GBD), we report the burden of primary headache disorders in the Eastern Mediterranean Region (EMR) from 1990 to 2016.

Authors: Kia Vosoughi, Lars Jacob Stovner, Timothy J. Steiner, Maziar Moradi-Lakeh, Seyed-Mohammad Fereshtehnejad, Farshad Farzadfar, Pouria Heydarpour, Reza Malekzadeh, Mohsen Naghavi, Mohammad Ali Sahraian, Sadaf G. Sepanlou, Arash Tehrani-Banihashemi, Reza Majdzadeh, Valery L. Feigin, Theo Vos, Ali H. Mokdad…