Articles

Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)

Authors: Paolo Martelletti, Lars Edvinsson and Messoud Ashina

The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension

Elevation of intracranial pressure in idiopathic intracranial hypertension induces an edema of the prelaminar section of the optic nerve (papilledema). Beside the commonly observed optic nerve sheath distentio...

Authors: Jan Hoffmann, Katharina Maria Kreutz, Christoph Csapó-Schmidt, Nils Becker, Hagen Kunte, Lucius Samo Fekonja, Anas Jadan and Edzard Wiener

Correction to: European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

Abstract

Authors: Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti

Aids to management of headache disorders in primary care (2nd edition)

The Aids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the ...

Authors: T. J. Steiner, R. Jensen, Z. Katsarava, M. Linde, E. A. MacGregor, V. Osipova, K. Paemeleire, J. Olesen, M. Peters and P. Martelletti

Optimising migraine treatment: from drug-drug interactions to personalized medicine

Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functio...

Authors: Leda Marina Pomes, Martina Guglielmetti, Enrico Bertamino, Maurizio Simmaco, Marina Borro and Paolo Martelletti

Correction to: Therapeutic novelties in migraine: new drugs, new hope?

After publication of the original article 1, the authors have notified us that the row corresponding to the “Alniditan” drug shouldn’t have been included in Table 1. Table 1 should therefore be presented as be...

Authors: Thien Phu Do, Song Guo and Messoud Ashina

The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse

The treatment of migraine is impeded by several difficulties, among which insufficient headache relief, side effects, and risk for developing medication overuse headache (MOH). Thus, new acutely acting antimig...

Authors: Willem Sebastiaan van Hoogstraten and Antoinette MaassenVanDenBrink

Hypoechogenicity of brainstem raphe correlates with depression in migraine patients

Brainstem raphe (BR) hypoechogenicity in transcranial sonography (TCS) has been depicted in patients with major depression (MD) and in depressed patients with different neurodegenerative diseases. But, up to d...

Authors: Wei-Wei Tao, Xin-Ting Cai, Jie Shen, Xue-Gong Shi and Yu Wang

The changing faces of migraine

Authors: Paolo Martelletti, Messoud Ashina and Lars Edvinsson

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migrain...

Authors: Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello and Gianluca Serafini

Physician and patient preferences for dosing options in migraine prevention

Adherence to a therapy, though a key factor for successful treatment, is low among patients with chronic conditions such as migraine. Dose frequency plays a major role in adherence. This study evaluated the im...

Authors: Robert Cowan, Joshua M. Cohen, Erik Rosenman and Ravi Iyer

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice

Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden. Preventive treatments are required to reduc...

Authors: Cindy Tiseo, Raffaele Ornello, Francesca Pistoia and Simona Sacco

Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field stre...

Authors: Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize th...

Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Kristian A. Haanes, René de Vries, Ruben Dammers, A. J. J. C. Bogers, Antoon van den Bogaerdt, Bruce L. Daugherty, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink

Advanced visual network and cerebellar hyperresponsiveness to trigeminal nociception in migraine with aura

Despite the growing body of advanced studies investigating the neuronal correlates of pain processing in patients with migraine without aura (MwoA), only few similar studies have been conducted in patients wit...

Authors: Antonio Russo, Alessandro Tessitore, Marcello Silvestro, Federica Di Nardo, Francesca Trojsi, Teresa Del Santo, Rosa De Micco, Fabrizio Esposito and Gioacchino Tedeschi

Spreading depression as a preclinical model of migraine

Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine au...

Authors: Andrea M. Harriott, Tsubasa Takizawa, David Y. Chung and Shih-Pin Chen

Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor bloc...

Authors: Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan and Cen Xu

The effect of orofacial complete Freund’s adjuvant treatment on the expression of migraine-related molecules

Migraine is a neurovascular primary headache disorder, which causes significant socioeconomic problems worldwide. The pathomechanism of disease is enigmatic, but activation of the trigeminovascular system (TS)...

Authors: Tamás Körtési, Bernadett Tuka, Aliz Nyári, László Vécsei and János Tajti

Clinical neurophysiology of migraine with aura

The purpose of this review is to provide a comprehensive overview of the findings of clinical electrophysiology studies aimed to investigate changes in information processing of migraine with aura patients.

Authors: Gianluca Coppola, Cherubino Di Lorenzo, Vincenzo Parisi, Marco Lisicki, Mariano Serrao and Francesco Pierelli

A narrative review on the burden of migraine: when the burden is the impact on people’s life

The burden of headache disorders, and of migraine in particular, is multifaceted and fragmented. The aim of this narrative review is to provide a description the main topics underlying the concepts of burden a...

Authors: Matilde Leonardi and Alberto Raggi

The burden of headache disorders in the Eastern Mediterranean Region, 1990-2016: findings from the Global Burden of Disease study 2016

Using the findings of the Global Burden of Disease Study (GBD), we report the burden of primary headache disorders in the Eastern Mediterranean Region (EMR) from 1990 to 2016.

Authors: Kia Vosoughi, Lars Jacob Stovner, Timothy J. Steiner, Maziar Moradi-Lakeh, Seyed-Mohammad Fereshtehnejad, Farshad Farzadfar, Pouria Heydarpour, Reza Malekzadeh, Mohsen Naghavi, Mohammad Ali Sahraian, Sadaf G. Sepanlou, Arash Tehrani-Banihashemi, Reza Majdzadeh, Valery L. Feigin, Theo Vos, Ali H. Mokdad…

CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA

Some variables have been proposed as predictors of efficacy of OnabotulinumtoxinA in chronic migraine patients, but data available are inconclusive. We aimed to analyse the influence of single nucleotide polym...

Authors: R. Moreno-Mayordomo, M. Ruiz, J. Pascual, M. Gallego de la Sacristana, I. Vidriales, M. Sobrado, E. Cernuda-Morollon, A. B. Gago-Veiga, D. Garcia-Azorin, J. J. Telleria and A. L. Guerrero

Female versus male migraine: an event-related potential study of visual neurocognitive processing

Several studies have suggested cognitive deficits in migraineurs, and sex differences have also been observed in migraine, such as a higher prevalence in females. Nevertheless, little is known about gender-rel...

Authors: Yunliang Guo, Song Xu, Shanjing Nie, Mimi Han, Yue Zhang, Jian Chen, Xunyao Hou, Yan Hong and Xueping Liu

Therapeutic novelties in migraine: new drugs, new hope?

In the past decade, migraine research has identified novel drug targets. In this review, we discuss recent data on emerging anti-migraine therapies.

Authors: Thien Phu Do, Song Guo and Messoud Ashina

Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with ...

Authors: Jingjing Su, Mengxing Wang, Shiyu Ban, Liang Wang, Xin Cheng, Fengchun Hua, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du and Jianren Liu

Primary headaches during lifespan

Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of sym...

Authors: Andreas Straube and Anna Andreou

Clinical characteristics of nummular headache and differentiation between spontaneous and posttraumatic variant: an observational study

Head trauma has been described as a precipitating event in Nummular Headache (NH). We aimed to describe the largest NH published series and compare characteristics between idiopathic and post-traumatic cases.

Authors: Javier Trigo, David García-Azorín, Enrique Martinez Pias, Álvaro Sierra, Alba Chavarría and Angel Luis Guerrero

Migraine and episodic Vertigo: a cohort survey study of their relationship

Migraine headache and vestibular-type vertigo co-occur in the general population about three times more often than expected by chance. Attacks of episodic vertigo (eV) are currently not recognized as migraine ...

Authors: Christian Lampl, Alan Rapoport, Moris Levin and Elisabeth Bräutigam

Neuroimaging clues of migraine aura

While migraine headaches can be provoked, or predicted by the presence of an aura or premonitory symptoms, the prediction or elicitation of the aura itself is more problematic. Therefore, imaging studies direc...

Authors: Nouchine Hadjikhani and Maurice Vincent

Predicting treatment response using pharmacy register in migraine

Precision medicine may offer new strategies to treat migraine, and access to existing large cohorts may be a key resource to increase statistical power. Treatment response data is not routinely collected for l...

Authors: Thomas Folkmann Hansen, Mona Ameri Chalmer, Thilde Marie Haspang, Lisette Kogelman and Jes Olesen

Histamine and migraine revisited: mechanisms and possible drug targets

To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine.

Authors: Jacob Worm, Katrine Falkenberg and Jes Olesen

Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study

To investigate the whole-brain resting-state functional connectivity in patients with chronic migraine (CM) using a data-driven method.

Authors: Mi Ji Lee, Bo-yong Park, Soohyun Cho, Sung Tae Kim, Hyunjin Park and Chin-Sang Chung

Development of an education and self-management intervention for chronic headache – CHESS trial (Chronic Headache Education and Self-management Study)

Self-management interventions are well recognised and widely used in chronic conditions. Their application to chronic headaches has been limited and generally of low quality. We describe here our process for d...

Authors: Shilpa Patel, Rachel Potter, Manjit Matharu, Dawn Carnes, Stephanie J. C. Taylor, Vivien Nichols, Tamar Pincus, Martin Underwood and Harbinder Sandhu

CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?

Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors ...

Authors: Valentina Favoni, Luca Giani, Linda Al-Hassany, Gian Maria Asioli, Calogera Butera, Irene de Boer, Martina Guglielmetti, Chrysoula Koniari, Theodoros Mavridis, Marge Vaikjärv, Iris Verhagen, Angela Verzina, Bart Zick, Paolo Martelletti and Simona Sacco

An open-label prospective study of the real-life use of onabotulinumtoxinA for the treatment of chronic migraine: the REPOSE study

The PREEMPT Studies established onabotulinumtoxinA as preventive treatment for adults with chronic migraine (CM). The purpose of the REal-life use of botulinum toxin for the symptomatic treatment of adults with c...

Authors: Fayyaz Ahmed, Charly Gaul, Juan Carlos García-Moncó, Katherine Sommer and Paolo Martelletti

ROS/TRPA1/CGRP signaling mediates cortical spreading depression

The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand their mechanisms in migraine by inve...

Authors: Liwen Jiang, Dongqing Ma, Blair D. Grubb and Minyan Wang

Headache service quality: the role of specialized headache centres within structured headache services, and suggested standards and criteria as centres of excellence

In joint initiatives, the European Headache Federation and Lifting The Burden have described a model of structured headache services (with their basis in primary care), defined service quality in this context, an...

Authors: T. J. Steiner, H. Göbel, R. Jensen, C. Lampl, K. Paemeleire, M. Linde, M. Braschinsky, D. Mitsikostas, R. Gil-Gouveia and Z. Katsarava

Favourable prognosis of trigeminal neuralgia when enrolled in a multidisciplinary management program - a two-year prospective real-life study

Prognosis of medically treated trigeminal neuralgia patients is assumed to be poor, but the evidence is lacking. Thus, prospective real-life studies of medical management of trigeminal neuralgia are warranted.

Authors: Tone Bruvik Heinskou, Stine Maarbjerg, Frauke Wolfram, Per Rochat, Jannick Brennum, Jes Olesen and Lars Bendtsen

Letter to the editor regarding European Headache Federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

Authors: Russell Nichols, Vladimir Skljarevski, Grazia Dell’Agnello, Hans-Peter Hundemer and Sheena K. Aurora

The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study

Disrupted sleep is associated with a reciprocal influence on headaches and is one of the contributing factors in the process of chronicity. The goal of the present study was to investigate the influence of sle...

Authors: Seong Hoon Kim, Ju Yeon Park, Hae Eun Shin, Si baek Lee, Dong Woo Ryu, Tae Won Kim and Jeong Wook Park

Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options

Trigeminal neuralgia is one of the most characteristic and difficult to treat neuropathic pain conditions in patients with multiple sclerosis. The present narrative review addresses the current evidence on dia...

Authors: Giulia Di Stefano, Stine Maarbjerg and Andrea Truini

Real world preventative drug management of migraine among Spanish neurologists

Many different preventatives have showed efficacy in the treatment of migraine. National guidelines differ in their recommendations and patients’ characteristics are usually taken into account in their selecti...

Authors: D. García-Azorin, S. Santos-Lasaosa, A. B. Gago-Veiga, J. Viguera Romero and A. L. Guerrero-Peral

Migraine-provoking substances evoke periorbital allodynia in mice

Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks. Although migraine provoking substances are normally vasodilators, d...

Authors: Francesco De Logu, Lorenzo Landini, Malvin N. Janal, Simone Li Puma, Francesco De Cesaris, Pierangelo Geppetti and Romina Nassini

Efficacy of psychological treatment for headache disorder: a systematic review and meta-analysis

Headache disorder is not only a common complaint but also a global burden. Pharmacotherapeutic and non-pharmacotherapeutic approaches have been developed for its treatment and prophylaxis. The present study in...

Authors: Hye Jeong Lee, Jin Hyeok Lee, Eun Young Cho, Sun Mi Kim and Seoyoung Yoon

The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis

In patients with frequent migraine, prophylactic treatments are used. Patients often request non-pharmacological alternatives. One treatment option can be aerobic exercise. The value of aerobic exercise as pro...

Authors: Joris Lemmens, Joke De Pauw, Timia Van Soom, Sarah Michiels, Jan Versijpt, Eric van Breda, René Castien and Willem De Hertogh

Development and validation of the ID-EC - the ITALIAN version of the identify chronic migraine

Case-finding tools, such as the Identify Chronic Migraine (ID-CM) questionnaire, can improve detection of CM and alleviate its significant societal burden. We aimed to develop and validate the Italian version ...

Authors: Simona Sacco, Silvia Benemei, Sabina Cevoli, Gianluca Coppola, Pietro Cortelli, Francesco De Cesaris, Roberto De Icco, Cristiano Maria De Marco, Cherubino Di Lorenzo, Pierangelo Geppetti, Alessia Manni, Andrea Negro, Raffaele Ornello, Giulia Pierangeli, Francesco Pierelli, Lanfranco Pellesi…

Correction to: A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

Following publication of the original article [1], we have been notified that the name of author five was spelled incorrectly as M. Ferrili, when the correct spelling is MAN Ferilli.

Authors: D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. A. N. Ferilli, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese

Burden of migraine in Finland: health care resource use, sick-leaves and comorbidities in occupational health care

The highest prevalence of migraine is detected among people who are of working age. The aim of this study was to assess the burden of migraine in an occupational health care setting using real world data colle...

Authors: Minna A. Korolainen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Madlaina Costa-Scharplatz, Timo Purmonen and Markku Nissilä

Effects of onabotulinumtoxinA treatment in chronic migraine patients with and without daily headache at baseline: results from the COMPEL Study

OnabotulinumtoxinA is effective in preventing chronic migraine (CM); however, the benefit of onabotulinumtoxinA in patients with CM with daily headache is unknown because these patients are typically excluded ...

Authors: William B. Young, J. Ivan Lopez, John F. Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B. Lipton and Andrew M. Blumenfeld

Behavioral and cognitive animal models in headache research

Animal models have provided a growing body of information about the pathophysiology of headaches and novel therapeutic targets. In recent years, experiments in awake animals have gained attention as more relev...

Authors: Doga Vuralli, Anne-Sophie Wattiez, Andrew F. Russo and Hayrunnisa Bolay