Articles

Use of outpatient medical care by headache patients in Germany: a population-based cross-sectional study

Headache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study...

Authors: Britta Müller, Thomas Dresler, Charly Gaul, Tim Jürgens, Peter Kropp, Anna Rehfeld, Olaf Reis, Ruth Ruscheweyh, Andreas Straube and Stefanie Förderreuther

Sensory processing patterns affect headache severity among adolescents with migraine

To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine.

Authors: Jacob Genizi, Ayelet Halevy, Mitchell Schertz, Khaled Osman, Nurit Assaf, Idan Segal, Isaac Srugo, Aharon Kessel and Batya Engel-Yeger

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information process...

Authors: Zhaoxia Qin, Jingjing Su, Xin-Wei He, Shiyu Ban, Qian Zhu, Yangyang Cui, Jilei Zhang, Yue Hu, Yi-Sheng Liu, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu and Xiaoxia Du

Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study

Tinnitus due to hyperactivity across neuronal ensembles along the auditory pathway is reported. We hypothesized that trigeminal neuralgia patients may subsequently suffer from tinnitus. Using nationwide, popul...

Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin

Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database

Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people, and with increasing trends in general populations. Differ...

Authors: Alberto Raggi, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Muhammad Z. Hossin, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…

Direct and indirect costs of cluster headache: a prospective analysis in a tertiary level headache centre

Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy ...

Authors: Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti and Francesco Saverio Mennini

From transformation to chronification of migraine: pathophysiological and clinical aspects

Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic...

Authors: M. Torres-Ferrús, F. Ursitti, A. Alpuente, F. Brunello, D. Chiappino, T. de Vries, S. Di Marco, S. Ferlisi, L. Guerritore, N. Gonzalez-Garcia, A. Gonzalez-Martinez, D. Khutorov, M. Kritsilis, A. Kyrou, T. Makeeva, A. Minguez-Olaondo…

A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication

Migraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, ar...

Authors: Louise Lombard, Mallory Farrar, Wenyu Ye, Yongin Kim, Sarah Cotton, Andrew S. Buchanan, James Jackson and Shivang Joshi

Sustained response to onabotulinumtoxin A in patients with chronic migraine: real-life data

Treatment with onabotulinumtoxin A (BT-A) is safe and effective for chronic migraine (CM). Several studies assessed possible predictors of response to treatment with BT-A, but there is little knowledge on the ...

Authors: Raffaele Ornello, Simona Guerzoni, Carlo Baraldi, Luana Evangelista, Ilaria Frattale, Carmine Marini, Cindy Tiseo, Francesca Pistoia and Simona Sacco

Brain morphologic abnormalities in migraine patients: an observational study

Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.

Authors: Lilla Bonanno, Viviana Lo Buono, Simona De Salvo, Claudio Ruvolo, Viviana Torre, Placido Bramanti, Silvia Marino and Francesco Corallo

Headache medication and the COVID-19 pandemic

The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and providing the best possible care to infected patients, a...

Authors: Antoinette MaassenVanDenBrink, Tessa de Vries and A. H. Jan Danser

Prevalence of familial cluster headache: a systematic review and meta-analysis

The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a s...

Authors: Emer O’Connor, Benjamin S. Simpson, Henry Houlden, Jana Vandrovcova and Manjit Matharu

An unexpected and suspended time

Authors: Paolo Martelletti

Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain

The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund’s adjuvant (C...

Authors: Edina K. Cseh, Gábor Veres, Tamás Körtési, Helga Polyák, Nikolett Nánási, János Tajti, Árpád Párdutz, Péter Klivényi, László Vécsei and Dénes Zádori

Short-latency afferent inhibition and somato-sensory evoked potentials during the migraine cycle: surrogate markers of a cycling cholinergic thalamo-cortical drive?

Short-latency afferent inhibition (SAI) consists of motor cortex inhibition induced by sensory afferents and depends on the excitatory effect of cholinergic thalamocortical projections on inhibitory GABAergic ...

Authors: Gianluca Coppola, Davide Di Lenola, Chiara Abagnale, Fabio Ferrandes, Gabriele Sebastianelli, Francesco Casillo, Cherubino Di Lorenzo, Mariano Serrao, Maurizio Evangelista, Jean Schoenen and Francesco Pierelli

Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine

Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients wi...

Authors: Soo-Kyoung Kim, Catherine D. Chong, Gina Dumkrieger, Katherine Ross, Visar Berisha and Todd J. Schwedt

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy

We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study

The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...

Authors: Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares and Raquel Gil-Gouveia

Phase dependent hypothalamic activation following trigeminal input in cluster headache

Task-free imaging approaches using PET have shown the posterior hypothalamus to be specifically activated during but not outside cluster headache attacks. Evidence from task related functional imaging approach...

Authors: Laura H. Schulte, Ame Abdu Haji and Arne May

The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine

The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, ...

Authors: Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang

European Headache Federation recommendations for neurologists managing giant cell arteritis

Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms o...

Authors: S. P. Mollan, K. Paemeleire, J. Versijpt, R. Luqmani and A. J. Sinclair

Migraine, headache, and mortality in women: a cohort study

Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased ...

Authors: Jessica L. Rohmann, Pamela M. Rist, Julie E. Buring and Tobias Kurth

Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies

Authors: Kristian Agmund Haanes, Lars Edvinsson and Anette Sams

Rapid referral for headache management from emergency department to headache centre: four years data

Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency faci...

Authors: Andrea Negro, Valerio Spuntarelli, Paolo Sciattella and Paolo Martelletti

Time trends of major headache diagnoses and predictive factors. Data from three Nord-Trøndelag health surveys

The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal ass...

Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study

Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) freq...

Authors: Dawn C. Buse, Michael L. Reed, Kristina M. Fanning, Ryan Bostic, David W. Dodick, Todd J. Schwedt, Sagar Munjal, Preeti Singh and Richard B. Lipton

The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial

Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migrai...

Authors: Zeinab Ghorbani, Pegah Rafiee, Akbar Fotouhi, Samane Haghighi, Reyhaneh Rasekh Magham, Zeynab Sadat Ahmadi, Mahmoud Djalali, Mahnaz Zareei, Soodeh Razeghi Jahromi, Sahar Shahemi, Maryam Mahmoudi and Mansoureh Togha

Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study

Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT_1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of...

Authors: Richard B. Lipton, Louise Lombard, Dustin D. Ruff, John H. Krege, Li Shen Loo, Andrew Buchanan, Thomas E. Melby and Dawn C. Buse

Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache

Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache pr...

Authors: Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Matias Metcalf-Clausen, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study

To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

Authors: Di Zhang, Xiaobin Huang, Wen Su, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu

Fluctuations in local and widespread mechanical sensitivity throughout the migraine cycle: a prospective longitudinal study

People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity thr...

Authors: Gwendolyne G. M. Scholten-Peeters, Michel W. Coppieters, Tom S. C. Durge and René F. Castien

Gut-brain Axis and migraine headache: a comprehensive review

The terminology “gut-brain axis “points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some...

Authors: Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco and Mansoureh Togha

Different doses of galcanezumab versus placebo in patients with migraine and cluster headache: a meta-analysis of randomized controlled trials

Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomiz...

Authors: Yanbo Yang, Zilan Wang, Bixi Gao, He Xuan, Yun Zhu, Zhouqing Chen and Zhong Wang

Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthines...

Authors: Yating Zhao, Ruixia Zhu, Tongling Xiao and Xu Liu

Exploring naturally occurring clinical subgroups of post-traumatic headache

To explore naturally occurring clinical subgroups of post-traumatic headache.

Authors: T. L. H. Chan and Y. W. Woldeamanuel

The prevalence of primary headache disorders in Saudi Arabia: a cross-sectional population-based study

The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include most of Eastern Mediterranean Region (EMR). Following a nationwide population-based study in Pakistan, we...

Authors: Mohammed Al Jumah, Ali M. Al Khathaami, Suleman Kojan, Mohamed Hussain, Hallie Thomas and Timothy J. Steiner

The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine

Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology.

Authors: Karin Warfvinge, Diana Krause and Lars Edvinsson

Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study

To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarker...

Authors: Ane Mínguez-Olaondo, Iván Martínez-Valbuena, Sonia Romero, Gema Frühbeck, María Rosario Luquin, Eduardo Martínez-Vila and Pablo Irimia

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age u...

Authors: Minna A. Korolainen, Samuli Tuominen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Timo Purmonen, Jaana Santaholma and Markku Nissilä

Two decades, a new editorial stylistic feature

Authors: Paolo Martelletti

Dural arteriovenous fistulas and headache features: an observational study

Dural arteriovenous fistulas are intracranial vascular malformations, fed by dural arteries and draining venous sinuses or meningeal veins. Clinical course varies widely and ranges from benign with spontaneous...

Authors: Ilenia Corbelli, Francesca De Maria, Paolo Eusebi, Michele Romoli, Gabriela Cardaioli, Mohammed Hamam, Piero Floridi, Letizia Maria Cupini, Paola Sarchielli and Paolo Calabresi

Prevalence and risk factors associated with headache amongst medical staff in South China

A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey wa...

Authors: Wei Xie, Ruibing Li, Mianwang He, Fang Cui, Tingting Sun, Jianmei Xiong, Dengfa Zhao, Weinan Na, Ruozhuo Liu and Shengyuan Yu

Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk betwe...

Authors: Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen and Jiying Zhou

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and ...

Authors: Bereket Duko, Mohammed Ayalew and Alemayehu Toma

ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account ...

Authors: Carl H. Göbel, Sarah C. Karstedt, Thomas F. Münte, Hartmut Göbel, Sebastian Wolfrum, Elena R. Lebedeva, Jes Olesen and Georg Royl

White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is l...

Authors: Álvaro Planchuelo-Gómez, David García-Azorín, Ángel L. Guerrero, Santiago Aja-Fernández, Margarita Rodríguez and Rodrigo de Luis-García

Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre

Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated with a...

Authors: Andrea Negro, Paolo Sciattella, Daniele Rossi, Martina Guglielmetti, Paolo Martelletti and Francesco Saverio Mennini

The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials

To evaluate the crossover design in migraine preventive treatment trials by assessing dropout rate, and potential period and carryover effect in four placebo-controlled randomized controlled trials (RCTs).

Authors: Astrid Bjørke Jenssen, Lars Jacob Stovner, Erling Tronvik, Trond Sand, Grethe Helde, Gøril Bruvik Gravdahl and Knut Hagen

Correction to: Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2)

After publication of our article [1] we were notified that the data presented in the upper row of Fig. 7 was inadvertently the least square mean change from baseline (standard error) at Month 6 rather than the...

Authors: Stephen D. Silberstein, Virginia L. Stauffer, Katie A. Day, Sarah Lipsius and Maria-Carmen Wilson

Mechanisms of migraine as a chronic evolutive condition

Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has bee...

Authors: Anna P. Andreou and Lars Edvinsson