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  1. Hyperbaric oxygen (HBO) has the potential to relieve neuropathic pain. The purpose of this study was to determine whether the NO-cGMP-PKG signaling pathway is involved in the analgesic effects of early hyperba...

    Authors: Yuanyuan Ding, Peng Yao, Tao Hong, Zhenkai Han, Baisong Zhao and Weimin Chen
    Citation: The Journal of Headache and Pain 2017 18:51
    Content type: Research article Published on:

  2. Sleep disorder and sleep complaints are common in subjects with migraine. Although the association between sleep disorders and migraine has been reported, the association between perceived insufficient sleep a...

    Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2017 18:50
    Content type: Research article Published on:

  4. Little is known about the long-term course of headache in patients with moderate-to-severe headache due to traumatic brain injury (TBI). We evaluated the course of headache in patients with moderate-to-severe...

    Authors: Chang-Ki Hong, Jin-Yang Joo, Yu Shik Shim, Sook Young Sim, Min A Kwon, Yong Bae Kim and Joonho Chung
    Citation: The Journal of Headache and Pain 2017 18:48
    Content type: Research article Published on:

  5. Recent studies have shown a significant association between restless legs syndrome (RLS) and primary headache disorders. Nevertheless, information regarding the association between tension-type headache (TTH) ...

    Authors: Pil-Wook Chung, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2017 18:47
    Content type: Research article Published on:

  6. The prevalence of migraine with co-existing tension-type headache and neck pain is high in the general population. However, there is very little literature on the characteristics of these combined conditions. ...

    Authors: Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Maria Lurenda Westergaard, Trine Nielsen, Louise Bönsdorff Sloth, Rigmor Højland Jensen and Gunvor Gard
    Citation: The Journal of Headache and Pain 2017 18:46
    Content type: Research article Published on:

  9. Identification of subgroups of patients with different levels of sensitization and clinical features can help to identify groups at risk and the development of better therapeutic strategies. The aim of this st...

    Authors: César Fernández-de-las-Peñas, Elena Benito-González, María Palacios-Ceña, Kelun Wang, Matteo Castaldo and Lars Arendt-Nielsen
    Citation: The Journal of Headache and Pain 2017 18:43
    Content type: Research article Published on:

  10. Migraine has been recognized as one of the leading causes of disability in the 2013 Global Burden of Disease Study and seriously affects the quality of patients’ life, current treatment options are not ideal. ...

    Authors: Min Hou, Haiyan Xing, Yongqing Cai, Bin Li, Xianfeng Wang, Pan Li, Xiaolin Hu and Jianhong Chen
    Citation: The Journal of Headache and Pain 2017 18:42
    Content type: Research article Published on:

  11. Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to supp...

    Authors: Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlović, Julie Roth, Lucille Rathier and Dale S. Bond
    Citation: The Journal of Headache and Pain 2017 18:41
    Content type: Research article Published on:

  12. Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly. There is no s...

    Authors: Dimos D. Mitsikostas, Srdjan Ljubisavljevic and Christina I. Deligianni
    Citation: The Journal of Headache and Pain 2017 18:40
    Content type: Research article Published on:

  13. Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...

    Authors: M. Lukács, K. Warfvinge, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson
    Citation: The Journal of Headache and Pain 2017 18:39
    Content type: Research article Published on:

  14. Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

    Authors: Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin
    Citation: The Journal of Headache and Pain 2017 18:38
    Content type: Review article Published on:

  15. Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

    Authors: Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal
    Citation: The Journal of Headache and Pain 2017 18:37
    Content type: Research article Published on:

  16. The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered func...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:36
    Content type: Research article Published on:

  17. Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

    Authors: Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell
    Citation: The Journal of Headache and Pain 2017 18:35
    Content type: Research article Published on:

  18. Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

    Authors: Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina
    Citation: The Journal of Headache and Pain 2017 18:34
    Content type: Research article Published on:

  20. Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

    Authors: Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen
    Citation: The Journal of Headache and Pain 2017 18:32
    Content type: Review article Published on:

  21. DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

    Authors: Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport
    Citation: The Journal of Headache and Pain 2017 18:31
    Content type: Research article Published on:

  22. The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

    Authors: S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg
    Citation: The Journal of Headache and Pain 2017 18:30
    Content type: Research article Published on:

  24. The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

    Authors: A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner
    Citation: The Journal of Headache and Pain 2017 18:28
    Content type: Research article Published on:

  25. Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

    Authors: Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:27
    Content type: Research article Published on:

  26. A large number patients struggle with migraine which is classified as a chronic disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine play a key role in managing thi...

    Authors: Aijie He, Dehua Song, Lei Zhang and Chen Li
    Citation: The Journal of Headache and Pain 2017 18:26
    Content type: Research article Published on:

  27. Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:25
    Content type: Research article Published on:

  28. Cardiac cephalalgia (CC) is a rare disease occurring during an episode of myocardial ischemia and relieved by nitroglycerine. Though more than 30 cases of CC have been reported since 1997, the mechanism is yet...

    Authors: Miao Wang, Lu Wang, Changfu Liu, Xiangbing Bian, Zhao Dong and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:24
    Content type: Review article Published on:

  29. OnabotulinumtoxinA (OnabotA) is considered effective in in patients with chronic migraine (CM) who failed on traditional therapies. This study was designed to evaluate the effect of OnabotA injection series on...

    Authors: Elif Ilgaz Aydinlar, Pinar Yalinay Dikmen, Seda Kosak and Ayse Sagduyu Kocaman
    Citation: The Journal of Headache and Pain 2017 18:23
    Content type: Research article Published on:

  30. In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus stan...

    Authors: Charly Gaul, Delphine Magis, Eric Liebler and Andreas Straube
    Citation: The Journal of Headache and Pain 2017 18:22
    Content type: Short report Published on:

  31. In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out.

    Authors: Claudine Angela Blum, Bettina Winzeler, Nicole Nigro, Philipp Schuetz, Silke Biethahn, Timo Kahles, Cornelia Mueller, Katharina Timper, Katharina Haaf, Janina Tepperberg, Margareth Amort, Andreas Huber, Roland Bingisser, Peter Stephan Sándor, Krassen Nedeltchev, Beat Müller…
    Citation: The Journal of Headache and Pain 2017 18:21
    Content type: Research article Published on:

  32. Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the...

    Authors: Claudia Francesca Gasparini, Robert Anthony Smith and Lyn Robyn Griffiths
    Citation: The Journal of Headache and Pain 2017 18:20
    Content type: Review article Published on:

  33. A better understanding of potential relationship between mood disorders, sleep quality, pain, and headache frequency may assist clinicians in determining optimal therapeutic programs. The aim of the current st...

    Authors: María Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Lars Arendt-Nielsen and César Fernández-de-las-Peñas
    Citation: The Journal of Headache and Pain 2017 18:19
    Content type: Research article Published on:

  34. Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia.

    Authors: Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber
    Citation: The Journal of Headache and Pain 2017 18:18
    Content type: Short report Published on:

    The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:33

  35. A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

    Authors: Roger K. Cady, Sagar Munjal, Ryan J. Cady, Heather R. Manley and Elimor Brand-Schieber
    Citation: The Journal of Headache and Pain 2017 18:17
    Content type: Research article Published on:

  36. Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms.

    Authors: Ashley L. Tyburski, Lan Cheng, Soroush Assari, Kurosh Darvish and Melanie B. Elliott
    Citation: The Journal of Headache and Pain 2017 18:16
    Content type: Research article Published on:

  37. Chronic Migraine (CM) is a disabling condition, worsened when associated with Medication Overuse (MO). Mindfulness is an emerging technique, effective in different pain conditions, but it has yet to be explore...

    Authors: Licia Grazzi, Emanuela Sansone, Alberto Raggi, Domenico D’Amico, Andrea De Giorgio, Matilde Leonardi, Laura De Torres, Francisco Salgado-García and Frank Andrasik
    Citation: The Journal of Headache and Pain 2017 18:15
    Content type: Research article Published on:

  38. Periaqueductal gray (PAG) is the descending pain modulatory center, and PAG dysfunction had been recognized in migraine. Here we propose to investigate altered PAG texture features (quantitative approach for e...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:14
    Content type: Research article Published on:

  39. Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migrain...

    Authors: Xiaoying Cai, Xiaolei Shi, Ximeng Zhang, Aiwu Zhang, Minying Zheng and Yannan Fang
    Citation: The Journal of Headache and Pain 2017 18:13
    Content type: Review article Published on:

  40. Periaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headach...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:12
    Content type: Research article Published on:

  41. Authors: Paolo Martelletti
    Citation: The Journal of Headache and Pain 2017 18:11
    Content type: Erratum Published on:

    The original article was published in The Journal of Headache and Pain 2015 16:A52

    The original article was published in The Journal of Headache and Pain 2015 16:A160

    The original article was published in The Journal of Headache and Pain 2015 16:A87

    The original article was published in The Journal of Headache and Pain 2015 16:A1

    The original article was published in The Journal of Headache and Pain 2015 16:A49

    The original article was published in The Journal of Headache and Pain 2015 16:A106

    The original article was published in The Journal of Headache and Pain 2015 16:A99

    The original article was published in The Journal of Headache and Pain 2015 16:A90

    The original article was published in The Journal of Headache and Pain 2015 16:A54

    The original article was published in The Journal of Headache and Pain 2015 16:A91

    The original article was published in The Journal of Headache and Pain 2015 16:A59

    The original article was published in The Journal of Headache and Pain 2015 16:A158

    The original article was published in The Journal of Headache and Pain 2015 16:A55

    The original article was published in The Journal of Headache and Pain 2015 16:A58

  42. We investigated the prevalence of post-procedural headache in patients who have undergone thrombectomy for ischemic stroke, and correlated history of migraine with risk of peri-procedural complications. A tota...

    Authors: Sabrina Khan, Faisal Mohammad Amin, Markus Holtmannspötter, Klaus Hansen, Anna Maria Florescu, Zainab Fakhril-Din, Julie Falkenberg Petersen, Hashmat Ghanizada, Cenk Ayata, David Gaist and Messoud Ashina
    Citation: The Journal of Headache and Pain 2017 18:10
    Content type: Short report Published on:

  43. Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrence of this...

    Authors: Sebastian Bao Dinh Bui, Torben Petersen, Jeppe Nørgaard Poulsen and Parisa Gazerani
    Citation: The Journal of Headache and Pain 2017 18:9
    Content type: Research article Published on:

  44. Migraine is one of the most severe primary headache disorders. The nature of the headache and the associated symptoms during the attack suggest underlying functional alterations in the brain. In this study, we...

    Authors: Péter Faragó, Bernadett Tuka, Eszter Tóth, Nikoletta Szabó, András Király, Gergő Csete, Délia Szok, János Tajti, Árpád Párdutz, László Vécsei and Zsigmond Tamás Kincses
    Citation: The Journal of Headache and Pain 2017 18:8
    Content type: Research article Published on:

  45. The amygdala is a large grey matter complex in the limbic system, and it may contribute in the neurolimbic pain network in migraine. However, the detailed neuromechanism remained to be elucidated. The objectiv...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:7
    Content type: Research article Published on:

  47. The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can b...

    Authors: Ram Kandasamy, Andrea T. Lee and Michael M. Morgan
    Citation: The Journal of Headache and Pain 2017 18:5
    Content type: Research article Published on:

  48. Intracranial hypotension, especially spontaneous intracranial hypotension (SIH), is a well—recognized entity associated with cerebrospinal fluid (CSF) leaks, and has being recognized better in resent years, wh...

    Authors: Jin-ping Lin, Shu-dong Zhang, Fei-fang He, Min-jun Liu and Xiao-xu Ma
    Citation: The Journal of Headache and Pain 2017 18:4
    Content type: Review article Published on:

  49. There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine pati...

    Authors: Akio Iwasaki, Keisuke Suzuki, Hidehiro Takekawa, Ryotaro Takashima, Ayano Suzuki, Shiho Suzuki and Koichi Hirata
    Citation: The Journal of Headache and Pain 2017 18:3
    Content type: Short report Published on:

  50. Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability. Previously, MEP thresholds were found t...

    Authors: Francesca Cortese, Gianluca Coppola, Davide Di Lenola, Mariano Serrao, Cherubino Di Lorenzo, Vincenzo Parisi and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2017 18:2
    Content type: Research article Published on:
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