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O028. Thalamo-cortical network changes during the migraine cycle: insights from MRI-based microstructural and functional resting-state network correlation analysis
The Journal of Headache and Pain volume 16, Article number: A52 (2015)
An Erratum to this article was published on 31 January 2017
Background
Abnormal structural and functional plasticity in cortical and subcortical brain regions may be an important aspect of migraine pathophysiology. Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Whether there is a relation between the plasticity of resting state networks and integrity of thalamic microstructure during the migraine cycle is not known. To verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients during and between attacks.
Methods
Twenty-four patients with untreated MO underwent 3T MRI scans during (n=10) or between attacks (n=14) and were compared to a group of 15 healthy volunteers. We used MRI to collect resting state data among four selected resting state networks, identified using group independent component (IC) analysis. Fractional anisotropy (FA) values of bilateral thalami were retrieved from a previous diffusion tensor imaging study on the same group of subjects and correlated with resting state ICs Z-scores.
Results
We found a significant reduced functional connectivity between the default mode network and the visuo-spatial system between attacks, and between the executive control network and the dorso-ventral attention system during attacks. When HV and migraine groups were combined, ictal and interictal selected ICs Z-scores correlated negatively with bilateral thalami FA values.
Conclusions
The present results are the first evidence supporting the hypothesis that abnormal dynamics of the connectivity between thalamus and functional cerebral networks at rest could contribute to the recurrence of migraine attacks.
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An erratum to this article is available at http://dx.doi.org/10.1186/s10194-016-0709-7.
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Coppola, G., Di Renzo, A., Tinelli, E. et al. O028. Thalamo-cortical network changes during the migraine cycle: insights from MRI-based microstructural and functional resting-state network correlation analysis. J Headache Pain 16 (Suppl 1), A52 (2015). https://doi.org/10.1186/1129-2377-16-S1-A52
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DOI: https://doi.org/10.1186/1129-2377-16-S1-A52