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  1. Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

    Authors: Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse
    Citation: The Journal of Headache and Pain 2017 18:101
    Content type: Research article Published on:

  2. Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targe...

    Authors: Martin Uglem, Petter Moe Omland, Marit Stjern, Gøril Bruvik Gravdahl and Trond Sand
    Citation: The Journal of Headache and Pain 2017 18:100
    Content type: Research article Published on:

  3. Pain is a very common condition in patient undergoing rehabilitation for neurological disease; however the presence of primary headaches and other cranio-facial pains, particularly when they are actually or ap...

    Authors: Cristina Tassorelli, Marco Tramontano, Mariangela Berlangieri, Vittorio Schweiger, Mariagrazia D’Ippolito, Valerio Palmerini, Sara Bonazza, Riccardo Rosa, Rosanna Cerbo and Maria Gabriella Buzzi
    Citation: The Journal of Headache and Pain 2017 18:99
    Content type: Research article Published on:

  4. To apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG and under visual stimulation by checkerboard gratings with 0.5 and 2.0 cpd as spatial fre...

    Authors: Marina de Tommaso, Gabriele Trotta, Eleonora Vecchio, Katia Ricci, R. Siugzdaite and Sebastiano Stramaglia
    Citation: The Journal of Headache and Pain 2017 18:98
    Content type: Research article Published on:

  6. Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than mi...

    Authors: Marie Deen, Edvige Correnti, Katharina Kamm, Tim Kelderman, Laura Papetti, Eloisa Rubio-Beltrán, Simone Vigneri, Lars Edvinsson and Antoinette Maassen Van Den Brink
    Citation: The Journal of Headache and Pain 2017 18:96
    Content type: Review article Published on:

  7. Tension-type headache (TTH) represents the most common type of headache among the general population. Although such headaches are usually mild in severity, some individuals with TTH experience severe symptoms ...

    Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2017 18:95
    Content type: Research article Published on:

  8. Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate t...

    Authors: Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi and Rosaria Greco
    Citation: The Journal of Headache and Pain 2017 18:94
    Content type: Research article Published on:

  9. Migraine is a debilitating neurological disorder that affects 14.1% of the US and 14.7% of the European populations. Chronic migraine (CM) is broadly defined as headache occurring on ≥15 days per month for ≥3 ...

    Authors: Brendan Davies, Charly Gaul, Paolo Martelletti, Juan Carlos García-Moncó and Stephanie Brown
    Citation: The Journal of Headache and Pain 2017 18:93
    Content type: Research article Published on:

  10. This article consists of a Letter to the Editor regarding Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery, recently published in The Jo...

    Authors: Salman Khazaei, Shiva Mansouri Hanis, Kamyar Mansori, Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen
    Citation: The Journal of Headache and Pain 2017 18:92
    Content type: Letter to the Editor Published on:

  11. Menstrually related migraine (MRM) in the hormone-free interval (HFI) of combined hormonal contraceptives (CHC) are according to the ICHD definition also estrogen withdrawal migraines (EWH). MRMs are less resp...

    Authors: Gabriele S. Merki-Feld, Gina Epple, Nina Caveng, Bruno Imthurn, Burkhardt Seifert, Peter Sandor and Andreas R. Gantenbein
    Citation: The Journal of Headache and Pain 2017 18:91
    Content type: Research article Published on:

  12. To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.

    Authors: Mohammad Al-Mahdi Al-Karagholi, Jakob Møller Hansen, Johanne Severinsen, Inger Jansen-Olesen and Messoud Ashina
    Citation: The Journal of Headache and Pain 2017 18:90
    Content type: Review article Published on:

  13. Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology. Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and the def...

    Authors: Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang and Wei-Ta Chen
    Citation: The Journal of Headache and Pain 2017 18:89
    Content type: Research article Published on:

  14. We have genotyped a Swedish cluster headache case-control population for three genetic variants representing the most significant markers identified in a recently published genome wide association study on clu...

    Authors: Caroline Ran, Carmen Fourier, Julia M. Michalska, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2017 18:88
    Content type: Research article Published on:

  15. The majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumat...

    Authors: Todd J. Schwedt, Catherine D. Chong, Jacob Peplinski, Katherine Ross and Visar Berisha
    Citation: The Journal of Headache and Pain 2017 18:87
    Content type: Research article Published on:

  16. As a non-invasive therapy, whether transcranial magnetic stimulation (TMS) is effective on migraine. This article was aimed to assess the efficacy of TMS on migraine based on randomized controlled trails (RCTs).

    Authors: Lihuan Lan, Xiaoni Zhang, Xiangpen Li, Xiaoming Rong and Ying Peng
    Citation: The Journal of Headache and Pain 2017 18:86
    Content type: Research article Published on:

  17. Excessive daytime sleepiness (EDS, defined as Epworth sleepiness scale score > 10) is a common symptom, with a prevalence of 10–20% in the general population. It is associated with headache and other chronic p...

    Authors: Espen Saxhaug Kristoffersen, Knut Stavem, Christofer Lundqvist and Michael Bjørn Russell
    Citation: The Journal of Headache and Pain 2017 18:85
    Content type: Short report Published on:

  18. Headache attributed to airplane travel, also named "airplane headache" (AH) is a headache that occurs during take-off and landing. Today, there are still uncertainties about the pathophysiology and treatment o...

    Authors: Sebastian Bao Dinh Bui and Parisa Gazerani
    Citation: The Journal of Headache and Pain 2017 18:84
    Content type: Review article Published on:

  19. The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the nonspecific PAG lesions were also observed in episodic migraine (EM) recently. However, the PAG volume change was not totally detec...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:83
    Content type: Research article Published on:

  20. The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse heada...

    Authors: Zhiye Chen, Zhihua Jia, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2017 18:82
    Content type: Research Published on:

  21. Several RCT studies including ours, seem to prove the role of Botulinum toxin type A (BTX-A) in the treatment of trigeminal neuralgia (TN), but no standardized dosing regimen has been established. In our study...

    Authors: Haifeng Zhang, Yajun Lian, Nanchang Xie, Chen Chen and Yake Zheng
    Citation: The Journal of Headache and Pain 2017 18:81
    Content type: Research article Published on:

  22. The available data on gender differences in clinical migraine parameters among pediatric patients are based on relatively few studies, which did not use the current version of the International Classification ...

    Authors: Tal Eidlitz-Markus and Avraham Zeharia
    Citation: The Journal of Headache and Pain 2017 18:80
    Content type: Research article Published on:

  24. OnabotulinumtoxinA has been shown to reduce headache-days among patients with chronic migraine (CM). The objective of this analysis was to determine whether onabotulinumtoxinA has an impact on headache-day sev...

    Authors: Manjit Matharu, Rashmi Halker, Patricia Pozo-Rosich, Ronald DeGryse, Aubrey Manack Adams and Sheena K. Aurora
    Citation: The Journal of Headache and Pain 2017 18:78
    Content type: Research article Published on:

  25. Cognitive decline is a major concern in patients with migraine. Depression, anxiety, and/or poor sleep quality are well-known comorbidities of migraine, but available evidence on the subjective cognitive decli...

    Authors: Sun Hwa Lee, Yeonwook Kang and Soo-Jin Cho
    Citation: The Journal of Headache and Pain 2017 18:77
    Content type: Research article Published on:

  27. OnabotulinumtoxinA has proven its efficacy in reducing the number of headache days in chronic migraine (CM) patients. The usual paradigm includes 31 pericranial injection sites with low dose (5 U) per site. Th...

    Authors: Danièle Ranoux, Gaelle Martiné, Gaëlle Espagne-Dubreuilh, Marlène Amilhaud-Bordier, François Caire and Laurent Magy
    Citation: The Journal of Headache and Pain 2017 18:75
    Content type: Research article Published on:

  28. Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that so...

    Authors: Jilei Zhang, Yi-Lan Wu, Jingjing Su, Qian Yao, Mengxing Wang, Ge-Fei Li, Rong Zhao, Yan-Hui Shi, Ying Zhao, Qiting Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Guo-Hong Cui, Jianqi Li, Jian-Ren Liu…
    Citation: The Journal of Headache and Pain 2017 18:74
    Content type: Research article Published on:

  30. Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of pre...

    Authors: Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti and Silvia Marino
    Citation: The Journal of Headache and Pain 2017 18:72
    Content type: Research article Published on:

  31. Hemicrania continua (HC), paroxysmal hemicrania (PH) and short lasting neuralgiform headache attacks (SUNCT and SUNA) are rare syndromes with a difficult therapeutic approach. The aim of this review is to summ...

    Authors: Carlo Baraldi, Lanfranco Pellesi, Simona Guerzoni, Maria Michela Cainazzo and Luigi Alberto Pini
    Citation: The Journal of Headache and Pain 2017 18:71
    Content type: Research article Published on:

  32. Neuroimaging data has implicated the temporal pole (TP) in migraine pathophysiology; the density and functional activity of the TP were reported to fluctuate in accordance with the migraine cycle. Yet, the exa...

    Authors: Francesca Cortese, Francesco Pierelli, Ilaria Bove, Cherubino Di Lorenzo, Maurizio Evangelista, Armando Perrotta, Mariano Serrao, Vincenzo Parisi and Gianluca Coppola
    Citation: The Journal of Headache and Pain 2017 18:70
    Content type: Research article Published on:

  33. Mainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age...

    Authors: Kai Le, Dafan Yu, Jiamin Wang, Abdoulaye Idriss Ali and Yijing Guo
    Citation: The Journal of Headache and Pain 2017 18:69
    Content type: Research article Published on:

  34. Authors: Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Nappi Giuseppe, Marcella Neri and Cristina Cereda
    Citation: The Journal of Headache and Pain 2017 18:68
    Content type: Erratum Published on:

    The original article was published in The Journal of Headache and Pain 2017 18:63

  35. Individually both migraine and post-traumatic stress disorder (PTSD) prevalence estimates are higher among women. However, there is limited data on the association of migraine and PTSD in women during pregnancy.

    Authors: Lauren E. Friedman, Christina Aponte, Rigoberto Perez Hernandez, Juan Carlos Velez, Bizu Gelaye, Sixto E. Sánchez, Michelle A. Williams and B. Lee Peterlin
    Citation: The Journal of Headache and Pain 2017 18:67
    Content type: Research article Published on:

  36. Chronic migraine is a complex clinical condition often undertreated. Onabotulinumtoxin A (OBT-A) was approved in Italy in 2013 for symptom relief in patients with chronic migraine who have failed, or do not to...

    Authors: Cristina Tassorelli, Marco Aguggia, Marina De Tommaso, Pierangelo Geppetti, Licia Grazzi, Luigi Alberto Pini, Paola Sarchielli, Gioacchino Tedeschi, Paolo Martelletti and Pietro Cortelli
    Citation: The Journal of Headache and Pain 2017 18:66
    Content type: Research article Published on:

  38. No evidence is available on the risks of neurologically asymptomatic minimal traumatic intracranial hemorrhage (mTIH) in patients with traumatic brain injury (TBI) for post-traumatic headache (PTH). The purpos...

    Authors: Chang-Ki Hong, Yu Shik Shim, Sook Young Sim, Jin-Yang Joo, Min A Kwon, Yong Bae Kim and Joonho Chung
    Citation: The Journal of Headache and Pain 2017 18:64
    Content type: Research article Published on:

  39. Sporadic Hemiplegic Migraine is a rare form of migraine headache. Mutations in three different genes, two ion-channel genes and one encoding an ATP exchanger, CACNA1A, ATP1A2 and SCN1A are all responsible for the...

    Authors: Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Giuseppe Nappi, Marcella Neri and Cristina Cereda
    Citation: The Journal of Headache and Pain 2017 18:63
    Content type: Case report Published on:

    The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:68

  40. It is widely recognised that there are associations between headache, psychiatric comorbidity and attachment insecurity in both adults and children. The aims of this study were: 1) to compare perceived attachm...

    Authors: Riccardo Williams, Luigi Leone, Noemi Faedda, Giulia Natalucci, Benedetta Bellini, Elisa Salvi, Paola Verdecchia, Rita Cerutti, Marco Arruda and Vincenzo Guidetti
    Citation: The Journal of Headache and Pain 2017 18:62
    Content type: Research article Published on:

  41. Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of th...

    Authors: André Erdling, Majid Sheykhzade and Lars Edvinsson
    Citation: The Journal of Headache and Pain 2017 18:61
    Content type: Research article Published on:

  42. Given that post-traumatic headache is one of the most prevalent and long-lasting post-concussion sequelae, causes significant morbidity, and might be associated with slower neurocognitive recovery, we sought t...

    Authors: Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen
    Citation: The Journal of Headache and Pain 2017 18:60
    Content type: Research article Published on:

  43. Central sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This stud...

    Authors: Marina de Tommaso, Vittorio Sciruicchio, Marianna Delussi, Eleonora Vecchio, Marvita Goffredo, Michele Simeone and Maria Grazia Foschino Barbaro
    Citation: The Journal of Headache and Pain 2017 18:59
    Content type: Research article Published on:

  44. Headache disorders are the third-highest cause of disability worldwide, with migraine and medication-overuse headache (MOH) the major contributors. In Ethiopia we have shown these disorders to be highly preval...

    Authors: Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas and Timothy J Steiner
    Citation: The Journal of Headache and Pain 2017 18:58
    Content type: Research article Published on:

  46. Drug withdrawal still remains the key element in the treatment of Medication Overuse Headache (MOH), but there is no consensus about the withdrawal procedure. Still debated is the role of the steroid therapy. ...

    Authors: Sabina Cevoli, Giulia Giannini, Valentina Favoni, Rossana Terlizzi, Elisa Sancisi, Marianna Nicodemo, Stefano Zanigni, Maria Letizia Bacchi Reggiani, Giulia Pierangeli and Pietro Cortelli
    Citation: The Journal of Headache and Pain 2017 18:56
    Content type: Research article Published on:

  47. Headache disorders are highly prevalent, and have a substantial and negative impact on health worldwide. They are largely treatable, but differences in structure, objectives, organization and delivery affect t...

    Authors: L. Pellesi, S. Benemei, V. Favoni, C. Lupi, E. Mampreso, A. Negro, M. Paolucci, T. J. Steiner, M. Ulivi, S. Cevoli and S. Guerzoni
    Citation: The Journal of Headache and Pain 2017 18:55
    Content type: Research article Published on:

  48. The aim of this study was to evaluate the changes in the cognitive performance of migraine patients using a comprehensive series of cognitive/behavioral and electrophysiological tests.

    Authors: Lifang Huang, Hong juan Dong, Xi Wang, Yan Wang and Zheman Xiao
    Citation: The Journal of Headache and Pain 2017 18:54
    Content type: Research article Published on:

  49. The Eurolight project assessed the impact of headache disorders in ten EU countries, using the same structured questionnaire but varying sampling methods. In Lithuania, sample selection employed methods in lin...

    Authors: Daiva Rastenytė, Dalia Mickevičienė, Lars Jacob Stovner, Hallie Thomas, Colette Andrée and Timothy J Steiner
    Citation: The Journal of Headache and Pain 2017 18:53
    Content type: Research article Published on:

  50. Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascul...

    Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Oswaldo Hernández-Abreu, Bruce L. Daugherty, Antoinette MaassenVanDenBrink and Carlos M. Villalón
    Citation: The Journal of Headache and Pain 2017 18:52
    Content type: Research article Published on:
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