The Journal of Headache and Pain is the official journal of the European Headache Federation, Lifting The Burden, and the Asian Regional Consortium for Headache.
Articles
Page 20 of 67
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Citation: The Journal of Headache and Pain 2018 19:32
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The NRP1 migraine risk variant shows evidence of association with menstrual migraine
In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificit...
Citation: The Journal of Headache and Pain 2018 19:31 -
Comment on Castien et al. (2018) pressure pain thresholds over the cranio-cervical region in headache - a systematic review and meta-analysis
Citation: The Journal of Headache and Pain 2018 19:30 -
Polygenic risk score: use in migraine research
The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing. T...
Citation: The Journal of Headache and Pain 2018 19:29 -
Discovery of PACAP and its receptors in the brain
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...
Citation: The Journal of Headache and Pain 2018 19:28 -
Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study
Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.
Citation: The Journal of Headache and Pain 2018 19:27 -
Altered muscle activity during rest and during mental or physical activity is not a trait symptom of migraine - a neck muscle EMG study
Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...
Citation: The Journal of Headache and Pain 2018 19:26 -
The epidemiology of headache disorders: a face-to-face interview of participants in HUNT4
The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.
Citation: The Journal of Headache and Pain 2018 19:25 -
Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures
The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...
Citation: The Journal of Headache and Pain 2018 19:24 -
PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...
Citation: The Journal of Headache and Pain 2018 19:23 -
The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system
Calcitonin gene-related peptide (CGRP) has long been a focus of migraine research, since it turned out that inhibition of CGRP or CGRP receptors by antagonists or monoclonal IgG antibodies was therapeutic in f...
Citation: The Journal of Headache and Pain 2018 19:22 -
PACAP and its role in primary headaches
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...
Citation: The Journal of Headache and Pain 2018 19:21 -
PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache
The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannu...
Citation: The Journal of Headache and Pain 2018 19:20 -
Protective effects of PACAP in ischemia
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...
Citation: The Journal of Headache and Pain 2018 19:19 -
Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey
Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...
Citation: The Journal of Headache and Pain 2018 19:18 -
Migraine is first cause of disability in under 50s: will health politicians now take notice?
Citation: The Journal of Headache and Pain 2018 19:17 -
PACAP and its receptors in cranial arteries and mast cells
In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...
Citation: The Journal of Headache and Pain 2018 19:16 -
The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility
Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...
Citation: The Journal of Headache and Pain 2018 19:15 -
Measurement and implications of the distance between the sphenopalatine ganglion and nasal mucosa: a neuroimaging study
Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...
Citation: The Journal of Headache and Pain 2018 19:14 -
Long-term study of the efficacy and safety of OnabotulinumtoxinA for the prevention of chronic migraine: COMPEL study
OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.
Citation: The Journal of Headache and Pain 2018 19:13 -
The Headache-Attributed Lost Time (HALT) Indices: measures of burden for clinical management and population-based research
The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...
Citation: The Journal of Headache and Pain 2018 19:12 -
Cilostazol induced migraine does not respond to sumatriptan in a double blind trial
Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...
Citation: The Journal of Headache and Pain 2018 19:11 -
Poor medical care for people with migraine in Europe – evidence from the Eurolight study
Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...
Citation: The Journal of Headache and Pain 2018 19:10 -
Pressure pain thresholds over the cranio-cervical region in headache: a systematic review and meta-analysis
Sensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. ...
Citation: The Journal of Headache and Pain 2018 19:9 -
Headache following head injury: a population-based longitudinal cohort study (HUNT)
Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether sub...
Citation: The Journal of Headache and Pain 2018 19:8 -
PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord
Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunit...
Citation: The Journal of Headache and Pain 2018 19:7 -
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry
Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcom...
Citation: The Journal of Headache and Pain 2018 19:6 -
Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation
Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with ...
Citation: The Journal of Headache and Pain 2018 19:5 -
Comparison of gray matter volume between migraine and “strict-criteria” tension-type headache
Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both t...
Citation: The Journal of Headache and Pain 2018 19:4 -
Effect of a calcitonin gene-related peptide-binding L-RNA aptamer on neuronal activity in the rat spinal trigeminal nucleus
Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues inc...
Citation: The Journal of Headache and Pain 2018 19:3 -
The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine
Migraine remains one of the biggest clinical case to be solved among the non-communicable diseases, second to low back pain for disability caused as reported by the Global Burden of Disease Study 2016. Despite...
Citation: The Journal of Headache and Pain 2018 19:2 -
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study
Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirme...
Citation: The Journal of Headache and Pain 2018 19:1 -
The burden of headache is associated to pain interference, depression and headache duration in chronic tension type headache: a 1-year longitudinal study
To investigate variables associated at one year (longitudinal design) with the physical or emotional component of burden in chronic tension type headache (CTTH).
Citation: The Journal of Headache and Pain 2017 18:119 -
Sphenopalatine ganglion: block, radiofrequency ablation and neurostimulation - a systematic review
Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its e...
Citation: The Journal of Headache and Pain 2017 18:118 -
Characterization of migraineurs presenting interictal widespread pressure hyperalgesia identified using a tender point count: a cross-sectional study
Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressu...
Citation: The Journal of Headache and Pain 2017 18:117 -
The enigma of site of action of migraine preventives: no effect of metoprolol on trigeminal pain processing in patients and healthy controls
Beta-blockers are a first choice migraine preventive medication. So far it is unknown how they exert their therapeutic effect in migraine. To this end we examined the neural effect of metoprolol on trigeminal ...
Citation: The Journal of Headache and Pain 2017 18:116 -
Cerebral gray matter volume in patients with chronic migraine: correlations with clinical features
To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morph...
Citation: The Journal of Headache and Pain 2017 18:115 -
Characteristics and diagnoses of acute headache in pregnant women – a retrospective cross-sectional study
Acute headache is one of the most frequent neurological symptoms in pregnant women. The early diagnosis of underlying secondary conditions has a major influence on patient outcome, especially in emergency sett...
Citation: The Journal of Headache and Pain 2017 18:114 -
11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches
Citation: The Journal of Headache and Pain 2017 18(Suppl 1):111 -
Experts’ opinion about the pediatric secondary headaches diagnostic criteria of the ICHD-3 beta
The 2013 International Classification of Headache Disorders-3 was published in a beta version to allow clinicians to confirm the validity of the criteria or suggest improvements based on field studies. The aim...
Citation: The Journal of Headache and Pain 2017 18:113 -
Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis
Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR...
Citation: The Journal of Headache and Pain 2017 18:112 -
PACAP38 in human models of primary headaches
To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.
Citation: The Journal of Headache and Pain 2017 18:110 -
Experts’ opinion about the primary headache diagnostic criteria of the ICHD-3rd edition beta in children and adolescents
The 2013 International Classification of Headache Disorders-3 (ICHD-3) was published in a beta version to allow the clinicians to confirm the validity of the criteria or to suggest improvements based on field ...
Citation: The Journal of Headache and Pain 2017 18:109 -
Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)
Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migra...
Citation: The Journal of Headache and Pain 2017 18:108 -
Caffeine in the management of patients with headache
Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmac...
Citation: The Journal of Headache and Pain 2017 18:107 -
Headache and pregnancy: a systematic review
This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...
Citation: The Journal of Headache and Pain 2017 18:106 -
Burden of migraine in a Kuwaiti population: a door-to-door survey
Migraine prevalence and disability imprints on Kuwaiti population are underreported. We aimed to measure the prevalence of migraine and to assess its burden in Kuwait.
Citation: The Journal of Headache and Pain 2017 18:105 -
The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats
Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α1/α2-adrenoceptors. Since activation of vascular α1/α2-adrenoceptors ...
Citation: The Journal of Headache and Pain 2017 18:104 -
Triptans and CGRP blockade – impact on the cranial vasculature
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...
Citation: The Journal of Headache and Pain 2017 18:103 -
Patients’ preferences for headache acute and preventive treatment
We aimed to explore patients’ preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo.
Citation: The Journal of Headache and Pain 2017 18:102
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