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  1. Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migr...

    Authors: Angela Koverech, Claudia Cicione, Luana Lionetto, Marta Maestri, Francesco Passariello, Elisabetta Sabbatini, Matilde Capi, Cristiano Maria De Marco, Martina Guglielmetti, Andrea Negro, Luisa Di Menna, Maurizio Simmaco, Ferdinando Nicoletti and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2019 20:61
    Content type: Research article Published on:

  3. Elevation of intracranial pressure in idiopathic intracranial hypertension induces an edema of the prelaminar section of the optic nerve (papilledema). Beside the commonly observed optic nerve sheath distentio...

    Authors: Jan Hoffmann, Katharina Maria Kreutz, Christoph Csapó-Schmidt, Nils Becker, Hagen Kunte, Lucius Samo Fekonja, Anas Jadan and Edzard Wiener
    Citation: The Journal of Headache and Pain 2019 20:59
    Content type: Research article Published on:

  4. Abstract

    Authors: Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2019 20:58
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2019 20:6

    The Letter to the Editor to this article has been published in The Journal of Headache and Pain 2019 20:67

    The Letter to the Editor to this article has been published in The Journal of Headache and Pain 2019 20:22

  5. The Aids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the ...

    Authors: T. J. Steiner, R. Jensen, Z. Katsarava, M. Linde, E. A. MacGregor, V. Osipova, K. Paemeleire, J. Olesen, M. Peters and P. Martelletti
    Citation: The Journal of Headache and Pain 2019 20:57
    Content type: Consensus article Published on:

  6. Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functio...

    Authors: Leda Marina Pomes, Martina Guglielmetti, Enrico Bertamino, Maurizio Simmaco, Marina Borro and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2019 20:56
    Content type: Review article Published on:

  7. After publication of the original article 1, the authors have notified us that the row corresponding to the “Alniditan” drug shouldn’t have been included in Table 1. Table 1 should therefore be presented as be...

    Authors: Thien Phu Do, Song Guo and Messoud Ashina
    Citation: The Journal of Headache and Pain 2019 20:55
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2019 20:37

  8. The treatment of migraine is impeded by several difficulties, among which insufficient headache relief, side effects, and risk for developing medication overuse headache (MOH). Thus, new acutely acting antimig...

    Authors: Willem Sebastiaan van Hoogstraten and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2019 20:54
    Content type: Review article Published on:

  9. Brainstem raphe (BR) hypoechogenicity in transcranial sonography (TCS) has been depicted in patients with major depression (MD) and in depressed patients with different neurodegenerative diseases. But, up to d...

    Authors: Wei-Wei Tao, Xin-Ting Cai, Jie Shen, Xue-Gong Shi and Yu Wang
    Citation: The Journal of Headache and Pain 2019 20:53
    Content type: Research article Published on:

  11. Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migrain...

    Authors: Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello and Gianluca Serafini
    Citation: The Journal of Headache and Pain 2019 20:51
    Content type: Review article Published on:

  13. Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden. Preventive treatments are required to reduc...

    Authors: Cindy Tiseo, Raffaele Ornello, Francesca Pistoia and Simona Sacco
    Citation: The Journal of Headache and Pain 2019 20:49
    Content type: Review article Published on:

  14. Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field stre...

    Authors: Casper Emil Christensen, Samaira Younis, Ulrich Lindberg, Vincent Oltman Boer, Patrick de Koning, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2019 20:48
    Content type: Methodology Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2019 20:62

  15. Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize th...

    Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Kristian A. Haanes, René de Vries, Ruben Dammers, A. J. J. C. Bogers, Antoon van den Bogaerdt, Bruce L. Daugherty, Alexander H. J. Danser, Carlos M. Villalón and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2019 20:47
    Content type: Research article Published on:

  16. Despite the growing body of advanced studies investigating the neuronal correlates of pain processing in patients with migraine without aura (MwoA), only few similar studies have been conducted in patients wit...

    Authors: Antonio Russo, Alessandro Tessitore, Marcello Silvestro, Federica Di Nardo, Francesca Trojsi, Teresa Del Santo, Rosa De Micco, Fabrizio Esposito and Gioacchino Tedeschi
    Citation: The Journal of Headache and Pain 2019 20:46
    Content type: Research article Published on:

  17. Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine au...

    Authors: Andrea M. Harriott, Tsubasa Takizawa, David Y. Chung and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2019 20:45
    Content type: Review article Published on:

  18. Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor bloc...

    Authors: Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan and Cen Xu
    Citation: The Journal of Headache and Pain 2019 20:44
    Content type: Research article Published on:

  19. Migraine is a neurovascular primary headache disorder, which causes significant socioeconomic problems worldwide. The pathomechanism of disease is enigmatic, but activation of the trigeminovascular system (TS)...

    Authors: Tamás Körtési, Bernadett Tuka, Aliz Nyári, László Vécsei and János Tajti
    Citation: The Journal of Headache and Pain 2019 20:43
    Content type: Research article Published on:

  20. The purpose of this review is to provide a comprehensive overview of the findings of clinical electrophysiology studies aimed to investigate changes in information processing of migraine with aura patients.

    Authors: Gianluca Coppola, Cherubino Di Lorenzo, Vincenzo Parisi, Marco Lisicki, Mariano Serrao and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2019 20:42
    Content type: Review article Published on:

  22. Using the findings of the Global Burden of Disease Study (GBD), we report the burden of primary headache disorders in the Eastern Mediterranean Region (EMR) from 1990 to 2016.

    Authors: Kia Vosoughi, Lars Jacob Stovner, Timothy J. Steiner, Maziar Moradi-Lakeh, Seyed-Mohammad Fereshtehnejad, Farshad Farzadfar, Pouria Heydarpour, Reza Malekzadeh, Mohsen Naghavi, Mohammad Ali Sahraian, Sadaf G. Sepanlou, Arash Tehrani-Banihashemi, Reza Majdzadeh, Valery L. Feigin, Theo Vos, Ali H. Mokdad…
    Citation: The Journal of Headache and Pain 2019 20:40
    Content type: Research article Published on:

  23. Some variables have been proposed as predictors of efficacy of OnabotulinumtoxinA in chronic migraine patients, but data available are inconclusive. We aimed to analyse the influence of single nucleotide polym...

    Authors: R. Moreno-Mayordomo, M. Ruiz, J. Pascual, M. Gallego de la Sacristana, I. Vidriales, M. Sobrado, E. Cernuda-Morollon, A. B. Gago-Veiga, D. Garcia-Azorin, J. J. Telleria and A. L. Guerrero
    Citation: The Journal of Headache and Pain 2019 20:39
    Content type: Research article Published on:

  24. Several studies have suggested cognitive deficits in migraineurs, and sex differences have also been observed in migraine, such as a higher prevalence in females. Nevertheless, little is known about gender-rel...

    Authors: Yunliang Guo, Song Xu, Shanjing Nie, Mimi Han, Yue Zhang, Jian Chen, Xunyao Hou, Yan Hong and Xueping Liu
    Citation: The Journal of Headache and Pain 2019 20:38
    Content type: Research article Published on:

  26. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with ...

    Authors: Jingjing Su, Mengxing Wang, Shiyu Ban, Liang Wang, Xin Cheng, Fengchun Hua, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du and Jianren Liu
    Citation: The Journal of Headache and Pain 2019 20:36
    Content type: Research article Published on:

  27. Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of sym...

    Authors: Andreas Straube and Anna Andreou
    Citation: The Journal of Headache and Pain 2019 20:35
    Content type: Review article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2019 20:71

  28. Head trauma has been described as a precipitating event in Nummular Headache (NH). We aimed to describe the largest NH published series and compare characteristics between idiopathic and post-traumatic cases.

    Authors: Javier Trigo, David García-Azorín, Enrique Martinez Pias, Álvaro Sierra, Alba Chavarría and Angel Luis Guerrero
    Citation: The Journal of Headache and Pain 2019 20:34
    Content type: Research article Published on:

  29. Migraine headache and vestibular-type vertigo co-occur in the general population about three times more often than expected by chance. Attacks of episodic vertigo (eV) are currently not recognized as migraine ...

    Authors: Christian Lampl, Alan Rapoport, Moris Levin and Elisabeth Bräutigam
    Citation: The Journal of Headache and Pain 2019 20:33
    Content type: Research article Published on:

  30. While migraine headaches can be provoked, or predicted by the presence of an aura or premonitory symptoms, the prediction or elicitation of the aura itself is more problematic. Therefore, imaging studies direc...

    Authors: Nouchine Hadjikhani and Maurice Vincent
    Citation: The Journal of Headache and Pain 2019 20:32
    Content type: Review article Published on:

  31. Precision medicine may offer new strategies to treat migraine, and access to existing large cohorts may be a key resource to increase statistical power. Treatment response data is not routinely collected for l...

    Authors: Thomas Folkmann Hansen, Mona Ameri Chalmer, Thilde Marie Haspang, Lisette Kogelman and Jes Olesen
    Citation: The Journal of Headache and Pain 2019 20:31
    Content type: Research article Published on:

  34. Self-management interventions are well recognised and widely used in chronic conditions. Their application to chronic headaches has been limited and generally of low quality. We describe here our process for d...

    Authors: Shilpa Patel, Rachel Potter, Manjit Matharu, Dawn Carnes, Stephanie J. C. Taylor, Vivien Nichols, Tamar Pincus, Martin Underwood and Harbinder Sandhu
    Citation: The Journal of Headache and Pain 2019 20:28
    Content type: Research article Published on:

  35. Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors ...

    Authors: Valentina Favoni, Luca Giani, Linda Al-Hassany, Gian Maria Asioli, Calogera Butera, Irene de Boer, Martina Guglielmetti, Chrysoula Koniari, Theodoros Mavridis, Marge Vaikjärv, Iris Verhagen, Angela Verzina, Bart Zick, Paolo Martelletti and Simona Sacco
    Citation: The Journal of Headache and Pain 2019 20:27
    Content type: Review article Published on:

  36. The PREEMPT Studies established onabotulinumtoxinA as preventive treatment for adults with chronic migraine (CM). The purpose of the REal-life use of botulinum toxin for the symptomatic treatment of adults with c...

    Authors: Fayyaz Ahmed, Charly Gaul, Juan Carlos García-Moncó, Katherine Sommer and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2019 20:26
    Content type: Research article Published on:

  37. The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand their mechanisms in migraine by inve...

    Authors: Liwen Jiang, Dongqing Ma, Blair D. Grubb and Minyan Wang
    Citation: The Journal of Headache and Pain 2019 20:25
    Content type: Research article Published on:

  38. In joint initiatives, the European Headache Federation and Lifting The Burden have described a model of structured headache services (with their basis in primary care), defined service quality in this context, an...

    Authors: T. J. Steiner, H. Göbel, R. Jensen, C. Lampl, K. Paemeleire, M. Linde, M. Braschinsky, D. Mitsikostas, R. Gil-Gouveia and Z. Katsarava
    Citation: The Journal of Headache and Pain 2019 20:24
    Content type: Brief report Published on:

  39. Prognosis of medically treated trigeminal neuralgia patients is assumed to be poor, but the evidence is lacking. Thus, prospective real-life studies of medical management of trigeminal neuralgia are warranted.

    Authors: Tone Bruvik Heinskou, Stine Maarbjerg, Frauke Wolfram, Per Rochat, Jannick Brennum, Jes Olesen and Lars Bendtsen
    Citation: The Journal of Headache and Pain 2019 20:23
    Content type: Research article Published on:

  40. Authors: Russell Nichols, Vladimir Skljarevski, Grazia Dell’Agnello, Hans-Peter Hundemer and Sheena K. Aurora
    Citation: The Journal of Headache and Pain 2019 20:22
    Content type: Letter to the Editor Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2019 20:58

  41. Disrupted sleep is associated with a reciprocal influence on headaches and is one of the contributing factors in the process of chronicity. The goal of the present study was to investigate the influence of sle...

    Authors: Seong Hoon Kim, Ju Yeon Park, Hae Eun Shin, Si baek Lee, Dong Woo Ryu, Tae Won Kim and Jeong Wook Park
    Citation: The Journal of Headache and Pain 2019 20:21
    Content type: Research article Published on:

  42. Trigeminal neuralgia is one of the most characteristic and difficult to treat neuropathic pain conditions in patients with multiple sclerosis. The present narrative review addresses the current evidence on dia...

    Authors: Giulia Di Stefano, Stine Maarbjerg and Andrea Truini
    Citation: The Journal of Headache and Pain 2019 20:20
    Content type: Review article Published on:

  43. Many different preventatives have showed efficacy in the treatment of migraine. National guidelines differ in their recommendations and patients’ characteristics are usually taken into account in their selecti...

    Authors: D. García-Azorin, S. Santos-Lasaosa, A. B. Gago-Veiga, J. Viguera Romero and A. L. Guerrero-Peral
    Citation: The Journal of Headache and Pain 2019 20:19
    Content type: Research article Published on:

  44. Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks. Although migraine provoking substances are normally vasodilators, d...

    Authors: Francesco De Logu, Lorenzo Landini, Malvin N. Janal, Simone Li Puma, Francesco De Cesaris, Pierangelo Geppetti and Romina Nassini
    Citation: The Journal of Headache and Pain 2019 20:18
    Content type: Research article Published on:

  45. Headache disorder is not only a common complaint but also a global burden. Pharmacotherapeutic and non-pharmacotherapeutic approaches have been developed for its treatment and prophylaxis. The present study in...

    Authors: Hye Jeong Lee, Jin Hyeok Lee, Eun Young Cho, Sun Mi Kim and Seoyoung Yoon
    Citation: The Journal of Headache and Pain 2019 20:17
    Content type: Research article Published on:

  46. In patients with frequent migraine, prophylactic treatments are used. Patients often request non-pharmacological alternatives. One treatment option can be aerobic exercise. The value of aerobic exercise as pro...

    Authors: Joris Lemmens, Joke De Pauw, Timia Van Soom, Sarah Michiels, Jan Versijpt, Eric van Breda, René Castien and Willem De Hertogh
    Citation: The Journal of Headache and Pain 2019 20:16
    Content type: Review article Published on:

  47. Case-finding tools, such as the Identify Chronic Migraine (ID-CM) questionnaire, can improve detection of CM and alleviate its significant societal burden. We aimed to develop and validate the Italian version ...

    Authors: Simona Sacco, Silvia Benemei, Sabina Cevoli, Gianluca Coppola, Pietro Cortelli, Francesco De Cesaris, Roberto De Icco, Cristiano Maria De Marco, Cherubino Di Lorenzo, Pierangelo Geppetti, Alessia Manni, Andrea Negro, Raffaele Ornello, Giulia Pierangeli, Francesco Pierelli, Lanfranco Pellesi…
    Citation: The Journal of Headache and Pain 2019 20:15
    Content type: Research article Published on:

  48. Following publication of the original article [1], we have been notified that the name of author five was spelled incorrectly as M. Ferrili, when the correct spelling is MAN Ferilli.

    Authors: D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. A. N. Ferilli, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese
    Citation: The Journal of Headache and Pain 2019 20:14
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2018 19:90

  49. The highest prevalence of migraine is detected among people who are of working age. The aim of this study was to assess the burden of migraine in an occupational health care setting using real world data colle...

    Authors: Minna A. Korolainen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Madlaina Costa-Scharplatz, Timo Purmonen and Markku Nissilä
    Citation: The Journal of Headache and Pain 2019 20:13
    Content type: Research article Published on:

  50. OnabotulinumtoxinA is effective in preventing chronic migraine (CM); however, the benefit of onabotulinumtoxinA in patients with CM with daily headache is unknown because these patients are typically excluded ...

    Authors: William B. Young, J. Ivan Lopez, John F. Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B. Lipton and Andrew M. Blumenfeld
    Citation: The Journal of Headache and Pain 2019 20:12
    Content type: Research article Published on:
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