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  1. Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy ...

    Authors: Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti and Francesco Saverio Mennini
    Citation: The Journal of Headache and Pain 2020 21:44
  2. Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic...

    Authors: M. Torres-Ferrús, F. Ursitti, A. Alpuente, F. Brunello, D. Chiappino, T. de Vries, S. Di Marco, S. Ferlisi, L. Guerritore, N. Gonzalez-Garcia, A. Gonzalez-Martinez, D. Khutorov, M. Kritsilis, A. Kyrou, T. Makeeva, A. Minguez-Olaondo…
    Citation: The Journal of Headache and Pain 2020 21:42
  3. Migraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, ar...

    Authors: Louise Lombard, Mallory Farrar, Wenyu Ye, Yongin Kim, Sarah Cotton, Andrew S. Buchanan, James Jackson and Shivang Joshi
    Citation: The Journal of Headache and Pain 2020 21:41
  4. Treatment with onabotulinumtoxin A (BT-A) is safe and effective for chronic migraine (CM). Several studies assessed possible predictors of response to treatment with BT-A, but there is little knowledge on the ...

    Authors: Raffaele Ornello, Simona Guerzoni, Carlo Baraldi, Luana Evangelista, Ilaria Frattale, Carmine Marini, Cindy Tiseo, Francesca Pistoia and Simona Sacco
    Citation: The Journal of Headache and Pain 2020 21:40
  5. Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.

    Authors: Lilla Bonanno, Viviana Lo Buono, Simona De Salvo, Claudio Ruvolo, Viviana Torre, Placido Bramanti, Silvia Marino and Francesco Corallo
    Citation: The Journal of Headache and Pain 2020 21:39
  6. The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and providing the best possible care to infected patients, a...

    Authors: Antoinette MaassenVanDenBrink, Tessa de Vries and A. H. Jan Danser
    Citation: The Journal of Headache and Pain 2020 21:38
  7. The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a s...

    Authors: Emer O’Connor, Benjamin S. Simpson, Henry Houlden, Jana Vandrovcova and Manjit Matharu
    Citation: The Journal of Headache and Pain 2020 21:37
  8. The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund’s adjuvant (C...

    Authors: Edina K. Cseh, Gábor Veres, Tamás Körtési, Helga Polyák, Nikolett Nánási, János Tajti, Árpád Párdutz, Péter Klivényi, László Vécsei and Dénes Zádori
    Citation: The Journal of Headache and Pain 2020 21:35
  9. Short-latency afferent inhibition (SAI) consists of motor cortex inhibition induced by sensory afferents and depends on the excitatory effect of cholinergic thalamocortical projections on inhibitory GABAergic ...

    Authors: Gianluca Coppola, Davide Di Lenola, Chiara Abagnale, Fabio Ferrandes, Gabriele Sebastianelli, Francesco Casillo, Cherubino Di Lorenzo, Mariano Serrao, Maurizio Evangelista, Jean Schoenen and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2020 21:34
  10. Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients wi...

    Authors: Soo-Kyoung Kim, Catherine D. Chong, Gina Dumkrieger, Katherine Ross, Visar Berisha and Todd J. Schwedt
    Citation: The Journal of Headache and Pain 2020 21:33
  11. We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

    Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco
    Citation: The Journal of Headache and Pain 2020 21:32
  12. The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...

    Authors: Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares and Raquel Gil-Gouveia
    Citation: The Journal of Headache and Pain 2020 21:31
  13. The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, ...

    Authors: Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2020 21:29
  14. Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms o...

    Authors: S. P. Mollan, K. Paemeleire, J. Versijpt, R. Luqmani and A. J. Sinclair
    Citation: The Journal of Headache and Pain 2020 21:28
  15. Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased ...

    Authors: Jessica L. Rohmann, Pamela M. Rist, Julie E. Buring and Tobias Kurth
    Citation: The Journal of Headache and Pain 2020 21:27
  16. Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency faci...

    Authors: Andrea Negro, Valerio Spuntarelli, Paolo Sciattella and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2020 21:25
  17. The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal ass...

    Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart
    Citation: The Journal of Headache and Pain 2020 21:24
  18. Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) freq...

    Authors: Dawn C. Buse, Michael L. Reed, Kristina M. Fanning, Ryan Bostic, David W. Dodick, Todd J. Schwedt, Sagar Munjal, Preeti Singh and Richard B. Lipton
    Citation: The Journal of Headache and Pain 2020 21:23
  19. Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migrai...

    Authors: Zeinab Ghorbani, Pegah Rafiee, Akbar Fotouhi, Samane Haghighi, Reyhaneh Rasekh Magham, Zeynab Sadat Ahmadi, Mahmoud Djalali, Mahnaz Zareei, Soodeh Razeghi Jahromi, Sahar Shahemi, Maryam Mahmoudi and Mansoureh Togha
    Citation: The Journal of Headache and Pain 2020 21:22
  20. Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of...

    Authors: Richard B. Lipton, Louise Lombard, Dustin D. Ruff, John H. Krege, Li Shen Loo, Andrew Buchanan, Thomas E. Melby and Dawn C. Buse
    Citation: The Journal of Headache and Pain 2020 21:20
  21. Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache pr...

    Authors: Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Matias Metcalf-Clausen, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2020 21:19
  22. To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

    Authors: Di Zhang, Xiaobin Huang, Wen Su, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu
    Citation: The Journal of Headache and Pain 2020 21:17
  23. People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity thr...

    Authors: Gwendolyne G. M. Scholten-Peeters, Michel W. Coppieters, Tom S. C. Durge and René F. Castien
    Citation: The Journal of Headache and Pain 2020 21:16
  24. The terminology “gut-brain axis “points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some...

    Authors: Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco and Mansoureh Togha
    Citation: The Journal of Headache and Pain 2020 21:15
  25. Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomiz...

    Authors: Yanbo Yang, Zilan Wang, Bixi Gao, He Xuan, Yun Zhu, Zhouqing Chen and Zhong Wang
    Citation: The Journal of Headache and Pain 2020 21:14
  26. Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthines...

    Authors: Yating Zhao, Ruixia Zhu, Tongling Xiao and Xu Liu
    Citation: The Journal of Headache and Pain 2020 21:13
  27. The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include most of Eastern Mediterranean Region (EMR). Following a nationwide population-based study in Pakistan, we...

    Authors: Mohammed Al Jumah, Ali M. Al Khathaami, Suleman Kojan, Mohamed Hussain, Hallie Thomas and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2020 21:11
  28. To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarker...

    Authors: Ane Mínguez-Olaondo, Iván Martínez-Valbuena, Sonia Romero, Gema Frühbeck, María Rosario Luquin, Eduardo Martínez-Vila and Pablo Irimia
    Citation: The Journal of Headache and Pain 2020 21:9
  29. Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age u...

    Authors: Minna A. Korolainen, Samuli Tuominen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Timo Purmonen, Jaana Santaholma and Markku Nissilä
    Citation: The Journal of Headache and Pain 2020 21:8
  30. Dural arteriovenous fistulas are intracranial vascular malformations, fed by dural arteries and draining venous sinuses or meningeal veins. Clinical course varies widely and ranges from benign with spontaneous...

    Authors: Ilenia Corbelli, Francesca De Maria, Paolo Eusebi, Michele Romoli, Gabriela Cardaioli, Mohammed Hamam, Piero Floridi, Letizia Maria Cupini, Paola Sarchielli and Paolo Calabresi
    Citation: The Journal of Headache and Pain 2020 21:6
  31. A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey wa...

    Authors: Wei Xie, Ruibing Li, Mianwang He, Fang Cui, Tingting Sun, Jianmei Xiong, Dengfa Zhao, Weinan Na, Ruozhuo Liu and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2020 21:5
  32. According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk betwe...

    Authors: Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen and Jiying Zhou
    Citation: The Journal of Headache and Pain 2020 21:4
  33. Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and ...

    Authors: Bereket Duko, Mohammed Ayalew and Alemayehu Toma
    Citation: The Journal of Headache and Pain 2020 21:3
  34. In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account ...

    Authors: Carl H. Göbel, Sarah C. Karstedt, Thomas F. Münte, Hartmut Göbel, Sebastian Wolfrum, Elena R. Lebedeva, Jes Olesen and Georg Royl
    Citation: The Journal of Headache and Pain 2020 21:2
  35. White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is l...

    Authors: Álvaro Planchuelo-Gómez, David García-Azorín, Ángel L. Guerrero, Santiago Aja-Fernández, Margarita Rodríguez and Rodrigo de Luis-García
    Citation: The Journal of Headache and Pain 2020 21:1
  36. Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated with a...

    Authors: Andrea Negro, Paolo Sciattella, Daniele Rossi, Martina Guglielmetti, Paolo Martelletti and Francesco Saverio Mennini
    Citation: The Journal of Headache and Pain 2019 20:120
  37. To evaluate the crossover design in migraine preventive treatment trials by assessing dropout rate, and potential period and carryover effect in four placebo-controlled randomized controlled trials (RCTs).

    Authors: Astrid Bjørke Jenssen, Lars Jacob Stovner, Erling Tronvik, Trond Sand, Grethe Helde, Gøril Bruvik Gravdahl and Knut Hagen
    Citation: The Journal of Headache and Pain 2019 20:119
  38. After publication of our article [1] we were notified that the data presented in the upper row of Fig. 7 was inadvertently the least square mean change from baseline (standard error) at Month 6 rather than the...

    Authors: Stephen D. Silberstein, Virginia L. Stauffer, Katie A. Day, Sarah Lipsius and Maria-Carmen Wilson
    Citation: The Journal of Headache and Pain 2019 20:118

    The original article was published in The Journal of Headache and Pain 2019 20:75

  39. Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has bee...

    Authors: Anna P. Andreou and Lars Edvinsson
    Citation: The Journal of Headache and Pain 2019 20:117
  40. Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions,...

    Authors: Heng-Le Wei, Xin Zhou, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Li-Jie Qu, Xindao Yin, Junrong Li and Hong Zhang
    Citation: The Journal of Headache and Pain 2019 20:116
  41. Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We a...

    Authors: Yu-Hsiang Ling, Shih-Pin Chen, Cathy Shen-Jang Fann, Shuu-Jiun Wang and Yen-Feng Wang
    Citation: The Journal of Headache and Pain 2019 20:115
  42. In the ongoing Global Campaign endeavour to improve knowledge and awareness of headache prevalence worldwide, Mongolia is a country of interest. It sits between Russia and China, in which prevalence is, respec...

    Authors: Otgonbayar Luvsannorov, Byambasuren Tsenddorj, Dorjkhand Baldorj, Selenge Enkhtuya, Delgermaa Purev, Hallie Thomas and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2019 20:114
  43. More than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-expert...

    Authors: Evangelos Kouremenos, Chrysa Arvaniti, Theodoros S. Constantinidis, Ermioni Giannouli, Nikolaos Fakas, Themistoklis Kalamatas, Evangelia Kararizou, Dimitrios Naoumis and Dimos D. Mitsikostas
    Citation: The Journal of Headache and Pain 2019 20:113