%PDF-1.3
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Migraine,Calcitonin gene-related peptide,Migraine prevention,Monoclonal antibodies,Erenumab,Real-life study
Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
application/pdf
10.1186/s10194-020-01102-9
The Journal of Headache and Pain
The Journal of Headache and Pain, 2020, doi:10.1186/s10194-020-01102-9
Migraine
Calcitonin gene-related peptide
Migraine prevention
Monoclonal antibodies
Erenumab
Real-life study
Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy
Raffaele Ornello
Alfonsina Casalena
Ilaria Frattale
Amleto Gabriele
Giannapia Affaitati
Maria Adele Giamberardino
Maurizio Assetta
Maurizio Maddestra
Fabio Marzoli
Stefano Viola
Davide Cerone
Carmine Marini
Francesca Pistoia
Simona Sacco
2020-04-07T12:58:45+02:00
2020-04-07T12:58:45+02:00
2020-04-02T23:33:01+08:00
Arbortext Advanced Print Publisher 9.1.440/W Unicode
uuid:cfaacce9-664a-4626-a967-0efff14fc264
uuid:3992dd5a-1dab-470f-b641-c9829fb66b06
default
1
converted
uuid:cfaacce9-664a-4626-a967-0efff14fc264
converted to PDF/A-2b
pdfToolbox
2020-04-03T01:18:08+08:00
2
B
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
editorInfo
Bag EditorInformation
external
Editor information: contains the name of each editor and his/her ORCID identifier.
seriesEditorInfo
Bag SeriesEditorInformation
external
Series editor information: contains the name of each series editor and his/her ORCID identifier.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
EditorInformation
http://springernature.com/ns/xmpExtensions/2.0/editorInfo/
editor
Specifies the types of editor information: name and ORCID of an editor.
name
Text
Gives the name of an editor.
orcid
URI
Gives the ORCID of an editor.
SeriesEditorInformation
http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/
seriesEditor
Specifies the types of series editor information: name and ORCID of a series editor.
name
Text
Gives the name of a series editor.
orcid
URI
Gives the ORCID of a series editor.
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/pdfx/1.3/
pdfx
PDF/X ID Schema
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
endstream
endobj
3 0 obj
<>stream
xَܽ$ّ%_a/8tf.jF$zdF#,fΕs/bM몦]9"~!oݏ~w7^KwçᏯ~O1߿7}y?vfM
c_ϫ|}n_:|ݻo~^WBW?:x3OwY;mgl7W_}/w2oҡK_wO>_S
ķYoji>|7{kWj^}/U]+^~z"ԫqM~%tOW7|]{;KJizY|/ݭZ)wO9_+_oCCӈ?}' 7꺌>Ǜi5OZA3lпel~Ե?
z?W?XzOu|c?תaVOCZ/R rC\5g?~cz/N̛rß{>\/9i=G,\qӚ+ݹ|܊rX2g-ڨp[i9wXKCZGWwwq@}>yv]Z"\>~Lo??//sʶgIvFI_$o&_O?|ի^߿~N;tE8L}ʺCMSNtF_?NhDZ9oϟ߾%6~O%L^;F-?jW\`b5\?O?ݾ~-f-qk6fC/9OvYʈ?A:o?tcLKnĶ&{xYbQm,U%
]^1%MOնQ_!Zhk"[B}Lk/ç^Mo?S}z݇[**]֤%fզuɁWOKY[?`">m[=&K?-Y_}f.75Tkie]pk,RLS2d]3m/y415_,1SʩſkGҦ iNkߤl:6 e&UXyy+FlCqO
|t`Z~~ZezYM&ѧ>.HVǒY풖_Zޗz\)M!3/*T*k|G߄>4O>zg7%εϕ7~Bi-01`5m~{y ]|jmjds<f֫W1Qcs:lo
Y1ka=Xמ/\qu%kb7={`]n=Dltyjjxi#1.%Y/jěMx{BQ|n?D]1)Iqq\i˽|KYڂMӟsOYqYtCK)9nnkt$
7/N\YGAcfffȟ֥{>of&J^Gھ\f{zC<]/Բӗ>Q/c?:Y
S NqAS*p/?]%9wairCm䗫 M_.Y6t'*/3
xJ;)^8;yrȈ5bu)-"`pK!.)
\ik #ڜXwFmf\قWz|j>d#5^Շ/w=~~}DKweUѓ'ޖ> µAMS[\\K,k6/zK{~{-vӮ7_嚋\i4Pƭ,y͕$l'|'9ݟ>`X|kxBπjհSf21KZ}cI3^0,Kkg?]b!&?JrMH^L(%)mZm-kl@
\>h5
4S}m+S>~=5r%7mf3orLϩYqlj_e Hy_eD[݃ +Y{Ysݽ!{.|vzmg<{xM^ji;ZZɎ]Б6;oO7A{t
<+o_]{;b8{՛0@G
Onߠ3>穏N9&ۏ>o6.*qs7ܯqp7yTؒ_Rz{"x6`/;m}8JmkR+SvuC7Ԙ/ǿhƁڼ=j|
ėaf^^Kدu%?.>ٲYB/6Kڠz
f?7ǐ60#=XF2yϞM~b|mgSs]
F/}||`9fv#?Ro_ߴm79lJI8zѥ)J}>~VK v~oG!^c.:4ew1uc/@}ccI%2նKk47V'֝|#]}-Xй|혣gk/>cؔj=d>1jJ["wge|ut:kWKv{~X؏5q-L$GKFkk#^b79J_ڙ0wGWgxG=u_>'cnݡ{vpg9Mo|`I)-j$ݗ76aFl8w?wd[Uan
ή/\r??fkmGV/)9{'bZo9߬.gtIeSrԾEjYs+>ݿLX8k\l h8ׁTՔO%.x~C@?K5;bww3>܈9Nr'cb>lGCi~[Hۣ0)%)f̊'![ yxG8vN4ww^O6ym4lS=%3F߹hQ+!qTNo'뿬Q_ϑZ/,0:{:{_*WJ[ߺb;0훤JY7z^`J>o*edpxTUK1ebsc8HoRW>~{Rºoܻrb) 3˟m't;Rvܾ}u/rテ~'ô-U/G^K>J\w%a܉4w5>@R7"LmH{}4#|hk'VrN7im?|圁[g4sNwP?ga}Qxg3#=rUttOp^ů@_C&uDCst?Ê\sJ8[76.鸅(:hl'ooXǭybrn x{Ur,lT@aݹ]w[o+?x]%\{~43v:j*W?#m>-=5o^pgROWV,W V{v3b_}UAAz
ѡ67f:\Vy:a^M*ۍݾ{Q}̶~WDRnn3x|{o~ZXp_߿*=/{n+ZkoJ})?m(z8)wXm^ݰ,h+6tWBwH}әon3B__ל>3#f;pf\sj>3[wpj웫[|f\Xf5g83.ÿ<?^3gleyOYI9)?y{_,<o_fX9,6}71bed`ֶ ^ \s߄vW[Zgvu??Wia%yIe^ҖGȵt35y]cջᕙsiiK|7F_c[K)ں)r./s_ҝAx.
3@jhy3?/:ʡ`PtXJQvԦÑ}Dsrs1G|0_v23@!-M`Ȇ.׆v2Z2se!~װ4}̬td?Ʃ_]^-0˺6·[ӷUY>v~`zK >q
n|>w7f
5϶>c='.
>voE'tW|d
%Zb%Wc*fe'm9cտ2TF]q72tԘ^}ߛmdmͣbQשvչt2H}ifʲv:.]eͧj,lc}X>.]T{w̰XCZ}77i=]/l?QۦRx6㞸l?Z<ʋ%a[}0瞸o=?ՖЋR~x dۋ.;.Clj9Cl}·N$ӹ|zqXV]U
uO|~ jۛvUWMo|UE/e{FoZm$'hmklf-li㉘Kݗ`fՈF^3nh`#!ą!G͔ӞPn fi0h&fLQf(2|$1aa ..0`7a֟YfʹmYxC}'e2^=^ZՎI`}4KƗގٛl:m5Z9i3~ RX)n1 0l^vF
Pv]3M[{%c/.!pF4M[RCto<_#ҁfDs]9IC# Pz}b=]:ͨ*6'۴ҲFE[eFYo'^10qh/:9M&\`eۋ>tlfӆrF
COW%!+s-Y7ƿy&ޖk`XRRxb.5/2fhٝll[H~wkSىZ͊[>cRrҤN&{>9fo\ify.:eEYfJXdWvܜpuF{2zqք(ENO8!hbĕ)O~dmů}6;p=D=0O"eXU!&o9+퓨E^wKA jSxpԇ)CzE]
ѭLq%W?2#be\CY`@YƲr-Rx.Q"{][8v.npǠQc
fAbsKMްLzIgɭ+emxq23~u{ogY9pxFÁ.d ϛ*[Fo1֯"ԤW˲n[0Z #{/=(uT]졶X4eSl