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  1. Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investig...

    Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart
    Citation: The Journal of Headache and Pain 2020 21:67
    Content type: Research article Published on:

  2. Migraine has been recognized as one of common diseases in the world whose current treatment options are not ideal. Lasmiditan, an oral 5-hydroxytryptamine (HT)1F receptor agonist, appears more promising for the a...

    Authors: Min Hou, Haiyan Xing, Chen Li, Xianfeng Wang, Dongmei Deng, Juan Li, Pan Zhang and Jianhong Chen
    Citation: The Journal of Headache and Pain 2020 21:66
    Content type: Research article Published on:

  3. The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and ...

    Authors: J. C. A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D’Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina…
    Citation: The Journal of Headache and Pain 2020 21:65
    Content type: Review article Published on:

  4. Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Giv...

    Authors: Irene de Boer, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg
    Citation: The Journal of Headache and Pain 2020 21:64
    Content type: Review article Published on:

  6. Calcitonin gene-related peptide (CGRP) has recently been implicated in the pathogenesis of post-traumatic headache (PTH), which raises the prospect for therapeutic use of monoclonal antibodies targeting CGRP o...

    Authors: Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Anna Kristina Eigenbrodt, Eigil Lindekilde Larsen, Amalie Middelboe Andersen, Kevin John Hansen, Karoline Bendix Bräuner, Thomas Mørch-Jessen, Basit Chaudhry, Sonja Antic, Casper Emil Christensen, Messoud Ashina, Faisal Mohammad Amin and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2020 21:62
    Content type: Research article Published on:

  7. Clinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab i...

    Authors: Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova and Anna P. Andreou
    Citation: The Journal of Headache and Pain 2020 21:61
    Content type: Research article Published on:

  9. There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribut...

    Authors: Tiffani J. Mungoven, Noemi Meylakh, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey and Luke A. Henderson
    Citation: The Journal of Headache and Pain 2020 21:59
    Content type: Research article Published on:

  10. Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.

    Authors: Byung-Su Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Jeong Wook Park, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae-Moon Kim, Soo-Kyoung Kim, Yun-Ju Choi, Jae Myun Chung…
    Citation: The Journal of Headache and Pain 2020 21:58
    Content type: Research article Published on:

  11. Neck pain in migraine patients is very prevalent between and during migraine attacks, but the underlying mechanism behind neck pain in migraine is unknown. The neck muscle rectus capitis posterior minor muscle...

    Authors: Jeppe Hvedstrup, Faisal Mohammad Amin, Anders Hougaard, Håkan Ashina, Casper Emil Christensen, Henrik Bo Wiberg Larsson, Messoud Ashina and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2020 21:57
    Content type: Research article Published on:

  12. Vestibular symptoms and balance changes are common in patients with migraine, especially in the ones with aura and chronic migraine. However, it is not known if the balance changes are determined by the presen...

    Authors: Letícia Zorzin, Gabriela F. Carvalho, Jens Kreitewolf, Roberto Teggi, Carina F. Pinheiro, Jéssica R. Moreira, Fabíola Dach and Débora Bevilaqua-Grossi
    Citation: The Journal of Headache and Pain 2020 21:56
    Content type: Research article Published on:

  13. Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops ...

    Authors: Alejandro Labastida-Ramírez, Silvia Benemei, Maria Albanese, Antonina D’Amico, Giovanni Grillo, Oxana Grosu, Devrimsel Harika Ertem, Jasper Mecklenburg, Elena Petrovna Fedorova, Pavel Řehulka, Francesca Schiano di Cola, Javier Trigo Lopez, Nina Vashchenko, Antoinette MaassenVanDenBrink and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2020 21:55
    Content type: Review article Published on:

  14. Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among...

    Authors: Yen-Feng Wang, Yung-Tai Chen, Ching-Wen Tsai, Yu-Chun Yen, Yi-Chun Chen, Ben-Chang Shia and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2020 21:54
    Content type: Research article Published on:

  15. Adult migraine remains underdiagnosed and undertreated, despite significant negative effects on physical and emotional functioning. Information on prescribing patterns and treatment costs of migraine in China ...

    Authors: Shengyuan Yu, Yanlei Zhang, Yuan Yao and Haijun Cao
    Citation: The Journal of Headache and Pain 2020 21:53
    Content type: Research article Published on:

  16. Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people. The aims of this study are to evaluate the temporal varia...

    Authors: Davide Guido, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Ilona Koupil, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…
    Citation: The Journal of Headache and Pain 2020 21:52
    Content type: Research article Published on:

  18. Estrogen influences susceptibility to migraine attacks and it has been suggested to affect jealousy in romantic relationships in women. Therefore, we hypothesized that migraine women may be more jealous.

    Authors: Daphne S. van Casteren, Florine A. C. van Willigenburg, Antoinette MaassenVanDenBrink and Gisela M. Terwindt
    Citation: The Journal of Headache and Pain 2020 21:51
    Content type: Research article Published on:

  19. This quality improvement project was implemented in order to highlight the association between headache, mTBI and depression on lost productivity and resource utilization.

    Authors: Virginia B. Baker, Christopher B. Sowers and Nawaz K. Hack
    Citation: The Journal of Headache and Pain 2020 21:50
    Content type: Research article Published on:

  20. Headache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study...

    Authors: Britta Müller, Thomas Dresler, Charly Gaul, Tim Jürgens, Peter Kropp, Anna Rehfeld, Olaf Reis, Ruth Ruscheweyh, Andreas Straube and Stefanie Förderreuther
    Citation: The Journal of Headache and Pain 2020 21:49
    Content type: Research article Published on:

  21. To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine.

    Authors: Jacob Genizi, Ayelet Halevy, Mitchell Schertz, Khaled Osman, Nurit Assaf, Idan Segal, Isaac Srugo, Aharon Kessel and Batya Engel-Yeger
    Citation: The Journal of Headache and Pain 2020 21:48
    Content type: Research article Published on:

  22. Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information process...

    Authors: Zhaoxia Qin, Jingjing Su, Xin-Wei He, Shiyu Ban, Qian Zhu, Yangyang Cui, Jilei Zhang, Yue Hu, Yi-Sheng Liu, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu and Xiaoxia Du
    Citation: The Journal of Headache and Pain 2020 21:47
    Content type: Research article Published on:

  23. Tinnitus due to hyperactivity across neuronal ensembles along the auditory pathway is reported. We hypothesized that trigeminal neuralgia patients may subsequently suffer from tinnitus. Using nationwide, popul...

    Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin
    Citation: The Journal of Headache and Pain 2020 21:46
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:113

  24. Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people, and with increasing trends in general populations. Differ...

    Authors: Alberto Raggi, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Muhammad Z. Hossin, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…
    Citation: The Journal of Headache and Pain 2020 21:45
    Content type: Research article Published on:

  25. Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy ...

    Authors: Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti and Francesco Saverio Mennini
    Citation: The Journal of Headache and Pain 2020 21:44
    Content type: Research article Published on:

  26. Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic...

    Authors: M. Torres-Ferrús, F. Ursitti, A. Alpuente, F. Brunello, D. Chiappino, T. de Vries, S. Di Marco, S. Ferlisi, L. Guerritore, N. Gonzalez-Garcia, A. Gonzalez-Martinez, D. Khutorov, M. Kritsilis, A. Kyrou, T. Makeeva, A. Minguez-Olaondo…
    Citation: The Journal of Headache and Pain 2020 21:42
    Content type: Review article Published on:

  27. Migraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, ar...

    Authors: Louise Lombard, Mallory Farrar, Wenyu Ye, Yongin Kim, Sarah Cotton, Andrew S. Buchanan, James Jackson and Shivang Joshi
    Citation: The Journal of Headache and Pain 2020 21:41
    Content type: Research article Published on:

  28. Treatment with onabotulinumtoxin A (BT-A) is safe and effective for chronic migraine (CM). Several studies assessed possible predictors of response to treatment with BT-A, but there is little knowledge on the ...

    Authors: Raffaele Ornello, Simona Guerzoni, Carlo Baraldi, Luana Evangelista, Ilaria Frattale, Carmine Marini, Cindy Tiseo, Francesca Pistoia and Simona Sacco
    Citation: The Journal of Headache and Pain 2020 21:40
    Content type: Research article Published on:

  29. Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.

    Authors: Lilla Bonanno, Viviana Lo Buono, Simona De Salvo, Claudio Ruvolo, Viviana Torre, Placido Bramanti, Silvia Marino and Francesco Corallo
    Citation: The Journal of Headache and Pain 2020 21:39
    Content type: Research article Published on:

  30. The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and providing the best possible care to infected patients, a...

    Authors: Antoinette MaassenVanDenBrink, Tessa de Vries and A. H. Jan Danser
    Citation: The Journal of Headache and Pain 2020 21:38
    Content type: Commentary Published on:

  31. The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a s...

    Authors: Emer O’Connor, Benjamin S. Simpson, Henry Houlden, Jana Vandrovcova and Manjit Matharu
    Citation: The Journal of Headache and Pain 2020 21:37
    Content type: Research article Published on:

  33. The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund’s adjuvant (C...

    Authors: Edina K. Cseh, Gábor Veres, Tamás Körtési, Helga Polyák, Nikolett Nánási, János Tajti, Árpád Párdutz, Péter Klivényi, László Vécsei and Dénes Zádori
    Citation: The Journal of Headache and Pain 2020 21:35
    Content type: Research article Published on:

  34. Short-latency afferent inhibition (SAI) consists of motor cortex inhibition induced by sensory afferents and depends on the excitatory effect of cholinergic thalamocortical projections on inhibitory GABAergic ...

    Authors: Gianluca Coppola, Davide Di Lenola, Chiara Abagnale, Fabio Ferrandes, Gabriele Sebastianelli, Francesco Casillo, Cherubino Di Lorenzo, Mariano Serrao, Maurizio Evangelista, Jean Schoenen and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2020 21:34
    Content type: Research article Published on:

  35. Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients wi...

    Authors: Soo-Kyoung Kim, Catherine D. Chong, Gina Dumkrieger, Katherine Ross, Visar Berisha and Todd J. Schwedt
    Citation: The Journal of Headache and Pain 2020 21:33
    Content type: Research article Published on:

  36. We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

    Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco
    Citation: The Journal of Headache and Pain 2020 21:32
    Content type: Research article Published on:

  37. The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...

    Authors: Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares and Raquel Gil-Gouveia
    Citation: The Journal of Headache and Pain 2020 21:31
    Content type: Research article Published on:

  39. The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, ...

    Authors: Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2020 21:29
    Content type: Research article Published on:

  40. Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms o...

    Authors: S. P. Mollan, K. Paemeleire, J. Versijpt, R. Luqmani and A. J. Sinclair
    Citation: The Journal of Headache and Pain 2020 21:28
    Content type: Consensus article Published on:

  41. Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased ...

    Authors: Jessica L. Rohmann, Pamela M. Rist, Julie E. Buring and Tobias Kurth
    Citation: The Journal of Headache and Pain 2020 21:27
    Content type: Research article Published on:

  43. Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency faci...

    Authors: Andrea Negro, Valerio Spuntarelli, Paolo Sciattella and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2020 21:25
    Content type: Research article Published on:

  44. The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal ass...

    Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart
    Citation: The Journal of Headache and Pain 2020 21:24
    Content type: Research article Published on:

  45. Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) freq...

    Authors: Dawn C. Buse, Michael L. Reed, Kristina M. Fanning, Ryan Bostic, David W. Dodick, Todd J. Schwedt, Sagar Munjal, Preeti Singh and Richard B. Lipton
    Citation: The Journal of Headache and Pain 2020 21:23
    Content type: Research article Published on:

  46. Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migrai...

    Authors: Zeinab Ghorbani, Pegah Rafiee, Akbar Fotouhi, Samane Haghighi, Reyhaneh Rasekh Magham, Zeynab Sadat Ahmadi, Mahmoud Djalali, Mahnaz Zareei, Soodeh Razeghi Jahromi, Sahar Shahemi, Maryam Mahmoudi and Mansoureh Togha
    Citation: The Journal of Headache and Pain 2020 21:22
    Content type: Research article Published on:

  47. Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of...

    Authors: Richard B. Lipton, Louise Lombard, Dustin D. Ruff, John H. Krege, Li Shen Loo, Andrew Buchanan, Thomas E. Melby and Dawn C. Buse
    Citation: The Journal of Headache and Pain 2020 21:20
    Content type: Research article Published on:

  48. Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache pr...

    Authors: Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Matias Metcalf-Clausen, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2020 21:19
    Content type: Research article Published on:

  49. To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

    Authors: Di Zhang, Xiaobin Huang, Wen Su, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu
    Citation: The Journal of Headache and Pain 2020 21:17
    Content type: Research article Published on:

  50. People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity thr...

    Authors: Gwendolyne G. M. Scholten-Peeters, Michel W. Coppieters, Tom S. C. Durge and René F. Castien
    Citation: The Journal of Headache and Pain 2020 21:16
    Content type: Research article Published on:
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