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  1. Chronic headache may persist after the remission of reversible cerebral vasoconstriction syndrome (RCVS) in some patients. We aimed to investigate the prevalence, characteristics, risk factors, and the impact ...

    Authors: Yu-Hsiang Ling, Yen-Feng Wang, Jiing-Feng Lirng, Jong-Ling Fuh, Shuu-Jiun Wang and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2021 22:14
  2. Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol in women ...

    Authors: Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi and Anna Ferrari
    Citation: The Journal of Headache and Pain 2021 22:13
  3. The mechanisms of genotype-phenotype interaction in Familiar Hemiplegic migraine type 2 (FHM2) are still far from clear. Different ATP1A2 mutations have been described, with a spectrum of phenotypes ranging from ...

    Authors: Fabio Antonaci, Sabrina Ravaglia, Gaetano S. Grieco, Stella Gagliardi, Cristina Cereda and Alfredo Costa
    Citation: The Journal of Headache and Pain 2021 22:12
  4. Migraine is one of the most common neurological diseases around the world and calcitonin gene-related peptide (CGRP) plays an important role in its pathophysiology. Therefore, in the present study, we evaluate...

    Authors: Zeya Yan, Tao Xue, Shujun Chen, Xin Wu, Xingyu Yang, Guangjie Liu, Shan Gao, Zhouqing Chen and Zhong Wang
    Citation: The Journal of Headache and Pain 2021 22:10
  5. Idiopatic trigeminal neuralgia purely paroxysmal (ITNp) distributed in the supraorbital and suprathrochlear dermatomes (SSd), refractory to conventional treatments have been linked to the hyperactivity of the ...

    Authors: Alessandro Gualdi, Janos Cambiaso-Daniel, Jonatann Gatti, Ziv M. Peled, Robert Hagan, Dario Bertossi, Paul Wurzer, Lars-Peter Kamolz, Saja Scherer and Giorgio Pietramaggiori
    Citation: The Journal of Headache and Pain 2021 22:9
  6. Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an ...

    Authors: Lars Michels, Nabin Koirala, Sergiu Groppa, Roger Luechinger, Andreas R. Gantenbein, Peter S. Sandor, Spyros Kollias, Franz Riederer and Muthuraman Muthuraman
    Citation: The Journal of Headache and Pain 2021 22:8
  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jasem Y. Al-Hashel, R. Alroughani, S. Shuaibi, A. AlAshqar, F. AlHamdan, H. AlThufairi, S. Owayed and Samar F. Ahmed
    Citation: The Journal of Headache and Pain 2021 22:7

    The original article was published in The Journal of Headache and Pain 2020 21:80

  8. Galcanezumab, a humanized monoclonal antibody that binds calcitonin gene-related peptide, has demonstrated a significant reduction in monthly migraine headache days compared with placebo. Here, we analyze data...

    Authors: Michael Ament, Kathleen Day, Virginia L Stauffer, Vladimir Skljarevski, Mallikarjuna Rettiganti, Eric Pearlman and Sheena K. Aurora
    Citation: The Journal of Headache and Pain 2021 22:6

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:100

  9. The CGRP antagonists offer a novel therapeutic approach in migraine. Their utility in patients with severe forms of chronic migraine is a subject of particular interest. We present outcomes of 9 months of eren...

    Authors: J. Talbot, R. Stuckey, L. Crawford, S. Weatherby and S. Mullin
    Citation: The Journal of Headache and Pain 2021 22:5
  10. The moment-to-moment variability of resting-state brain activity has been suggested to play an active role in chronic pain. Here, we investigated the regional blood-oxygen-level-dependent signal variability (BOLD

    Authors: Manyoel Lim, Hassan Jassar, Dajung J. Kim, Thiago D. Nascimento and Alexandre F. DaSilva
    Citation: The Journal of Headache and Pain 2021 22:4
  11. Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been shown to be effective in migraine prevention. Eptinezumab, erenumab, fremanezumab, and galcanezumb have shown...

    Authors: Joshua M. Cohen, Xiaoping Ning, Yoel Kessler, Michele Rasamoelisolo, Verena Ramirez Campos, Michael J. Seminerio, Lynda J. Krasenbaum, Honglue Shen and Jennifer Stratton
    Citation: The Journal of Headache and Pain 2021 22:3
  12. Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway, including the fully humanized monoclonal antibody (IgG2Δa) fremanezumab, have demonstrated safety and efficacy for migraine p...

    Authors: Stephen D. Silberstein, Joshua M. Cohen, Ronghua Yang, Sanjay K. Gandhi, Evelyn Du, Adelene E. Jann and Michael J. Marmura
    Citation: The Journal of Headache and Pain 2021 22:2
  13. Triptans and erenumab are both migraine-specific agents acting on the calcitonin gene-related peptide pathway. Therefore, response to triptans might be associated with response to erenumab.

    Authors: Ilaria Frattale, Valeria Caponnetto, Alfonsina Casalena, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Giannapia Affaitati, Maria Adele Giamberardino, Stefano Viola, Amleto Gabriele, Francesca Pistoia, Davide Cerone, Carmine Marini, Simona Sacco and Raffaele Ornello
    Citation: The Journal of Headache and Pain 2021 22:1
  14. Several neuromodulation methods exists for migraine treatment. The aim of the present study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) focusing on migraine trea...

    Authors: Xavier Moisset, Bruno Pereira, Daniel Ciampi de Andrade, Denys Fontaine, Michel Lantéri-Minet and Jérôme Mawet
    Citation: The Journal of Headache and Pain 2020 21:142
  15. To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS).

    Authors: Zhengjie Li, Jun Zhou, Lei Lan, Shirui Cheng, Ruirui Sun, Qiyong Gong, Max Wintermark, Fang Zeng and Fanrong Liang
    Citation: The Journal of Headache and Pain 2020 21:141
  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen
    Citation: The Journal of Headache and Pain 2020 21:140

    The original article was published in The Journal of Headache and Pain 2020 21:87

  17. The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization. Metabotropic glutamate re...

    Authors: Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou and Lixue Chen
    Citation: The Journal of Headache and Pain 2020 21:139
  18. Post-traumatic headache (PTH) is one of the most common and long-lasting symptoms following mild traumatic brain injury (TBI). However, the pathological mechanisms underlying the development of persistent PTH ...

    Authors: Kelly M. Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman and Fletcher A. White
    Citation: The Journal of Headache and Pain 2020 21:138
  19. Previous researches have reported gray and white matter microalterations in primary trigeminal neuralgia (TN) with neurovascular compression (NVC). The central mechanism underlying TN without NVC are unknown b...

    Authors: Min Wu, Xiaofeng Jiang, Jun Qiu, Xianming Fu and Chaoshi Niu
    Citation: The Journal of Headache and Pain 2020 21:136
  20. Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for...

    Authors: Xuan Niu, Lijun Bai, Yingxiang Sun, Yuan Wang, Guanghui Bai, Bo Yin, Shan Wang, Shuoqiu Gan, Xiaoyan Jia and Hongjuan Liu
    Citation: The Journal of Headache and Pain 2020 21:135
  21. Persistent post-traumatic headache (PTH) is a common sequela of mild traumatic brain injury (TBI) and retrospective assessments have found a migraine-like phenotype to be very frequent. This has raised a discu...

    Authors: HÃ¥kan Ashina, Afrim Iljazi, Faisal M. Amin, Messoud Ashina, Richard B. Lipton and Henrik W. Schytz
    Citation: The Journal of Headache and Pain 2020 21:134
  22. Pain sensitivity may determine the risk, severity, prognosis, and efficacy of treatment of clinical pain. Magnetic resonance imaging studies have linked thermal pain sensitivity to changes in brain structure. ...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Li-Ling Hope Pan and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2020 21:133
  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen
    Citation: The Journal of Headache and Pain 2020 21:132

    The original article was published in The Journal of Headache and Pain 2020 21:128

  24. Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding ...

    Authors: Karin Warfvinge, Diana N. Krause, Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson and Kristian A. Haanes
    Citation: The Journal of Headache and Pain 2020 21:131
  25. Trigeminal neuralgia (TN) causes severe episodic, unilateral facial pain and is initially treated with antiepileptic medications. For patients not responding or intolerant to medications, surgery is an option.

    Authors: Lasair O’Callaghan, Lysbeth Floden, Lisa Vinikoor-Imler, Tara Symonds, Kathryn Giblin, Chris Hartford and Joanna M. Zakrzewska
    Citation: The Journal of Headache and Pain 2020 21:130
  26. The Covid-19 pandemic is causing changes in delivery of medical care worldwide. It is not known how the management of headache patients was affected by the lockdown during the pandemic. The aim of the present ...

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen
    Citation: The Journal of Headache and Pain 2020 21:128

    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:132

  27. Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aur...

    Authors: Kazutaka Sugimoto, Andreia Morais, Homa Sadeghian, Tao Qin, David Y. Chung, Messoud Ashina, Anders Hougaard and Cenk Ayata
    Citation: The Journal of Headache and Pain 2020 21:127
  28. Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.

    Authors: Cindy Tiseo, Alessandro Vacca, Anton Felbush, Tamara Filimonova, Annalisa Gai, Tatyana Glazyrina, Irina Anna Hubalek, Yelena Marchenko, Lucas Hendrik Overeem, Serena Piroso, Alexander Tkachev, Paolo Martelletti and Simona Sacco
    Citation: The Journal of Headache and Pain 2020 21:126
  29. Migraine imposes a substantial personal and economic burden to many working age individuals. This study aimed to evaluate the burden and impact of migraine on work productivity in selected workplaces in the Ph...

    Authors: Nel Jason Haw, Ian Theodore Cabaluna, Germaine Erika Kaw, Joanna Feliz Cortez, Maria Pamela Chua and Kristel Guce
    Citation: The Journal of Headache and Pain 2020 21:125
  30. The introduction of monoclonal antibodies (mAbs) against calcitonin-gene related peptide (CGRP) or CGRP receptors in the treatment of migraine raised concerns on the possible risks associated to the long-term ...

    Authors: Giuseppe Tringali, Catello Vollono, Paolo Calabresi and Pierluigi Navarra
    Citation: The Journal of Headache and Pain 2020 21:124
  31. Focus on the frequency of migraine pain may undervalue the total burden of migraine as pain duration and severity may present unique, additive burden. A composite measure of total pain burden (TPB; frequency, ...

    Authors: Jessica Ailani, J. Scott Andrews, Mallikarjuna Rettiganti and Robert A. Nicholson
    Citation: The Journal of Headache and Pain 2020 21:123
  32. Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most con...

    Authors: Rosaria Greco, Roberto De Icco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Grazia Sances, Marta Allena and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2020 21:122
  33. Headache is the most common COVID-19-related neurological symptom. We aimed to reveal diagnostic clues of headache for COVID-19 infection and to investigate the course of primary headaches during the pandemic.

    Authors: Özge Uygun, Mustafa Ertaş, Esme Ekizoğlu, Hayrunnisa Bolay, Aynur Özge, Elif Kocasoy Orhan, Arif Atahan Çağatay and Betül Baykan
    Citation: The Journal of Headache and Pain 2020 21:121
  34. PROMISE-2 was a phase 3, randomized, double-blind, placebo-controlled study that evaluated the efficacy and safety of repeat intravenous (IV) doses of the calcitonin gene-related peptide–targeted monoclonal an...

    Authors: Stephen Silberstein, Merle Diamond, Nada A. Hindiyeh, David M. Biondi, Roger Cady, Joe Hirman, Brent Allan, Susan Pederson, Barbara Schaeffler and Jeff Smith
    Citation: The Journal of Headache and Pain 2020 21:120
  35. Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mecha...

    Authors: Guoliang Chen, Yansong Li, Zhao Dong, Rongfei Wang, Dengfa Zhao, Ignacio Obeso and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2020 21:119
  36. A global My Migraine Voice survey was conducted in 31 countries among 11,266 adults who suffered from ≥4 monthly migraine days (MMD). The aim of this retrospective observational survey-based study was to analyse ...

    Authors: Marja-Liisa Sumelahti, Markku Sumanen, Merika S. Sumanen, Samuli Tuominen, Johanna Vikkula, Sanna M. Honkala, Stina Rosqvist and Minna A. Korolainen
    Citation: The Journal of Headache and Pain 2020 21:118
  37. Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulat...

    Authors: Dimos D. Mitsikostas, Charlotte Blease, Elisa Carlino, Luana Colloca, Andrew L. Geers, Jeremy Howick, Andrea W. M. Evers, Magne A. Flaten, John M. Kelley, Irving Kirsch, Regine Klinger, Antoinette MaassenVanDenBrink, Daniel E. Moerman, Petros P. Sfikakis, Lene Vase, Tor D. Wager…
    Citation: The Journal of Headache and Pain 2020 21:117
  38. Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics. There are currently no evidence-based thera...

    Authors: Andreas Yiangou, James L. Mitchell, Vivek Vijay, Olivia Grech, Edward Bilton, Gareth G. Lavery, Claire Fisher, Julie Edwards, Susan P. Mollan and Alexandra J. Sinclair
    Citation: The Journal of Headache and Pain 2020 21:116
  39. Since the declaration COVID-19 as a pandemic, healthcare systems around the world have faced a huge challenge in managing patients with chronic diseases. Patients with migraine were specifically vulnerable to ...

    Authors: Jasem Y. Al-Hashel and Ismail Ibrahim Ismail
    Citation: The Journal of Headache and Pain 2020 21:115
  40. We evaluated the efficacy of fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, in patients with chronic migraine (CM) with and without medication ove...

    Authors: Stephen D. Silberstein, Joshua M. Cohen, Michael J. Seminerio, Ronghua Yang, Sait Ashina and Zaza Katsarava
    Citation: The Journal of Headache and Pain 2020 21:114
  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin
    Citation: The Journal of Headache and Pain 2020 21:113

    The original article was published in The Journal of Headache and Pain 2020 21:46

  42. Chronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level depen...

    Authors: Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli and Gianluca Coppola
    Citation: The Journal of Headache and Pain 2020 21:112
  43. Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functiona...

    Authors: Heng-Le Wei, Jing Chen, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Zhen-Zhen He, Lian Yang, Xindao Yin, Junrong Li and Hong Zhang
    Citation: The Journal of Headache and Pain 2020 21:111
  44. Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National ...

    Authors: Shoji Kikui, Yirong Chen, Hiroshi Todaka, Keiko Asao, Kenji Adachi and Takao Takeshima
    Citation: The Journal of Headache and Pain 2020 21:110
  45. The long-term safety and efficacy of fremanezumab were evaluated in a 52-week extension study (NCT02638103). Patient satisfaction with fremanezumab, dosing preferences, and patient-reported outcomes were asses...

    Authors: Dawn C. Buse, Sanjay K. Gandhi, Joshua M. Cohen, Verena Ramirez-Campos, Blaine Cloud, Ronghua Yang and Robert P. Cowan
    Citation: The Journal of Headache and Pain 2020 21:109
  46. The Global Burden of Disease (GBD) study establishes headache as the second-highest cause of disability worldwide. Because most headache data in GBD are from adults, leading to underestimation of headache-attr...

    Authors: Yared Zenebe Zewde, Mehila Zebenigus, Hanna Demissie, Redda Tekle-Haimanot, Derya Uluduz, Tayyar ÅžaÅŸmaz, Fatma Bozdag and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2020 21:108
  47. The Global Campaign against Headache collects data from children (7–11 years) and adolescents (12–17 years) both to inform health and education policies and to contribute to the Global Burden of Disease (GBD) ...

    Authors: Otgonbayar Luvsannorov, Tsengunmaa Anisbayar, Munkhzul Davaasuren, Otgonzaya Baatar, Khaliunaa Batmagnai, Khulan Tumurbaatar, Sarantuya Enkhbaatar, Derya Uluduz, Tayyar Şaşmaz, Elif Tuğçe Solmaz and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2020 21:107