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  1. Hyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during as...

    Authors: Baisong Zhao, Yongying Pan, Haiping Xu and Xingrong Song
    Citation: The Journal of Headache and Pain 2017 18:1
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2022 23:32

  2. Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been...

    Authors: Elena Bacchelli, Maria Michela Cainazzo, Cinzia Cameli, Simona Guerzoni, Angela Martinelli, Michele Zoli, Elena Maestrini and Luigi Alberto Pini
    Citation: The Journal of Headache and Pain 2016 17:114
    Content type: Research article Published on:

  4. OnabotulinumtoxinA (OnabotA) is effective in Chronic Migraine (CM) during first year of treatment and longer. In real clinical setting, CM patients with acute Medication Overuse (MO) or concurrently receiving ...

    Authors: I. Aicua-Rapun, E. Martínez-Velasco, A. Rojo, A. Hernando, M. Ruiz, A. Carreres, E. Porqueres, S. Herrero, F. Iglesias and A. L. Guerrero
    Citation: The Journal of Headache and Pain 2016 17:112
    Content type: Research article Published on:

  5. The study was a collaboration between Lifting The Burden (LTB) and the European Headache Federation (EHF). Its aim was to evaluate the implementation of quality indicators for headache care Europe-wide in special...

    Authors: Sara Schramm, Derya Uluduz, Raquel Gil Gouveia, Rigmor Jensen, Aksel Siva, Ugur Uygunoglu, Giorgadze Gvantsa, Maka Mania, Mark Braschinsky, Elena Filatova, Nina Latysheva, Vera Osipova, Kirill Skorobogatykh, Julia Azimova, Andreas Straube, Ozan Emre Eren…
    Citation: The Journal of Headache and Pain 2016 17:111
    Content type: Research article Published on:

  6. Knowledge of the epidemiology of primary headache disorders in sub-Saharan Africa (SSA) remains very limited. We performed a population-based survey in rural and urban areas of Ethiopia, using methods similar ...

    Authors: Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K. Worku, Hallie Thomas and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2016 17:110
    Content type: Research article Published on:

  8. Headache such as migraine is associated with stroke. Studies focused on primary headache disorders (PHDs) as a risk factor for stroke are limited. The purpose of this population-based cohort study was to explo...

    Authors: Chia-Lin Tsai, Chung-Hsing Chou, Pei-Jung Lee, Jiu-Haw Yin, Shao-Yuan Chen, Chun-Chieh Lin, Yueh-Feng Sung, Fu-Chi Yang, Chi-Hsiang Chung, Wu-Chien Chien, Chia-Kuang Tsai and Jiunn-Tay Lee
    Citation: The Journal of Headache and Pain 2016 17:108
    Content type: Research article Published on:

  9. The most commonly prescribed medications used to treat migraine acutely are single analgesics, ergots, opioids, and triptans. Due to varying mechanisms of action across drug classes, there is reason to believe...

    Authors: Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward J. Mills, Michel Lanteri-Minet and Stewart Tepper
    Citation: The Journal of Headache and Pain 2016 17:107
    Content type: Research article Published on:

  10. Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions. We present a ...

    Authors: Clinton Lauritsen, Santiago Mazuera, Richard B. Lipton and Sait Ashina
    Citation: The Journal of Headache and Pain 2016 17:106
    Content type: Research article Published on:

  11. State-related brain structural alterations in patients with episodic tension-type headache (ETTH) are unclear. We aimed to conduct a longitudinal study to explore dynamic gray matter (GM) changes between the p...

    Authors: Bing Chen, Yuan He, Lei Xia, Li-Li Guo and Jin-Long Zheng
    Citation: The Journal of Headache and Pain 2016 17:105
    Content type: Research article Published on:

  13. The objective was to compare and correlate disability, pain intensity, the impact of headache on daily life and the fear of movement between subgroups of patients with chronic temporomandibular disorder (TMD).

    Authors: Alfonso Gil-Martínez, Mónica Grande-Alonso, Ibai López-de-Uralde-Villanueva, Almudena López-López, Josué Fernández-Carnero and Roy La Touche
    Citation: The Journal of Headache and Pain 2016 17:103
    Content type: Research article Published on:

  14. Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal). It is of great interest whether resting-state electroencephalography (EEG) is differentiable between these phases.

    Authors: Zehong Cao, Chin-Teng Lin, Chun-Hsiang Chuang, Kuan-Lin Lai, Albert C. Yang, Jong-Ling Fuh and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2016 17:102
    Content type: Research article Published on:

  15. The specific periaqueductal gray (PAG) lesions with migraine-like headache were easily identified on conventional MR images in clinical practice, and the aim of this study is to investigate the nonspecific per...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2016 17:101
    Content type: Research article Published on:

  16. Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between brain networks at rest and its relationship wit...

    Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Chiara Lepre, Cherubino Di Lorenzo, Giorgio Di Lorenzo, Marco Scapeccia, Vincenzo Parisi, Mariano Serrao, Claudio Colonnese, Jean Schoenen and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2016 17:100
    Content type: Research article Published on:

  17. Antioxidants have been proven to weaken hyperalgesia in neuropathic pain. Endogenous antioxidant defense system may have a role in the prevention of hyperalgesia in migraine. In this study, we aimed to evaluat...

    Authors: Wei Di, Xiaolei Shi, Hua Lv, Jun Liu, Hong Zhang, Zhiwei Li and Yannan Fang
    Citation: The Journal of Headache and Pain 2016 17:99
    Content type: Research article Published on:

  18. The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resti...

    Authors: Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qian Yao, Qiting Zhang, Haifeng Lu, Hui Zhang, Shuo Wang, Ge-Fei Li, Yi-Lan Wu, Feng-Di Liu, Yan-Hui Shi, Jianqi Li, Jian-Ren Liu and Xiaoxia Du
    Citation: The Journal of Headache and Pain 2016 17:98
    Content type: Research article Published on:

  19. Although the comorbidity of migraine and restless legs syndrome (RLS) has been well-documented, the association between RLS and migraine frequency has yet to be elucidated. The present study aims to evaluate t...

    Authors: Guan-Yu Lin, Yu-Kai Lin, Jiunn-Tay Lee, Meei-Shyuan Lee, Chun-Chieh Lin, Chia-Kuang Tsai, Chi-Hsin Ting and Fu-Chi Yang
    Citation: The Journal of Headache and Pain 2016 17:97
    Content type: Research article Published on:

  21. The differential diagnosis of strictly unilateral hemicranial pain includes a large number of primary and secondary headaches and cranial neuropathies. It may arise from both intracranial and extracranial stru...

    Authors: Sanjay Prakash and Chaturbhuj Rathore
    Citation: The Journal of Headache and Pain 2016 17:95
    Content type: Review article Published on:

  22. The premonitory stage of migraine attacks, when symptomatology outside of pain can manifest hours to days before the onset of the headache, is well recognised. Such symptoms have been reported in adults in a n...

    Authors: N. Karsan, P. Prabhakar and P. J. Goadsby
    Citation: The Journal of Headache and Pain 2016 17:94
    Content type: Research article Published on:

  23. Migraine is a common neurovascular disorder affecting 10 to 20 % of the world population usually subdivided into migraine with auro (MA) and migraine without auro (MO). Homocysteine is involved in the pathophy...

    Authors: Ali Sazci, Gensay Sazci, Bilgen Sazci, Emel Ergul and Halil Atilla Idrisoglu
    Citation: The Journal of Headache and Pain 2016 17:93
    Content type: Research article Published on:

  24. Insomnia is a common complaint among individuals with migraine. The close association between insomnia and migraine has been reported in clinic-based and population-based studies. Probable migraine (PM) is a m...

    Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2016 17:92
    Content type: Research article Published on:

  25. Menstrual migraine and menstrually related migraine attacks are typically longer, more disabling, and less responsive to medications than non-menstrual attacks. The aim of this study was to evaluate the effica...

    Authors: Licia Grazzi, Gabriella Egeo, Anne H. Calhoun, Candace K. McClure, Eric Liebler and Piero Barbanti
    Citation: The Journal of Headache and Pain 2016 17:91
    Content type: Research article Published on:

  26. A previous study found that brain natriuretic peptide (BNP) inhibited inflammatory pain via activating its receptor natriuretic peptide receptor A (NPRA) in nociceptive sensory neurons. A recent study found th...

    Authors: Zheng-Wei Li, Bin Wu, Pin Ye, Zhi-Yong Tan and Yong-Hua Ji
    Citation: The Journal of Headache and Pain 2016 17:90
    Content type: Research article Published on:

  27. The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The ai...

    Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Siyun Shu, Lin Ma and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2016 17:89
    Content type: Research article Published on:

  29. Medication overuse headache (MOH) is a major clinical concern and a common health risk. Recent literature stressed the need to manage chronic headache by using integrated biobehavioral approaches. Few studies ...

    Authors: Marialuisa Rausa, Daniela Palomba, Sabina Cevoli, Luana Lazzerini, Elisa Sancisi, Pietro Cortelli and Giulia Pierangeli
    Citation: The Journal of Headache and Pain 2016 17:87
    Content type: Research article Published on:

  31. Chronic headache (CrH) occurs commonly in the population, and chronic migraine (CM) accounts for much of the CrH. Diagnostic criteria for CM remain controversial, and this could lead to undertreatment of CM. T...

    Authors: Huahua Jiang, Yong Deng, Yixin Zhang, Jieli Jin, Xueying Kong, Qiuwen Zhu, Kuiyun Wang and Jiying Zhou
    Citation: The Journal of Headache and Pain 2016 17:85
    Content type: Research article Published on:

  32. Chronic migraine is a disabling condition, with limited treatment options. We conducted an open label, single arm, prospective clinical trial, to assess the efficacy and safety of onabotulinumtoxin-A in Greek ...

    Authors: Michail Vikelis, Andreas A. Argyriou, Emmanouil V. Dermitzakis, Konstantinos C. Spingos and Dimos D. Mitsikostas
    Citation: The Journal of Headache and Pain 2016 17:84
    Content type: Research article Published on:

  33. Primary headache disorders are among the most common neurological complaints worldwide, and are significant causes of disability. Data are limited on the prevalence of primary headaches among individuals aged ...

    Authors: Yajing Zhang, Zhihong Shi, Duncan Hock, Wei Yue, Shuling Liu, Ying Zhang, Shuai Liu, Lei Zhao, Hui Lu, Yalin Guan, Xiaodan Wang, Thomas Wsiniewski and Yong Ji
    Citation: The Journal of Headache and Pain 2016 17:83
    Content type: Research article Published on:

  34. It is well documented that headache is a multifactorial disorder which includes not only genetic, biological, medical and neuropsychological factor but also psychological and personality traits. The close rela...

    Authors: Vincenzo Guidetti, Noemi Faedda and Michael Siniatchkin
    Citation: The Journal of Headache and Pain 2016 17:82
    Content type: Editorial Published on:

  35. Neurotrophic factors have been implicated in hyperalgesia and peripheral levels of these molecules are altered in migraine pathophysiology. Artemin, a vasculature-derived neurotrophic factor, contributes to pa...

    Authors: Hai-Qiong Shang, Yan Wang, Yan-Yan Mao, Li-Gang Kong, Gao-Ying Sun, Lei Xu, Dao-Gong Zhang, Yue-Chen Han, Jian-Feng Li, Hai-Bo Wang and Zhao-Min Fan
    Citation: The Journal of Headache and Pain 2016 17:81
    Content type: Research article Published on:

  36. Headache is the most frequent neurological symptom and the most prevalent pain in children and adolescents, and constitutes a serious health problem that may lead to impairment in several areas. Psychosocial f...

    Authors: Noemi Faedda, Rita Cerutti, Paola Verdecchia, Daniele Migliorini, Marco Arruda and Vincenzo Guidetti
    Citation: The Journal of Headache and Pain 2016 17:80
    Content type: Review article Published on:

  37. Cluster headache (CH) is a rare, excruciating and highly disabling primary headache disorder. Using non cluster headache specific measures, previous studies have shown that CH has a significant negative impact...

    Authors: Norazah Abu Bakar, Mariam Torkamani, Surat Tanprawate, Giorgio Lambru, Manjit Matharu and Marjan Jahanshahi
    Citation: The Journal of Headache and Pain 2016 17:79
    Content type: Research article Published on:

  38. Migraine and Cluster Headache (CH) are two primary headaches with severe disease burden. The disease expression and the mechanisms involved are poorly known. In some attacks of migraine and in most attacks of ...

    Authors: Anna Steinberg, Simona D Frederiksen, Frank W Blixt, Karin Warfvinge and Lars Edvinsson
    Citation: The Journal of Headache and Pain 2016 17:78
    Content type: Research article Published on:

    The Erratum to this article has been published in The Journal of Headache and Pain 2016 17:86

  39. Medical symptoms independent of body location burden individuals to varying degrees and may require care by more than one expert. Various paper and computer-based tools exist that aim to comprehensively captur...

    Authors: Dominik A. Ettlin, Isabelle Sommer, Ben Brönnimann, Sergio Maffioletti, Jörg Scheidt, Mei-Yin Hou, Nenad Lukic and Beat Steiger
    Citation: The Journal of Headache and Pain 2016 17:77
    Content type: Methodology Published on:

  40. The occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profil...

    Authors: Gabriella Santangelo, Antonio Russo, Luigi Trojano, Fabrizia Falco, Laura Marcuccio, Mattia Siciliano, Francesca Conte, Federica Garramone, Alessandro Tessitore and Gioacchino Tedeschi
    Citation: The Journal of Headache and Pain 2016 17:76
    Content type: Research article Published on:

  41. Tension-type headache and other primary headaches may be triggered or aggravated by disorders of pericranial muscles, which is possibly due to convergent or collateral afferent input from meningeal and muscula...

    Authors: Moritz Nöbel, Stephan Feistel, Jens Ellrich and Karl Messlinger
    Citation: The Journal of Headache and Pain 2016 17:75
    Content type: Research article Published on:

  42. The Global Campaign against Headache has pioneered evaluation of the prevalence and impact of headache on the preceding day (“headache yesterday”) as a new approach to the estimation of headache-attributed bur...

    Authors: Timothy J. Steiner, Girish N. Rao, Girish B. Kulkarni, Gopalkrishna Gururaj and Lars J. Stovner
    Citation: The Journal of Headache and Pain 2016 17:74
    Content type: Research article Published on:

  43. Though endovascular therapy (EVT) is increasingly applied in the treatment of intracranial vascular lesions, little is known about the effect of EVT on post-procedure headache. We aimed to investigate the prev...

    Authors: Sabrina Khan, Faisal Mohammad Amin, John Hauerberg, Markus Holtmannspötter, Julie Falkenberg Petersen, Zainab Fakhril-Din, David Gaist and Messoud Ashina
    Citation: The Journal of Headache and Pain 2016 17:73
    Content type: Research article Published on:

  44. Transforming growth factor-βs (TGF-βs) are a group of multifunctional proteins that have neuroprotective roles in various experimental models. We previously reported that intrathecal (i.t.) injections of TGF-β...

    Authors: Nan-Fu Chen, Wu-Fu Chen, Chun-Sung Sung, Ching-Hsiang Lu, Chun-Lin Chen, Han-Chun Hung, Chien-Wei Feng, Chun-Hong Chen, Kuan-Hao Tsui, Hsiao-Mei Kuo, Hui-Min David Wang, Zhi-Hong Wen and Shi-Ying Huang
    Citation: The Journal of Headache and Pain 2016 17:72
    Content type: Research article Published on:

  45. Caffeine has both excitatory and vasoconstrictive effects on central nervous system. Caffeine use might be associated with development and chronification of migraine. We aimed to evaluate the effect of caffein...

    Authors: Mi Ji Lee, Hyun Ah Choi, Hanna Choi and Chin-Sang Chung
    Citation: The Journal of Headache and Pain 2016 17:71
    Content type: Short report Published on:

  46. Menstrually-related headache and headaches associated with oestrogen withdrawal are common conditions, whose pathophysiology has not been completely elucidated. In this study we evaluated the influence of comb...

    Authors: Roberto De Icco, Laura Cucinella, Irene De Paoli, Silvia Martella, Grazia Sances, Vito Bitetto, Giorgio Sandrini, Giuseppe Nappi, Cristina Tassorelli and Rossella E. Nappi
    Citation: The Journal of Headache and Pain 2016 17:70
    Content type: Short report Published on:

  47. Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH...

    Authors: Bernadett Tuka, Nikoletta Szabó, Eszter Tóth, Zsigmond Tamás Kincses, Árpád Párdutz, Délia Szok, Tamás Körtési, Teréz Bagoly, Zsuzsanna Helyes, Lars Edvinsson, László Vécsei and János Tajti
    Citation: The Journal of Headache and Pain 2016 17:69
    Content type: Short report Published on:

  48. Chronic migraine affects up to 2 % of the general population and has a substantial impact on sufferers. Occipital nerve stimulation has been investigated as a potentially effective treatment for refractory chr...

    Authors: Sarah Miller, Laurence Watkins and Manjit Matharu
    Citation: The Journal of Headache and Pain 2016 17:68
    Content type: Research article Published on:

  49. Cluster headache (CH) is a debilitating headache disorder with severe consequences for patient quality of life. On-demand neuromodulation targeting the sphenopalatine ganglion (SPG) is effective in treating th...

    Authors: Mads C. J. Barloese, Tim P. Jürgens, Arne May, Jose Miguel Lainez, Jean Schoenen, Charly Gaul, Amy M. Goodman, Anthony Caparso and Rigmor Højland Jensen
    Citation: The Journal of Headache and Pain 2016 17:67
    Content type: Research article Published on:

  50. Paresthesia-free cervical 10 kHz spinal cord stimulation (HF10 SCS) may constitute a novel treatment modality for headache disorders, when pharmacological approaches fail. We report the results of a retrospect...

    Authors: Giorgio Lambru, Michele Trimboli, Stefano Palmisani, Thomas Smith and Adnan Al-Kaisy
    Citation: The Journal of Headache and Pain 2016 17:66
    Content type: Short report Published on:
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