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  1. India is a large and populous country where reliable data on headache disorders are relatively scarce. This study in northern India (Delhi and National Capital Territory Region [NCR], including surrounding dis...

    Authors: Debashish Chowdhury, Anand Krishnan, Ashish Duggal, Ritvik Amarchand, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:108
    Content type: Research Published on:

  2. Our recent studies have shown headache disorders to be very common in the central and western sub-Saharan countries of Benin and Cameroon. Here we report headache in nearby Mali, a strife-torn country that dif...

    Authors: Youssoufa Maiga, Seybou H. Diallo, Oumar Sangho, Leon Samuel Moskatel, Fatoumata Konipo, Abdoulaye Bocoum, Salimata Diallo, Awa Coulibaly, Mariam Daou, Housseini Dolo, Modibo Sangaré, Mohamed Albakaye, Zoumana Traoré, Thomas Coulibaly, Adama Sissoko, Guida Landouré…
    Citation: The Journal of Headache and Pain 2024 25:107
    Content type: Research Published on:

  3. Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and trea...

    Authors: Kyung-Hee Cho, Seol-Hee Baek, Sung-Hee Kim, Byung-Su Kim, Jong-Hee Sohn, Min Kyung Chu, Mi-Kyoung Kang, Hee Jung Mo, Sang-Hwa Lee, Hong-Kyun Park, Soohyun Cho, Sun-Young Oh, Jong-Geun Seo, Wonwoo Lee, Ju-Young Lee, Mi Ji Lee…
    Citation: The Journal of Headache and Pain 2024 25:106
    Content type: Research Published on:

  4. Non-steroidal anti-inflammatory drugs (NSAIDs) are considered first-line medications for acute migraine attacks. However, the response exhibits considerable variability among individuals. Thus, this study aime...

    Authors: Heng-Le Wei, Yu-Sheng Yu, Meng-Yao Wang, Gang-Ping Zhou, Junrong Li, Hong Zhang and Zhengyang Zhou
    Citation: The Journal of Headache and Pain 2024 25:104
    Content type: Research Published on:

  5. The development of several experimental migraine provocation models has significantly contributed to an understanding of the signaling mechanisms of migraine. The early history of this development and a view t...

    Authors: Jes Olesen
    Citation: The Journal of Headache and Pain 2024 25:105
    Content type: Review Published on:

  6. The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It is composed of functionally different subdivisions an...

    Authors: Fengfang Li, Di Zhang, Jun Ren, Chunhua Xing, Lanyue Hu, Zhengfei Miao, Liyan Lu and Xinying Wu
    Citation: The Journal of Headache and Pain 2024 25:103
    Content type: Research Published on:

  7. New onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its management poses a suitable means to enhance patients’ participation in professional, social,...

    Authors: Johanna Ruhnau, Max Blücher, Susanne Bahlmann, Almut Zieme, Antje Vogelgesang, Anke Steinmetz and Robert Fleischmann
    Citation: The Journal of Headache and Pain 2024 25:101
    Content type: Research Published on:

  8. Large conductance  calcium-activated potassium (BKCa) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-tra...

    Authors: Haidar M. Al-Khazali, Rune H. Christensen, David W. Dodick, Basit Ali Chaudhry, Anna G. Melchior, Rami Burstein and HÃ¥kan Ashina
    Citation: The Journal of Headache and Pain 2024 25:102
    Content type: Research Published on:

  10. Migraine is a complex neurological condition characterized by recurrent headaches, which is often accompanied by various neurological symptoms. Magnetic resonance imaging (MRI) is a powerful tool for investiga...

    Authors: Eunchan Noh, Jong Young Namgung, Yeongjun Park, Yurim Jang, Mi Ji Lee and Bo-yong Park
    Citation: The Journal of Headache and Pain 2024 25:99
    Content type: Research Published on:

  11. Endogeneous and exogeneous sex hormones can impact the frequency and severity of migraine attacks, but the underlying mechanisms are poorly understood. In this study, we investigate the relationship between fe...

    Authors: Elisabeth Storch, Lucas H. Overeem, Maria Terhart, Mira P. Fitzek, Kristin S. Lange, Uwe Reuter and Bianca Raffaelli
    Citation: The Journal of Headache and Pain 2024 25:98
    Content type: Research Published on:

  12. Mindfulness practice has gained interest in the management of Chronic Migraine associated with Medication Overuse Headache (CM-MOH). Mindfulness is characterized by present-moment self-awareness and relies on ...

    Authors: Davide Fedeli, Giuseppe Ciullo, Greta Demichelis, Jean Paul Medina Carrion, Maria Grazia Bruzzone, Emilio Ciusani, Alessandra Erbetta, Stefania Ferraro, Marina Grisoli, Erika Guastafierro, Domenico D’Amico, Alberto Raggi, Anna Nigri and Licia Grazzi
    Citation: The Journal of Headache and Pain 2024 25:97
    Content type: Research Published on:

  13. Migraine, a neurological disorder with a significant female predilection, is the leading cause of disability-adjusted life years (DALYs) in women of childbearing age (WCBA). There is currently a lack of compre...

    Authors: Jing Cen, Qian Wang, Lin Cheng, Qian Gao, Hongping Wang and Fengjun Sun
    Citation: The Journal of Headache and Pain 2024 25:96
    Content type: Research Published on:

  14. The pathogenesis of migraine remains unclear; however, a large body of evidence supports the hypothesis that immunological mechanisms play a key role. Therefore, we aimed to review current studies on altered i...

    Authors: Woo-Seok Ha and Min Kyung Chu
    Citation: The Journal of Headache and Pain 2024 25:95
    Content type: Review Published on:

  15. Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), t...

    Authors: Jianxiong Gui, Xiaoyue Yang, Chen Tan, Lingman Wang, Linxue Meng, Ziyao Han, Jie Liu and Li Jiang
    Citation: The Journal of Headache and Pain 2024 25:94
    Content type: Research Published on:

  17. Idiopathic intracranial hypertension (IIH) is a debilitating condition characterized by increased intracranial pressure often presenting with chronic migraine-like headache. Calcitonin gene-related peptide (CG...

    Authors: Nik Krajnc, Florian Frank, Stefan Macher, Martin Michl, Nina Müller, Sarah Maier, Sina Zaic, Christian Wöber, Berthold Pemp, Gregor Broessner and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2024 25:92
    Content type: Research Published on:

  19. Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have shown good efficacy in migraine prophylaxis. However, a subset of patients does not respond to the first mAb treat...

    Authors: Ja Bin Hong, Heike Israel-Willner, Andreas Peikert, Peter Schanbacher, Viola Tozzi, Monika Köchling, Uwe Reuter and Bianca Raffaelli
    Citation: The Journal of Headache and Pain 2024 25:90
    Content type: Research Published on:

  20. Medication-overuse headache (MOH), which potentially involves 1–2% of the population, is defined as a headache, on ≥ 15 days a month affected, along with overuse of one or other acute attack medications. MOH p...

    Authors: Helin Gosalia, David Moreno-Ajona and Peter J. Goadsby
    Citation: The Journal of Headache and Pain 2024 25:89
    Content type: Review Published on:

  21. The purpose of this study was to interrogate brain iron accumulation in participants with acute post-traumatic headache (PTH) due to mild traumatic brain injury (mTBI), and to determine if functional connectiv...

    Authors: Simona Nikolova, Catherine Chong, Jing Li, Teresa Wu, Gina Dumkrieger, Katherine Ross, Amaal Starling and Todd J. Schwedt
    Citation: The Journal of Headache and Pain 2024 25:88
    Content type: Research Published on:

  22. Pain, an evolutionarily conserved warning system, lets us recognize threats and motivates us to adapt to those threats. Headache pain from migraine affects approximately 15% of the global population. However, ...

    Authors: Hyeonwi Son, Yan Zhang, John Shannonhouse, Ruben Gomez and Yu Shin Kim
    Citation: The Journal of Headache and Pain 2024 25:87
    Content type: Research Published on:

  23. We recently found headache disorders to be highly prevalent among children (aged 6–11 years) and adolescents (aged 12–17) in Iran (gender- and age-adjusted 1-year prevalences: migraine 25.2%, tension-type head...

    Authors: Mansoureh Togha, Pegah Rafiee, Faraidoon Haghdoost, Shahram Rafie, Seyed Mohammad Hasan Paknejad, Sepideh Amouian, Tayyar ÅžaÅŸmaz, Derya Kale, Derya Uluduz and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:86
    Content type: Research Published on:

  24. The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface ...

    Authors: Jacob C. A. Edvinsson, Caroline Ran, Felicia Jennysdotter Olofsgård, Anna Steinberg, Lars Edvinsson and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2024 25:85
    Content type: Research Published on:

  25. Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebr...

    Authors: Zhengwei Chen, Yueji Liu, Cunxin Lin, Zhining Li, Junjun Shan, Zuowei Duan, Liangqun Rong, Xiue Wei, Lijie Xiao and Haiyan Liu
    Citation: The Journal of Headache and Pain 2024 25:84
    Content type: Research Published on:

  26. Atogepant is an oral calcitonin gene–related peptide receptor antagonist approved for the preventive treatment of migraine in adults. These analyses evaluated the proportions of clinical trial participants who...

    Authors: Richard B. Lipton, Stephanie J. Nahas, Patricia Pozo-Rosich, Tanya Bilchik, Peter McAllister, Michelle Finnegan, Yingyi Liu, Natty Chalermpalanupap, Brett Dabruzzo and David W. Dodick
    Citation: The Journal of Headache and Pain 2024 25:83
    Content type: Research Published on:

  27. Lifestyle are closely related to migraine. However, there is a lack of studies investigating the association between Healthy lifestyle or Life’s Essential 8 (LE8) and the risk of migraine. The objective of thi...

    Authors: Yuexiu Lei, Lili Zhang, Zhengming Shan, Quan Gan, Qingfang Xie, Ying Huang, Wen Yan and Zheman Xiao
    Citation: The Journal of Headache and Pain 2024 25:82
    Content type: Research Published on:

  28. Recent animal and clinical findings consistently highlight the critical role of calcitonin gene-related peptide (CGRP) in chronic migraine (CM) and related emotional responses. CGRP antibodies and receptor ant...

    Authors: Yang Li, Chenhao Li, Qi-Yu Chen, Shun Hao, Jingrui Mao, Wenwen Zhang, Xun Han, Zhao Dong, Ruozhuo Liu, Wenjing Tang, Min Zhuo, Shengyuan Yu and Yinglu Liu
    Citation: The Journal of Headache and Pain 2024 25:81
    Content type: Research Published on:

  29. Migraine lacks biomarkers that can trace the biological pathways of the disease and predict the effectiveness of treatments. Monoclonal antibodies targeting calcitonin gene-related peptide pathway – including ...

    Authors: Raffaele Ornello, Veronica Zelli, Chiara Compagnoni, Valeria Caponnetto, Eleonora De Matteis, Cindy Tiseo, Alessandra Tessitore and Simona Sacco
    Citation: The Journal of Headache and Pain 2024 25:80
    Content type: Research Published on:

  30. Eptinezumab is a monoclonal antibody that targets calcitonin gene-related peptide (CGRP mAb) and is used for migraine prophylaxis. Efficacy data are mainly from clinical trials, real-world data are hardly avai...

    Authors: Armin Scheffler, Pauline Wenzel, Merle Bendig, Astrid Gendolla, Jale Basten, Christoph Kleinschnitz, Michael Nsaka, Diana Lindner, Steffen Naegel, Philipp Burow, Robert Fleischmann and Dagny Holle
    Citation: The Journal of Headache and Pain 2024 25:79
    Content type: Research Published on:

  31. Cross-sectional and longitudinal studies have been conducted to investigate the association between migraine and any headache and white matter hyperintensities (WMH). However, studies are inconsistent regardin...

    Authors: Sara Helena Schramm, I. Tenhagen, M. Jokisch, J. Gronewold, S. Moebus, S. Caspers, Z. Katsarava, R. Erbel, A. Stang and B. Schmidt
    Citation: The Journal of Headache and Pain 2024 25:78
    Content type: Research Published on:

  32. Chronic headache disorders are disabling. The CHESS trial studied the effects of a short non-pharmacological intervention of education with self-management support for people affected by migraine and/or tensio...

    Authors: Siew Wan Hee, Shilpa Patel, Harbinder Sandhu, Manjit S. Matharu and Martin Underwood
    Citation: The Journal of Headache and Pain 2024 25:77
    Content type: Research Published on:

  33. Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of the insular cortex (IC) is thought to involve several neuro...

    Authors: Jaisan Islam, Md Taufiqur Rahman, Elina KC and Young Seok Park
    Citation: The Journal of Headache and Pain 2024 25:76
    Content type: Review Published on:

  34. GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit con...

    Authors: Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay and Yildirim Sara
    Citation: The Journal of Headache and Pain 2024 25:75
    Content type: Research Published on:

  35. Chronic migraine (CM) is a debilitating neurofunctional disorder primarily affecting females, characterized by central sensitization. Central sensitization refers to the enhanced response to sensory stimulatio...

    Authors: Lei Wang, Xiaoming Liu, Chenlu Zhu, Shouyi Wu, Zhilei Li, Lipeng Jing, Zhenchang Zhang, Yuhong Jing and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:74
    Content type: Research Published on:

  36. Management of idiopathic intracranial hypertension (IIH) is complex requiring contributions from multiple specialized disciplines. In practice, this creates considerable organizational and communicational chal...

    Authors: Gabriel Bsteh, Stefan Macher, Nik Krajnc, Wolfgang Marik, Martin Michl, Nina Müller, Sina Zaic, Jürgen Harreiter, Klaus Novak, Christian Wöber and Berthold Pemp
    Citation: The Journal of Headache and Pain 2024 25:73
    Content type: Research Published on:

  37. Due to the high mortality and disability rate of intracranial hemorrhage, headache is not the main focus of research on cerebral arteriovenous malformation (AVM), so research on headaches in AVM is still scarc...

    Authors: Haibin Zhang, Heze Han, Li Ma, Ruinan Li, Zhipeng Li, Anqi Li, Kexin Yuan, Qinghui Zhu, Chengzhuo Wang, Yukun Zhang, Hongwei Zhang, Dezhi Gao, Geng Guo, Shuai Kang, Xun Ye, Youxiang Li…
    Citation: The Journal of Headache and Pain 2024 25:72
    Content type: Research Published on:

  38. There are no robust population-based Australian data on prevalence and attributed burden of migraine and medication-overuse headache (MOH) data. In this pilot cross-sectional study, we aimed to capture the par...

    Authors: Emma Foster, Zhibin Chen, Claire E Wakefield, Zanfina Ademi, Elspeth Hutton, Timothy J Steiner and Alessandro S Zagami
    Citation: The Journal of Headache and Pain 2024 25:71
    Content type: Research Published on:

  39. Recently, diagnostic criteria including a standardized MRI criterion were presented to identify patients suffering from idiopathic intracranial hypertension (IIH) proposing that IIH might be defined by two out...

    Authors: Stefan Macher, Wolfgang Marik, Nik Krajnc, Christoph Mitsch, Martin Michl, Nina Mueller, Klaus Novak, Sina Zaic, Christian Woeber, Berthold Pemp and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2024 25:70
    Content type: Research Published on:

  40. Calcitonin gene-related peptide (CGRP) is the most promising candidate to become the first migraine biomarker. However, literature shows clashing results and suggests a methodological source for such discrepan...

    Authors: Gabriel Gárate, Julio Pascual, Marta Pascual-Mato, Jorge Madera, María Muñoz-San Martín and Vicente González-Quintanilla
    Citation: The Journal of Headache and Pain 2024 25:69
    Content type: Research Published on:

  41. Acupuncture showed better improvement than sham acupuncture in reducing attack frequency of tension-type headache (TTH), but its effectiveness relative to first-line drugs for TTH is unknown, which impedes the...

    Authors: Qing-Feng Tao, Yan-Bing Huang, Lu Yuan, Yun-Zhou Shi, Di Qin, Kun Ye, Wen-Yan Peng, Chao-Rong Xie and Hui Zheng
    Citation: The Journal of Headache and Pain 2024 25:67
    Content type: Research Published on:

  42. Several studies have focused on the use of triptan and the risk of acute vascular events but the existence of such association is still debated and has never been quantified in patients over 65 years. To asses...

    Authors: Phuong Thao Tran, Maryse Lapeyre-Mestre, Baricault Berangere, Michel Lanteri-Minet, Aurore Palmaro, Anne Donnet and Joëlle Micallef
    Citation: The Journal of Headache and Pain 2024 25:68
    Content type: Research Published on:

  43. We have previously shown headache to be highly prevalent among adults in Saudi Arabia. Here we estimate associated symptom burden and impaired participation (impaired use of time, lost productivity and disenga...

    Authors: Mohammed Al Jumah, Ali M. Al Khathaami, Suleman Kojan, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:66
    Content type: Research Published on:

  44. Despite recent advancements in migraine treatment, some patients continue to endure significant disease burden. Due to the controlled nature of randomized trials in migraine prevention, many real-world patient...

    Authors: Charles Argoff, Steven P. Herzog, Ryan M. Smith, Sameer V. Kotak, Liza Sopina, Yvonna Saltarska, Seema Soni-Brahmbhatt and Fawad A. Khan
    Citation: The Journal of Headache and Pain 2024 25:65
    Content type: Research Published on:

  45. Postdural puncture headache (PDPH) is an acknowledged consequence of procedures like lumbar punctures, epidural analgesia, and neurosurgical interventions. Persistence over more than three months, however has ...

    Authors: Ali Kapan, Thomas Waldhör, Tobias Schiffler, Jürgen Beck and Christian Wöber
    Citation: The Journal of Headache and Pain 2024 25:64
    Content type: Research Published on:

  46. Sexual dimorphism has been revealed for many neurological disorders including chronic pain. Prelicinal studies and post-mortem analyses from male and female human donors reveal sexual dimorphism of nociceptors...

    Authors: Shagun Singh, Caroline M. Kopruszinski, Moe Watanabe, David W. Dodick, Edita Navratilova and Frank Porreca
    Citation: The Journal of Headache and Pain 2024 25:63
    Content type: Review Published on:

  48. Chronic migraine (CM) negatively impacts the quality of life of 2 to 4% of pediatric patients. In adults, CM is frequently linked to medication overuse headache (MOH), but there is a much lower prevalence of M...

    Authors: Ilaria Frattale, Michela Ada Noris Ferilli, Fabiana Ursitti, Giorgia Sforza, Gabriele Monte, Martina Proietti Checchi, Samuela Tarantino, Luigi Mazzone, Massimiliano Valeriani and Laura Papetti
    Citation: The Journal of Headache and Pain 2024 25:61
    Content type: Research Published on:

  50. Migraine is a complex neurological disorder with significant heterogeneity in its clinical presentation and molecular mechanisms. Calcitonin gene-related peptide (CGRP) has emerged as a key player in migraine ...

    Authors: Alicia Alpuente, Victor J. Gallardo, Laila Asskour, Edoardo Caronna, Marta Torres-Ferrus and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2024 25:58
    Content type: Research Published on:
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