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Effects of URB937 on an animal model of migraine pain

Several studies have suggested the existence of interactions between the endocannabinoids and migraine. URB937, a FAAH inhibitor specific to peripheral tissues, causes analgesia in animal models of pain [1]. In this study, we evaluated whether the URB937 administration may alter nociceptive responses in an animal model of migraine based on nitroglycerin (NTG)-induced hyperalgesia [2]. Rats received systemic NTG and URB937 before being evaluated at the Tail flick test or at the Formalin test. The findings show that URB937 did inhibit NTG-induced hyperalgesia at the Formalin test with only a minimal influence on the hyperalgesia at the Tail flick. The data suggest that availability of anandamide probably at the meningeal level is effective in the migraine pain.


  1. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D: Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci 2010, 13(10):1265–70. 10.1038/nn.2632

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  2. Tassorelli C, Greco R, Wang D, Sandrini M, Sandrini G, Nappi G: Nitroglycerin induces hyperalgesia in rats--a time-course study. Eur J Pharmacol 2003, 464(2–3):159–62. 10.1016/S0014-2999(03)01421-3

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Greco, R., Mangione, A., De Icco, R. et al. Effects of URB937 on an animal model of migraine pain. J Headache Pain 14 (Suppl 1), P68 (2013).

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