Skip to main content
Download PDF
Download ePub

Volume 14 Supplement 1

Abstract Book of The European Headache and Migraine Trust International Congress

  • Poster presentation
  • Open access
  • Published:

Effects of URB937 on an animal model of migraine pain

The Journal of Headache and Pain volume 14, Article number: P68 (2013) Cite this article

Several studies have suggested the existence of interactions between the endocannabinoids and migraine. URB937, a FAAH inhibitor specific to peripheral tissues, causes analgesia in animal models of pain [1]. In this study, we evaluated whether the URB937 administration may alter nociceptive responses in an animal model of migraine based on nitroglycerin (NTG)-induced hyperalgesia [2]. Rats received systemic NTG and URB937 before being evaluated at the Tail flick test or at the Formalin test. The findings show that URB937 did inhibit NTG-induced hyperalgesia at the Formalin test with only a minimal influence on the hyperalgesia at the Tail flick. The data suggest that availability of anandamide probably at the meningeal level is effective in the migraine pain.

References

  1. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D: Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci 2010, 13(10):1265–70. 10.1038/nn.2632

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Tassorelli C, Greco R, Wang D, Sandrini M, Sandrini G, Nappi G: Nitroglycerin induces hyperalgesia in rats--a time-course study. Eur J Pharmacol 2003, 464(2–3):159–62. 10.1016/S0014-2999(03)01421-3

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Headache Science Centre, IRCCS National Neurological Institute “C. Mondino” Foundation, Pavia, Italy

    R Greco, AS Mangione & R De Icco

  2. Medicinal Chemistry Drug Discovery and Development, Italian Institute of Technology, Genova, Italy

    T Bandiera

  3. Headache Science Centre, IRCCS National Neurological Institute “C. Mondino” Foundation, UCADH, Pavia, Italy

    G Sandrini, G Nappi & C Tassorelli

  4. Departments of Pharmacology and Biological Chemistry, University of California, Irvine, CA, USA

    D Piomelli

Authors
  1. R Greco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. AS Mangione
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R De Icco
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Bandiera
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G Sandrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G Nappi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D Piomelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C Tassorelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Greco, R., Mangione, A., De Icco, R. et al. Effects of URB937 on an animal model of migraine pain. J Headache Pain 14 (Suppl 1), P68 (2013). https://doi.org/10.1186/1129-2377-14-S1-P68

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1129-2377-14-S1-P68

Keywords

The Journal of Headache and Pain

ISSN: 1129-2377

Contact us