The Journal of Headache and Pain is the official journal of the European Headache Federation and Lifting the Burden.
Articles
Page 1 of 62
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Citation: The Journal of Headache and Pain 2023 24:67
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PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine
Chronic migraine (CM) is a common neurological disorder with complex pathogenesis. Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces migraine-like attacks and may be potenti...
Citation: The Journal of Headache and Pain 2023 24:66 -
SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop
Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller ...
Citation: The Journal of Headache and Pain 2023 24:65 -
Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients
Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age res...
Citation: The Journal of Headache and Pain 2023 24:63 -
Estrogen modulation of cortical spreading depression
Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a h...
Citation: The Journal of Headache and Pain 2023 24:62 -
Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor
Migraine is a highly disabling health burden with multiple symptoms; however, it remains undertreated because of an inadequate understanding of its neural mechanisms. Neuropeptide Y (NPY) has been demonstrated...
Citation: The Journal of Headache and Pain 2023 24:61 -
The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study
Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate...
Citation: The Journal of Headache and Pain 2023 24:60 -
Imaging the brain and vascular reactions to headache treatments: a systematic review
Neuroimaging studies have made an important contribution to our understanding of headache pathophysiology. This systematic review aims to provide a comprehensive overview and critical appraisal of mechanisms o...
Citation: The Journal of Headache and Pain 2023 24:58 -
Real-world effectiveness of fremanezumab in patients with migraine switching from another mAb targeting the CGRP pathway: a subgroup analysis of the Finesse Study
Monoclonal antibodies targeting the CGRP pathway are effective and safe for prophylactic treatment of episodic (EM) and chronic migraine (CM). In case of treatment failure of a CGRP pathway targeting mAb, phys...
Citation: The Journal of Headache and Pain 2023 24:59 -
Verification of a clinical decision support system for the diagnosis of headache disorders based on patient–computer interactions: a multi-center study
Although headache disorders are common, the current diagnostic approach is unsatisfactory. Previously, we designed a guideline-based clinical decision support system (CDSS 1.0) for diagnosing headache disorder...
Citation: The Journal of Headache and Pain 2023 24:57 -
The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis
While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We c...
Citation: The Journal of Headache and Pain 2023 24:56 -
Migraine with aura: less control over pain and fragrances?
Accumulating data emphasizes the importance of olfaction in migraine pathophysiology. However, there are only a few studies evaluating how the migraine brain processes olfactory stimulation, and virtually no s...
Citation: The Journal of Headache and Pain 2023 24:55 -
Parahippocampus hypertrophy drives gray matter morphological alterations in migraine patients without aura
The aberrance of gray matter morphology in migraineurs has been widely investigated. However, it remains largely unknown whether there are illness duration-related hierarchical changes in the gray matter struc...
Citation: The Journal of Headache and Pain 2023 24:53 -
The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression
Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatmen...
Citation: The Journal of Headache and Pain 2023 24:54 -
Employees of the banking sector in Guizhou Province in China: prevalence of migraine, symptoms, disability and occupational risk factors
Although studies have identified a high prevalence of migraine among employees in the banking sector, the symptoms of migraine, related disability and occupational risk factors are not well understood.
Citation: The Journal of Headache and Pain 2023 24:52 -
Radiosurgery for classical trigeminal neuralgia: impact of the shot size on clinical outcome
This study compares the outcome of patients suffering from medically refractory classical trigeminal neuralgia (TN) after treatment with radiosurgery using two different shot sizes (5- and 6-mm).
Citation: The Journal of Headache and Pain 2023 24:51 -
Descending serotonergic modulation from rostral ventromedial medulla to spinal trigeminal nucleus is involved in experimental occlusal interference-induced chronic orofacial hyperalgesia
Dental treatment associated with unadaptable occlusal alteration can cause chronic primary myofascial orofacial pain. The serotonin (5-HT) pathway from the rostral ventromedial medulla (RVM) exerts descending ...
Citation: The Journal of Headache and Pain 2023 24:50 -
Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors
Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.
Citation: The Journal of Headache and Pain 2023 24:49 -
Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine
Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an analgesic effect in several pain models, does not have side effects and has low toxicity. The data about CBD mechanisms of...
Citation: The Journal of Headache and Pain 2023 24:48 -
Social cognition in chronic migraine with medication overuse: a cross-sectional study on different aspects of mentalization and social relationships
Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO...
Citation: The Journal of Headache and Pain 2023 24:47 -
Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study
The pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional connectivity (FC) in patients with NDPH using resting-state functional magnetic resonance ima...
Citation: The Journal of Headache and Pain 2023 24:46 -
Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI
New daily persistent headache (NDPH) is a rare but debilitating primary headache disorder that poses a significant burden on individuals and society. Despite its clinical importance, the underlying pathophysio...
Citation: The Journal of Headache and Pain 2023 24:45 -
Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model
Central sensitization has been widely accepted as an underlying pathophysiological mechanism of chronic migraine (CM), activation of cannabinoid type-1 receptor (CB1R) exerts antinociceptive effects by relievi...
Citation: The Journal of Headache and Pain 2023 24:44 -
Neuroanatomical restoration of salience network links reduced headache impact to cognitive function improvement in mild traumatic brain injury with posttraumatic headache
Neuroanatomical alterations have been associated with cognitive deficits in mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal gray matter volume in widespread brain regions...
Citation: The Journal of Headache and Pain 2023 24:43 -
PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model
Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache response...
Citation: The Journal of Headache and Pain 2023 24:42 -
Periaqueductal gray matter echogenicity as a marker of migraine chronification: a case control study
Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the ech...
Citation: The Journal of Headache and Pain 2023 24:41 -
Migraine symptoms, healthcare resources utilization and disease burden in a large Polish migraine cohort
The Migraine in Poland study is the first large scale nationwide cross-sectional online survey of symptoms, approaches to management, treatment patterns, quality of life, and sociodemographic characteristics o...
Citation: The Journal of Headache and Pain 2023 24:40 -
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 1: amitriptyline
The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.
Citation: The Journal of Headache and Pain 2023 24:39 -
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide...
Citation: The Journal of Headache and Pain 2023 24:38 -
Cluster headache and kynurenines
The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement n...
Citation: The Journal of Headache and Pain 2023 24:35 -
Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG)
Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socio...
Citation: The Journal of Headache and Pain 2023 24:37 -
Cytokines in primary headache disorders: a systematic review and meta-analysis
The role of inflammation and cytokines in the pathophysiology of primary headache disorders is uncertain. We performed a systematic review and meta-analysis to synthesise the results of studies comparing perip...
Citation: The Journal of Headache and Pain 2023 24:36 -
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both are vasodilatory peptides that c...
Citation: The Journal of Headache and Pain 2023 24:34 -
Is the right way to go in between?
In the study by Johnston et al., gepants were meant to be taken to treat emergent migraine. It is tempting to speculate what the effect would be if patients were instructed to take a gepant as needed (PRN) or ...
Citation: The Journal of Headache and Pain 2023 24:33 -
Disease burden of migraine and tension-type headache in non-high-income East and Southeast Asia from 1990 to 2019
The world faces severe challenges from migraine and tension-type headache (TTH), which cause grave disability to patients and place a heavy burden on their caregivers. However, headaches in specific individual...
Citation: The Journal of Headache and Pain 2023 24:32 -
Prolactin and oxytocin: potential targets for migraine treatment
Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuat...
Citation: The Journal of Headache and Pain 2023 24:31 -
Early and sustained efficacy of fremanezumab over 24-weeks in migraine patients with multiple preventive treatment failures: the multicenter, prospective, real-life FRIEND2 study
To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic migraine (CM: ≥ 15 days/month)...
Citation: The Journal of Headache and Pain 2023 24:30 -
FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability
Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 2...
Citation: The Journal of Headache and Pain 2023 24:28 -
A study on the correlation of the asymmetric regulation between the periaqueductal gray and the bilateral trigeminal nucleus caudalis in migraine male rats
The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of...
Citation: The Journal of Headache and Pain 2023 24:27 -
A novel score to estimate thrombus burden and predict intracranial hypertension in cerebral venous sinus thrombosis
Current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intrac...
Citation: The Journal of Headache and Pain 2023 24:29 -
Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders
The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, an...
Citation: The Journal of Headache and Pain 2023 24:26 -
The variability of diagnosed migraine epidemiology amongst different municipalities in southern Israel
Appropriate and timely diagnosis is one of the most important milestones in effective migraine care and is affected by public awareness, access to medical care, health care systems, and physicians’ knowledge. ...
Citation: The Journal of Headache and Pain 2023 24:25 -
Cross-sectional, hospital-based analysis of headache types using ICHD-3 criteria in the Middle East, Asia, and Africa: the Head-MENAA study
Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essentia...
Citation: The Journal of Headache and Pain 2023 24:24 -
Predicting response to CGRP-monoclonal antibodies in patients with migraine in Japan: a single-centre retrospective observational study
Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are a favourable option for patients with migraine who experience distressful headache disability and fail to respond to traditional preven...
Citation: The Journal of Headache and Pain 2023 24:23 -
Correction: Investigation of cortical thickness and volume during spontaneous attacks of migraine without aura: a 3-Tesla MRI study
Citation: The Journal of Headache and Pain 2023 24:22 -
The HARDSHIP databases: a forthcoming free good from the Global Campaign against Headache
In order to pursue its purpose of reducing the global burden of headache, the Global Campaign against Headache has gathered data on headache-attributed burden from countries worldwide. These data, from the ind...
Citation: The Journal of Headache and Pain 2023 24:21 -
Should migraine without aura be further divided? A study of 1444 female patients with migraine without aura
To explore the possibility of further dividing migraine without aura (MWA), 1444 female patients fulfilled the criterion were recruited, and grouped basing on the association of MWA onset with menarche and chi...
Citation: The Journal of Headache and Pain 2023 24:20 -
The applicability research of the diagnostic criteria for 10.2 Heamodialysis-related headache in the international classification of headache disorders-3rd edition
Headache during hemodialysis (HDH) is prevalent but not negligible. Despite the high prevalence of dialysis headaches, they have rarely been studied. Therefore, this study aimed to evaluate the prevalence, ris...
Citation: The Journal of Headache and Pain 2023 24:19 -
Clinical evaluation of super-responders vs. non-responders to CGRP(-receptor) monoclonal antibodies: a real-world experience
Clinical trials and real-world studies revealed a spectrum of response to CGRP(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at all to total migraine freedom. In this ...
Citation: The Journal of Headache and Pain 2023 24:16 -
White matter hyperintensities and cerebral microbleeds in persistent post-traumatic headache attributed to mild traumatic brain injury: a magnetic resonance imaging study
To examine whether white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs) are more prevalent in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI), com...
Citation: The Journal of Headache and Pain 2023 24:15
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