Articles

Improvements in pain, medication use and quality of life in onabotulinumtoxinA-resistant chronic migraine patients following erenumab treatment – real world outcomes

The CGRP antagonists offer a novel therapeutic approach in migraine. Their utility in patients with severe forms of chronic migraine is a subject of particular interest. We present outcomes of 9 months of eren...

Authors: J. Talbot, R. Stuckey, L. Crawford, S. Weatherby and S. Mullin

Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine

The moment-to-moment variability of resting-state brain activity has been suggested to play an active role in chronic pain. Here, we investigated the regional blood-oxygen-level-dependent signal variability (BOLD

Authors: Manyoel Lim, Hassan Jassar, Dajung J. Kim, Thiago D. Nascimento and Alexandre F. DaSilva

Immunogenicity of biologic therapies for migraine: a review of current evidence

Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been shown to be effective in migraine prevention. Eptinezumab, erenumab, fremanezumab, and galcanezumb have shown...

Authors: Joshua M. Cohen, Xiaoping Ning, Yoel Kessler, Michele Rasamoelisolo, Verena Ramirez Campos, Michael J. Seminerio, Lynda J. Krasenbaum, Honglue Shen and Jennifer Stratton

Treatment benefit among migraine patients taking fremanezumab: results from a post hoc responder analysis of two placebo-controlled trials

Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway, including the fully humanized monoclonal antibody (IgG2Δa) fremanezumab, have demonstrated safety and efficacy for migraine p...

Authors: Stephen D. Silberstein, Joshua M. Cohen, Ronghua Yang, Sanjay K. Gandhi, Evelyn Du, Adelene E. Jann and Michael J. Marmura

Association between response to triptans and response to erenumab: real-life data

Triptans and erenumab are both migraine-specific agents acting on the calcitonin gene-related peptide pathway. Therefore, response to triptans might be associated with response to erenumab.

Authors: Ilaria Frattale, Valeria Caponnetto, Alfonsina Casalena, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Giannapia Affaitati, Maria Adele Giamberardino, Stefano Viola, Amleto Gabriele, Francesca Pistoia, Davide Cerone, Carmine Marini, Simona Sacco and Raffaele Ornello

Neuromodulation techniques for acute and preventive migraine treatment: a systematic review and meta-analysis of randomized controlled trials

Several neuromodulation methods exists for migraine treatment. The aim of the present study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) focusing on migraine trea...

Authors: Xavier Moisset, Bruno Pereira, Daniel Ciampi de Andrade, Denys Fontaine, Michel Lantéri-Minet and Jérôme Mawet

Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS).

Authors: Zhengjie Li, Jun Zhou, Lei Lan, Shirui Cheng, Ruirui Sun, Qiyong Gong, Max Wintermark, Fang Zeng and Fanrong Liang

Correction to: The knockdown of Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion

An amendment to this paper has been published and can be accessed via the original article.

Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen

Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal

The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization. Metabotropic glutamate re...

Authors: Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou and Lixue Chen

The role of deficient pain modulatory systems in the development of persistent post-traumatic headaches following mild traumatic brain injury: an exploratory longitudinal study

Post-traumatic headache (PTH) is one of the most common and long-lasting symptoms following mild traumatic brain injury (TBI). However, the pathological mechanisms underlying the development of persistent PTH ...

Authors: Kelly M. Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman and Fletcher A. White

Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019

Authors: T. J. Steiner, L. J. Stovner, R. Jensen, D. Uluduz and Z. Katsarava

Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression

Previous researches have reported gray and white matter microalterations in primary trigeminal neuralgia (TN) with neurovascular compression (NVC). The central mechanism underlying TN without NVC are unknown b...

Authors: Min Wu, Xiaofeng Jiang, Jun Qiu, Xianming Fu and Chaoshi Niu

Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain

Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for...

Authors: Xuan Niu, Lijun Bai, Yingxiang Sun, Yuan Wang, Guanghui Bai, Bo Yin, Shan Wang, Shuoqiu Gan, Xiaoyan Jia and Hongjuan Liu

Interrelations between migraine-like headache and persistent post-traumatic headache attributed to mild traumatic brain injury: a prospective diary study

Persistent post-traumatic headache (PTH) is a common sequela of mild traumatic brain injury (TBI) and retrospective assessments have found a migraine-like phenotype to be very frequent. This has raised a discu...

Authors: Håkan Ashina, Afrim Iljazi, Faisal M. Amin, Messoud Ashina, Richard B. Lipton and Henrik W. Schytz

Individual pain sensitivity is associated with resting-state cortical activities in healthy individuals but not in patients with migraine: a magnetoencephalography study

Pain sensitivity may determine the risk, severity, prognosis, and efficacy of treatment of clinical pain. Magnetic resonance imaging studies have linked thermal pain sensitivity to changes in brain structure. ...

Authors: Fu-Jung Hsiao, Wei-Ta Chen, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Li-Ling Hope Pan and Shuu-Jiun Wang

Correction to: Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway

An amendment to this paper has been published and can be accessed via the original article.

Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen

Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects

Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding ...

Authors: Karin Warfvinge, Diana N. Krause, Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson and Kristian A. Haanes

Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England

Trigeminal neuralgia (TN) causes severe episodic, unilateral facial pain and is initially treated with antiepileptic medications. For patients not responding or intolerant to medications, surgery is an option.

Authors: Lasair O’Callaghan, Lysbeth Floden, Lisa Vinikoor-Imler, Tara Symonds, Kathryn Giblin, Chris Hartford and Joanna M. Zakrzewska

OnabotulinumtoxinA for chronic migraine during pregnancy: a real world experience on 45 patients

To report the pregnancy outcomes on patients with chronic migraine exposed to onabotulinumtoxinA from Hull Headache Clinic.

Authors: Ho-Tin Wong, Modar Khalil and Fayyaz Ahmed

Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway

The Covid-19 pandemic is causing changes in delivery of medical care worldwide. It is not known how the management of headache patients was affected by the lockdown during the pandemic. The aim of the present ...

Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen

Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations

Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aur...

Authors: Kazutaka Sugimoto, Andreia Morais, Homa Sadeghian, Tao Qin, David Y. Chung, Messoud Ashina, Anders Hougaard and Cenk Ayata

Migraine and sleep disorders: a systematic review

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.

Authors: Cindy Tiseo, Alessandro Vacca, Anton Felbush, Tamara Filimonova, Annalisa Gai, Tatyana Glazyrina, Irina Anna Hubalek, Yelena Marchenko, Lucas Hendrik Overeem, Serena Piroso, Alexander Tkachev, Paolo Martelletti and Simona Sacco

A cross-sectional study on the burden and impact of migraine on work productivity and quality of life in selected workplaces in the Philippines

Migraine imposes a substantial personal and economic burden to many working age individuals. This study aimed to evaluate the burden and impact of migraine on work productivity in selected workplaces in the Ph...

Authors: Nel Jason Haw, Ian Theodore Cabaluna, Germaine Erika Kaw, Joanna Feliz Cortez, Maria Pamela Chua and Kristel Guce

A proof-of-concept study on CGRP plasma levels of migraineurs during a 6-month treatment with ERENUMAB

The introduction of monoclonal antibodies (mAbs) against calcitonin-gene related peptide (CGRP) or CGRP receptors in the treatment of migraine raised concerns on the possible risks associated to the long-term ...

Authors: Giuseppe Tringali, Catello Vollono, Paolo Calabresi and Pierluigi Navarra

Impact of galcanezumab on total pain burden: findings from phase 3 randomized, double-blind, placebo-controlled studies in patients with episodic or chronic migraine (EVOLVE-1, EVOLVE-2, and REGAIN trials)

Focus on the frequency of migraine pain may undervalue the total burden of migraine as pain duration and severity may present unique, additive burden. A composite measure of total pain burden (TPB; frequency, ...

Authors: Jessica Ailani, J. Scott Andrews, Mallikarjuna Rettiganti and Robert A. Nicholson

Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most con...

Authors: Rosaria Greco, Roberto De Icco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Grazia Sances, Marta Allena and Cristina Tassorelli

Headache characteristics in COVID-19 pandemic-a survey study

Headache is the most common COVID-19-related neurological symptom. We aimed to reveal diagnostic clues of headache for COVID-19 infection and to investigate the course of primary headaches during the pandemic.

Authors: Özge Uygun, Mustafa Ertaş, Esme Ekizoğlu, Hayrunnisa Bolay, Aynur Özge, Elif Kocasoy Orhan, Arif Atahan Çağatay and Betül Baykan

Eptinezumab for the prevention of chronic migraine: efficacy and safety through 24 weeks of treatment in the phase 3 PROMISE-2 (Prevention of migraine via intravenous ALD403 safety and efficacy–2) study

PROMISE-2 was a phase 3, randomized, double-blind, placebo-controlled study that evaluated the efficacy and safety of repeat intravenous (IV) doses of the calcitonin gene-related peptide–targeted monoclonal an...

Authors: Stephen Silberstein, Merle Diamond, Nada A. Hindiyeh, David M. Biondi, Roger Cady, Joe Hirman, Brent Allan, Susan Pederson, Barbara Schaeffler and Jeff Smith

Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations

Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mecha...

Authors: Guoliang Chen, Yansong Li, Zhao Dong, Rongfei Wang, Dengfa Zhao, Ignacio Obeso and Shengyuan Yu

My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland

A global My Migraine Voice survey was conducted in 31 countries among 11,266 adults who suffered from ≥4 monthly migraine days (MMD). The aim of this retrospective observational survey-based study was to analyse ...

Authors: Marja-Liisa Sumelahti, Markku Sumanen, Merika S. Sumanen, Samuli Tuominen, Johanna Vikkula, Sanna M. Honkala, Stina Rosqvist and Minna A. Korolainen

European Headache Federation recommendations for placebo and nocebo terminology

Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulat...

Authors: Dimos D. Mitsikostas, Charlotte Blease, Elisa Carlino, Luana Colloca, Andrew L. Geers, Jeremy Howick, Andrea W. M. Evers, Magne A. Flaten, John M. Kelley, Irving Kirsch, Regine Klinger, Antoinette MaassenVanDenBrink, Daniel E. Moerman, Petros P. Sfikakis, Lene Vase, Tor D. Wager…

Calcitonin gene related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension

Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics. There are currently no evidence-based thera...

Authors: Andreas Yiangou, James L. Mitchell, Vivek Vijay, Olivia Grech, Edward Bilton, Gareth G. Lavery, Claire Fisher, Julie Edwards, Susan P. Mollan and Alexandra J. Sinclair

Impact of coronavirus disease 2019 (COVID-19) pandemic on patients with migraine: a web-based survey study

Since the declaration COVID-19 as a pandemic, healthcare systems around the world have faced a huge challenge in managing patients with chronic diseases. Patients with migraine were specifically vulnerable to ...

Authors: Jasem Y. Al-Hashel and Ismail Ibrahim Ismail

The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study

We evaluated the efficacy of fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, in patients with chronic migraine (CM) with and without medication ove...

Authors: Stephen D. Silberstein, Joshua M. Cohen, Michael J. Seminerio, Ronghua Yang, Sait Ashina and Zaza Katsarava

Correction to: Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin

Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine

Chronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level depen...

Authors: Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli and Gianluca Coppola

Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura

Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functiona...

Authors: Heng-Le Wei, Jing Chen, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Zhen-Zhen He, Lian Yang, Xindao Yin, Junrong Li and Hong Zhang

Burden of migraine among Japanese patients: a cross-sectional National Health and Wellness Survey

Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National ...

Authors: Shoji Kikui, Yirong Chen, Hiroshi Todaka, Keiko Asao, Kenji Adachi and Takao Takeshima

Improvements across a range of patient-reported domains with fremanezumab treatment: results from a patient survey study

The long-term safety and efficacy of fremanezumab were evaluated in a 52-week extension study (NCT02638103). Patient satisfaction with fremanezumab, dosing preferences, and patient-reported outcomes were asses...

Authors: Dawn C. Buse, Sanjay K. Gandhi, Joshua M. Cohen, Verena Ramirez-Campos, Blaine Cloud, Ronghua Yang and Robert P. Cowan

The prevalence of headache disorders in children and adolescents in Ethiopia: a schools-based study

The Global Burden of Disease (GBD) study establishes headache as the second-highest cause of disability worldwide. Because most headache data in GBD are from adults, leading to underestimation of headache-attr...

Authors: Yared Zenebe Zewde, Mehila Zebenigus, Hanna Demissie, Redda Tekle-Haimanot, Derya Uluduz, Tayyar Şaşmaz, Fatma Bozdag and Timothy J. Steiner

The prevalence of headache disorders in children and adolescents in Mongolia: a nationwide schools-based study

The Global Campaign against Headache collects data from children (7–11 years) and adolescents (12–17 years) both to inform health and education policies and to contribute to the Global Burden of Disease (GBD) ...

Authors: Otgonbayar Luvsannorov, Tsengunmaa Anisbayar, Munkhzul Davaasuren, Otgonzaya Baatar, Khaliunaa Batmagnai, Khulan Tumurbaatar, Sarantuya Enkhbaatar, Derya Uluduz, Tayyar Şaşmaz, Elif Tuğçe Solmaz and Timothy J. Steiner

Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down

Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear.

Authors: Jaisan Islam, Elina KC, Byeong Ho Oh, Soochong Kim, Sang-hwan Hyun and Young Seok Park

Altered levels of salivary and plasma pain related markers in temporomandibular disorders

Different pain syndromes may be characterized by different profiles of mediators reflecting pathophysiological differences, and these alterations may be measured in a simple saliva sample. The aims of the curr...

Authors: Hajer Jasim, Bijar Ghafouri, Björn Gerdle, Britt Hedenberg-Magnusson and Malin Ernberg

Correction to: Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia

An amendment to this paper has been published and can be accessed via the original article.

Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U. Bahkt Sultan Shah

Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy

Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unf...

Authors: Binbin Lin, Yuting Wang, Piao Zhang, Yanyan Yuan, Ying Zhang and Gang Chen

Conversion from chronic to episodic migraine in patients treated with erenumab: real-life data from an Italian region

Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study.

Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Valeria Caponnetto, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats

Although migraine is one of the most common primary headaches, its therapy is still limited in many cases. The use of animal models is crucial in the development of novel therapeutic strategies, but unfortunat...

Authors: Klaudia Flóra Laborc, Eleonóra Spekker, Zsuzsanna Bohár, Mónika Szűcs, Gábor Nagy-Grócz, Annamária Fejes-Szabó, László Vécsei and Árpád Párdutz

The status and high risk factors of severe psychological distress in migraine patients during nCOV-2019 outbreak in Southwest China: a cross-sectional study

Psychological distress is highly prevalent among migraineurs during public health emergencies. The coronavirus disease 2019 (nCOV-2019) has created mass panic in China due to its highly contagious by contact a...

Authors: Mengmeng Ma, Jinghuan Fang, Changling Li, Jiajia Bao, Yang Zhang, Ning Chen, Jian Guo and Li He

Economic consequences of migraine in Sweden and implications for the cost-effectiveness of onabotulinumtoxinA (Botox) for chronic migraine in Sweden and Norway

Migraine is a common and incapacitating condition, with severe impact on the quality of life (QoL) of the afflicted and their families, and negative economic consequences through decreased workforce participat...

Authors: Amanda Hansson-Hedblom, Isabelle Axelsson, Lena Jacobson, Joakim Tedroff and Fredrik Borgström

Migraine, obesity and body fat distribution – a population-based study

Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between o...

Authors: Espen Saxhaug Kristoffersen, Sigrid Børte, Knut Hagen, John-Anker Zwart and Bendik Slagsvold Winsvold