Articles

Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study

Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all ...

Authors: Sabrina Islamoska, Åse Marie Hansen, Hui-Xin Wang, Anne Helene Garde, Per Kragh Andersen, Ellen Garde, Jakob Møller Hansen, Gunhild Waldemar and Kirsten Nabe-Nielsen

Migraine, obesity and body fat distribution – a population-based study

Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between o...

Authors: Espen Saxhaug Kristoffersen, Sigrid Børte, Knut Hagen, John-Anker Zwart and Bendik Slagsvold Winsvold

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of t...

Authors: Nuria García-Magro, Pilar Negredo, Yasmina B. Martin, Ángel Nuñez and Carlos Avendaño

Efficacy and safety of erenumab in women with a history of menstrual migraine

We performed a post hoc, subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled study of erenumab for prevention of episodic migraine (STRIVE) to determine the efficacy and safety of eren...

Authors: Jelena M. Pavlovic, Koen Paemeleire, Hartmut Göbel, Jo Bonner, Alan Rapoport, Risa Kagan, Feng Zhang, Hernan Picard and Daniel D. Mikol

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if pati...

Authors: Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente…

Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury

Post-traumatic headache (PTH) is one of the most frequent symptoms following mild traumatic brain injury (mTBI). Neuroimaging studies implicate hypothalamic function connectivity (FC) disruption as an importan...

Authors: Liyan Lu, Fengfang Li, Peng Wang, Huiyou Chen, Yu-Chen Chen and Xindao Yin

Patients with chronic migraine without history of medication overuse are characterized by a peculiar white matter fiber bundle profile

We investigated intracerebral fiber bundles using a tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data to verify microstructural integrity in patients with episodic (MO) and ...

Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

Cognitive and sensorimotor function in participants being treated for trigeminal neuralgia pain

Trigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, wi...

Authors: Rachel O. Coats, Kirsty L. Crossley, Naomi Conlin, Jianhua Wu, Joanna M. Zakrzewska, Sue H. Pavitt, Nicholas Phillips and Mark Mon-Williams

Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence

According to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days ...

Authors: Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías, Petr Mikulenka, Olga Tikhonova, Paolo Martelletti and Antoinette MaassenVanDenBrink

Is there a reliable brain morphological signature for migraine?

Voxel-based morphometry (VBM) is a popular non-invasive magnetic resonance imaging technique to investigate brain gray matter (GM) differences between groups. Recently, two VBM studies in migraine have been pu...

Authors: Hong Zhou Wang, Wan Hua Wang, Hai Cun Shi and Cong Hu Yuan

Influence of headache pain intensity and frequency on migraine-related disability in chronic migraine patients treated with OnabotulinumtoxinA

There is a need to establish which are the more relevant headache-related outcomes that have an impact on our patient’s lives to accurately evaluate treatment response in daily clinical practice.

Authors: Marta Torres-Ferrus, Victor José Gallardo, Alicia Alpuente and Patricia Pozo-Rosich

Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion

Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related ...

Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen

Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization

Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarizati...

Authors: Andrea Negro, Jessica L. Seidel, Thijs Houben, Esther S. Yu, Ike Rosen, Andrea J. Arreguin, Nilufer Yalcin, Lea Shorser-Gentile, Lea Pearlman, Homa Sadhegian, Ramalingam Vetrivelan, Nancy L. Chamberlin, Cenk Ayata, Paolo Martelletti, Michael A. Moskowitz and Katharina Eikermann-Haerter

Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis

Migraine is a frequent headache disorder with high disease burden. The aims of this study were to determine the administrative prevalence and incidence of migraine in Germany; and to elucidate disease characte...

Authors: Tatjana Roessler, Juergen Zschocke, Anne Roehrig, Michael Friedrichs, Heiko Friedel and Zaza Katsarava

Erenumab in highly therapy-refractory migraine patients: First German real-world evidence

Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding ef...

Authors: Armin Scheffler, Olga Messel, Sebastian Wurthmann, Michael Nsaka, Christoph Kleinschnitz, Martin Glas, Steffen Naegel and Dagny Holle

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals

Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA recepto...

Authors: Diego Currò, Pierluigi Navarra, Irene Samengo and Maria Martire

Pitfals in recognition and management of trigeminal neuralgia

Trigeminal neuralgia (TN) is a severe, disabling form of painful cranial neuropathy. Even though TN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. In order to inv...

Authors: F. Antonaci, S. Arceri, M. Rakusa, D. D. Mitsikostas, I. Milanov, V. Todorov, M. Cotta Ramusino and A. Costa

Migraine start, course and features over the cycle of combined hormonal contraceptive users with menstrual migraine – temporal relation to bleeding and hormone withdrawal: a prospective diary-based study

Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researc...

Authors: Gabriele S. Merki-Feld, Nina Caveng, Gina Speiermann and E. Anne MacGregor

Impact of primary headache disorder on quality of life among school students in Kuwait

Primary headache disorders have being increasingly reported in younger populations. They can have significant effects on their quality of life and academic achievement and may cause significant distress to the...

Authors: Jasem Y. Al-Hashel, R. Alroughani, S. Shauibi, A. AlAshqar, F. AlHamdan, H. AlThufairi, S. Owayed and Samar F. Ahmed

Effect of age on pharmacokinetics, efficacy, and safety of galcanezumab treatment in adult patients with migraine: results from six phase 2 and phase 3 randomized clinical trials

Migraine clinical profile may change with age, making it necessary to verify that migraine treatments are equally safe and effective in older patients. These analyses evaluated the effects of patient age on th...

Authors: Virginia L. Stauffer, Ira Turner, Phebe Kemmer, William Kielbasa, Kathleen Day, Martha Port, Tonya Quinlan and Angelo Camporeale

The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies

Chronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophys...

Authors: Yuanyuan Yin, Shushu He, Jingchen Xu, Wanfang You, Qian Li, Jingyi Long, Lekai Luo, Graham J. Kemp, John A. Sweeney, Fei Li, Song Chen and Qiyong Gong

Addressing chronic persistent headaches after MTBI as a neuropathic pain state

An increasing number of patients with chronic persistent post-traumatic headache (PPTH) after mild traumatic brain injury (MTBI) are being referred to headache or pain specialists as conventional treatment opt...

Authors: Albert Leung

European headache federation consensus on the definition of resistant and refractory migraine

Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments. It is the aim of the present document to provi...

Authors: Simona Sacco, Mark Braschinsky, Anne Ducros, Christian Lampl, Patrick Little, Antoinette Maassen van den Brink, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Zaza Katsarava and Paolo Martelletti

Validation of an algorithm for automated classification of migraine and tension-type headache attacks in an electronic headache diary

This study evaluates the accuracy of an automated classification tool of single attacks of the two major primary headache disorders migraine and tension-type headache used in an electronic headache diary.

Authors: Aaron Roesch, Markus A Dahlem, Lars Neeb and Tobias Kurth

Low-value care practice in headache: a Spanish mixed methods research study

Headache is one of the most prevalent diseases. The Global Burden of Disease Study ranks it as the seventh most common disease overall and the second largest neurological cause of disability in the world. The ...

Authors: Patricia Pozo-Rosich, Almudena Layos-Romero, Jimmy Martin-Delgado, Julio Pascual, Cristina Bailón, Ana Tentor, Alejandro Santiago, Emilio Ignacio, Antonio Torrés and José Joaquín Mira

The prevalence of headache disorders in children and adolescents in Lithuania: a schools-based study

While the Global Burden of Disease (GBD) study reports headache disorders as the second-highest cause of disability worldwide, the headache data in GBD come very largely from adults. This national study in Lit...

Authors: Diana Genc, Nerija Vaičienė-Magistris, Apolinaras Zaborskis, Tayyar Şaşmaz, Aylin Yeniocak Tunç, Derya Uluduz and Timothy J. Steiner

Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine

Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to migraine had not been well elucidated. Thus, the present study investi...

Authors: Yun Zhang, Yixin Zhang, Ke Tian, Yunfeng Wang, Xiaoping Fan, Qi Pan, Guangcheng Qin, Dunke Zhang, Lixue Chen and Jiying Zhou

Lasmiditan mechanism of action – review of a selective 5-HT_1F agonist

Migraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this neurological disease led to the discovery that calcitonin gene-rela...

Authors: David B. Clemow, Kirk W. Johnson, Helen M. Hochstetler, Michael H. Ossipov, Ann M. Hake and Andrew M. Blumenfeld

Sentinel headache as a warning symptom of ischemic stroke

There are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors a...

Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev and Jes Olesen

Multidimensional assessment of the effects of erenumab in chronic migraine patients with previous unsuccessful preventive treatments: a comprehensive real-world experience

erenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report the clinical experience from an Italian real-world setting using ere...

Authors: Antonio Russo, Marcello Silvestro, Fabrizio Scotto di Clemente, Francesca Trojsi, Alvino Bisecco, Simona Bonavita, Alessandro Tessitore and Gioacchino Tedeschi

Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia

Productivity and monetary loss due to migraine in the workplace may be substantial. This study aimed to determine the impact of migraine on productivity and monetary lost among employees in the banking sectors...

Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U Bahkt Sultan Shah

High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019

Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investig...

Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

Short-term efficacy and safety of lasmiditan, a novel 5-HT_1F receptor agonist, for the acute treatment of migraine: a systematic review and meta-analysis

Migraine has been recognized as one of common diseases in the world whose current treatment options are not ideal. Lasmiditan, an oral 5-hydroxytryptamine (HT)_1F receptor agonist, appears more promising for the a...

Authors: Min Hou, Haiyan Xing, Chen Li, Xianfeng Wang, Dongmei Deng, Juan Li, Pan Zhang and Jianhong Chen

The fifth cranial nerve in headaches

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and ...

Authors: J. C. A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D’Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina…

Genetics of migraine aura: an update

Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Giv...

Authors: Irene de Boer, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg

On the utility of the trail making test in migraine with and without aura: a meta-analysis

This meta-analytical review assesses the utility of the Trail Making Test (TMT), versions A and B, in detecting migraine-related cognitive deficits. A comprehensive literature search was performed in two elect...

Authors: Antonino Vallesi

Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study

Calcitonin gene-related peptide (CGRP) has recently been implicated in the pathogenesis of post-traumatic headache (PTH), which raises the prospect for therapeutic use of monoclonal antibodies targeting CGRP o...

Authors: Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Anna Kristina Eigenbrodt, Eigil Lindekilde Larsen, Amalie Middelboe Andersen, Kevin John Hansen, Karoline Bendix Bräuner, Thomas Mørch-Jessen, Basit Chaudhry, Sonja Antic, Casper Emil Christensen, Messoud Ashina, Faisal Mohammad Amin and Henrik Winther Schytz

A prospective real-world analysis of erenumab in refractory chronic migraine

Clinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab i...

Authors: Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova and Anna P. Andreou

The applicability of web-based solutions in headache epidemiology research

Epidemiological research of headache is vital but resource consuming prerequisite for evidence-based development in the field. Rapid evolution of information technology may provide new opportunities for popula...

Authors: Kati Toom, Aire Raidvee and Mark Braschinsky

Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging

There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribut...

Authors: Tiffani J. Mungoven, Noemi Meylakh, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey and Luke A. Henderson

The impact of remission and coexisting migraine on anxiety and depression in cluster headache

Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.

Authors: Byung-Su Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Jeong Wook Park, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae-Moon Kim, Soo-Kyoung Kim, Yun-Ju Choi, Jae Myun Chung…

Volume of the rectus capitis posterior minor muscle in migraine patients: a cross-sectional structural MRI study

Neck pain in migraine patients is very prevalent between and during migraine attacks, but the underlying mechanism behind neck pain in migraine is unknown. The neck muscle rectus capitis posterior minor muscle...

Authors: Jeppe Hvedstrup, Faisal Mohammad Amin, Anders Hougaard, Håkan Ashina, Casper Emil Christensen, Henrik Bo Wiberg Larsson, Messoud Ashina and Henrik Winther Schytz

Subdiagnosis, but not presence of vestibular symptoms, predicts balance impairment in migraine patients – a cross sectional study

Vestibular symptoms and balance changes are common in patients with migraine, especially in the ones with aura and chronic migraine. However, it is not known if the balance changes are determined by the presen...

Authors: Letícia Zorzin, Gabriela F. Carvalho, Jens Kreitewolf, Roberto Teggi, Carina F. Pinheiro, Jéssica R. Moreira, Fabíola Dach and Débora Bevilaqua-Grossi

Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence

Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops ...

Authors: Alejandro Labastida-Ramírez, Silvia Benemei, Maria Albanese, Antonina D’Amico, Giovanni Grillo, Oxana Grosu, Devrimsel Harika Ertem, Jasper Mecklenburg, Elena Petrovna Fedorova, Pavel Řehulka, Francesca Schiano di Cola, Javier Trigo Lopez, Nina Vashchenko, Antoinette MaassenVanDenBrink and Paolo Martelletti

Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study

Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among...

Authors: Yen-Feng Wang, Yung-Tai Chen, Ching-Wen Tsai, Yu-Chun Yen, Yi-Chun Chen, Ben-Chang Shia and Shuu-Jiun Wang

Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database

Adult migraine remains underdiagnosed and undertreated, despite significant negative effects on physical and emotional functioning. Information on prescribing patterns and treatment costs of migraine in China ...

Authors: Shengyuan Yu, Yanlei Zhang, Yuan Yao and Haijun Cao

Pain rates in general population for the period 1991–2015 and 10-years prediction: results from a multi-continent age-period-cohort analysis

Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people. The aims of this study are to evaluate the temporal varia...

Authors: Davide Guido, Matilde Leonardi, Blanca Mellor-Marsá, Maria V. Moneta, Albert Sanchez-Niubo, Stefanos Tyrovolas, Iago Giné-Vázquez, Josep M. Haro, Somnath Chatterji, Martin Bobak, Jose L. Ayuso-Mateos, Holger Arndt, Ilona Koupil, Jerome Bickenbach, Seppo Koskinen, Beata Tobiasz-Adamczyk…

13th European Headache Federation Congress 2019: Meeting Abstracts - part 2

Authors:

Jealousy in women with migraine: a cross-sectional case-control study

Estrogen influences susceptibility to migraine attacks and it has been suggested to affect jealousy in romantic relationships in women. Therefore, we hypothesized that migraine women may be more jealous.

Authors: Daphne S. van Casteren, Florine A. C. van Willigenburg, Antoinette MaassenVanDenBrink and Gisela M. Terwindt

Lost productivity associated with headache and depression: a quality improvement project identifying a patient population at risk

This quality improvement project was implemented in order to highlight the association between headache, mTBI and depression on lost productivity and resource utilization.

Authors: Virginia B. Baker, Christopher B. Sowers and Nawaz K. Hack