Articles

Therapeutic novelties in migraine: new drugs, new hope?

In the past decade, migraine research has identified novel drug targets. In this review, we discuss recent data on emerging anti-migraine therapies.

Authors: Thien Phu Do, Song Guo and Messoud Ashina

Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with ...

Authors: Jingjing Su, Mengxing Wang, Shiyu Ban, Liang Wang, Xin Cheng, Fengchun Hua, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du and Jianren Liu

Primary headaches during lifespan

Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of sym...

Authors: Andreas Straube and Anna Andreou

Clinical characteristics of nummular headache and differentiation between spontaneous and posttraumatic variant: an observational study

Head trauma has been described as a precipitating event in Nummular Headache (NH). We aimed to describe the largest NH published series and compare characteristics between idiopathic and post-traumatic cases.

Authors: Javier Trigo, David García-Azorín, Enrique Martinez Pias, Álvaro Sierra, Alba Chavarría and Angel Luis Guerrero

Migraine and episodic Vertigo: a cohort survey study of their relationship

Migraine headache and vestibular-type vertigo co-occur in the general population about three times more often than expected by chance. Attacks of episodic vertigo (eV) are currently not recognized as migraine ...

Authors: Christian Lampl, Alan Rapoport, Moris Levin and Elisabeth Bräutigam

Neuroimaging clues of migraine aura

While migraine headaches can be provoked, or predicted by the presence of an aura or premonitory symptoms, the prediction or elicitation of the aura itself is more problematic. Therefore, imaging studies direc...

Authors: Nouchine Hadjikhani and Maurice Vincent

Predicting treatment response using pharmacy register in migraine

Precision medicine may offer new strategies to treat migraine, and access to existing large cohorts may be a key resource to increase statistical power. Treatment response data is not routinely collected for l...

Authors: Thomas Folkmann Hansen, Mona Ameri Chalmer, Thilde Marie Haspang, Lisette Kogelman and Jes Olesen

Histamine and migraine revisited: mechanisms and possible drug targets

To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine.

Authors: Jacob Worm, Katrine Falkenberg and Jes Olesen

Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study

To investigate the whole-brain resting-state functional connectivity in patients with chronic migraine (CM) using a data-driven method.

Authors: Mi Ji Lee, Bo-yong Park, Soohyun Cho, Sung Tae Kim, Hyunjin Park and Chin-Sang Chung

Development of an education and self-management intervention for chronic headache – CHESS trial (Chronic Headache Education and Self-management Study)

Self-management interventions are well recognised and widely used in chronic conditions. Their application to chronic headaches has been limited and generally of low quality. We describe here our process for d...

Authors: Shilpa Patel, Rachel Potter, Manjit Matharu, Dawn Carnes, Stephanie J. C. Taylor, Vivien Nichols, Tamar Pincus, Martin Underwood and Harbinder Sandhu

CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?

Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors ...

Authors: Valentina Favoni, Luca Giani, Linda Al-Hassany, Gian Maria Asioli, Calogera Butera, Irene de Boer, Martina Guglielmetti, Chrysoula Koniari, Theodoros Mavridis, Marge Vaikjärv, Iris Verhagen, Angela Verzina, Bart Zick, Paolo Martelletti and Simona Sacco

An open-label prospective study of the real-life use of onabotulinumtoxinA for the treatment of chronic migraine: the REPOSE study

The PREEMPT Studies established onabotulinumtoxinA as preventive treatment for adults with chronic migraine (CM). The purpose of the REal-life use of botulinum toxin for the symptomatic treatment of adults with c...

Authors: Fayyaz Ahmed, Charly Gaul, Juan Carlos García-Moncó, Katherine Sommer and Paolo Martelletti

ROS/TRPA1/CGRP signaling mediates cortical spreading depression

The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand their mechanisms in migraine by inve...

Authors: Liwen Jiang, Dongqing Ma, Blair D. Grubb and Minyan Wang

Headache service quality: the role of specialized headache centres within structured headache services, and suggested standards and criteria as centres of excellence

In joint initiatives, the European Headache Federation and Lifting The Burden have described a model of structured headache services (with their basis in primary care), defined service quality in this context, an...

Authors: T. J. Steiner, H. Göbel, R. Jensen, C. Lampl, K. Paemeleire, M. Linde, M. Braschinsky, D. Mitsikostas, R. Gil-Gouveia and Z. Katsarava

Favourable prognosis of trigeminal neuralgia when enrolled in a multidisciplinary management program - a two-year prospective real-life study

Prognosis of medically treated trigeminal neuralgia patients is assumed to be poor, but the evidence is lacking. Thus, prospective real-life studies of medical management of trigeminal neuralgia are warranted.

Authors: Tone Bruvik Heinskou, Stine Maarbjerg, Frauke Wolfram, Per Rochat, Jannick Brennum, Jes Olesen and Lars Bendtsen

Letter to the editor regarding European Headache Federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

Authors: Russell Nichols, Vladimir Skljarevski, Grazia Dell’Agnello, Hans-Peter Hundemer and Sheena K. Aurora

The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study

Disrupted sleep is associated with a reciprocal influence on headaches and is one of the contributing factors in the process of chronicity. The goal of the present study was to investigate the influence of sle...

Authors: Seong Hoon Kim, Ju Yeon Park, Hae Eun Shin, Si baek Lee, Dong Woo Ryu, Tae Won Kim and Jeong Wook Park

Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options

Trigeminal neuralgia is one of the most characteristic and difficult to treat neuropathic pain conditions in patients with multiple sclerosis. The present narrative review addresses the current evidence on dia...

Authors: Giulia Di Stefano, Stine Maarbjerg and Andrea Truini

Real world preventative drug management of migraine among Spanish neurologists

Many different preventatives have showed efficacy in the treatment of migraine. National guidelines differ in their recommendations and patients’ characteristics are usually taken into account in their selecti...

Authors: D. García-Azorin, S. Santos-Lasaosa, A. B. Gago-Veiga, J. Viguera Romero and A. L. Guerrero-Peral

Migraine-provoking substances evoke periorbital allodynia in mice

Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks. Although migraine provoking substances are normally vasodilators, d...

Authors: Francesco De Logu, Lorenzo Landini, Malvin N. Janal, Simone Li Puma, Francesco De Cesaris, Pierangelo Geppetti and Romina Nassini

Efficacy of psychological treatment for headache disorder: a systematic review and meta-analysis

Headache disorder is not only a common complaint but also a global burden. Pharmacotherapeutic and non-pharmacotherapeutic approaches have been developed for its treatment and prophylaxis. The present study in...

Authors: Hye Jeong Lee, Jin Hyeok Lee, Eun Young Cho, Sun Mi Kim and Seoyoung Yoon

The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis

In patients with frequent migraine, prophylactic treatments are used. Patients often request non-pharmacological alternatives. One treatment option can be aerobic exercise. The value of aerobic exercise as pro...

Authors: Joris Lemmens, Joke De Pauw, Timia Van Soom, Sarah Michiels, Jan Versijpt, Eric van Breda, René Castien and Willem De Hertogh

Development and validation of the ID-EC - the ITALIAN version of the identify chronic migraine

Case-finding tools, such as the Identify Chronic Migraine (ID-CM) questionnaire, can improve detection of CM and alleviate its significant societal burden. We aimed to develop and validate the Italian version ...

Authors: Simona Sacco, Silvia Benemei, Sabina Cevoli, Gianluca Coppola, Pietro Cortelli, Francesco De Cesaris, Roberto De Icco, Cristiano Maria De Marco, Cherubino Di Lorenzo, Pierangelo Geppetti, Alessia Manni, Andrea Negro, Raffaele Ornello, Giulia Pierangeli, Francesco Pierelli, Lanfranco Pellesi…

Correction to: A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

Following publication of the original article [1], we have been notified that the name of author five was spelled incorrectly as M. Ferrili, when the correct spelling is MAN Ferilli.

Authors: D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. A. N. Ferilli, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese

Burden of migraine in Finland: health care resource use, sick-leaves and comorbidities in occupational health care

The highest prevalence of migraine is detected among people who are of working age. The aim of this study was to assess the burden of migraine in an occupational health care setting using real world data colle...

Authors: Minna A. Korolainen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Madlaina Costa-Scharplatz, Timo Purmonen and Markku Nissilä

Effects of onabotulinumtoxinA treatment in chronic migraine patients with and without daily headache at baseline: results from the COMPEL Study

OnabotulinumtoxinA is effective in preventing chronic migraine (CM); however, the benefit of onabotulinumtoxinA in patients with CM with daily headache is unknown because these patients are typically excluded ...

Authors: William B. Young, J. Ivan Lopez, John F. Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B. Lipton and Andrew M. Blumenfeld

Behavioral and cognitive animal models in headache research

Animal models have provided a growing body of information about the pathophysiology of headaches and novel therapeutic targets. In recent years, experiments in awake animals have gained attention as more relev...

Authors: Doga Vuralli, Anne-Sophie Wattiez, Andrew F. Russo and Hayrunnisa Bolay

Effects of onabotulinumtoxinA treatment in patients with and without allodynia: results of the COMPEL study

OnabotulinumtoxinA is effective in treating chronic migraine (CM), but there are limited data assessing how allodynia affects preventive treatment responses. This subanalysis of the 108-week, multicenter, open...

Authors: William B. Young, J. Ivan Lopez, John F. Rothrock, Amelia Orejudos, Aubrey Manack Adams, Richard B. Lipton and Andrew M. Blumenfeld

Pain-related avoidance and endurance behaviour in migraine: an observational study

The role of avoidance and endurance behaviour is well established in chronic musculoskeletal pain, but less is known about its significance in migraine.

Authors: Ruth Ruscheweyh, Diana Pereira, Monika I. Hasenbring and Andreas Straube

Quantitative magnetic resonance imaging of the upper trapezius muscles – assessment of myofascial trigger points in patients with migraine

Research in migraine points towards central-peripheral complexity with a widespread pattern of structures involved. Migraine-associated neck and shoulder muscle pain has clinically been conceptualized as myofa...

Authors: Nico Sollmann, Nina Mathonia, Dominik Weidlich, Michaela Bonfert, Sebastian A. Schroeder, Katharina A. Badura, Tabea Renner, Florian Trepte-Freisleder, Carl Ganter, Sandro M. Krieg, Claus Zimmer, Ernst J. Rummeny, Dimitrios C. Karampinos, Thomas Baum, Mirjam N. Landgraf and Florian Heinen

Abnormality of visual neuromagnetic activation in female migraineurs without aura between attacks

The present study aimed to preliminary explore the abnormal neuromagnetic activation in female migraine patients between attacks using magnetoencephalography (MEG) and pattern reversed visual evoked magnetic f...

Authors: Zhi Y. Zhou, Yan W. Yu, Di Wu, Hong X. Liu, Jing Xiang, Ting Wu, Qi Q. Chen and Xiao S. Wang

European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-relat...

Authors: Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti

Novel hypotheses emerging from GWAS in migraine?

Recent technical advances in genetics made large-scale genome-wide association studies (GWAS) in migraine feasible and have identified over 40 common DNA sequence variants that affect risk for migraine types. ...

Authors: Arn M. J. M. van den Maagdenberg, Dale R. Nyholt and Verneri Anttila

Influence of hemispheric white matter lesions and migraine characteristics on cortical thickness and volume

Migraine-related intracerebral white matter lesions (WMLs) are likely to be microvascular in nature and can be found in all hemispheric lobes. The aim of this study was to investigate migraine patients with or wi...

Authors: Hedvig Komáromy, Mingchen He, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Edit Bosnyák, David Kamson Olayinka, Flóra John, Anita Trauninger and Zoltán Pfund

Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study

Although altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research in migraine patients during resting state, it is unknown whether this alteration can be detected in task-...

Authors: Jing Ren, Jing Xiang, Yueqiu Chen, Feng Li, Ting Wu and Jingping Shi

Development and validation of a telephone classification interview for common chronic headache disorders

For a trial of supportive self-management for people with chronic headache we needed to develop and validate a telephone classification interview that can be used by a non-headache specialist to classify commo...

Authors: Rachel Potter, Siew Wan Hee, Frances Griffiths, Katherine Dodd, Eleanor Hoverd, Martin Underwood and Manjit Matharu

Correction to: Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial

Following publication of the original article [1], the authors notified us that a part of the Figure 3 legend was omitted during proofing stage.

Authors: Licia Grazzi, Cristina Tassorelli, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler and Piero Barbanti

Preventive effects of galcanezumab in adult patients with episodic or chronic migraine are persistent: data from the phase 3, randomized, double-blind, placebo-controlled EVOLVE-1, EVOLVE-2, and REGAIN studies

Maintenance of effect following treatment with galcanezumab compared to placebo in adult patients with episodic or chronic migraine was evaluated.

Authors: Stefanie Förderreuther, Qi Zhang, Virginia L. Stauffer, Sheena K. Aurora and Miguel J. A. Láinez

Correction to: Consistent effects of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: additional findings from the randomized, sham-controlled, double-blind PRESTO trial

Following publication of the original article [1], the authors notified us o that the Table 1 citation within the legend was not presented as initially requested.

Authors: Paolo Martelletti, Piero Barbanti, Licia Grazzi, Giulia Pierangeli, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Cristina Tassorelli, Eric Liebler and Marina de Tommaso

Correction to: 12th European Headache Federation Congress jointly with 32nd National Congress of the Italian Society for the Study of Headaches

After publication of this supplement [1], it was brought to our attention that e-mail errors were apparent in the following abstracts. This has now been included in this correction.

Authors:

Use of traditional medicine for primary headache disorders in Kuwait

Traditional Medicine (TM) is widely accepted to be used for the treatment headache disorders in Kuwait however, researches remain poorly documented. We aimed to study the frequency of TM use and its impact in ...

Authors: Jasem Y. Al-Hashel, Samar Farouk Ahmed, Fatemah J Alshawaf and Raed Alroughani

Male and female sex hormones in primary headaches

The three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence. These gender differences suggest that both male and fem...

Authors: Zoë Delaruelle, Tatiana A. Ivanova, Sabrina Khan, Andrea Negro, Raffaele Ornello, Bianca Raffaelli, Alberto Terrin, Dimos D. Mitsikostas and Uwe Reuter

Health-care utilization for headache disorders in Nepal: a population-based door-to-door survey

Headache disorders are an important global public-health problem, but under-diagnosed, undertreated and under-prioritized. Deficiencies in health care for headache, present everywhere, are likely to be greater...

Authors: Kedar Manandhar, Ajay Risal, Mattias Linde and Timothy J. Steiner

My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed

Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine direct...

Authors: Paolo Martelletti, Todd J. Schwedt, Michel Lanteri-Minet, Rebeca Quintana, Veruska Carboni, Hans-Christoph Diener, Elena Ruiz de la Torre, Audrey Craven, Annette Vangaa Rasmussen, Simon Evans, Annik K. Laflamme, Rachel Fink, Donna Walsh, Paula Dumas and Pamela Vo

Non-invasive vagus nerve stimulation for treatment of cluster headache: early UK clinical experience

Evidence supports the use of non-invasive vagus nerve stimulation (nVNS; gammaCore®) as a promising therapeutic option for patients with cluster headache (CH). We conducted this audit of real-world data from p...

Authors: Juana Marin, Nicola Giffin, Elizabeth Consiglio, Candace McClure, Eric Liebler and Brendan Davies

Lifestyle modifications as therapy for medication refractory post-traumatic headache (PTHA) in the military population of Okinawa

Our aim was 1) to reduce disability, as characterized by headache frequency, duration and severity in patients with post-traumatic headache (PTHA), 2) to reduce the number of medical boards and work limitation...

Authors: Virginia B. Baker, Kathryn M. Eliasen and Nawaz K. Hack

Post-concussion syndrome among patients experiencing head injury attending emergency department of Hawassa University Comprehensive specialized hospital, Hawassa, southern Ethiopia

Post-concussion syndrome (PCS) is defined as the presence of 3 or more of the following signs and symptoms after experiencing head injury such as headache, dizziness, fatigue, irritability, insomnia, difficult...

Authors: Asres Bedaso, Ephrem Geja, Mohammed Ayalew, Zewdie Oltaye and Bereket Duko

Association of migraines with brain tumors: a nationwide population-based study

Several studies examined headaches as a symptom of brain neoplasms. Nevertheless, very few studies attempted to specifically evaluate the role of headaches as a risk factor. This study aimed to investigate the...

Authors: Chao-Hung Chen, Jau-Jiuan Sheu, Yi-Chun Lin and Herng-Ching Lin

The publication trend of neuropathic pain in the world and China: a 20–years bibliometric analysis

There has been tremendous change on neuropathic pain research in the past 20 years in China and around the world. We analyzed the global trend of neuropathic pain research and compared China’s quantity and qua...

Authors: Jishi Ye, Huang Ding, Juan Ren and Zhongyuan Xia

Cognitive dysfunction and migraine

Cognitive dysfunction has recently gained attention as a significant problem among migraine sufferers. All of the clinical studies show poor cognitive performance during migraine attacks, though, the intericta...

Authors: Doga Vuralli, Cenk Ayata and Hayrunnisa Bolay