Articles

The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial

Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migrai...

Authors: Zeinab Ghorbani, Pegah Rafiee, Akbar Fotouhi, Samane Haghighi, Reyhaneh Rasekh Magham, Zeynab Sadat Ahmadi, Mahmoud Djalali, Mahnaz Zareei, Soodeh Razeghi Jahromi, Sahar Shahemi, Maryam Mahmoudi and Mansoureh Togha

Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study

Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT_1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of...

Authors: Richard B. Lipton, Louise Lombard, Dustin D. Ruff, John H. Krege, Li Shen Loo, Andrew Buchanan, Thomas E. Melby and Dawn C. Buse

Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache

Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache pr...

Authors: Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Matias Metcalf-Clausen, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study

To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

Authors: Di Zhang, Xiaobin Huang, Wen Su, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu

Fluctuations in local and widespread mechanical sensitivity throughout the migraine cycle: a prospective longitudinal study

People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity thr...

Authors: Gwendolyne G. M. Scholten-Peeters, Michel W. Coppieters, Tom S. C. Durge and René F. Castien

Gut-brain Axis and migraine headache: a comprehensive review

The terminology “gut-brain axis “points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some...

Authors: Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco and Mansoureh Togha

Different doses of galcanezumab versus placebo in patients with migraine and cluster headache: a meta-analysis of randomized controlled trials

Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomiz...

Authors: Yanbo Yang, Zilan Wang, Bixi Gao, He Xuan, Yun Zhu, Zhouqing Chen and Zhong Wang

Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthines...

Authors: Yating Zhao, Ruixia Zhu, Tongling Xiao and Xu Liu

Exploring naturally occurring clinical subgroups of post-traumatic headache

To explore naturally occurring clinical subgroups of post-traumatic headache.

Authors: T. L. H. Chan and Y. W. Woldeamanuel

The prevalence of primary headache disorders in Saudi Arabia: a cross-sectional population-based study

The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include most of Eastern Mediterranean Region (EMR). Following a nationwide population-based study in Pakistan, we...

Authors: Mohammed Al Jumah, Ali M. Al Khathaami, Suleman Kojan, Mohamed Hussain, Hallie Thomas and Timothy J. Steiner

The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine

Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology.

Authors: Karin Warfvinge, Diana Krause and Lars Edvinsson

Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study

To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarker...

Authors: Ane Mínguez-Olaondo, Iván Martínez-Valbuena, Sonia Romero, Gema Frühbeck, María Rosario Luquin, Eduardo Martínez-Vila and Pablo Irimia

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age u...

Authors: Minna A. Korolainen, Samuli Tuominen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Timo Purmonen, Jaana Santaholma and Markku Nissilä

Two decades, a new editorial stylistic feature

Authors: Paolo Martelletti

Dural arteriovenous fistulas and headache features: an observational study

Dural arteriovenous fistulas are intracranial vascular malformations, fed by dural arteries and draining venous sinuses or meningeal veins. Clinical course varies widely and ranges from benign with spontaneous...

Authors: Ilenia Corbelli, Francesca De Maria, Paolo Eusebi, Michele Romoli, Gabriela Cardaioli, Mohammed Hamam, Piero Floridi, Letizia Maria Cupini, Paola Sarchielli and Paolo Calabresi

Prevalence and risk factors associated with headache amongst medical staff in South China

A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey wa...

Authors: Wei Xie, Ruibing Li, Mianwang He, Fang Cui, Tingting Sun, Jianmei Xiong, Dengfa Zhao, Weinan Na, Ruozhuo Liu and Shengyuan Yu

Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk betwe...

Authors: Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen and Jiying Zhou

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and ...

Authors: Bereket Duko, Mohammed Ayalew and Alemayehu Toma

ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account ...

Authors: Carl H. Göbel, Sarah C. Karstedt, Thomas F. Münte, Hartmut Göbel, Sebastian Wolfrum, Elena R. Lebedeva, Jes Olesen and Georg Royl

White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is l...

Authors: Álvaro Planchuelo-Gómez, David García-Azorín, Ángel L. Guerrero, Santiago Aja-Fernández, Margarita Rodríguez and Rodrigo de Luis-García

Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre

Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated with a...

Authors: Andrea Negro, Paolo Sciattella, Daniele Rossi, Martina Guglielmetti, Paolo Martelletti and Francesco Saverio Mennini

The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials

To evaluate the crossover design in migraine preventive treatment trials by assessing dropout rate, and potential period and carryover effect in four placebo-controlled randomized controlled trials (RCTs).

Authors: Astrid Bjørke Jenssen, Lars Jacob Stovner, Erling Tronvik, Trond Sand, Grethe Helde, Gøril Bruvik Gravdahl and Knut Hagen

Correction to: Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2)

After publication of our article [1] we were notified that the data presented in the upper row of Fig. 7 was inadvertently the least square mean change from baseline (standard error) at Month 6 rather than the...

Authors: Stephen D. Silberstein, Virginia L. Stauffer, Katie A. Day, Sarah Lipsius and Maria-Carmen Wilson

Mechanisms of migraine as a chronic evolutive condition

Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has bee...

Authors: Anna P. Andreou and Lars Edvinsson

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions,...

Authors: Heng-Le Wei, Xin Zhou, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Li-Jie Qu, Xindao Yin, Junrong Li and Hong Zhang

TRPM8 genetic variant is associated with chronic migraine and allodynia

Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We a...

Authors: Yu-Hsiang Ling, Shih-Pin Chen, Cathy Shen-Jang Fann, Shuu-Jiun Wang and Yen-Feng Wang

Primary headache disorders among the adult population of Mongolia: prevalences and associations from a population-based survey

In the ongoing Global Campaign endeavour to improve knowledge and awareness of headache prevalence worldwide, Mongolia is a country of interest. It sits between Russia and China, in which prevalence is, respec...

Authors: Otgonbayar Luvsannorov, Byambasuren Tsenddorj, Dorjkhand Baldorj, Selenge Enkhtuya, Delgermaa Purev, Hallie Thomas and Timothy J. Steiner

Consensus of the Hellenic Headache Society on the diagnosis and treatment of migraine

More than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-expert...

Authors: Evangelos Kouremenos, Chrysa Arvaniti, Theodoros S. Constantinidis, Ermioni Giannouli, Nikolaos Fakas, Themistoklis Kalamatas, Evangelia Kararizou, Dimitrios Naoumis and Dimos D. Mitsikostas

13^th European Headache Federation Congress 2019 - Abstracts

Authors:

Alterations of individual thalamic nuclei volumes in patients with migraine

The aim of this study is to investigate the alterations of thalamic nuclei volumes and the intrinsic thalamic network in patients with migraine.

Authors: Kyong Jin Shin, Ho-Joon Lee and Kang Min Park

Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature

The objective of this review was to determine the unmet needs for migraine in East Asian adults and children.

Authors: Takao Takeshima, Qi Wan, Yanlei Zhang, Mika Komori, Serina Stretton, Narayan Rajan, Tamas Treuer and Kaname Ueda

Cortical GABA in migraine with aura -an ultrashort echo magnetic resonance spectroscopy study

The aim of this cross-sectional study was to investigate the cortical metabolite concentrations in patients suffering from migraine with aura (MWA). We hypothesized that occipital γ-aminobutyric acid (GABA) le...

Authors: Tobias G. Stærmose, Marie K. Knudsen, Helge Kasch and Jakob U. Blicher

Functional connectivity studies in migraine: what have we learned?

Resting-state functional connectivity (FC) MRI has widely been used to understand migraine pathophysiology and to identify an imaging marker of the disorder. Here, we review what we have learned from FC studies.

Authors: Kirill Skorobogatykh, Willem Sebastiaan van Hoogstraten, Diana Degan, Anastasia Prischepa, Anastasya Savitskaya, Biondo Michela Ileen, Enrico Bentivegna, Iaroslav Skiba, Laura D’Acunto, Livia Ferri, Simona Sacco, Jakob Møller Hansen and Faisal Mohammad Amin

Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene

Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transpor...

Authors: R. Barbieri, S. Bertelli, M. Pusch and P. Gavazzo

Association of diet and headache

The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in...

Authors: Soodeh Razeghi Jahromi, Zeinab Ghorbani, Paolo Martelletti, Christian Lampl and Mansoureh Togha

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brai...

Authors: Jacob C. A. Edvinsson, Karin Warfvinge, Diana N. Krause, Frank W. Blixt, Majid Sheykhzade, Lars Edvinsson and Kristian A. Haanes

Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura

Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substa...

Authors: Xiaobin Huang, Di Zhang, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xinying Wu and Xindao Yin

Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive f...

Authors: Jingjing Su, Shiyu Ban, Mengxing Wang, Fengchun Hua, Liang Wang, Xin Cheng, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du and Jianren Liu

Burden of headache disorders in China, 1990–2017: findings from the Global Burden of Disease Study 2017

Headache has emerged as a global public health concern. However, little is known about the burden from headache disorders in China. The aim of this work was to quantify the spatial patterns and temporal trends...

Authors: Chengye Yao, Yu Wang, Lijun Wang, Yunning Liu, Jiangmei Liu, Jinlei Qi, Yun Lin, Peng Yin and Maigeng Zhou

Prevalence and burden of headache in children and adolescents in Austria – a nationwide study in a representative sample of pupils aged 10–18 years

Headache disorders are highly prevalent worldwide, but not so well investigated in children and adolescents as in adults: few studies have included representative nationwide samples. No data exist for Austria ...

Authors: Julia Philipp, Michael Zeiler, Christian Wöber, Gudrun Wagner, Andreas F. K. Karwautz, Timothy J. Steiner and Çiçek Wöber-Bingöl

Headaches in the emergency department –a survey of patients’ characteristics, facts and needs

Headache is very often the cause for seeking an emergency department (ED). However, less is known about the different diagnosis of headache disorders in the ED, their management and treatment. The aim of this ...

Authors: Alberto Doretti, Irina Shestaritc, Daniela Ungaro, John-Ih Lee, Loukas Lymperopoulos, Lili Kokoti, Martina Guglielmetti, Dimos Dimitrios Mitsikostas and Christian Lampl

The appropriate dosing of erenumab for migraine prevention after multiple preventive treatment failures: a critical appraisal

Erenumab, a fully human monoclonal antibody directed against the calcitonin gene-related peptide receptor, was approved for the prevention of episodic (EM) or chronic migraine (CM) at the monthly dose of 70 mg...

Authors: Raffaele Ornello, Cindy Tiseo, Ilaria Frattale, Giulia Perrotta, Carmine Marini, Francesca Pistoia and Simona Sacco

Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review

Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH trea...

Authors: Eigil Lindekilde Larsen, Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Kristoffer Seem, Messoud Ashina, Sait Ashina and Henrik Winther Schytz

New diagnostic criteria for headache attributed to transient ischemic attacks

The International Classification of Headache Disorders diagnostic criteria for Headache Attributed to Transient Ischemic Attack (TIA) and many other secondary headaches are based primarily on the opinion of ex...

Authors: Elena R. Lebedeva, Natalia M. Gurary and Jes Olesen

Differences in treatment response between migraine with aura and migraine without aura: lessons from clinical practice and RCTs

Migraine is a major public health problem afflicting approximately 10% of the general population and is a leading cause of disability worldwide, yet our understanding of the basis mechanisms of migraine remain...

Authors: Jakob Møller Hansen and Andrew Charles

Identifying menstrual migraine– improving the diagnostic criteria using a statistical method

To develop a robust statistical tool for the diagnosis of menstrually related migraine.

Authors: Mathias Barra, Fredrik A. Dahl, E. Anne MacGregor and Kjersti Grøtta Vetvik

Aura and Head pain: relationship and gaps in the translational models

Migraine is a complex brain disorder and initiating events for acute attacks still remain unclear. It seems difficult to explain the development of migraine headache with one mechanism and/or a single anatomic...

Authors: Hayrunnisa Bolay, Doga Vuralli and Peter J. Goadsby

Structural changes of cerebellum and brainstem in migraine without aura

Increasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, the descending pain system of the brainstem is the major site of trigeminal pain processing and modulati...

Authors: Zhaoxia Qin, Xin-Wei He, Jilei Zhang, Shuai Xu, Ge-Fei Li, Jingjing Su, Yan-Hui Shi, Shiyu Ban, Yue Hu, Yi-Sheng Liu, Mei-Ting Zhuang, Rong Zhao, Xiao-Lei Shen, Jianqi Li, Jian-Ren Liu and Xiaoxia Du

Current and emerging evidence-based treatment options in chronic migraine: a narrative review

Chronic migraine is a disabling condition that is currently underdiagnosed and undertreated. In this narrative review, we discuss the future of chronic migraine management in relation to recent progress in evi...

Authors: Elio Clemente Agostoni, Piero Barbanti, Paolo Calabresi, Bruno Colombo, Pietro Cortelli, Fabio Frediani, Pietrangelo Geppetti, Licia Grazzi, Massimo Leone, Paolo Martelletti, Luigi Alberto Pini, Maria Pia Prudenzano, Paola Sarchielli, Gioacchino Tedeschi and Antonio Russo

Lasmiditan for acute treatment of migraine in patients with cardiovascular risk factors: post-hoc analysis of pooled results from 2 randomized, double-blind, placebo-controlled, phase 3 trials

In addition to the increased risk for cardiovascular (CV) disease and CV events associated with migraine, patients with migraine can also present with a number of CV risk factors (CVRFs). Existing treatment op...

Authors: Robert E. Shapiro, Helen M. Hochstetler, Ellen B. Dennehy, Rashna Khanna, Erin Gautier Doty, Paul H. Berg and Amaal J. Starling