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  1. Although acute headache following COVID-19 vaccination is widely acknowledged, the long-term progression of these headaches remains poorly understood. Our objective was to identify various phenotypes of prolon...

    Authors: Arife Çimen Atalar, Ayşe Nur Özdağ Acarlı, Betül Baykan, Paolo Martelletti, Hayrunnisa Bolay, Mustafa Ertaş, Esme Ekizoğlu, Ömer Karadaş, Burcu Polat, Işıl Yazıcı Gençdal, David Garcia Azorin, Dimos Mitsikostas, Loukia Apostolakopoulou, Hamit Genç, Pınar Yalınay Dikmen, Esra Acıman Demirel…
    Citation: The Journal of Headache and Pain 2023 24:132
    Content type: Research Published on:

  3. Migraine is a disorder associated with neuropeptide release, pain and inflammation. Tau protein has recently been linked to inflammatory diseases and can be influenced by neuropeptides such as CGRP, a key neur...

    Authors: Lucas Hendrik Overeem, Bianca Raffaelli, Robert Fleischmann, Marie Süße, Antje Vogelgesang, Aleksandra Maleska Maceski, Athina Papadopoulou, Klemens Ruprecht, Wendy Su, Mirja Koch, Anke Siebert, Michal Arkuszewski, Nadia Tenenbaum, Jens Kuhle and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:130
    Content type: Research Published on:

  4. Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic an...

    Authors: Christina I. Deligianni, Simona Sacco, Esme Ekizoglu, Derya Uluduz, Raquel Gil-Gouveia, Antoinette MaassenVanDenBrink, Raffaele Ornello, Margarita Sanchez-del-Rio, Uwe Reuter, Jan Versijpt, Tessa de Vries, Muizz Hussain, Dena Zeraatkar and Christian Lampl
    Citation: The Journal of Headache and Pain 2023 24:128
    Content type: Review Published on:

  5. Intranasal agents may be ideal for the treatment of migraine patients. Many new acute intranasal-specific therapies have been developed, but few of them have been directly compared. The aim of this network met...

    Authors: Guanglu Li, Shaojie Duan, Tiantian Zhu, Zhiying Ren, Hui Xia, Ziyao Wang, Lei Liu and Zunjing Liu
    Citation: The Journal of Headache and Pain 2023 24:129
    Content type: Review Published on:

  6. Headaches are the most common complaints among pediatric populations. Determining the cause and appropriate treatment for headaches may be challenging and costly, and the impact of headaches on the lives of pa...

    Authors: S. Ombashi, E. Tsangaris, A. G. Heeres, V. van Roey, R. F. Neuteboom, M. L. C. van Veelen-Vincent, K. Jansson, I. M. J. Mathijssen, A. F. Klassen and S. L. Versnel
    Citation: The Journal of Headache and Pain 2023 24:127
    Content type: Review Published on:

  7. In recent years, headache disorders have garnered significant attention as a pressing global health issue. This concern is especially pronounced in low- to middle-income countries and exhibits a notable increa...

    Authors: Xin-yu Li, Cheng-hao Yang, Jia-jie Lv, Hui Liu, Lu-yu Zhang, Min-yi Yin, Zhi-lin Guo and Ru-hong Zhang
    Citation: The Journal of Headache and Pain 2023 24:126
    Content type: Research Published on:

  8. Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review f...

    Authors: Alejandro Labastida-Ramírez, Edoardo Caronna, Cédric Gollion, Emily Stanyer, Austeja Dapkute, Diana Braniste, Hoda Naghshineh, Liga Meksa, Nino Chkhitunidze, Tamari Gudadze, Patricia Pozo-Rosich, Rami Burstein and Jan Hoffmann
    Citation: The Journal of Headache and Pain 2023 24:125
    Content type: Review Published on:

  9. There is a bidirectional link between sleep and migraine, however causality is difficult to determine. This study aimed to investigate this relationship using data collected from a smartphone application.

    Authors: Emily C. Stanyer, Jack Brookes, Jia Rong Pang, Alexandre Urani, Philip R. Holland and Jan Hoffmann
    Citation: The Journal of Headache and Pain 2023 24:123
    Content type: Research Published on:

  10. Although the involvement of calcitonin gene-related peptide (CGRP) in migraines is well-established, its specific role in investigating the aura phase, which often precedes the headache, remains largely unexpl...

    Authors: Haidar M. Al-Khazali, Håkan Ashina, Astrid Wiggers, Kathrine Rose, Afrim Iljazi, Rune Häckert Christensen, Henrik Winther Schytz, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:124
    Content type: Research Published on:

  11. Migraine, a complex brain disorder, is regarded as a possible clinical manifestation of brain energy dysfunction. The trigeminovascular system is considered the basis for the pathogenesis of migraine, hence we...

    Authors: Wei Xie, Ruibing Li, Wenjing Tang, Zhenjie Ma, Shuai Miao, Chenhao Li, Chunxiao Yang, Bozhi Li, Tao Wang, Zihua Gong, Yue Zhou and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:122
    Content type: Research Published on:

  12. Treatment for cluster headache is currently based on a trial-and-error approach. The available preventive treatment is unspecific and based on few and small studies not adhering to modern standards. Therefore,...

    Authors: Nunu Laura Timotheussen Lund, Anja Sofie Petersen, Rolf Fronczek, Jacob Tfelt-Hansen, Andrea Carmine Belin, Tore Meisingset, Erling Tronvik, Anna Steinberg, Charly Gaul and Rigmor Højland Jensen
    Citation: The Journal of Headache and Pain 2023 24:121
    Content type: Consensus Article Published on:

  13. Migraine is a highly prevalent primary headache disorder and a leading cause of disability. Difficulties in access to care during diagnostic and therapeutic journey contribute to the disease burden. Several ta...

    Authors: Gloria Vaghi, Roberto De Icco, Cristina Tassorelli, Peter J. Goadsby, Teófila Vicente-Herrero and Elena Ruiz de la Torre
    Citation: The Journal of Headache and Pain 2023 24:120
    Content type: Research Published on:

  14. Headache disorders are widely prevalent and pose a considerable economic burden on individuals and society. Globally, misdiagnosis and inadequate treatment of primary headache disorders remain significant chal...

    Authors: Huanxian Liu, Ming Dong, Kaiming Liu, Zhihua Jia, Wei Gui, Yingying Cheng, Yudan Lv, Kang Qu, Hongru Zhao, Jianjun Chen, Dan Zhang, Zhiliang Fan, Xiaosu Yang, Dongmei Hu, Hongyan Xie, Mingxin Li…
    Citation: The Journal of Headache and Pain 2023 24:119
    Content type: Research Published on:

  15. Central sensitisation is an important mechanism in migraine chronification. It is presumed to occur in second and third order neurons sequentially, resulting in an analogous spatial distribution of cutaneous a...

    Authors: Judith A. Pijpers, Dennis A. Kies, Erik W. van Zwet, Irene de Boer and Gisela M. Terwindt
    Citation: The Journal of Headache and Pain 2023 24:118
    Content type: Research Published on:

  16. Adipokines, including adiponectin, are implicated in nociceptive pain; however, the underlying cellular and molecular mechanisms remain unknown.

    Authors: Yuan Zhang, Yuan Wei, Tingting Zheng, Yu Tao, Yufang Sun, Dongsheng Jiang and Jin Tao
    Citation: The Journal of Headache and Pain 2023 24:117
    Content type: Research Published on:

  17. Data are limited regarding the combined impact of headache frequency and failure of preventive medication (efficacy and/or tolerability) on the humanistic/economic burden of migraine.

    Authors: Dawn C. Buse, Patricia Pozo-Rosich, Laure Dupont-Benjamin, Bridget L. Balkaran, Lulu Lee, Adam Jauregui, Pranav Gandhi, Mousam Parikh and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:115
    Content type: Research Published on:

  18. Headache is one of the most common neurological symptoms. Many previous studies have indicated a relationship between primary headaches and alcohol. Drinking has been associated with increased risk of tension-...

    Authors: Bartłomiej Błaszczyk, Marcin Straburzyński, Mieszko Więckiewicz, Sławomir Budrewicz, Piotr Niemiec, Martyna Staszkiewicz and Marta Waliszewska-Prosół
    Citation: The Journal of Headache and Pain 2023 24:116
    Content type: Research Published on:

  19. Cluster headache (CH) is a primary headache disorder which is characterized by circadian timing of headache attacks, usually at nighttime, in around two thirds of patients. Patients with CH often report sleep ...

    Authors: Caroline Ran, Felicia Jennysdotter Olofsgård, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind, Anna Dahlgren and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2023 24:114
    Content type: Research Published on:

  22. Primary headache disorders are a group of highly prevalent and disabling neurological diseases that mainly consist of migraine and tension-type headache (TTH). A previous study showed that the burden of headac...

    Authors: Rongguang Ge, Jie Chang and Yongjun Cao
    Citation: The Journal of Headache and Pain 2023 24:110
    Content type: Research Published on:

  23. While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine. We emp...

    Authors: Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu…
    Citation: The Journal of Headache and Pain 2023 24:111
    Content type: Research Published on:

  24. It is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and whether it is a unique disorder from chronic migraine and chronic tension-type headache. ...

    Authors: Sanjay Cheema, Anker Stubberud, Khadija Rantell, Parashkev Nachev, Erling Tronvik and Manjit Matharu
    Citation: The Journal of Headache and Pain 2023 24:109
    Content type: Research Published on:

  25. Calcitonin gene-related peptide (CGRP) is involved in migraine pathophysiology and blood pressure regulation. Although clinical trials have established the cardio-cerebrovascular safety profile of anti-CGRP tr...

    Authors: Kaicheng Wang, Brenda T. Fenton, Vinh X. Dao, Alexander B. Guirguis, Sarah E. Anthony, Melissa Skanderson and Jason J. Sico
    Citation: The Journal of Headache and Pain 2023 24:108
    Content type: Research Published on:

  26. Authors: Adrian Scutelnic, Hristina Drangova, Antonia Klein, Nedelina Slavova, Morin Beyeler, Julian Lippert, Norbert Silimon, Thomas R. Meinel, Marcel Arnold, Urs Fischer, Franz Riederer, Heinrich P. Mattle, Simon Jung and Christoph J. Schankin
    Citation: The Journal of Headache and Pain 2023 24:107
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:100

  28. There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms. The mechanism...

    Authors: Marina Vitale, Angelita Tottene, Maral Zarin Zadeh, KC Brennan and Daniela Pietrobon
    Citation: The Journal of Headache and Pain 2023 24:105
    Content type: Research Published on:

  29. Migraine is a cyclic, neurosensory disorder characterized by recurrent headaches and altered sensory processing. The latter is manifested in hypersensitivity to visual stimuli, measured with questionnaires and...

    Authors: Angela Marti-Marca, Adrià Vilà-Balló, Xim Cerda-Company, Nara Ikumi, Marta Torres-Ferrus, Edoardo Caronna, Victor J. Gallardo, Alicia Alpuente, Mireia Torralba Cuello, Salvador Soto-Faraco and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2023 24:104
    Content type: Research Published on:

  30. The phase 3 randomized PERSIST study demonstrated the efficacy and tolerability of galcanezumab, a humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody for prevention of episodic migraines...

    Authors: Jiying Zhou, Lianmei Zhong, Debashish Chowdhury, Kirill Skorobogatykh, Guogang Luo, Xiaosu Yang, Mingjie Zhang, Lingli Sun, Hui Liu, Chenxi Qian and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:103
    Content type: Research Published on:

  31. Individuals using onabotulinumtoxinA as a preventive migraine treatment often use acute treatments for breakthrough attacks. Data on real-world effectiveness of the small-molecule calcitonin gene–related pepti...

    Authors: Aubrey Manack Adams, Susan Hutchinson, Ella Engstrom, Nicolai D. Ayasse, Daniel Serrano, Linda Davis, Katherine Sommer, Janette Contreras-De Lama and Richard B. Lipton
    Citation: The Journal of Headache and Pain 2023 24:102
    Content type: Research Published on:

  32. To date, real-world evidence on persistence to anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies (mAbs) or onabotulinumtoxinA have excluded eptinezumab. This retrospective cohort study was...

    Authors: Larry Charleston IV, Brian Talon, Christine Sullivan, Carlton Anderson, Steven Kymes, Stephane A. Regnier, Seema Soni-Brahmbhatt and Stephanie J. Nahas
    Citation: The Journal of Headache and Pain 2023 24:101
    Content type: Research Published on:

  33. Given the similar presentation of migraine aura and acute ischemic stroke, advancing patient age might change the characteristics of migraine with aura (MA) and be clinically important. Clinical data, however,...

    Authors: Adrian Scutelnic, Hristina Drangova, Antonia Klein, Nedelina Slavova, Morin Beyeler, Julian Lippert, Norbert Silimon, Thomas R. Meinel, Marcel Arnold, Urs Fischer, Franz Riederer, Heinrich P. Mattle, Simon Jung and Christoph J. Schankin
    Citation: The Journal of Headache and Pain 2023 24:100
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:107

  34. The monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP) pathway, collectively called here “anti-CGRP/rec mAbs”, have dramatically improved preventive migraine treatment. Although t...

    Authors: Jean Schoenen, Annelies Van Dycke, Jan Versijpt and Koen Paemeleire
    Citation: The Journal of Headache and Pain 2023 24:99
    Content type: Review Published on:

  35. Whether migraine is related to the risk of cardiovascular diseases (CVDs) remains unclear. Therefore, we conducted a longitudinal follow-up study to address the association between migraine and the development...

    Authors: Mi Jung Kwon, Hyo Geun Choi, Yoo Hwan Kim, Joo-Hee Kim, Hyun Taek Rim, Heui Seung Lee, Jae Keun Oh, In Bok Chang, Joon Ho Song and Ji Hee Kim
    Citation: The Journal of Headache and Pain 2023 24:98
    Content type: Research Published on:

  36. In idiopathic intracranial hypertension (IIH), certain MRI features are promising diagnostic markers, but whether these have prognostic value is currently unknown.

    Authors: Gabriel Bsteh, Wolfgang Marik, Nik Krajnc, Stefan Macher, Christoph Mitsch, Philip Pruckner, Klaus Novak, Christian Wöber and Berthold Pemp
    Citation: The Journal of Headache and Pain 2023 24:97
    Content type: Research Published on:

  37. The evidence supporting the efficacy of dietary preventive therapy in migraine is rising, particularly regarding the ketogenic diet. However, less evidence exists for the Low-Glycemic Index Diet and the 2:1 KD...

    Authors: Yan Tereshko, Simone Dal Bello, Cherubino Di Lorenzo, Sara Pez, Alice Pittino, Roberto Sartor, Francesca Filippi, Christian Lettieri, Enrico Belgrado, Riccardo Garbo, Giovanni Merlino, Gian Luigi Gigli and Mariarosaria Valente
    Citation: The Journal of Headache and Pain 2023 24:95
    Content type: Research Published on:

  39. Cortical spreading depolarization (CSD), the neurophysiological correlate of the migraine aura, can activate trigeminal pain pathways, but the neurobiological mechanisms and behavioural consequences remain unc...

    Authors: Anisa Dehghani, Maarten Schenke, Sandra H. van Heiningen, Hulya Karatas, Else A. Tolner and Arn M. J. M. van den Maagdenberg
    Citation: The Journal of Headache and Pain 2023 24:96
    Content type: Research Published on:

  40. Migraine headache attacks and accompanying sensory augmentation can be induced by several agents including levcromakalim (LVC), that is also capable of provoking aura-like symptoms in migraineurs. We investiga...

    Authors: Berkay Alpay, Bariscan Cimen, Elif Akaydin, Hayrunnisa Bolay and Yildirim Sara
    Citation: The Journal of Headache and Pain 2023 24:93
    Content type: Research Published on:

  41. Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3rd edition of the International Classification of Headache Disorders. Migraine...

    Authors: Dilara Onan, Samaira Younis, William David Wellsgatnik, Fatemeh Farham, Saulius Andruškevičius, Ana Abashidze, Asel Jusupova, Yuriy Romanenko, Oxana Grosu, Meerimgul Zamirbekovna Moldokulova, Ulkar Mursalova, Saida Saidkhodjaeva, Paolo Martelletti and Sait Ashina
    Citation: The Journal of Headache and Pain 2023 24:92
    Content type: Review Published on:

  42. Migraine is more prevalent in females, raising the possibility that sex and gonadal hormones modulate migraine. We recently demonstrated that minimally invasive optogenetic spreading depolarization (opto-SD) e...

    Authors: Andrea M. Harriott, Angel Waruinge, Viola Appiah-Danquah, Leah Berhanu, Andreia Morais and Cenk Ayata
    Citation: The Journal of Headache and Pain 2023 24:85
    Content type: Research Published on:

  43. Trigeminal neuralgia (TN) is a debilitating pain disorder that still lacks an ideal treatment option. Pulsed radiofrequency (PRF), especially with high output voltage, is a novel and minimally invasive techniq...

    Authors: Yitong Jia, Hao Cheng, Niti Shrestha, Hao Ren, Chunmei Zhao, Kunpeng Feng and Fang Luo
    Citation: The Journal of Headache and Pain 2023 24:91
    Content type: Research Published on:

  44. In idiopathic intracranial hypertension (IIH), sustained weight loss is the main pillar in modifying disease course, whereby glucagon-like peptide-1 receptor agonists (GLP-1-RAs) could present an attractive tr...

    Authors: Nik Krajnc, Bianca Itariu, Stefan Macher, Wolfgang Marik, Jürgen Harreiter, Martin Michl, Klaus Novak, Christian Wöber, Berthold Pemp and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2023 24:89
    Content type: Research Published on:

  46. Insights into the burden, needs and treatment of migraine from internet-based surveys in diverse real-world migraine populations are needed, especially at a time when novel preventive migraine medications are ...

    Authors: Julio Pascual, Tommaso Panni, Grazia Dell’Agnello, Saygin Gonderten, Diego Novick and Stefan Evers
    Citation: The Journal of Headache and Pain 2023 24:88
    Content type: Review Published on:

  47. The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors and t...

    Authors: Yan Zhang, Tingting Wang, Sanlan Wu, Li Tang, Jia Wang, Jinghan Yang, Shanglong Yao and Yan Zhang
    Citation: The Journal of Headache and Pain 2023 24:87
    Content type: Review Published on:

  48. Mindfulness gained considerable attention for migraine management, but RCTs are lacking. We aimed to assess the efficacy of a six-sessions mindfulness-based treatment added to treatment as usual (TaU) in patie...

    Authors: Licia Grazzi, Domenico D’Amico, Erika Guastafierro, Greta Demichelis, Alessandra Erbetta, Davide Fedeli, Anna Nigri, Emilio Ciusani, Corso Barbara and Alberto Raggi
    Citation: The Journal of Headache and Pain 2023 24:86
    Content type: Research Published on:

  49. Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigem...

    Authors: Nico Sollmann, Paul Schandelmaier, Dominik Weidlich, Jonathan Stelter, Gabby B. Joseph, Corinna Börner, Severin Schramm, Meinrad Beer, Claus Zimmer, Mirjam N. Landgraf, Florian Heinen, Dimitrios C. Karampinos, Thomas Baum and Michaela V. Bonfert
    Citation: The Journal of Headache and Pain 2023 24:84
    Content type: Research Published on:

  50. Migraine is a very common headache disorder on the population level, characterized by symptomatic attacks (activity). For many people with migraine, the migraine symptoms intermittently or permanently cease du...

    Authors: Marco Piccininni, Ralph Brinks, Jessica L. Rohmann and Tobias Kurth
    Citation: The Journal of Headache and Pain 2023 24:83
    Content type: Research Published on:
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