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  1. Most real-world data on CGRP mAbs have been published from high-income countries such as the USA, Western countries, Japan, Korea, and Singapore. However, data from low- and middle-income countries in Southeas...

    Authors: Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Sekh Thanprasertsuk and Wanakorn Rattanawong
    Citation: The Journal of Headache and Pain 2024 25:150
    Content type: Brief Report Published on:

  2. Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies have emerged as promising therapeutic options for the treatment of chronic migraine. However, treatment response varies considerably among indi...

    Authors: Yu-Chin An, Kuo-Sheng Hung, Chih-Sung Liang, Chia-Kuang Tsai, Chia-Lin Tsai, Sy-Jou Chen, Yu-Kai Lin, Guan-Yu Lin, Po-Kuan Yeh and Fu-Chi Yang
    Citation: The Journal of Headache and Pain 2024 25:149
    Content type: Research Published on:

  3. Migraine is a highly prevalent and complex neurovascular disease. However, the currently available therapeutic drugs often fall to adequately meet clinical needs due to limited effectiveness and numerous undes...

    Authors: Zhonghua Xiong, Lei Zhao, Yanliang Mei, Dong Qiu, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Jin Cao and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:148
    Content type: Research Published on:

  4. Magnetoencephalography/electroencephalography (M/EEG) can provide insights into migraine pathophysiology and help develop clinically valuable biomarkers. To integrate and summarize the existing evidence on cha...

    Authors: Paul Theo Zebhauser, Henrik Heitmann, Elisabeth S. May and Markus Ploner
    Citation: The Journal of Headache and Pain 2024 25:147
    Content type: Review Published on:

  5. Having previously shown headache disorders to be prevalent in Mongolia, here we elaborate on headache as a public-health concern in this country, reporting symptom burden and headache-attributed impaired parti...

    Authors: Otgonbayar Luvsannorov, Byambasuren Tsenddorj, Dorjkhand Baldorj, Selenge Enkhtuya, Delgermaa Purev, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:146
    Content type: Research Published on:

  6. Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by increased intracranial pressure. Whilst lumbar puncture (LP) is necessary for the diagnosis of IIH, its therapeutic effect...

    Authors: Sina Zaic, Nik Krajnc, Stefan Macher, Martin Michl, Nina Müller, Christoph Mitsch, Wolfgang Marik, Klaus Novak, Christian Wöber, Berthold Pemp and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2024 25:145
    Content type: Research Published on:

  7. There have been limited data on idiopathic intracranial hypertension (IIH) in Asians and there remain uncertainties whether a cerebrospinal fluid (CSF) pressure of 250 mm CSF is an optimum diagnostic cutoff. T...

    Authors: Hsiang-Ting Hsu, Hui-Chen Cheng, Tsung-Wei Hou, Yi-Shiang Tzeng, Jong-Ling Fuh, Shih-Pin Chen, Wei-Ta Chen, Wei-Ju Lee, Yen-Wei Pai, Yi-Chung Lee, Jiing-Feng Lirng, Shuu-Jiun Wang and Yen-Feng Wang
    Citation: The Journal of Headache and Pain 2024 25:144
    Content type: Research Published on:

  8. About a quarter of migraine cases among women have menstrual migraine (MM), which is usually more severe, longer lasting, and less responsive to treatment than typical migraine. Randomized controlled trials (R...

    Authors: Cindy Ciat-Wuah Khoo, Chan-Cheng Liu, Michael Lu, Yu-Chen Huang and Hsing-Yu Weng
    Citation: The Journal of Headache and Pain 2024 25:143
    Content type: Research Published on:

  9. Magnetic resonance spectroscopy (MRS) studies have indicated that the imbalance between gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx) levels was the potential cause of migraine development. Howe...

    Authors: Tong Chen, Xiaoyan Bai, Wei Wang, Xue Zhang, Xun Pei, Xueyan Zhang, Ziyu Yuan, Yuanbin Zhao, Qi Yang, Yonggang Wang and Binbin Sui
    Citation: The Journal of Headache and Pain 2024 25:142
    Content type: Research Published on:

  10. Orally administered second-generation gepants are effective for the treatment of migraine. The intranasal administration of the third-generation gepant zavegepant might have additional benefits including a rap...

    Authors: Deirdre M. Boucherie, Ruben Dammers, Arnaud Vincent, A. H. Jan Danser and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2024 25:141
    Content type: Research Published on:

  11. Widespread neuropathic pain usually affects a wide range of body areas and inflicts huge suffering on patients. However, little is known about how it happens and effective therapeutic interventions are lacking.

    Authors: Yu Du, Shi-Da Lin, Xue-Qing Wu, Bao-Yu Xue, Yi-La Ding, Jia-Hang Zhang, Bei Tan, Guo-Dong Lou, Wei-Wei Hu, Zhong Chen and Shi-Hong Zhang
    Citation: The Journal of Headache and Pain 2024 25:140
    Content type: Research Published on:

  12. miR-155 is involved in the generation and maintenance of inflammation and pain, endothelial function and immune system homeostasis, all functions that are relevant for migraine. The present study aims to asses...

    Authors: Rosaria Greco, Federico Bighiani, Chiara Demartini, Annamaria Zanaboni, Miriam Francavilla, Sara Facchetti, Gloria Vaghi, Marta Allena, Daniele Martinelli, Elena Guaschino, Natascia Ghiotto, Sara Bottiroli, Michele Corrado, Francescantonio Cammarota, Alessandro Antoniazzi, Elena Mazzotta…
    Citation: The Journal of Headache and Pain 2024 25:138
    Content type: Research Published on:

  13. Cluster headache (CH) is a significant health concern due to its major socioeconomic consequences and most patients being refractory to conventional strategies. For treatment resistant CH, occipital nerve stim...

    Authors: Linda Kollenburg, H. Arnts, M. Heitkamp, S. Geerts, C. Robinson, M. Dominguez, W. Mulleners and E. Kurt
    Citation: The Journal of Headache and Pain 2024 25:139
    Content type: Research Published on:

  14. This commentary addresses the use of rimegepant for situational prevention in migraine management. While the approach of using prophylactic treatments during high-risk periods is not new, its application with ...

    Authors: Lanfranco Pellesi and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2024 25:137
    Content type: Comment Published on:

  15. A global schools-based programme within the Global Campaign against Headache is estimating the burden of headache in children (6–11 years) and adolescents (12–17 years), cluster-sampling the world by conductin...

    Authors: Mendinatou Agbetou Houessou, Thierry Adoukonou, Willy Tchuenga Fokom, Nelly Dovoedo, Tayyar ÅžaÅŸmaz, Fatma BozdaÄŸ, Derya Uluduz and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:135
    Content type: Research Published on:

  16. Migraine is a neurological disorder characterized by complex, widespread, and sudden attacks with an unclear pathogenesis, particularly in chronic migraine (CM). Specific brain regions, including the insula, a...

    Authors: Shaobo Xiao, Guangshuang Lu, Jiayi Liu, Wenjie Su, Chenhao Li, Yingyuan Liu, Fanchao Meng, Jinjing Zhao, Nan Gao, Yan Chang, Xinghao Guo, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2024 25:136
    Content type: Research Published on:

  17. To assess rates of traversing barriers to care to access optimal clinical outcomes in people with migraine internationally.

    Authors: Michel Lanteri-Minet, Elizabeth Leroux, Zaza Katsarava, Richard B. Lipton, Fumihiko Sakai, Manjit Matharu, Kristina Fanning, Aubrey Manack Adams, Katherine Sommer, Michael Seminerio and Dawn C. Buse
    Citation: The Journal of Headache and Pain 2024 25:134
    Content type: Research Published on:

  18. We have previously shown headache to be highly prevalent in Cameroon. Here we present the attributed burden. We also perform a headache-care needs assessment.

    Authors: Callixte Kuate Tegueu, Anastase Dzudie Tamdja, Franklin Kom, Blaise Forgwa Barche, Peter Ebasone, Mélanie Magnerou, Paul Mbonda, Yannick Fogang, Daniel Massi Gams, Jacques Doumbe, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:133
    Content type: Research Published on:

  20. While growing evidence suggests a relationship between migraine and cardiovascular disease, the genetic evidence for a causal relationship between migraine and cardiovascular disease is still scarce. Investiga...

    Authors: Xirui Duan, Xiaolan Du, Guangrong Zheng, Xinyan Zhou, Na Tan, Guochen Li, Bin Liu, Mei Zhu, Tengfei Ke and Chengde Liao
    Citation: The Journal of Headache and Pain 2024 25:130
    Content type: Research Published on:

  21. Migraine, a widespread neurological condition, substantially affects the quality of life, particularly for adolescents and young adults. While its impact is significant, there remains a paucity of comprehensiv...

    Authors: Zhi-feng Chen, Xiang-meng Kong, Cheng-hao Yang, Xin-yu Li, Hong Guo and Zhao-wei Wang
    Citation: The Journal of Headache and Pain 2024 25:131
    Content type: Research Published on:

  22. Migraine, a primary headache disorder whose mechanism remains incompletely understood, appears to involve the activation of the trigeminovascular system (TS) during attacks. Research suggests that inflammatory...

    Authors: Tamás Körtési, Gábor Nagy-Grócz and László Vécsei
    Citation: The Journal of Headache and Pain 2024 25:129
    Content type: Review Published on:

  23. Cluster headache (CH) is associated with high disability. The Cluster Headache Impact Questionnaire (CHIQ) is a short, disease-specific disability questionnaire first developed and validated in German. Here, w...

    Authors: Katharina Kamm, Andreas Straube, Mark Burish and Ruth Ruscheweyh
    Citation: The Journal of Headache and Pain 2024 25:128
    Content type: Research Published on:

  24. Management of idiopathic intracranial hypertension (IIH) is complex requiring contributions from multiple specialized disciplines. In practice, this creates considerable organizational and communicational chal...

    Authors: Gabriel Bsteh, Stefan Macher, Nik Krajnc, Wolfgang Marik, Martin Michl, Nina Müller, Sina Zaic, Jürgen Harreiter, Klaus Novak, Christian Wöber and Berthold Pemp
    Citation: The Journal of Headache and Pain 2024 25:127
    Content type: Research Published on:

  26. Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine...

    Authors: Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen and Sarah Louise Christensen
    Citation: The Journal of Headache and Pain 2024 25:126
    Content type: Research Published on:

  27. The initiation of migraine headaches and the involvement of neuroinflammatory signaling between parenchymal and meningeal cells remain unclear. Experimental evidence suggests that a cascade of inflammatory sig...

    Authors: Turgay Dalkara, Zeynep Kaya and Åžefik Evren Erdener
    Citation: The Journal of Headache and Pain 2024 25:124
    Content type: Review Published on:

  29. The relationship between lifestyle and migraine is complex, as it remains uncertain which specific lifestyle factors play the most prominent role in the development of migraine, or which modifiable metabolic t...

    Authors: Quan Gan, Enfeng Song, Lily Zhang, Yanjie Zhou, Lintao Wang, Zhengming Shan, Jingjing Liang, Shanghua Fan, Songqing Pan, Kegang Cao and Zheman Xiao
    Citation: The Journal of Headache and Pain 2024 25:122
    Content type: Research Published on:

  30. Migraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in opening of pannexin 1 meg...

    Authors: Burak Uzay, Buket Donmez-Demir, Sinem Yilmaz Ozcan, Emine Eren Kocak, Muge Yemisci, Yasemin Gursoy Ozdemir, Turgay Dalkara and Hulya Karatas
    Citation: The Journal of Headache and Pain 2024 25:120
    Content type: Research Published on:

  31. The aim of this paper is to critically re-appraise the published trials assessing propranolol for migraine prophylaxis.

    Authors: Jan Versijpt, Christina Deligianni, Muizz Hussain, Faisal Amin, Uwe Reuter, Margarita Sanchez-del-Rio, Derya Uluduz, Deirdre Boucherie, Dena Zeraatkar, Antoinette MaassenVanDenBrink, Simona Sacco, Christian Lampl and Raquel Gil-Gouveia
    Citation: The Journal of Headache and Pain 2024 25:119
    Content type: Research Published on:

  32. Cluster headache is characterized by activation of the trigeminovascular pathway with subsequent pain signalling in the meningeal vessels, and inflammation has been suggested to play a role in the pathophysiol...

    Authors: Caroline Ran, Felicia Jennysdotter Olofsgård, Katrin Wellfelt, Anna Steinberg and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2024 25:121
    Content type: Research Published on:

  33. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since the diffusion tensor model ca...

    Authors: Yungang Cao, Mei Huang, Fangwang Fu, Keyang Chen, Kun Liu, Jinming Cheng, Yan Li and Xiaozheng Liu
    Citation: The Journal of Headache and Pain 2024 25:118
    Content type: Research Published on:

  34. Migraine, as a complex neurological disease, brings heavy burden to patients and society. Despite the availability of established therapies, existing medications have limited efficacy. Thus, we aimed to find t...

    Authors: Xinyue Sun, Bohong Chen, Yi Qi, Meng Wei, Wanying Chen, Xiaoyu Wu, Qingfan Wang, Jiahao Li, Xiangyu Lei and Guogang Luo
    Citation: The Journal of Headache and Pain 2024 25:117
    Content type: Research Published on:

  35. Migraine is one of the most common diseases worldwide while current treatment options are not ideal. New therapeutic classes of migraine, the calcitonin gene-related peptide (CGRP) antagonists, have been devel...

    Authors: Min Hou, Xiaofeng Luo, Shuangshuang He, Xue Yang, Qing Zhang, Meihua Jin, Pan Zhang, Yang Li, Xiaoting Bi, Juan Li, Caiyi Cheng, Qiang Xue, Haiyan Xing and Yao Liu
    Citation: The Journal of Headache and Pain 2024 25:116
    Content type: Research Published on:

  37. Migraine has been associated with functional brain changes including altered connectivity and activity both during and between headache attacks. Recent studies established that the variability of the blood-oxy...

    Authors: Dániel Veréb, Nikoletta Szabó, Bálint Kincses, Laura Szücs-Bencze, Péter Faragó, Máté Csomós, Szabolcs Antal, Krisztián Kocsis, Bernadett Tuka and Zsigmond Tamás Kincses
    Citation: The Journal of Headache and Pain 2024 25:114
    Content type: Research Published on:

  38. Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the lep...

    Authors: Anna A. Karan, Konstantin A. Gerasimov, Yulia S. Spivak, Elena M. Suleymanova and Lyudmila V. Vinogradova
    Citation: The Journal of Headache and Pain 2024 25:113
    Content type: Brief Report Published on:

  39. Glucagon-like peptide-1 (GLP-1) plays a crucial role in metabolic disorders by enhancing insulin secretion, inhibiting glucagon release, and slowing gastric emptying, thereby improving glycemic control. In rec...

    Authors: Wael Halloum, Yousef Al Dughem, Dagmar Beier and Lanfranco Pellesi
    Citation: The Journal of Headache and Pain 2024 25:112
    Content type: Review Published on:

  40. Pediatric headache is an increasing medical problem that has adverse effects on children’s quality of life, academic performance, and social functioning. Children with primary headaches exhibit enhanced sensor...

    Authors: Michal Pieniak, Berit Höfer, Jenny Knipping, Vanda Faria, Matthias Richter, Valentin A. Schriever, Antje Haehner and Gudrun Gossrau
    Citation: The Journal of Headache and Pain 2024 25:111
    Content type: Research Published on:

  41. New daily persistent headache (NDPH) is a rare primary headache with unclear pathogenesis. Neuroimaging studies of NDPH are limited, and controversy still exists. Diffusion tensor imaging (DTI) is commonly use...

    Authors: Zhilei Li, Yanliang Mei, Wei Wang, Lei Wang, Shouyi Wu, Kaibo Zhang, Dong Qiu, Zhonghua Xiong, Xiaoshuang Li, Ziyu Yuan, Peng Zhang, Mantian Zhang, Qiuling Tong, Zhenchang Zhang and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:110
    Content type: Research Published on:

  42. Management of patients with migraine who have concomitant medication overuse (MO) or medication overuse headache (MOH) is a major problem in clinical practice. Detoxification of acute analgesics before or duri...

    Authors: Armin Scheffler, Jale Basten, Lennart Menzel, Dominik Binz, Wolfgang Alexander Becker, Vincent Breunung, Hannah Schenk, Christoph Kleinschnitz, Michael Nsaka, Diana Lindner and Dagny Holle
    Citation: The Journal of Headache and Pain 2024 25:109
    Content type: Research Published on:

  43. India is a large and populous country where reliable data on headache disorders are relatively scarce. This study in northern India (Delhi and National Capital Territory Region [NCR], including surrounding dis...

    Authors: Debashish Chowdhury, Anand Krishnan, Ashish Duggal, Ritvik Amarchand, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:108
    Content type: Research Published on:

  44. Our recent studies have shown headache disorders to be very common in the central and western sub-Saharan countries of Benin and Cameroon. Here we report headache in nearby Mali, a strife-torn country that dif...

    Authors: Youssoufa Maiga, Seybou H. Diallo, Oumar Sangho, Leon Samuel Moskatel, Fatoumata Konipo, Abdoulaye Bocoum, Salimata Diallo, Awa Coulibaly, Mariam Daou, Housseini Dolo, Modibo Sangaré, Mohamed Albakaye, Zoumana Traoré, Thomas Coulibaly, Adama Sissoko, Guida Landouré…
    Citation: The Journal of Headache and Pain 2024 25:107
    Content type: Research Published on:

  45. Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and trea...

    Authors: Kyung-Hee Cho, Seol-Hee Baek, Sung-Hee Kim, Byung-Su Kim, Jong-Hee Sohn, Min Kyung Chu, Mi-Kyoung Kang, Hee Jung Mo, Sang-Hwa Lee, Hong-Kyun Park, Soohyun Cho, Sun-Young Oh, Jong-Geun Seo, Wonwoo Lee, Ju-Young Lee, Mi Ji Lee…
    Citation: The Journal of Headache and Pain 2024 25:106
    Content type: Research Published on:

  46. Non-steroidal anti-inflammatory drugs (NSAIDs) are considered first-line medications for acute migraine attacks. However, the response exhibits considerable variability among individuals. Thus, this study aime...

    Authors: Heng-Le Wei, Yu-Sheng Yu, Meng-Yao Wang, Gang-Ping Zhou, Junrong Li, Hong Zhang and Zhengyang Zhou
    Citation: The Journal of Headache and Pain 2024 25:104
    Content type: Research Published on:

  47. The development of several experimental migraine provocation models has significantly contributed to an understanding of the signaling mechanisms of migraine. The early history of this development and a view t...

    Authors: Jes Olesen
    Citation: The Journal of Headache and Pain 2024 25:105
    Content type: Review Published on:

  48. The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It is composed of functionally different subdivisions an...

    Authors: Fengfang Li, Di Zhang, Jun Ren, Chunhua Xing, Lanyue Hu, Zhengfei Miao, Liyan Lu and Xinying Wu
    Citation: The Journal of Headache and Pain 2024 25:103
    Content type: Research Published on:

  49. New onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its management poses a suitable means to enhance patients’ participation in professional, social,...

    Authors: Johanna Ruhnau, Max Blücher, Susanne Bahlmann, Almut Zieme, Antje Vogelgesang, Anke Steinmetz and Robert Fleischmann
    Citation: The Journal of Headache and Pain 2024 25:101
    Content type: Research Published on:

  50. Large conductance  calcium-activated potassium (BKCa) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-tra...

    Authors: Haidar M. Al-Khazali, Rune H. Christensen, David W. Dodick, Basit Ali Chaudhry, Anna G. Melchior, Rami Burstein and HÃ¥kan Ashina
    Citation: The Journal of Headache and Pain 2024 25:102
    Content type: Research Published on:
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ISSN: 1129-2377

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