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  1. To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic migraine (CM: ≥ 15 days/month)...

    Authors: Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Paola Torelli, Cinzia Finocchi, Florindo d’Onofrio, Luigi d’Onofrio, Renata Rao, Stefano Messina, Laura Di Clemente, Angelo Ranieri, Massimo Autunno, Giuliano Sette, Bruno Colombo, Antonio Carnevale, Marco Aguggia…
    Citation: The Journal of Headache and Pain 2023 24:30
    Content type: Research Published on:

  2. Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 2...

    Authors: Jiahui He, Mengting Zhou, Fanglin Zhao, Hongrong Cheng, Hao Huang, Xiaopei Xu, Jian Han, Wenwu Hong, Faming Wang, Yujin Xiao, Jinjin Xia and Kaiming Liu
    Citation: The Journal of Headache and Pain 2023 24:28
    Content type: Research Published on:

  3. The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of...

    Authors: Zhijian Cao, Wenjing Yu, Luping Zhang, Jiajia Yang, Jiafei Lou, Maosheng Xu and Zhengxiang Zhang
    Citation: The Journal of Headache and Pain 2023 24:27
    Content type: Research Published on:

  4. Current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intrac...

    Authors: Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji and Ran Meng
    Citation: The Journal of Headache and Pain 2023 24:29
    Content type: Research Published on:

  5. The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, an...

    Authors: Sait Ashina, Agustin Melo-Carrillo, Ajayi Toluwanimi, Nicolas Bolo, Edina Szabo, David Borsook and Rami Burstein
    Citation: The Journal of Headache and Pain 2023 24:26
    Content type: Research Published on:

  6. Appropriate and timely diagnosis is one of the most important milestones in effective migraine care and is affected by public awareness, access to medical care, health care systems, and physicians’ knowledge. ...

    Authors: Ido Peles, Mohnnad Asla, Mariya Abayev, Michal Gordon, Ali Alhoashle, Victor Novack, Rinat Ribalov, Tamar Lengil, Ron Maor, Mayera Elizur and Gal Ifergane
    Citation: The Journal of Headache and Pain 2023 24:25
    Content type: Research Published on:

  7. Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essentia...

    Authors: H. Genc, B. Baykan, H. Bolay, D. Uluduz, I. Unal-Cevik, N. Kissani, O. Luvsannorov, M. Togha, A. A. Ozdemir and A. Ozge
    Citation: The Journal of Headache and Pain 2023 24:24
    Content type: Research Published on:

  8. Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are a favourable option for patients with migraine who experience distressful headache disability and fail to respond to traditional preven...

    Authors: Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Naoki Miyazaki, Kei Ishizuchi, Satoko Hori, Ryo Takemura, Jin Nakahara and Tsubasa Takizawa
    Citation: The Journal of Headache and Pain 2023 24:23
    Content type: Research Published on:

  9. Authors: Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra M. Raghava, Frauke Wolfram, Henrik B. W. Larsson and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:22
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2021 22:98

  10. In order to pursue its purpose of reducing the global burden of headache, the Global Campaign against Headache has gathered data on headache-attributed burden from countries worldwide. These data, from the ind...

    Authors: Timothy J. Steiner, Andreas Husøy, Hallie Thomas and Lars Jacob Stovner
    Citation: The Journal of Headache and Pain 2023 24:21
    Content type: Comment Published on:

  11. To explore the possibility of further dividing migraine without aura (MWA), 1444 female patients fulfilled the criterion were recruited, and grouped basing on the association of MWA onset with menarche and chi...

    Authors: Xiaolin Wang, Weinan Na, Ying Yang, Wenwen Zhang, Junxia Zhao, Tingting Zhang, Yuanji Zhou, Hua Liu, Dong Zhao and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:20
    Content type: Research Published on:

  12. Headache during hemodialysis (HDH) is prevalent but not negligible. Despite the high prevalence of dialysis headaches, they have rarely been studied. Therefore, this study aimed to evaluate the prevalence, ris...

    Authors: Ying Yang, Fanchao Meng, Hanyu Zhu, Lei Zhang, Guangshuang Lu, Shaobo Xiao, Jiaji He, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2023 24:19
    Content type: Research Published on:

  13. Clinical trials and real-world studies revealed a spectrum of response to CGRP(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at all to total migraine freedom. In this ...

    Authors: Bianca Raffaelli, Mira Fitzek, Lucas H. Overeem, Elisabeth Storch, Maria Terhart and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:16
    Content type: Research Published on:

  14. Worldwide, far from all of those who would benefit make use of headache services, largely because of clinical, social, and political barriers to access. Identifying the factors contributing to low healthcare u...

    Authors: Thien Phu Do, Mikala Dømgaard, Simon Stefansen, Timothy J. Steiner and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:18
    Content type: Research Published on:

  15. To examine whether white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs) are more prevalent in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI), com...

    Authors: Håkan Ashina, Rune H. Christensen, Haidar Muhsen Al-Khazali, Afrim Iljazi, Daniel Tolnai, Anna K. Eigenbrodt, Henrik B. W. Larsson, Henrik W. Schytz, Ulrich Lindberg and Faisal Mohammad Amin
    Citation: The Journal of Headache and Pain 2023 24:15
    Content type: Research Published on:

  16. New daily persistent headache (NPDH) is a rare primary headache that is highly disabling. The pathophysiology of NDPH is still unclear, and we aimed to reveal the underlying mechanism of NDPH through functiona...

    Authors: Xueyan Zhang, Wei Wang, Xiaoyan Bai, Yanliang Mei, Hefei Tang, Ziyu Yuan, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:14
    Content type: Research Published on:

  17. This study aimed to combine voxel-based morphometry, deformation-based morphometry, and surface-based morphometry to analyze gray matter volume and cortex shape in classical trigeminal neuralgia patients.

    Authors: Xiuhong Ge, Luoyu Wang, Lei Pan, Haiqi Ye, Xiaofen Zhu, Sandra Fan, Qi Feng, Quan Du, Wenhua Yu and Zhongxiang Ding
    Citation: The Journal of Headache and Pain 2023 24:17
    Content type: Research Published on:

  18. The changes in resting-state functional networks and their correlations with clinical traits remain to be clarified in migraine. Here we aim to investigate the brain spatio-temporal dynamics of resting-state n...

    Authors: Yan Zhou, Liusheng Gong, Yushu Yang, Linjie Tan, Lili Ruan, Xiu Chen, Hua Luo and Jianghai Ruan
    Citation: The Journal of Headache and Pain 2023 24:13
    Content type: Research Published on:

  19. Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with her...

    Authors: Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska-Prosół, Dilara Onan, Karol Marschollek, Wietse Wiels, Petr Mikulenka, Fatemeh Farham, Cédric Gollion and Anne Ducros
    Citation: The Journal of Headache and Pain 2023 24:12
    Content type: Review Published on:

  20. Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing e...

    Authors: V. J. Gallardo, J. B. Gómez-Galván, L. Asskour, M. Torres-Ferrús, A. Alpuente, E. Caronna and P. Pozo-Rosich
    Citation: The Journal of Headache and Pain 2023 24:11
    Content type: Research Published on:

  21. Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested to be related to migraine in recent stu...

    Authors: Lei Zhao, Wenhui Zhao, Jin Cao and Yiheng Tu
    Citation: The Journal of Headache and Pain 2023 24:10
    Content type: Research Published on:

  22. Migraine prophylactic therapy has changed over recent years with the development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway. As new therapies emer...

    Authors: Linda Al-Hassany, Hannah S. Lyons, Deirdre M. Boucherie, Fatemeh Farham, Kristin S. Lange, Karol Marschollek, Dilara Onan, Umberto Pensato, Elisabeth Storch, Angelo Torrente, Marta Waliszewska-Prosół and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:9
    Content type: Review Published on:

  23. Headache is the most prevalent neurological manifestation in adults and one of the leading causes of disability worldwide. In children and adolescents, headaches are arguably responsible for a remarkable impac...

    Authors: Agnese Onofri, Umberto Pensato, Chiara Rosignoli, William Wells-Gatnik, Emily Stanyer, Raffaele Ornello, Hui Zhou Chen, Federico De Santis, Angelo Torrente, Petr Mikulenka, Gabriele Monte, Karol Marschollek, Marta Waliszewska-Prosół, Wietse Wiels, Deirdre M. Boucherie, Dilara Onan…
    Citation: The Journal of Headache and Pain 2023 24:8
    Content type: Review Published on:

  24. In an earlier paper, we examined the relationship between headache-attributed disability, measured as proportion of time in ictal state, and lost productivity. In a linear model, we found positive and signific...

    Authors: Andreas Husøy, Zaza Katsarava and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2023 24:7
    Content type: Research Published on:

  25. Chronic headaches and sports-related concussions are among the most common neurological morbidities in adolescents and young adults. Given that the two can overlap in presentation, studying the effects of one ...

    Authors: Muhammad Ali, Nek Asghar, Theodore Hannah, Alexander J Schupper, Adam Li, Nickolas Dreher, Muhammad Murtaza-Ali, Vikram Vasan, Zaid Nakadar, Husni Alasadi, Anthony Lin, Eugene Hrabarchuk, Addison Quinones, Lily McCarthy, Zerubabbel Asfaw, Jonathan Dullea…
    Citation: The Journal of Headache and Pain 2023 24:6
    Content type: Research Published on:

  26. Many migraine patients do not respond adequately to conventional preventive treatments and are therefore described as treatment/medically resistant or difficult to treat cases. Calcitonin gene-related peptide ...

    Authors: Emma Troy, Arif A. Shrukalla, Alina Buture, Katie Conaty, Esther Macken, Roisin Lonergan, Jane Melling, Niamh Long, Eamonn Shaikh, Kieran Birrane, Esther M. Tomkins, Peter J. Goadsby and Martin H. Ruttledge
    Citation: The Journal of Headache and Pain 2023 24:5
    Content type: Research Published on:

  27. While new genetic analysis methods are widely used in the clinic, few researchers have focused on trigeminal neuralgia (TN) with familial clustering (≥ 2 TN patients in one kindred family). Previous literature...

    Authors: Anni Wang, Zimu Song, Xu Zhang, LiFei Xiao, Yan Feng, Chong Qi, Guohuan Zhang, Jinbo Bai, Yang Liu, Tao Sun, Fangang Meng and Feng Wang
    Citation: The Journal of Headache and Pain 2023 24:4
    Content type: Research Published on:

  28. Despite the pervasiveness of migraine, the underlying pathophysiological mechanisms initiating migraine attacks are far from well understood and are matter of scientific debate.

    Authors: Thien Phu Do, Anders Hougaard, Greg Dussor, K. C. Brennan and Faisal Mohammad Amin
    Citation: The Journal of Headache and Pain 2023 24:3
    Content type: Review Published on:

  29. Sphenopalatine ganglion (SPG) is a peripheral structure that plays an important role in cluster headache (CH). Hence, a reliable method to measure the volume of SPG is crucial for studying the peripheral mecha...

    Authors: Jr-Wei Wu, Shu-Ting Chen, Yen-Feng Wang, Kuan-Lin Lai, Ting-Yi Chen, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2023 24:2
    Content type: Research Published on:

  30. Migraine is a major health burden worldwide with complex pathophysiology and multifarious underlying mechanisms. One poorly understood issue concerns the early steps in the generation of migraine pain. To eluc...

    Authors: R. Giniatullin and A. Nistri
    Citation: The Journal of Headache and Pain 2023 24:1
    Content type: Review Published on:

  31. Authors: Fumihiko Sakai, Koichi Hirata, Hisaka Igarashi, Takao Takeshima, Takeo Nakayama, Hiromi Sano, Hiroyuki Kondo, Yoshiyuki Shibasaki and Nobuyuki Koga
    Citation: The Journal of Headache and Pain 2022 23:164
    Content type: Author Correction Published on:

    The original article was published in The Journal of Headache and Pain 2022 23:70

  32. Migraine is common among females of reproductive age (estimated prevalence:17–24%) and may be associated with reproductive health through underlying central nervous system excitability, autoimmune conditions, ...

    Authors: Holly M. Crowe, Amelia K. Wesselink, Lauren A. Wise, Susan S. Jick, Kenneth J. Rothman, Ellen M. Mikkelsen, Henrik T. Sørensen and Elizabeth E. Hatch
    Citation: The Journal of Headache and Pain 2022 23:162
    Content type: Research Published on:

  33. Authors: Andreas R. Gantenbein, Reto Agosti, Christian P. Kamm, Gunther Landmann, Niklaus Meier, Gabriele Susanne Merki-Feld, Jens A. Petersen, Heiko Pohl, Philippe Ryvlin, Christoph J. Schankin, Dragana Viceic, Chiara Zecca, Elisabeth Schäfer, Ina Meyer and Michael E. Arzt
    Citation: The Journal of Headache and Pain 2022 23:161
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2022 23:142

  34. Understanding migraine epidemiology and its burden is crucial for planning health policies and interventions at the local level as well as at the global level. National policies in Israel rely on global estima...

    Authors: Ido Peles, Mohnnad Asla, Mariya Abayev, Michal Gordon, Victor Novack, Rinat Ribalov, Tamar Lengil, Ron Maor, Mayera Elizur and Gal Ifergane
    Citation: The Journal of Headache and Pain 2022 23:160
    Content type: Research Published on:

  35. Migraine involves central and peripheral nervous system mechanisms. Erenumab, an anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody with little central nervous system penetrance, is effec...

    Authors: Todd J. Schwedt, Simona Nikolova, Gina Dumkrieger, Jing Li, Teresa Wu and Catherine D. Chong
    Citation: The Journal of Headache and Pain 2022 23:159
    Content type: Research Published on:

  38. New daily persistent headache (NDPH) and chronic migraine (CM) are two different types of headaches that might involve vascular dysregulation. There is still a lack of clarity about altered brain perfusion in ...

    Authors: Xiaoyan Bai, Wei Wang, Xueyan Zhang, Zhangxuan Hu, Yingkui Zhang, Zhiye Li, Xue Zhang, Ziyu Yuan, Hefei Tang, Yaqing Zhang, Xueying Yu, Peng Zhang, Yonggang Wang and Binbin Sui
    Citation: The Journal of Headache and Pain 2022 23:156
    Content type: Research Published on:

  40. Calcitonin gene-related peptide (CGRP) antagonizing drugs represents the most important advance in migraine therapy for decades. However, these new drugs are only effective in 50–60% of patients. Recent studie...

    Authors: Song Guo, Charlotte Ernstsen, Anders Hay-Schmidt, Messoud Ashina, Jes Olesen and Sarah Louise Christensen
    Citation: The Journal of Headache and Pain 2022 23:155
    Content type: Research Published on:

  41. The definitive pathogenic mechanisms underlying chronic migraine (CM) remain unclear. Mounting evidence from functional and structural magnetic resonance imaging (MRI) studies suggests that the caudate nucleus...

    Authors: Ziyu Yuan, Wei Wang, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Peng Zhang, Dong Qiu, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2022 23:154
    Content type: Research Published on:

  42. The multinational phase 3b DELIVER trial was designed to evaluate the efficacy and safety of eptinezumab for migraine prevention in patients with prior preventive treatment failures across 17 countries. In the...

    Authors: Piero Barbanti, Peter J. Goadsby, Giorgio Lambru, Anders Ettrup, Cecilie Laurberg Christoffersen, Mette Krog Josiassen, Ravinder Phul and Bjørn Sperling
    Citation: The Journal of Headache and Pain 2022 23:153
    Content type: Research Published on:

  43. Hypothalamus is a key region in migraine attacks. In addition, women are disproportionately affected by migraine. The calcitonin gene-related peptide (CGRP) system is an important key player in migraine pathop...

    Authors: Aida Maddahi, Lars Edvinsson and Karin Warfvinge
    Citation: The Journal of Headache and Pain 2022 23:152
    Content type: Research Published on:

  44. Cluster headache and migraine are regarded as distinct primary headaches. While cluster headache and migraine differ in multiple aspects such as gender-related and headache specific features (e.g., attack dura...

    Authors: Mohammad Al-Mahdi Al-Karagholi, Kuan-Po Peng, Anja Sofie Petersen, Irene De Boer, Gisela M. Terwindt and Messoud Ashina
    Citation: The Journal of Headache and Pain 2022 23:151
    Content type: Review Published on:

  47. Headache recurrence is a common feature of acute therapies, whether approved or still in development, and continues to be a significant problem for both the patient and the clinician. Further complicating this...

    Authors: Stewart J. Tepper, Jessica Ailani, Sutapa Ray, Joe Hirman, Stephen B. Shrewsbury and Sheena K. Aurora
    Citation: The Journal of Headache and Pain 2022 23:148
    Content type: Review Published on:

  48. Cluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies (GWAS) recently identified replicable genomic loci for cluster headac...

    Authors: Shih-Pin Chen, Chia-Lin Hsu, Yen-Feng Wang, Fu-Chi Yang, Ting-Huei Chen, Jia-Hsin Huang, Li-Ling Hope Pan, Jong-Ling Fuh, Hsueh-Chen Chang, Yi-Lun Lee, Hung-Ching Chang, Ko-Han Lee, Yu-Chuan Chang, Cathy Shen-Jang Fann and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2022 23:147
    Content type: Research Published on:

  49. DRAGON was a phase 3, randomised, double-blind, placebo-controlled study which evaluated the efficacy and safety of erenumab in patients with chronic migraine (CM) from Asia not adequately represented in the g...

    Authors: Shengyuan Yu, Byung-Kun Kim, Hebo Wang, Jiying Zhou, Qi Wan, Tingmin Yu, Yajun Lian, Michal Arkuszewski, Laurent Ecochard, Shihua Wen, Fangfang Yin, Zheng Li, Wendy Su and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2022 23:146
    Content type: Research Published on:

  50. Trigeminal neuralgia is a severe facial pain disorder. Microvascular decompression is first choice surgical treatment of patients with classical TN. There exist few prospective studies with an independent eval...

    Authors: Anne Sofie Schott Andersen, Tone Bruvik Heinskou, Per Rochat, Jacob Bertram Springborg, Navid Noory, Emil Andonov Smilkov, Lars Bendtsen and Stine Maarbjerg
    Citation: The Journal of Headache and Pain 2022 23:145
    Content type: Research Published on:
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