Articles

Guideline on the use of onabotulinumtoxinA in chronic migraine: a consensus statement from the European Headache Federation

OnabotulinumtoxinA is being increasingly used in the management of chronic migraine (CM). Treatment with onabotulinumtoxinA poses challenges compared with traditional therapy with orally administered preventat...

Authors: Lars Bendtsen, Simona Sacco, Messoud Ashina, Dimos Mitsikostas, Fayyaz Ahmed, Patricia Pozo-Rosich and Paolo Martelletti

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

Primary headache are prevalent and debilitating disorders. Acute pain cessation is one of the key points in their treatment. Many drugs have been studied but the design of the trials is not usually homogeneous...

Authors: D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. Ferrili, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese

Migraine and cluster headache – the common link

Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related...

Authors: Anne Luise Vollesen, Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Messoud Ashina and Christian Lampl

Using the child behavior checklist to determine associations between psychosocial aspects and TMD-related pain in children and adolescents

Since children and adolescents are frequently experiencing emotional and behavioral consequences due to pain, their parents should be aware of this emotional and behavioral status. Therefore, the aim of this s...

Authors: Amal Al-Khotani, Mattias Gjelset, Aron Naimi-Akbar, Britt Hedenberg-Magnusson, Malin Ernberg and Nikolaos Christidis

12th European Headache Federation Congress jointly with 32nd National Congress of the Italian Society for the Study of Headaches

Authors:

Sustained onabotulinumtoxinA therapeutic benefits in patients with chronic migraine over 3 years of treatment

Evidence on whether the therapeutic effect and good safety profile of onabotulinumtoxinA (Botox®) in chronic migraine (CM) patients is maintained over long term treatment is still limited. We herein aimed at a...

Authors: Michail Vikelis, Andreas A. Argyriou, Emmanouil V. Dermitzakis, Konstantinos C. Spingos, Nikolaos Makris and Evangelia Kararizou

Impact of migraine on the clinical presentation of insomnia: a population-based study

Insomnia and migraine are closely related; insomnia aggravates migraine symptoms. This study was conducted to investigate the impact of migraine on the clinical presentation of insomnia symptoms.

Authors: Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Validation of a self-reported instrument to assess work-related difficulties in patients with migraine: the HEADWORK questionnaire

The degree to which work-related difficulties are recognized in headache research is poor and often carried out with inadequate information such as “reduced ability to work as usual”, which do not capture at a...

Authors: Alberto Raggi, Venusia Covelli, Erika Guastafierro, Matilde Leonardi, Chiara Scaratti, Licia Grazzi, Marco Bartolini, Giovanna Viticchi, Sabina Cevoli, Giulia Pierangeli, Gioacchino Tedeschi, Antonio Russo, Piero Barbanti, Cinzia Aurilia, Carlo Lovati, Luca Giani…

Myofascial trigger points in migraine and tension-type headache

A myofascial trigger point is defined as a hyperirritable spot in skeletal muscle that is associated with a hypersensitive palpable nodule in a taut band. It has been suggested that myofascial trigger points t...

Authors: Thien Phu Do, Gerda Ferja Heldarskard, Lærke Tørring Kolding, Jeppe Hvedstrup and Henrik Winther Schytz

The association between migraine and physical exercise

There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role ...

Authors: Faisal Mohammad Amin, Stavroula Aristeidou, Carlo Baraldi, Ewa K. Czapinska-Ciepiela, Daponte D. Ariadni, Davide Di Lenola, Cherilyn Fenech, Konstantinos Kampouris, Giorgos Karagiorgis, Mark Braschinsky and Mattias Linde

Patients’ perspective on the burden of migraine in Europe: a cross-sectional analysis of survey data in France, Germany, Italy, Spain, and the United Kingdom

Migraine is a distinct neurological disease that imposes a significant burden on patients, society, and the healthcare system. This study aimed to characterize the incremental burden of migraine in individuals...

Authors: Pamela Vo, Juanzhi Fang, Aikaterini Bilitou, Annik K. Laflamme and Shaloo Gupta

Correction to: Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)

Following the publication of this article [1], the authors noticed that they incorrectly reported the Absolute risk of ischemic stroke in women aged 20 to 44 years in relation to the use of hormonal contracept...

Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

Long-term follow-up of a community sample of adolescents with frequent headaches

Several outcome studies have reported on the short- and long-term effects of migraine in selected clinical samples of children and adolescents. However, current knowledge of the course, incidence, and outcome ...

Authors: Bo Larsson, Johannes Foss Sigurdson and Anne Mari Sund

Impact of cluster headache on employment status and job burden: a prospective cross-sectional multicenter study

Cluster headaches (CH) are recurrent severe headaches, which impose a major burden on the life of patients. We investigated the impact of CH on employment status and job burden.

Authors: Yun-Ju Choi, Byung-Kun Kim, Pil-Wook Chung, Mi Ji Lee, Jung-Wook Park, Min Kyung Chu, Jin-Young Ahn, Byung-Su Kim, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Kwang-Soo Lee, Soo-Kyoung Kim, Kwang-Yeol Park, Jae Myun Chung, Heui-Soo Moon…

Prolonged migraine aura: new insights from a prospective diary-aided study

There is limited literature on prolonged aura (PA - defined as an aura including at least one symptom for > 1 h and < 7d), and there are no prospective studies.

Authors: Michele Viana, Grazia Sances, Mattias Linde, Giuseppe Nappi, Farihah Khaliq, Peter J. Goadsby and Cristina Tassorelli

Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)

We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was unde...

Authors: Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Andreas R. Gantenbein, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Koen Paemeleire, Per Morten Sandset…

New CACNA1A deletions are associated to migraine phenotypes

Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected. Here have been desc...

Authors: G. S. Grieco, S. Gagliardi, I. Ricca, O. Pansarasa, M. Neri, F. Gualandi, G. Nappi, A. Ferlini and C. Cereda

Vascular wall imaging in reversible cerebral vasoconstriction syndrome – a 3-T contrast-enhanced MRI study

Limited histopathology studies have suggested that reversible cerebral vasoconstriction syndromes (RCVS) does not present with vascular wall inflammation. Previous vascular imaging studies have had inconsisten...

Authors: Chun-Yu Chen, Shih-Pin Chen, Jong-Ling Fuh, Jiing-Feng Lirng, Feng-Chi Chang, Yen-Feng Wang and Shuu-Jiun Wang

Neurophysiological correlates of clinical improvement after greater occipital nerve (GON) block in chronic migraine: relevance for chronic migraine pathophysiology

Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating with clinical efficacy is available to ...

Authors: Alessandro Viganò, Maria Claudia Torrieri, Massimiliano Toscano, Francesca Puledda, Barbara Petolicchio, Tullia Sasso D’Elia, Angela Verzina, Sonia Ruggiero, Marta Altieri, Edoardo Vicenzini, Jean Schoenen and Vittorio Di Piero

Anodal frontal tDCS for chronic cluster headache treatment: a proof-of-concept trial targeting the anterior cingulate cortex and searching for nociceptive correlates

Percutaneous occipital nerve stimulation (ONS) is effective in refractory chronic cluster headache (rCCH) patients. Responders to ONS differ from non-responders by greater glucose metabolism in subgenual anter...

Authors: Delphine Magis, Kevin D’Ostilio, Marco Lisicki, Chany Lee and Jean Schoenen

Pre-treatment with sumatriptan for cilostazol induced headache in healthy volunteers

Previous studies indicate that sumatriptan is not effective when second messenger levels are high as after cilostazol provocation. Therefore, we have conducted the present study, where sumatriptan is administr...

Authors: Katrine Falkenberg and Jes Olesen

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: an 8-week open-label extension study

DFN-11, a 3 mg sumatriptan subcutaneous (SC) autoinjector for acute treatment of migraine, has not been assessed previously in multiple attacks. The objective of this study was to evaluate the efficacy, tolera...

Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study

In a previous randomized, double-blind, proof-of-concept study in rapidly escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated with fewer and shorter triptan sensations than a 6...

Authors: Stephen Landy, Sagar Munjal, Elimor Brand-Schieber and Alan M. Rapoport

Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation

Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is al...

Authors: Efstratia Vatzaki, Sabine Straus, Jean-Michel Dogne, Juan Garcia Burgos, Thomas Girard and Paolo Martelletti

Aggression and its association with suicidality in migraine patients: a case-control study

To identify aggression and its association with suicidality in migraine patients.

Authors: Sung-Pa Park and Jong-Geun Seo

Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. ...

Authors: Lena Ohlsson, Erik Kronvall, Jennifer Stratton and Lars Edvinsson

Intracortical facilitation within the migraine motor cortex depends on the stimulation intensity. A paired-pulse TMS study

Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evo...

Authors: Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M. Capitano, Brigida Fierro and Filippo Brighina

PACAP38 and PAC₁ receptor blockade: a new target for headache?

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent i...

Authors: Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink and Lars Edvinsson

The missclassification of obesity affects the course of migraine

Authors: Laura Di Renzo, Andrea Cammarano and Antonino De Lorenzo

Psychological distress, neuroticism and disability associated with secondary chronic headache in the general population – the Akershus study of chronic headache

Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with secondary chron...

Authors: Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist and Michael Bjørn Russell

Fibromyalgia in migraine: a retrospective cohort study

Migraine is a common and disabling disorder. Fibromyalgia has been shown to be commonly comorbid in patients with migraine and can intensify disability. The aim of this study was to determine if patients with ...

Authors: Mark Whealy, Sanjeev Nanda, Ann Vincent, Jay Mandrekar and F. Michael Cutrer

Headache in transient ischemic attacks

Headache is a common feature in acute cerebrovascular disease but no studies have evaluated the prevalence of specific headache types in patients with transient ischemic attacks (TIA). The purpose of the prese...

Authors: Elena R. Lebedeva, Natalia M. Gurary and Jes Olesen

Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700 m

High-altitude headache (HAH) is the most common sickness occurred in healthy people after rapid ascending to high altitude, and its risk factors were still not well understood. To investigate physiological, he...

Authors: Kun Wang, Menghan Zhang, Yi Li, Weilin Pu, Yanyun Ma, Yi Wang, Xiaoyu Liu, Longli Kang, Xiaofeng Wang, Jiucun Wang, Bin Qiao and Li Jin

Poor sleep quality in migraine and probable migraine: a population study

Probable migraine (PM) is a subtype of migraine that is prevalent in the general population. Previous studies have shown that poor sleep quality is common among migraineurs and is associated with an exacerbati...

Authors: Tae-Jin Song, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

Survival outcome and mortality rate in patients with migraine: a population-based cohort study

Whether the patients with migraine have an elevated mortality risk in Taiwan is unclear.

Authors: Tomor Harnod, Cheng-Li Lin and Chia-Hung Kao

Migraine and greater pain symptoms at 10-year follow-up among patients with major depressive disorder

No study has investigated the associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD). This study aimed to investigate this issue.

Authors: Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang and Shuu-Jiun Wang

Increased thalamic glutamate/glutamine levels in migraineurs

Increased cortical excitability has been hypothesized to play a critical role in various neurological disorders, such as restless legs syndrome, epilepsy and migraine. Particularly for migraine, local hyperexc...

Authors: Adina Bathel, Lauren Schweizer, Philipp Stude, Benjamin Glaubitz, Niklas Wulms, Sibel Delice and Tobias Schmidt-Wilcke

Vitamin D deficiency in patients with cluster headache: a preliminary study

Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D leve...

Authors: Jong-Hee Sohn, Min-Kyung Chu, Kwang-Yeol Park, Hong-Yup Ahn and Soo-Jin Cho

Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal

Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chro...

Authors: Mi Ji Lee, Sook-Yeon Lee, Soohyun Cho, Eun-Suk Kang and Chin-Sang Chung

Multigroup latent class model of musculoskeletal pain combinations in children/adolescents: identifying high-risk groups by gender and age

To investigate the combinations of Musculoskeletal pain (MSP) (neck, shoulder, upper and low back pain) among a sample of Iranian school children.

Authors: Iman Dianat, Arezou Alipour and Mohammad Asghari Jafarabadi

Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing

Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CG...

Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni and Cristina Tassorelli

Medication-overuse headache: a widely recognized entity amidst ongoing debate

Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to h...

Authors: Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire and Zaza Katsarava

Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing ¹⁸FDG-PET and visual evoked potentials

Migraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abn...

Authors: Marco Lisicki, Kevin D’Ostilio, Gianluca Coppola, Felix Scholtes, Alain Maertens de Noordhout, Vincenzo Parisi, Jean Schoenen and Delphine Magis

Exploration of intrinsic brain activity in migraine with and without comorbid depression

Major depressive disorder is a common comorbidity in migraineurs. Depression may affect the progression and prognosis of migraine. Few studies have examined the brain function in migraineurs that may cause thi...

Authors: Mengmeng Ma, Junran Zhang, Ning Chen, Jian Guo, Yang Zhang and Li He

Upper cervical two-point discrimination thresholds in migraine patients and headache-free controls

Chronic pain including migraine is associated with structural and functional changes in the somatosensory cortex. Previous reports proposed two-point discrimination (TPD) as a measurement for cortical alterati...

Authors: Kerstin Luedtke, Waclaw Adamczyk, Katrin Mehrtens, Inken Moeller, Louisa Rosenbaum, Axel Schaefer, Janine Schroeder, Tibor Szikszay, Christian Zimmer and Bettina Wollesen

Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study

Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (N...

Authors: Junpeng Liu, Jiajia Zhu, Fei Yuan, Xuejun Zhang and Quan Zhang

OnabotulinumtoxinA in the treatment of refractory chronic cluster headache

Cluster headache (CH) is a clinically well-defined primary headache disorder, approximately 20% of cluster headache sufferers experience recurrent attacks without periods of significant remission. For the trea...

Authors: Christian Lampl, Mirjam Rudolph and Elisabeth Bräutigam

Effects of sildenafil and calcitonin gene-related peptide on brainstem glutamate levels: a pharmacological proton magnetic resonance spectroscopy study at 3.0 T

Studies involving human pharmacological migraine models have predominantly focused on the vasoactive effects of headache-inducing drugs, including sildenafil and calcitonin gene-related peptide (CGRP). However...

Authors: Samaira Younis, Anders Hougaard, Casper Emil Christensen, Mark Bitsch Vestergaard, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson and Messoud Ashina

Novel capsaicin-induced parameters of microcirculation in migraine patients revealed by imaging photoplethysmography

The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors ...

Authors: Alexei A. Kamshilin, Maxim A. Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V. Amelin, Oleg V. Mamontov and Rashid Giniatullin

Effectiveness of transcutaneous electrical nerve stimulation for the treatment of migraine: a meta-analysis of randomized controlled trials

Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulat...

Authors: Huimin Tao, Teng Wang, Xin Dong, Qi Guo, Huan Xu and Qi Wan