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  1. Central sensitization is one of the characters of chronic migraine (CM). Aberrant synaptic plasticity can induce central sensitization. Oxytocin (OT), which is a hypothalamic hormone, plays an important antino...

    Authors: Yunfeng Wang, Qi Pan, Ruimin Tian, Qianwen Wen, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang and Jiying Zhou
    Citation: The Journal of Headache and Pain 2021 22:84
    Content type: Research article Published on:

  2. To investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI).

    Authors: Håkan Ashina, Haidar Muhsen Al-Khazali, Afrim Iljazi, Sait Ashina, Faisal Mohammad Amin, Richard B. Lipton and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2021 22:83
    Content type: Research article Published on:

  3. Changes in speech can be detected objectively before and during migraine attacks. The goal of this study was to interrogate whether speech changes can be detected in subjects with post-traumatic headache (PTH)...

    Authors: Catherine D. Chong, Jianwei Zhang, Jing Li, Teresa Wu, Gina Dumkrieger, Simona Nikolova, Katherine Ross, Gabriela Stegmann, Julie Liss, Todd J. Schwedt, Suren Jayasuriya and Visar Berisha
    Citation: The Journal of Headache and Pain 2021 22:82
    Content type: Research article Published on:

  4. In patients with migraine, overuse of acute medication, including migraine-specific medication (MSM) such as triptans and ergots, can lead to adverse health outcomes, including development of medication overus...

    Authors: Stewart J Tepper, Messoud Ashina, Uwe Reuter, Yngve Hallström, Gregor Broessner, Jo H Bonner, Hernan Picard, Sunfa Cheng, Denise E Chou, Feng Zhang, Jan Klatt and Daniel D Mikol
    Citation: The Journal of Headache and Pain 2021 22:81
    Content type: Research article Published on:

  5. Headache is one of the most common symptoms after concussion, and mild traumatic brain injury (mTBI) is a risk factor for chronic migraine (CM). However, there remains a paucity of data regarding the impact of...

    Authors: Ryotaro Ishii, Todd J. Schwedt, Meesha Trivedi, Gina Dumkrieger, Melissa M. Cortez, K. C. Brennan, Kathleen Digre and David W. Dodick
    Citation: The Journal of Headache and Pain 2021 22:80
    Content type: Research article Published on:

  6. Migraine is the most common neurological disease, with high social-economical burden. Although there is growing evidence of brain structural and functional abnormalities in patients with migraine, few studies ...

    Authors: Alessia Guarnera, Francesca Bottino, Antonio Napolitano, Giorgia Sforza, Marco Cappa, Laura Chioma, Luca Pasquini, Maria Camilla Rossi-Espagnet, Giulia Lucignani, Lorenzo Figà-Talamanca, Chiara Carducci, Claudia Ruscitto, Massimiliano Valeriani, Daniela Longo and Laura Papetti
    Citation: The Journal of Headache and Pain 2021 22:79
    Content type: Research article Published on:

  7. In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more effi...

    Authors: Timothy J. Steiner, Rigmor Jensen, Zaza Katsarava, Lars Jacob Stovner, Derya Uluduz, Latifa Adarmouch, Mohammed Al Jumah, Ali M. Al Khathaami, Messoud Ashina, Mark Braschinsky, Susan Broner, Jon H. Eliasson, Raquel Gil-Gouveia, Juan B. Gómez-Galván, Larus S. Gudmundsson, Akbar A. Herekar…
    Citation: The Journal of Headache and Pain 2021 22:78
    Content type: Consensus article Published on:

  8. Sensory hypersensitivities such as photophobia, phonophobia, and osmophobia are common in patients with migraine. We investigated the burden of these multiple sensory hypersensitivities in migraine.

    Authors: Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Madoka Okamura, Yasuo Haruyama, Muneto Tatsumoto and Koichi Hirata
    Citation: The Journal of Headache and Pain 2021 22:77
    Content type: Research article Published on:

  9. The paroxysmal nature of migraine is a hallmark of the disease. Some patients report increased attack frequency at certain seasons or towards the end of the week, while others experience diurnal variations of ...

    Authors: Amanda Holmen Poulsen, Samaira Younis, Janu Thuraiaiyah and Messoud Ashina
    Citation: The Journal of Headache and Pain 2021 22:76
    Content type: Review article Published on:

  10. To describe interictal brain structural and metabolic differences between patients with episodic migraine (EM), chronic migraine (CM) and healthy controls (HC).

    Authors: Marta Torres-Ferrus, Deborah Pareto, Victor J Gallardo, Gemma Cuberas-Borrós, Alicia Alpuente, Edoardo Caronna, Adrià Vila-Balló, Carles Lorenzo-Bosquet, Joan Castell-Conesa, Alex Rovira and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2021 22:75
    Content type: Research article Published on:

  11. Erenumab was approved in Europe for migraine prevention in patients with ≥ 4 monthly migraine days (MMDs). In Spain, Novartis started a personalized managed access program, which allowed free access to erenuma...

    Authors: Robert Belvís, Pablo Irimia, Patricia Pozo-Rosich, Carmen González-Oria, Antonio Cano, Javier Viguera, Belén Sánchez, Francisco Molina, Isabel Beltrán, Agustín Oterino, Elisa Cuadrado, Angel Gómez-Camello, Miguel Alberte-Woodward, Carmen Jurado, Teresa Oms, David Ezpeleta…
    Citation: The Journal of Headache and Pain 2021 22:74
    Content type: Research article Published on:

  12. Headache disorders are disabling and have a significant impact on productivity. The relationship between these two consequences is of considerable economic and political interest. We enquired into it through a...

    Authors: Simple Futarmal Kothari, Rigmor Hølland Jensen and Timothy J Steiner
    Citation: The Journal of Headache and Pain 2021 22:73
    Content type: Research article Published on:

  13. Migraine constitutes a global health burden, and its pathophysiology is not well-understood; research evaluating cerebral perfusion and altered blood flow between brain areas using non-invasive imaging techniq...

    Authors: Di Zhang, Xiaobin Huang, Cunnan Mao, Yuchen Chen, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xinying Wu and Xindao Yin
    Citation: The Journal of Headache and Pain 2021 22:72
    Content type: Research article Published on:

  14. Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of hea...

    Authors: Valeria Caponnetto, Manuela Deodato, Micaela Robotti, Maria Koutsokera, Valeria Pozzilli, Cristina Galati, Giovanna Nocera, Eleonora De Matteis, Gioacchino De Vanna, Emanuela Fellini, Gleni Halili, Daniele Martinelli, Gabriele Nalli, Serena Serratore, Irene Tramacere, Paolo Martelletti…
    Citation: The Journal of Headache and Pain 2021 22:71
    Content type: Review article Published on:

  15. Migraine is a complex neurological disorder that is characterized by throbbing head pain, increased sensitivity to light, sound, and touch, as well as nausea and fatigue. It is one of the most common and most ...

    Authors: Amanda Avona, Theodore J Price and Gregory Dussor
    Citation: The Journal of Headache and Pain 2021 22:70
    Content type: Research article Published on:

  16. Pressure pain thresholds (PPTs) are commonly assessed to quantify mechanical sensitivity in various conditions, including migraine. Digital and analogue algometers are used, but the concurrent validity between...

    Authors: René F. Castien, Michel W. Coppieters, Tom S. C. Durge and Gwendolyne G. M. Scholten-Peeters
    Citation: The Journal of Headache and Pain 2021 22:69
    Content type: Research article Published on:

  17. Fremanezumab, a fully humanized monoclonal antibody (IgG2Δa) selectively targets the calcitonin gene-related peptide and has proven efficacy for the preventive treatment of migraine. In this study, we evaluate...

    Authors: Messoud Ashina, Joshua M. Cohen, Maja Galic, Verena Ramirez Campos, Steve Barash, Xiaoping Ning, Yoel Kessler, Lindsay Janka and Hans-Christoph Diener
    Citation: The Journal of Headache and Pain 2021 22:68
    Content type: Research article Published on:

  18. Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without evidence of a tumor or any other underlying cause. Headache and visual disturbances are frequent complaint...

    Authors: Max Witry, Christine Kindler, Johannes Weller, Andreas Linder and Ullrich Wüllner
    Citation: The Journal of Headache and Pain 2021 22:67
    Content type: Research article Published on:

  19. Migraine is a complex neurological disorder that is considered the most common disabling brain disorder affecting 14 % of people worldwide. The present study sought to infer potential causal relationships betw...

    Authors: Luis M. García-Marín, Adrián I. Campos, Nicholas G. Martin, Gabriel Cuéllar-Partida and Miguel E. Rentería
    Citation: The Journal of Headache and Pain 2021 22:66
    Content type: Research article Published on:

  20. Migraine affects roughly 10% of youth aged 5–15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains...

    Authors: Tiffany Bell, Akashroop Khaira, Mehak Stokoe, Megan Webb, Melanie Noel, Farnaz Amoozegar and Ashley D. Harris
    Citation: The Journal of Headache and Pain 2021 22:65
    Content type: Research article Published on:

  21. Authors: Tatiane Teru Takahashi, Raffaele Ornello, Giuseppe Quatrosi, Angelo Torrente, Maria Albanese, Simone Vigneri, Martina Guglielmetti, Cristiano Maria De Marco, Camille Dutordoir, Enrico Colangeli, Matteo Fuccaro, Davide Di Lenola, Valerio Spuntarelli, Laura Pilati, Salvatore Di Marco, Annelies Van Dycke…
    Citation: The Journal of Headache and Pain 2021 22:64
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2021 22:32

  22. The first manuscript in this series delineated a model of structured headache services, potentially cost-effective but requiring formal cost-effectiveness analysis (CEA). We envisaged a need for a new outcome ...

    Authors: Timothy J Steiner, Mattias Linde and Petra Schnell-Inderst
    Citation: The Journal of Headache and Pain 2021 22:63
    Content type: Research article Published on:

  23. Circadian patterns of migraine attacks have been reported by patients but remain understudied. In animal models, circadian phases are generally not taken into consideration. In particular, rodents are nocturna...

    Authors: Anne-Sophie Wattiez, Olivia J. Gaul, Adisa Kuburas, Erik Zorrilla, Jayme S. Waite, Bianca N. Mason, William C. Castonguay, Mengya Wang, Bennett R. Robertson and Andrew F. Russo
    Citation: The Journal of Headache and Pain 2021 22:62
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:115

  24. Migraine is often accompanied with chronic tinnitus that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between migraine and tinnitus remain...

    Authors: Zhen-Gui Xu, Jin-Jing Xu, Yu-Chen Chen, Jinghua Hu, Yuanqing Wu and Yuan Xue
    Citation: The Journal of Headache and Pain 2021 22:61
    Content type: Research article Published on:

  25. Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to...

    Authors: Bernadett Tuka, Aliz Nyári, Edina Katalin Cseh, Tamás Körtési, Dániel Veréb, Ferenc Tömösi, Gábor Kecskeméti, Tamás Janáky, János Tajti and László Vécsei
    Citation: The Journal of Headache and Pain 2021 22:60
    Content type: Research article Published on:

  26. Lockdown measures due to the COVID-19 pandemic have led to lifestyle changes, which in turn may have an impact on the course of headache disorders. We aimed to assess changes in primary headache characteristic...

    Authors: Bianca Raffaelli, Jasper Mecklenburg, Simon Scholler, Lucas Hendrik Overeem, Ana Sofia Oliveira Gonçalves, Uwe Reuter and Lars Neeb
    Citation: The Journal of Headache and Pain 2021 22:59
    Content type: Short report Published on:

  27. We searched for differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the thalamus between migraine with pure visual auras (MA), and m...

    Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Vincenzo Parisi, Mariano Serrao, Camillo Porcaro, Marco Fiorelli, Francesca Caramia, Jean Schoenen, Vittorio Di Piero and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2021 22:58
    Content type: Research article Published on:

  28. Migraine is a multifactorial disorder that is more frequent (two to four times) in women than in men. In recent years, our research group has focused on the role of neurotransmitter release and its regulation....

    Authors: Miguel Alves-Ferreira, Marlene Quintas, Jorge Sequeiros, Alda Sousa, José Pereira-Monteiro, Isabel Alonso, João Luís Neto and Carolina Lemos
    Citation: The Journal of Headache and Pain 2021 22:57
    Content type: Research article Published on:

  30. Neuroinflammation has an important role in the pathophysiology of migraine, which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight findings of cortical spreading depolariz...

    Authors: Oguzhan Kursun, Muge Yemisci, Arn M. J. M. van den Maagdenberg and Hulya Karatas
    Citation: The Journal of Headache and Pain 2021 22:55
    Content type: Review article Published on:

  32. To assess the impacts of social situation changes due to the coronavirus disease 2019 (COVID-19) pandemic on headache-related disability and other symptoms in patients with migraine in Japan.

    Authors: Keisuke Suzuki, Takao Takeshima, Hisaka Igarashi, Noboru Imai, Daisuke Danno, Toshimasa Yamamoto, Eiichiro Nagata, Yasuo Haruyama, Takashi Mitsufuji, Shiho Suzuki, Yasuo Ito, Mamoru Shibata, Hisanori Kowa, Shoji Kikui, Tomohiko Shiina, Madoka Okamura…
    Citation: The Journal of Headache and Pain 2021 22:53
    Content type: Research article Published on:

  33. Cluster headache (CH) is a trigeminal autonomic cephalalgia (TAC) characterized by a highly disabling headache that negatively impacts quality of life and causes limitations in daily functioning as well as soc...

    Authors: Davide Cappon, Agata Ryterska, Harith Akram, Susie Lagrata, Sanjay Cheema, Jonathan Hyam, Ludvic Zrinzo, Manjit Matharu and Marjan Jahanshahi
    Citation: The Journal of Headache and Pain 2021 22:52
    Content type: Research article Published on:

  34. The presence of headache during the acute phase of COVID-19 could be associated with the innate response and the cytokine release. We aim to compare the cytokine and interleukin profile in hospitalized COVID-1...

    Authors: Javier Trigo, David García-Azorín, Álvaro Sierra-Mencía, Álvaro Tamayo-Velasco, Pedro Martínez-Paz, Eduardo Tamayo, Angel Luis Guerrero and Hugo Gonzalo-Benito
    Citation: The Journal of Headache and Pain 2021 22:51
    Content type: Research article Published on:

  35. Chronic migraine (CM) is associated with substantial economic burden. Real-world data suggests that onabotulinumtoxinA treatment for CM reduces healthcare resource utilisation (HRU) and related costs.

    Authors: Katja Kollewe, Charly Gaul, Astrid Gendolla and Katherine Sommer
    Citation: The Journal of Headache and Pain 2021 22:50
    Content type: Research article Published on:

  36. Headache disorders are highly prevalent worldwide, but not well investigated in adolescents. Few studies have included representative nationwide samples. This study aimed to present the prevalence and burden o...

    Authors: Margot J. Wilkes, M. Dilani Mendis, Leanne Bisset, Felix T. Leung, Christopher T. Sexton and Julie A. Hides
    Citation: The Journal of Headache and Pain 2021 22:49
    Content type: Research article Published on:

  37. Patients with episodic migraine (EM) with a higher-frequency of migraine headache days (HFEM: 8–14 migraine headache days/month) have a greater disease burden and a higher risk of progressing to chronic migrai...

    Authors: Jakub Jedynak, Eric Eross, Astrid Gendolla, Mallikarjuna Rettiganti and Virginia L. Stauffer
    Citation: The Journal of Headache and Pain 2021 22:48
    Content type: Research article Published on:

  38. Preceding studies have reported the association of chronic neuropathic orofacial pain with altered ongoing function in the ventrolateral periaqueductal gray (vlPAG). However, its role in trigeminal neuralgia (...

    Authors: K. C. Elina, Byeong Ho Oh, Jaisan Islam, Soochong Kim and Young Seok Park
    Citation: The Journal of Headache and Pain 2021 22:47
    Content type: Research article Published on:

  39. Authors: Timothy R. Smith, Egilius L. H. Spierings, Roger Cady, Joe Hirman, Barbara Schaeffler, Vivienne Shen, Bjørn Sperling, Thomas Brevig, Mette Krog Josiassen, Elizabeth Brunner, Loan Honeywell and Lahar Mehta
    Citation: The Journal of Headache and Pain 2021 22:46
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2021 22:16

  40. Migraine is a neurological, primary headache disorder affecting more than 1 billion people worldwide, with a multi-faceted burden that can significantly impact the everyday life of a patient, both during and b...

    Authors: Byung-Kun Kim, Min Kyung Chu, Soo Jin Yu, Grazia Dell’Agnello, Jeong Hee Han and Soo-Jin Cho
    Citation: The Journal of Headache and Pain 2021 22:45
    Content type: Research article Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:56

  41. Post-traumatic trigeminal neuropathy (PTN) can have a substantial effect on patient well-being. However, the relation between the neuropathic symptoms and their effect on psychosocial functioning remains a mat...

    Authors: Jeroen Meewis, Tara Renton, Reinhilde Jacobs, Constantinus Politis and Fréderic Van der Cruyssen
    Citation: The Journal of Headache and Pain 2021 22:44
    Content type: Research article Published on:

  42. There is currently a wide therapeutic arsenal for migraine patients, without a single first-line preventive drug and we choose the different available alternatives taking into account comorbidities, national g...

    Authors: AB Gago-Veiga, J-I Huhn, N Latysheva, A Vieira Campos, M Torres-Ferrus, A Alpuente Ruiz, S Sacco, I Frattale, R Ornello, R Ruscheweyh, IB Marques, A Gryglas-Dworak, C Stark, VJ Gallardo and P Pozo-Rosich
    Citation: The Journal of Headache and Pain 2021 22:43
    Content type: Research article Published on:

  43. Headache attributed to Temporomandibular Disorder (HATMD) is a secondary headache that may have features resulting in diagnostic overlap with primary headaches, namely, tension-type (TTH) or migraine. This cro...

    Authors: Inna E. Tchivileva, Richard Ohrbach, Roger B. Fillingim, Feng-Chang Lin, Pei Feng Lim, Samuel J. Arbes Jr and Gary D. Slade
    Citation: The Journal of Headache and Pain 2021 22:42
    Content type: Research article Published on:

  44. Coronavirus disease 2019 (COVID-19) bring about a range of psychological distress and symptom deterioration to headache patients especially to some migraineurs. Compared to migraineurs or normal control, medic...

    Authors: Changling Li, Yanbo Li, Mengmeng Ma, Yang Zhang, Jiajia Bao, Wenjing Ge, Yanqin Liu, Cheng Peng and Li He
    Citation: The Journal of Headache and Pain 2021 22:41
    Content type: Research article Published on:

  45. Migraine is a common neurological disease that is often accompanied by psychiatric comorbidities. However, the relationship between abnormal brain function and psychiatric comorbidities in migraine patients re...

    Authors: Heng-Le Wei, Jian Li, Xi Guo, Gang-Ping Zhou, Jin-Jin Wang, Yu-Chen Chen, Yu-Sheng Yu, Xindao Yin, Junrong Li and Hong Zhang
    Citation: The Journal of Headache and Pain 2021 22:40
    Content type: Research article Published on:

  46. New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment e...

    Authors: Simona Sacco, Christian Lampl, Antoinette Maassen van den Brink, Valeria Caponnetto, Mark Braschinsky, Anne Ducros, Patrick Little, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Paolo Martelletti and Zaza Katsarava
    Citation: The Journal of Headache and Pain 2021 22:39
    Content type: Research article Published on:

  47. In this study, we investigated the possible analgesic effects of Botulinum toxin type A (BoNT/A) on trigeminal neuralgia (TN). A modified TN mouse model was established by chronic constriction injury of the di...

    Authors: Wei-Jia Chen, Jing-Qi Niu, Yi-Ting Chen, Wen-Jing Deng, Ying-Ying Xu, Jing Liu, Wei-Feng Luo and Tong Liu
    Citation: The Journal of Headache and Pain 2021 22:38
    Content type: Research article Published on:

  49. Behaviors of substance dependence are common among patients with medication-overuse headache (MOH). Whether MOH, like other substance use disorders, is associated with an increased risk for suicide is unknown.

    Authors: Yen-Feng Wang, Chia-Chun Yu, Ai Seon Kuan, Shih-Pin Chen and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2021 22:36
    Content type: Research article Published on:

  50. The clinical benefit of galcanezumab, demonstrated in randomized clinical trials (RCTs), remains to be quantified in real life. This study aimed at evaluating the effectiveness, safety and tolerability of galc...

    Authors: Fabrizio Vernieri, Claudia Altamura, Nicoletta Brunelli, Carmelina Maria Costa, Cinzia Aurilia, Gabriella Egeo, Luisa Fofi, Valentina Favoni, Giulia Pierangeli, Carlo Lovati, Marco Aguggia, Florindo d’Onofrio, Alberto Doretti, Paola Di Fiore, Cinzia Finocchi, Renata Rao…
    Citation: The Journal of Headache and Pain 2021 22:35
    Content type: Research article Published on:
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