The Journal of Headache and Pain is the official journal of the European Headache Federation and Lifting The Burden.
HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain
Whether neuroinflammation causes comorbid mood disorders in neuropathic pain remains elusive. Here we investigated the role of high mobility group box 1 protein (HMGB1), a proinflammatory cytokine, in the medi...