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  1. A significant number of women with migraine has to face the choice of reliable hormonal contraception during their fertile life. Combined hormonal contraceptives (CHCs) may be used in the majority of women wit...

    Authors: Rossella E Nappi, Gabriele S Merki-Feld, Erica Terreno, Alice Pellegrinelli and Michele Viana
    Citation: The Journal of Headache and Pain 2013 14:66
    Content type: Review article Published on:

  2. The phenomena of habituation and sensitization are considered most useful for studying the neuronal substrates of information processing in the CNS. Both were studied in primary headaches, that are functional ...

    Authors: Gianluca Coppola, Cherubino Di Lorenzo, Jean Schoenen and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2013 14:65
    Content type: Review article Published on:

  3. Previous studies in primary headache disorders showed microstructural alterations in the white matter as measured by diffusion imaging. However these investigations are not in full agreement and some of those,...

    Authors: Nikoletta Szabó, Zsigmond Tamás Kincses, Árpád Párdutz, Eszter Tóth, Délia Szok, Gergő Csete and László Vécsei
    Citation: The Journal of Headache and Pain 2013 14:64
    Content type: Research article Published on:

  4. Patients with a patent foramen ovale have a high prevalence of migraine with aura (MA). However, whether patients with an atrial septal defect (ASD) have a high prevalence of migraine remains unclear. The pres...

    Authors: Yuji Kato, Takeshi Hayashi, Toshiki Kobayashi and Norio Tanahashi
    Citation: The Journal of Headache and Pain 2013 14:63
    Content type: Short report Published on:

  5. Spreading depression (SD) is a slowly propagating wave of neuronal and glial depolarization lasting a few minutes, that can develop within the cerebral cortex or other brain areas after electrical, mechanical ...

    Authors: Cinzia Costa, Alessandro Tozzi, Innocenzo Rainero, Letizia Maria Cupini, Paolo Calabresi, Cenk Ayata and Paola Sarchielli
    Citation: The Journal of Headache and Pain 2013 14:62
    Content type: Review article Published on:

  6. Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and ...

    Authors: Innocenzo Rainero, Elisa Rubino, Koen Paemeleire, Annalisa Gai, Alessandro Vacca, Paola De Martino, Salvatore Gentile, Paola Sarchielli and Lorenzo Pinessi
    Citation: The Journal of Headache and Pain 2013 14:61
    Content type: Review article Published on:

  7. Migraineurs are more often afflicted by comorbid conditions than those without primary headache disorders, though the linking pathophysiological mechanism(s) is not known. We previously reported that phosphati...

    Authors: Alfred N Fonteh, Janice M Pogoda, Rainbow Chung, Robert P Cowan and Michael G Harrington
    Citation: The Journal of Headache and Pain 2013 14:60
    Content type: Research article Published on:

  8. Medication Overuse Headache (MOH) can be related in some patients to dependence-related behaviour characterised by craving, a deficit in controlling substance intake, which is associated to orbitofrontal corte...

    Authors: Françoise Radat, Sandra Chanraud, Georges Di Scala, Virginie Dousset and Michèle Allard
    Citation: The Journal of Headache and Pain 2013 14:59
    Content type: Short report Published on:

  10. The relationships between sleep and headaches are complex and manifold. About the variety of phenomena that can disrupt the sleep macrostructure and can impact its restorative function, the periodic limb movem...

    Authors: Maria Esposito, Pasquale Parisi, Silvia Miano and Marco Carotenuto
    Citation: The Journal of Headache and Pain 2013 14:57
    Content type: Research article Published on:

  11. We discuss the comments on our article “Sleep quality, arousal and pain thresholds in migraineurs. A blinded controlled polysomnographic study” published in JHP 2013 Feb 14;14(1):12. We hypothesize that migrai...

    Authors: Morten Engstrøm, Knut Hagen, Marte Bjørk and Trond Sand
    Citation: The Journal of Headache and Pain 2013 14:56
    Content type: Letter to the Editor Published on:

  12. The term omics consist of three main areas of molecular biology, such as genomics, proteomics and metabolomics. The omics synergism recognise migraine as an ideal study model, due to its multifactorial nature. In...

    Authors: Luana Lionetto, Giovanna Gentile, Elisa Bellei, Matilde Capi, Donata Sabato, Francesco Marsibilio, Maurizio Simmaco, Luigi Alberto Pini and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2013 14:55
    Content type: Review article Published on:

  13. Primary headaches and Learning difficulties are both common in the pediatric population. The goal of our study was to assess the prevalence of learning disabilities and attention deficit disorder in children a...

    Authors: Jacob Genizi, Shiri Gordon, Nogah C Kerem, Isaac Srugo, Eli Shahar and Sarit Ravid
    Citation: The Journal of Headache and Pain 2013 14:54
    Content type: Research article Published on:

  15. Migraine with aura is associated with patent foramen ovale and right-left-shunt. Jugular venous valve insufficiency is a further vascular anomaly. It is a frequent finding in transient global amnesia which is ...

    Authors: Kasja Rabe, Michael Küper, Dagny Holle, Irini Savidou, Oliver Kastrup, Andreas Jähne-Blasberg, Hans Christoph Diener, Zaza Katsarava and Markus Frings
    Citation: The Journal of Headache and Pain 2013 14:52
    Content type: Research article Published on:

  16. Many studies have reported that hypertension is common in chronic daily headache (CDH) and its subtype chronic migraine (CM), but the reason is still poorly understood. Our clinical literature review suggested...

    Authors: Qingqing Huang, Wangwen Li, Nan Li, Jing Wang, Ge Tan, Lixue Chen, Guangcheng Qin, Xiping Liang and Jiying Zhou
    Citation: The Journal of Headache and Pain 2013 14:51
    Content type: Research article Published on:

  17. We discuss the hypothesis proposed by Engstrom and coworkers that Migraineurs have a relative sleep deprivation, which lowers the pain threshold and predispose to attacks. Previous data indicate that Migraineu...

    Authors: Catello Vollono, Elisa Testani, Anna Losurdo, Salvatore Mazza and Giacomo Della Marca
    Citation: The Journal of Headache and Pain 2013 14:50
    Content type: Letter to the Editor Published on:

  18. Cephalalgiaphobia is the fear of having a headache attack during a pain-free period that may induce patients to use analgesic in the absence of pain to prevent headache and to improve their performances. This ...

    Authors: Giulia Giannini, Stefano Zanigni, Daniela Grimaldi, Roberto Melotti, Giulia Pierangeli, Pietro Cortelli and Sabina Cevoli
    Citation: The Journal of Headache and Pain 2013 14:49
    Content type: Research article Published on:

  19. The majority of patients suffering from cluster headache (CH) are smokers and it has been suggested that smoking may trigger the development of CH. The aim of this pilot survey was to describe: 1. the differen...

    Authors: Anna Ferrari, Maurizio Zappaterra, Federica Righi, Michela Ciccarese, Ilaria Tiraferri, Luigi Alberto Pini, Simona Guerzoni and Maria Michela Cainazzo
    Citation: The Journal of Headache and Pain 2013 14:48
    Content type: Research article Published on:

  20. In order to know the status quo of health care for primary headache disorders in China, questions about headache consultation and diagnosis were included in a nationwide population-based survey initiated by Lifti...

    Authors: Ruozhuo Liu, Shengyuan Yu, Mianwang He, Gang Zhao, Xiaosu Yang, Xiangyang Qiao, Jiachun Feng, Yannan Fang, Xiutang Cao and Timothy J Steiner
    Citation: The Journal of Headache and Pain 2013 14:47
    Content type: Research article Published on:

  21. Erectile dysfunction (ED), defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance, is a common condition. The psychological, hormonal, neurogenic and arteria...

    Authors: Durdane Aksoy, Volkan Solmaz, Betul Cevik, Yusuf Gencten, Fikret Erdemir and Semiha Gulsum Kurt
    Citation: The Journal of Headache and Pain 2013 14:46
    Content type: Research article Published on:

  23. The present study aimed to evaluate the efficacy of local lidocaine injections into the myofascial trigger points (TPs) located at the pericranial muscles in patients with episodic tension-type headache (ETTH).

    Authors: Ömer Karadaş, Hakan L Gül and Levent E İnan
    Citation: The Journal of Headache and Pain 2013 14:44
    Content type: Research article Published on:

  24. Medication overuse headache (MOH) is a chronic headache disorder, caused by overuse of acute medication. To date, it remains unclear why some people overuse these medications. The aim of this qualitative study...

    Authors: Pernilla Jonsson, Annika Jakobsson, Gunnel Hensing, Mattias Linde, Crystal Dea Moore and Tove Hedenrud
    Citation: The Journal of Headache and Pain 2013 14:43
    Content type: Research article Published on:

  25. Headache only triggered by coughing is a rather uncommon condition. The aim of the present review is to present an overview of the diagnosis, clinical characteristics, pathophysiology and treatment of both pri...

    Authors: Ann Cordenier, Willem De Hertogh, Jacques De Keyser and Jan Versijpt
    Citation: The Journal of Headache and Pain 2013 14:42
    Content type: Review article Published on:

  26. Framing education on headache disorders into the Global Burden of Disease Study 2010. The European Headache Federation stands ready.

    Authors: Paolo Martelletti, Dimos-Dimitrios Mitsikostas, Christian Lampl, Zaza Katsarava, Vera Osipova, Koen Paemeleire, Lars Edvinsson, Aksel Siva, Dominique Valade, Timothy J Steiner and Rigmor H Jensen
    Citation: The Journal of Headache and Pain 2013 14:41
    Content type: Editorial Published on:

  27. We evaluated risk factors associated with chronic headache (CH) such as age, gender, smoking, frequent drinking of alcoholic beverages (drinking), obesity, education and frequent intake of acute pain drugs to ...

    Authors: Sara H Schramm, Mark Obermann, Zaza Katsarava, Hans-Christoph Diener, Susanne Moebus and Min-Suk Yoon
    Citation: The Journal of Headache and Pain 2013 14:40
    Content type: Research article Published on:

  28. Psychological factors can increase severity and intensity of headaches. While great attention has been placed on the presence of anxiety and/or depression as a correlate to a high frequency of migraine attacks...

    Authors: Samuela Tarantino, Cristiana De Ranieri, Cecilia Dionisi, Monica Citti, Alessandro Capuano, Federica Galli, Vincenzo Guidetti, Federico Vigevano, Simonetta Gentile, Fabio Presaghi and Massimiliano Valeriani
    Citation: The Journal of Headache and Pain 2013 14:39
    Content type: Research article Published on:

  31. Chronic headache is associated with disability and high utilisation of health care including complementary and alternative medicine (CAM).

    Authors: Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist and Michael Bjørn Russell
    Citation: The Journal of Headache and Pain 2013 14:36
    Content type: Short report Published on:

  32. This prospective and observational study aimed to identify demographic, physiological and psychological risk factors associated with high-altitude headache (HAH) upon acute high-altitude exposure.

    Authors: Shi-Zhu Bian, Ji-Hang Zhang, Xu-Bin Gao, Ming Li, Jie Yu, Xi Liu, Jun-Qing Dong, Guo-Zhu Chen and Lan Huang
    Citation: The Journal of Headache and Pain 2013 14:35
    Content type: Research article Published on:

  33. The aim of this study was to investigate the prevalence of migraine and associated psychiatric disorders among university students at Cumhuriyet University of Sivas in Turkey.

    Authors: Murat Semiz, İlteriş Ahmet Şentürk, Hatice Balaban, Ayşegül Kartal Yağız and Önder Kavakçı
    Citation: The Journal of Headache and Pain 2013 14:34
    Content type: Research article Published on:

  34. Nasal insufflation of CO2 has been shown to exert antinociceptive respectively antihyperalgesic effects in animal pain models using topical capsaicin with activation of TRPV1-receptor positive nociceptive neurons...

    Authors: Tim P Jürgens, Romy Reetz and Arne May
    Citation: The Journal of Headache and Pain 2013 14:33
    Content type: Research article Published on:

  38. The objectives of this cross-sectional, observational study were to determine the prevalence of self-reported headache among the employees of the large Swiss university hospital, to measure the impact of heada...

    Authors: Emina Sokolovic, Franz Riederer, Thomas Szucs, Reto Agosti and Peter Stefan Sándor
    Citation: The Journal of Headache and Pain 2013 14:29
    Content type: Research article Published on:

  39. Recent studies suggested an important role for vascular factors in migraine etiopathogenesis. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maint...

    Authors: Elisa Rubino, Pierpaola Fenoglio, Salvatore Gallone, Flora Govone, Alessandro Vacca, Paola De Martino, Maria Laura Giobbe, Silvia Boschi, Lorenzo Pinessi, Salvatore Gentile and Innocenzo Rainero
    Citation: The Journal of Headache and Pain 2013 14:28
    Content type: Short report Published on:

  41. Paroxysmal hemicrania (PH) is a probably underreported primary headache disorder. It is characterized by repeated attacks of severe, strictly unilateral pain lasting 2 to 30 minutes localized to orbital, supra...

    Authors: Sanjay Prakash, Pooja Belani, Ashish Susvirkar, Aditi Trivedi, Sunil Ahuja and Animesh Patel
    Citation: The Journal of Headache and Pain 2013 14:26
    Content type: Research article Published on:

  42. The aims of this study were to examine whether patients’ psychosocial profiles influence the location of pain, and to identify the clinical and psychosocial predictors of high levels of pain-related disability...

    Authors: Meltem Ozdemir-Karatas, Kadriye Peker, Ali Balık, Omer Uysal and Erman B Tuncer
    Citation: The Journal of Headache and Pain 2013 14:17
    Content type: Research article Published on:

  43. Lack of habituation during repetitive stimulation is the most consistent interictal abnormality of cortical information processing observed in migraine. Preventive migraine treatments might act by stabilizing ...

    Authors: Laura Di Clemente, Francesca Puledda, Antonella Biasiotta, Alessandro Viganò, Edoardo Vicenzini, Andrea Truini, Giorgio Cruccu and Vittorio Di Piero
    Citation: The Journal of Headache and Pain 2013 14:25
    Content type: Research article Published on:

  44. A strong relationship between insomnia and painful disorders has been found, but it is still unclear whether chronic pain leads to insomnia. There is a need of large-scale prospective studies to evaluate if th...

    Authors: Siv Steinsmo Ødegård, Trond Sand, Morten Engstrøm, John-Anker Zwart and Knut Hagen
    Citation: The Journal of Headache and Pain 2013 14:24
    Content type: Research article Published on:

  45. Preventive pharmacotherapy for migraine is not satisfactory because of the low efficacy/tolerability ratio of many available drugs. Novel and more efficient preventive strategies are therefore warranted. Abnor...

    Authors: Alessandro Viganò, Tullia Sasso D’Elia, Simona Liliana Sava, Maurie Auvé, Victor De Pasqua, Alfredo Colosimo, Vittorio Di Piero, Jean Schoenen and Delphine Magis
    Citation: The Journal of Headache and Pain 2013 14:23
    Content type: Research article Published on:

  46. Previous studies suggest that patients with Chronic Daily Headache (CDH) have higher levels of anxiety and depressive disorders than patients with episodic migraine or tension-type headache. However, no study ...

    Authors: Marialuisa Rausa, Sabina Cevoli, Elisa Sancisi, Daniela Grimaldi, Gabriella Pollutri, Michela Casoria, Daniela Grieco, Alberto Bisi, Pietro Cortelli, Euro Pozzi and Giulia Pierangeli
    Citation: The Journal of Headache and Pain 2013 14:22
    Content type: Research article Published on:

  47. Headache is the most common cause for chronic or recurrent pain in childhood and adolescence. Chronic pain may have a long-term effect on adolescents. It might contribute to functional limitations, such as poo...

    Authors: Jacob Genizi, Isaac Srugo and Nogah C Kerem
    Citation: The Journal of Headache and Pain 2013 14:21
    Content type: Research article Published on:

  48. The interictal deficit of habituation to repetitive visual stimuli in migraine patients could be due to deficient intracortical inhibition and/or to low cortical pre-activation levels. Which of these abnormali...

    Authors: Gianluca Coppola, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Delphine Magis, Jean Schoenen and Francesco Pierelli
    Citation: The Journal of Headache and Pain 2013 14:20
    Content type: Research article Published on:

  50. Migraine is a type of primary headache widely known for its impact on quality of life of patients. Although the psychological aspects of the disease are receiving increasing attention in current research, some...

    Authors: Rebeca Veras de Andrade Vieira, Daniel Chaves Vieira, William Barbosa Gomes and Gustavo Gauer
    Citation: The Journal of Headache and Pain 2013 14:18
    Content type: Research article Published on:
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