Ashina M, Terwindt GM, Al-Karagholi MA-M et al (2021) Migraine: disease characterisation, biomarkers, and precision medicine. Lancet 397:1496–1504
Article
CAS
Google Scholar
Ashina M (2020) Migraine. N Engl J Med 383:1866–1876
Article
CAS
Google Scholar
Ashina M, Hansen JM, Do TP et al (2019) Migraine and the trigeminovascular system—40 years and counting. Lancet Neurol 18:795–804
Article
Google Scholar
Olesen J, Burstein R, Ashina M et al (2009) Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol 8:679–690
Article
Google Scholar
Ashina M, Hansen JM, Á Dunga BO et al (2017) Human models of migraine-short-Term pain for long-Term gain. Nat Rev Neurol 13:713–724
Article
Google Scholar
Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38(1):1–211. https://doi.org/10.1177/0333102417738202
Karsan N, Goadsby PJ (2018) Biological insights from the premonitory symptoms of migraine. Nat Rev Neurol 14:699–710
Article
Google Scholar
Eigenbrodt AK, Christensen RH, Ashina H et al (2022) Premonitory symptoms in migraine: a systematic review and meta-analysis of observational studies reporting prevalence or relative frequency. J Headache Pain 23:140
Article
Google Scholar
Ricci JA, Chee E, Lorandeau AL et al (2007) Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. J Occup Environ Med 49:1–10
Article
Google Scholar
Lassen L, Haderslev P, Jacobsen V et al (2002) Cgrp May Play A Causative Role in Migraine. Cephalalgia 22:54–61
Article
CAS
Google Scholar
Schytz HW, Birk S, Wienecke T et al (2009) PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 132:16–25
Article
Google Scholar
Guo S, Vollesen ALH, Olesen J et al (2016) Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine. Pain 157:2773–2781
Article
CAS
Google Scholar
Schulte LH, May A (2016) The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 139:1987–1993
Article
Google Scholar
Derbyshire SWG, Jones AKP, Creed F et al (2002) Cerebral Responses to Noxious Thermal Stimulation in Chronic Low Back Pain Patients and Normal Controls. Neuroimage 16:158–168
Article
CAS
Google Scholar
Hsieh J-C, Ståhle-Bäckdahl M, Hägermark Ö et al (1996) Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study. Pain 64:303–314
Article
Google Scholar
Iadarola M (1998) Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET. Brain 121:931–947
Article
Google Scholar
Petrovic P, Ingvar M, Stone-Elander S et al (1999) A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy. Pain 83:459–470
Article
CAS
Google Scholar
Haas DC, Kent PF, Friedman DI (1993) Headache Caused by a Single Lesion of Multiple Sclerosis in the Periaqueductal Gray Area. Headache J Head Face Pain 33:452–454
Article
CAS
Google Scholar
Afridi S (2003) New onset migraine with a brain stem cavernous angioma. J Neurol Neurosurg Psychiatry 74:680–681
Article
CAS
Google Scholar
Goadsby P (2002) Neurovascular Headache and A Midbrain Vascular Malformation: Evidence for A Role of the Brainstem in Chronic Migraine. Cephalalgia 22:107–111
Article
CAS
Google Scholar
Burstein R, Yarnitsky D, Goor-Aryeh I et al (2000) An association between migraine and cutaneous allodynia. Ann Neurol 47:614–624
Article
CAS
Google Scholar
Lipton RB, Bigal ME, Ashina S et al (2008) Cutaneous allodynia in the migraine population. Ann Neurol 63:148–158
Article
Google Scholar
Burstein R, Collins B, Jakubowski M (2004) Defeating migraine pain with triptans: A race against the development of cutaneous allodynia. Ann Neurol 55:19–26
Article
CAS
Google Scholar
Pietrobon D, Moskowitz MA (2014) Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci 15:379–393
Article
CAS
Google Scholar
Rasmussen BK, Olesen J (1992) Migraine With Aura and Migraine Without Aura: An Epidemiological Study. Cephalalgia 12:221–228
Article
CAS
Google Scholar
Hansen JM, Lipton RB, Dodick DW et al (2012) Migraine headache is present in the aura phase: A prospective study. Neurology 79:2044–2049
Article
Google Scholar
Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine. Ann Neurol 9:344–352
Article
CAS
Google Scholar
Hadjikhani N, Sanchez del Rio M, Wu O et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci 98:4687–4692
Article
CAS
Google Scholar
Olesen J, Lauritzen M, Tfelt-Hansen P et al (1982) Spreading Cerebral Oligemia in Classical- and Normal Cerebral Blood Flow in Common Migraine. Headache J Head Face Pain 22:242–248
Article
CAS
Google Scholar
Aiba S, Tatsumoto M, Saisu A et al (2010) Prevalence of typical migraine aura without headache in Japanese ophthalmology clinics. Cephalalgia 30:962–967
Article
Google Scholar
Amos JF, Fleming JB (2000) Clinical description and review of migraine aura without headache. Optometry 71:372–380
CAS
Google Scholar
Fisher CM (1986) Late-life migraine accompaniments–further experience. Stroke 17:1033–1042
Article
CAS
Google Scholar
Wijman CAC, Wolf PA, Kase CS et al (1998) Migrainous Visual Accompaniments Are Not Rare in Late Life. Stroke 29:1539–1543
Article
CAS
Google Scholar
Hansen JM, Hauge AW, Olesen J et al (2010) Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia 30:1179–1186
Article
Google Scholar
Wiggers A, Ashina H, Hadjikhani N et al (2022) Brain barriers and their potential role in migraine pathophysiology. J Headache Pain 23:16
Article
Google Scholar
Amin FM, Hougaard A, Cramer SP et al (2017) Intact blood−brain barrier during spontaneous attacks of migraine without aura: a 3T DCE-MRI study. Eur J Neurol 24:1116–1124
Article
CAS
Google Scholar
Hougaard A, Amin FM, Christensen CE et al (2017) Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura. Brain 140:1633–1642
Article
Google Scholar
Donnelly A, Sinnott B, Boyle R, et al. Beware the middle-aged migraine: internal carotid artery dissection mimicking migraine in the emergency department. BMJ Case Rep. 2017;bcr-2017–221774.
Ramadan NM, Tietjen GE, Levine SR et al (1991) Scintillating scotomata associated with internal carotid artery dissection: Report of three cases. Neurology 41:1084–1084
Article
CAS
Google Scholar
Thomsen AV, Sørensen MT, Ashina M et al (2021) Symptomatic migraine: a systematic review to establish a clinically important diagnostic entity. Headache J Head Face Pain 61:1180–1193
Article
Google Scholar
van den Maagdenberg AMJ, Pietrobon D, Pizzorusso T et al (2004) A cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 41:701–710
Article
Google Scholar
Eikermann-Haerter K, Dileköz E, Kudo C, et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest. Epub ahead of print 22 December 2008. https://doi.org/10.1172/JCI36059.
van den Maagdenberg AMJM, Pizzorusso T, Kaja S et al (2010) High cortical spreading depression susceptibility and migraine-associated symptoms in Ca v 2.1 S218L mice. Ann Neurol 67:85–98
Article
Google Scholar
Leo L, Gherardini L, Barone V et al (2011) Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet 7:e1002129
Article
CAS
Google Scholar
Nyholt DR, LaForge KS, Kallela M et al (2008) A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum Mol Genet 17:3318–3331
Article
CAS
Google Scholar
Kirchmann M, Thomsen LL, Olesen J (2006) The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura. Am J Med Genet Part B Neuropsychiatr Genet 141B:250–256
Article
CAS
Google Scholar
Jen JC, Kim GW, Dudding KA et al (2004) No Mutations in CACNA1A and ATP1A2 in Probands With Common Types of Migraine. Arch Neurol 61:926
Article
Google Scholar
Wieser T, Mueller C, Evers S, et al. Absence of Known Familial Hemiplegic Migraine (FHM) Mutations in the CACNA1A Gene in Patients with common Migraine: Implications for Genetic Testing. Clin Chem Lab Med; 41. Epub ahead of print 24 January 2003. https://doi.org/10.1515/CCLM.2003.042.
Younis S, Do TP, Ashina M (2021) Human Models. In: Maassen van den Brink, A., Martelletti P. (eds) Monoclonal Antibodies in Headache . Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-69032-8_5
Ghanizada H, Al-Karagholi MA-M, Arngrim N et al (2020) PACAP27 induces migraine-like attacks in migraine patients. Cephalalgia 40:57–67
Article
Google Scholar
Amin FM, Hougaard A, Schytz HW et al (2014) Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38. Brain 137:779–794
Article
Google Scholar
Pecile A, Guidobono F, Netti C et al (1987) Calcitonin gene-related peptide: antinociceptive activity in rats, comparison with calcitonin. Regul Pept 18:189–199
Article
CAS
Google Scholar
Candeletti S, Ferri S (1990) Antinociceptive profile of intracerebroventricular salmon calcitonin and calcitonin gene-related peptide in the mouse formalin test. Neuropeptides 17:93–98
Article
CAS
Google Scholar
Zhang YZ, Sjőlund B, Moller K et al (1993) Pituitary adenylate cyclase activating peptide produces a marked and long-lasting depression of a C-fibre-evoked flexion reflex. Neuroscience 57:733–737
Article
CAS
Google Scholar
Yamamoto T, Tatsuno I (1995) Antinociceptive effect of intrathecally administered pituitary adenylate cyclase activating polypeptide (PACAP) on the rat formalin test. Neurosci Lett 184:32–35
Article
CAS
Google Scholar
Fontaine D, Almairac F, Santucci S et al (2018) Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies. Brain 141:1040–1048
Article
Google Scholar
Al-Karagholi MA-M, Ghanizada H, Nielsen CAW, et al. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain. Epub ahead of print March 2021. https://doi.org/10.1093/brain/awab136.
Al-Karagholi MA-M, Ghanizada H, Waldorff Nielsen CA, et al. Opening of BKCa channels causes migraine attacks. Pain; Publish Ah. Epub ahead of print 16 March 2021. https://doi.org/10.1097/j.pain.0000000000002238.
Al-Karagholi MA-M, Ghanizada H, Hansen JM et al (2019) Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects. Cephalalgia 39:1789–1797
Article
Google Scholar
Kullmann DM, Waxman SG (2010) Neurological channelopathies: new insights into disease mechanisms and ion channel function. J Physiol 588:1823–1827
Article
CAS
Google Scholar
Kremeyer B, Lopera F, Cox JJ et al (2010) A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome. Neuron 66:671–680
Article
CAS
Google Scholar
Hautakangas H, Winsvold BS, Ruotsalainen SE et al (2022) Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nat Genet 54:152–160
Article
CAS
Google Scholar
Winsvold BS, Nelson CP, Malik R et al (2015) Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet 1:e10
Article
Google Scholar
Malik R, Freilinger T, Winsvold BS et al (2015) Shared genetic basis for migraine and ischemic stroke: a genome-wide analysis of common variants. Neurology 84:2132–2145
Article
CAS
Google Scholar
Sacco S, Ornello R, Ripa P et al (2015) Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies. Eur J Neurol 22:1001–1011
Article
CAS
Google Scholar
Schurks M, Rist PM, Bigal ME et al (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339:b3914–b3914
Article
Google Scholar
Mahmoud AN, Mentias A, Elgendy AY et al (2018) Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects. BMJ Open 8:e020498
Article
Google Scholar
Dichgans M, Mayer M, Uttner I et al (1998) The phenotypic spectrum of CADASIL: Clinical findings in 102 cases. Ann Neurol 44:731–739
Article
CAS
Google Scholar
Montagna P, Gallassi R, Medori R et al (1988) MELAS syndrome: Characteristic migrainous and epileptic features and maternal transmission. Neurology 38:751–751
Article
CAS
Google Scholar
Ohama E, Ohara S, Ikuta F et al (1987) Mitochondrial angiopathy in cerebral blood vessels of mitochondrial eneephalomyopathy. Acta Neuropathol 74:226–233
Article
CAS
Google Scholar
Ashina M, Buse DC, Ashina H et al (2021) Migraine: integrated approaches to clinical management and emerging treatments. Lancet 397:1505–1518
Article
Google Scholar
Ashina M, Goadsby PJ, Dodick DW et al (2022) Assessment of Erenumab Safety and Efficacy in Patients With Migraine With and Without Aura. JAMA Neurol 79:159
Article
Google Scholar
Ashina M, McAllister P, Cady R, Hirman J, Ettrup A (2022) Efficacy and safety of eptinezumab in patients with migraine and self-reported aura: Post hoc analysis of PROMISE-1 and PROMISE-2. Cephalalgia 42(8):696–704. https://doi.org/10.1177/03331024221077646. Epub 2022 Mar 18
Burstein R, Blumenfeld AM, Silberstein SD et al (2020) Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review. Headache J Head Face Pain 60:1259–1272
Article
Google Scholar
Gfrerer L, Xu W, Austen W et al (2022) OnabotulinumtoxinA alters inflammatory gene expression and immune cells in chronic headache patients. Brain 145:2436–2449
Article
Google Scholar
Lucioni A, Bales GT, Lotan TL et al (2008) Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation. BJU Int 101:366–370
Article
CAS
Google Scholar
Durham PL, Cady R, Cady R (2004) Regulation of Calcitonin Gene-Related Peptide Secretion From Trigeminal Nerve Cells by Botulinum Toxin Type A: Implications for Migraine Therapy. Headache J Head Face Pain 44:35–43
Article
Google Scholar
Schankin CJ, Maniyar FH, Seo Y et al (2016) Ictal lack of binding to brain parenchyma suggests integrity of the blood–brain barrier for 11 C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain 139:1994–2001
Article
Google Scholar
Levy D, Jakubowski M, Burstein R (2004) Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci 101:4274–4279
Article
CAS
Google Scholar
Khan S, Mohammad Amin F, Emil Christensen C et al (2019) Meningeal contribution to migraine pain: a magnetic resonance angiography study. Brain 142:93–102
Article
Google Scholar
Laurell K, Artto V, Bendtsen L et al (2016) Premonitory symptoms in migraine: A cross-sectional study in 2714 persons. Cephalalgia 36:951–959
Article
Google Scholar
Giffin NJ, Ruggiero L, Lipton RB et al (2003) Premonitory symptoms in migraine: An electronic diary study. Neurology 60:935–940
Article
CAS
Google Scholar
Maniyar FH, Sprenger T, Monteith T et al (2014) Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain 137:232–241
Article
Google Scholar
Schulte LH, Mehnert J, May A (2020) Longitudinal Neuroimaging over 30 Days: Temporal Characteristics of Migraine. Ann Neurol 87:646–651
Article
Google Scholar
Russell MB, Olesen J (1996) A nosographic analysis of the migraine aura in a general population. Brain 119:355–361
Article
Google Scholar
Lashley KS (1941) Patterns, of cerebral integration indicated by the scotomas of migraine. Arch Neurol Psychiatry 46:331
Article
Google Scholar
Ayata C, Lauritzen M (2015) Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev 95:953–993
Article
CAS
Google Scholar
Olesen J, Friberg L, Olsen TS et al (1990) Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol 28:791–798
Article
CAS
Google Scholar
Hadjikhani N, Albrecht DS, Mainero C et al (2020) Extra-Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura. Ann Neurol 87:939–949
Article
Google Scholar
Zhang X, Levy D, Noseda R et al (2010) Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura. J Neurosci 30:8807–8814
Article
CAS
Google Scholar
Harriott AM, Chung DY, Uner A et al (2021) Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior. Ann Neurol 89:99–110
Article
Google Scholar
de Boer I, Terwindt GM, van den Maagdenberg AMJM (2020) Genetics of migraine aura: an update. J Headache Pain 21:64
Article
Google Scholar
Nozari A, Dilekoz E, Sukhotinsky I et al (2010) Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol 67:221–229
Article
Google Scholar
Kurth T, Chabriat H, Bousser M-G (2012) Migraine and stroke: a complex association with clinical implications. Lancet Neurol 11:92–100
Article
Google Scholar
Wienecke T, Olesen J, Ashina M (2011) Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin D 2 (PGD 2). Cephalalgia 31:65–76
Article
Google Scholar
Ashina M, Tfelt-Hansen P, Dalgaard P et al (2011) Lack of correlation between vasodilatation and pharmacologically induced immediate headache in healthy subjects. Cephalalgia 31:683–690
Article
Google Scholar
Amin FM, Asghar MS, Hougaard A et al (2013) Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol 12:454–461
Article
Google Scholar
Deen M, Hougaard A, Hansen HD et al (2019) Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT 1B Receptor Binding. JAMA Neurol 76:834
Article
Google Scholar
Rubio-Beltrán E, Labastida-Ramírez A, Villalón CM et al (2018) Is selective 5-HT1F receptor agonism an entity apart from that of the triptans in antimigraine therapy? Pharmacol Ther 186:88–97
Article
Google Scholar
Labastida-Ramírez A, Rubio-Beltrán E, Haanes KA et al (2020) Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system. Pain 161:1092–1099
Article
Google Scholar
Felgenhauer K (1974) Protein size and cerebrospinal fluid composition. Klin Wochenschr 52:1158–1164
Article
CAS
Google Scholar
Al-Karagholi MA-M, Ghanizada H, Nielsen CAW, et al. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain. Epub ahead of print 26 March 2021. https://doi.org/10.1093/brain/awab136.
Goadsby PJ, Edvinsson L, Ekman R (1988) Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 23:193–196
Article
CAS
Google Scholar