- Open Access
Cardiac cephalalgia: a narrative review and ICHD-3 criteria evaluation
The Journal of Headache and Pain volume 23, Article number: 136 (2022)
Cardiac cephalalgia is an unusual condition that occurs during an episode of myocardial ischemia. Information about cardiac cephalalgia is scarce and its characteristics and physiopathology remain unclear. Our aim is to provide a narrative review of clinical characteristics and physiopathology of cardiac cephalalgia and to evaluate the current diagnostic criteria.
A search through PubMed was undertaken for studies on cardiac cephalalgia published until 20th September 2022. We summarized the literature and provide a comprehensive review of the headache characteristics and possible mechanisms. We also evaluated current International Classification of Headache Disorders third edition diagnostic criteria based on prior reported cases.
In total, 88 cases were found. Headache characteristics were variable. Occipital location and throbbing pain were the most frequently reported. Headache was accompanied in most cases by cardiac symptoms. Criterion B was fulfilled by 98% of cases, criterion C1 by 72%, and criteria C2a and C2b by 37 and 93.2%, respectively. Regarding headache features described in diagnostic criterion C3, ‘moderate to severe intensity’, ‘accompanied by nausea’, ‘not accompanied by photophobia or phonophobia’ and ‘aggravated by exertion’, were reported in 75, 31, 55 and 55% of cases, respectively.
Cardiac cephalalgia characteristics are variable and the headache features described in the diagnostic criterion C3 might not be adequate. Given that cardiac cephalalgia can be the manifestation of a life-threatening condition it is important to increase the knowledge about this entity.
Comorbidities of primary headache disorders include cardiovascular conditions and ischemic heart disease prevalence is higher in patients with primary headache that in general population (7% vs. 2.6%) . Nonetheless, headache itself can be an infrequent presentation of myocardial ischemia. With regard to previous studies that evaluated presenting symptoms of myocardial ischemia, it has been reported that only 5.2 – 6% of patients with acute myocardial ischemia presented headache as an accompanying symptom [2, 3]. In 3.5% of cases headache was the main pain location  but headache was not reported as the sole symptom by any patient .
Cardiac cephalalgia is an unusual condition that occurs in relation to an episode of myocardial ischemia. This term was first proposed by Lipton et al. in 1997  and, since then, several case reports have been published. Nevertheless, prevalence of cardiac cephalalgia is unknown, information about cardiac cephalalgia characteristics is scarce and its physiopathology is yet to be elucidated.
Since cardiac cephalalgia can be the main or even the only clinical manifestation of a myocardial infarction, a life-threatening condition, recognizing this entity is of great importance. Therefore, our aim is to review the clinical characteristics of cardiac cephalalgia and the proposed pathogenic mechanisms and to evaluate the current International Classification of Headache Disorders third edition (ICHD-3)  diagnostic criteria on the basis of previous case reports.
We performed a literature search in Pubmed database on 20 September 2022. We used the following search lines: “Cardiac”[Title/Abstract] and “Cephalgia”[Title/Abstract], “Cardiac”[Title/Abstract] and “Cephalalgia”[Title/Abstract], “Acute myocardial infarction”[Title/Abstract] and “Headache”[Title/Abstract], “Myocardial Infarction”[MeSH] and “Headache”[MeSH], “Myocardial Ischemia”[MeSH]) and “Headache”[MeSH], “Acute Coronary Syndrome”[MeSH] and “Headache”[MeSH], “Angina”[MeSH] and “Headache”[MeSH]. Only manuscripts written in English and Spanish were included. We applied no time limits. We selected all publications relevant to our topic and we also reviewed the references of these papers in order to find other useful material to our review.
We identified 227 records of which, after deduplication, 155 remained for further analysis. A total of 66 articles were screened by abstract. After a further screening process, 50 publications were finally included, three of them from the review of the references of selected papers (Fig. 1).
For the evaluation of the current diagnostic criteria, we calculated the proportion of cases that fulfilled the ICHD-3 diagnostic criteria B, C1, C2, C3 and C4 in relation to the total of cases. Non-specified cases were classified as ‘no’.
In 1997 Lipton et al. were the first to coin the term cardiac cephalalgia . They reported two patients with exertional headache in relation to myocardial ischemia and reviewed five previously published cases. Although initially in this first description cardiac cephalalgia was exclusively an exertional headache, in subsequent publications patients with onset at rest were also reported.
Cardiac cephalalgia was introduced in the second edition of the International Classification of Headache Disorders (ICHD-2) as a secondary headache in the category of ‘headache attributed to disorder of homeostasis’ . ICH-2 diagnostic criteria can be seen in Table 1.
In 2004, Chen et al.  performed a literature review and evaluated ICHD-2 diagnostic criteria based on 22 prior reported cases. All cases fulfilled ICHD-2 criteria B and C. However, regarding headache characteristics described in criterion A, severe intensity was reported by 59% of cases, aggravation by exertion by 50% and, interestingly, only 23% of cases reported nausea. Moreover, resolution of headache in criterion D was fulfilled by 83% but in some patients headache recurred.
In the ICHD-3 , cardiac cephalalgia is described as a migraine-like headache, usually but not always aggravated by exercise, occurring during an episode of myocardial ischemia. Table 2 shows ICHD-3 diagnostic criteria for cardiac cephalalgia.
We found a total of 88 cases of cardiac cephalalgia, 58 from case reports [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53] (a complete description of these cases can be seen in supplementary material) and 30 patients from a recent observational study . Among case reports, mean age at onset was 62.3 years (± 13.1) and most patients were males (n = 36; 62.1%). These data are in line with the study from Xu et al. that reported a mean age of 64.6 years (± 11.9) and a predominance of male patients (53.3%) . History of cardiovascular risk factors was common. It was present in 41 (70.7%) of the case reports and in all the patients from the observational study . History of headache was reported only in 5 patients (8.6%). Nevertheless, it was not specified in most case reports and was not assessed in the observational study  (Table 3).
Regarding headache features, location of pain was variable and occipital pain was the most frequently reported among previous case reports (n = 16, 27,6%) [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53]. Nevertheless, pain located in the frontotemporal region was the most frequent in the study by Xu et al. (n = 14, 46.6%) . Bilateral headache was reported in 24 patients (41.4%) and unilateral headache in 7 (12.1%) of the case reports (Table 3). Headache quality was also very variable. Among case reports, throbbing (n = 8, 13.8%) and pressing pain (n = 7, 12.1%) were the most frequent but in one-half of the cases headache quality was not specified. Xu et al. found that pulsating quality was the most frequent (33.3%) followed by dull (16.7%) and stuffy pain (16.7%)  (Fig. 2).
In total, more than half of the 88 cases reported severe intensity (n = 51, 57.9%), moderate intensity was described by 15 cases (17%), mild intensity by 6 (6.8%) and variable intensity by 3 (3.4%). In 13 patients (14.7%) headache intensity was not specified. Headache was accompanied by nausea in 28 cases (31.8%), was not accompanied by photophobia or phonophobia in 49 patients (55.7%) and was aggravated or induced by exertion in 49 (55.7%). It is also interesting that two cases reported tearing and one case reported rhinorrhoea .
Myocardial ischemia features
In 21 patients from the case reports headache was the only symptom of the myocardial ischemia [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53]. Nevertheless, in line with the results from the study from Xu et al. , most patients presented other cardiac symptoms including typical angina manifestations (Table 4). 23 patients underwent stress test, which was positive in most cases and in 17 patients headache was reproduced during the stress test (Table 4). Coronary angiography was performed in 78 patients (88.6%) and most patients presented severe coronary disease. Single-vessel disease was reported in 21 cases (23.9%), double-vessel disease in 15 cases (17%), triple-vessel or multivessel disease in 39 cases (44.3%), vasospasm was found in one case  and two cases presented normal coronary arteries [30, 35]. Although the affected vascular territory was variable, the left anterior descending artery (n = 27, 30.7%) and the right coronary artery (n = 26, 29.5%) were the most frequently affected (Table 4). 22 patients (42.3%) were treated by percutaneous transluminal coronary angioplasty, 12 cases (23.1%) required coronary artery bypass and 12 patients (23.1%) received medical treatment. Headache improved or resolved in all cases after treatment of the myocardial ischemia. Although the follow-up period was variable, 37 patients (42%) experienced complete resolution, 33 (37.5%) improved, five patients (5.7%) experienced headache recurrence, eight patients (9.1%) died in the acute phase or during the follow-up period and in five cases (5.7%) outcome was not specified. Four of the patients with headache recurrence experienced simultaneous myocardial ischemia recurrence [11, 15, 18, 42].
ICHD-3 diagnostic criteria evaluation
Criterion B ‘Acute myocardial ischemia has been demonstrated’ was fulfilled by 87 cases (98.9%). In one case of headache with and without exertion relieved by nitrates myocardial ischemia was not demonstrated because patient died suddenly without electrocardiogram and cardiac enzymes determination  (Table 5).
To evaluate criterion C1 `Headache has developed in temporal relation to the onset of acute myocardial ischaemia’ it is necessary to observe the temporal relationship of headache and cardiac symptoms but it can only be confirmed if we observe the onset of headache during a stress test. We considered that 34 patients from the case reports met this criterion. 17 patients reported headache onset in relation to onset of cardiac symptoms and in 17 cases stress tests confirmed the temporal relationship between myocardial ischemia and headache. All 30 patients from the study from Xu et al. met this criterion  (Table 5).
Regarding criterion C2 most patients (93.2%) fulfilled criterion C2b ‘Headache has significantly improved or resolved in parallel with improvement in or resolution of the myocardial ischaemia’. However, evaluate criterion C2a is difficult because it is hard to determine the worsening of myocardial ischemia. For this reason, we considered that only three cases who presented worsening of headache in relation to confirmed worsening of the myocardial ischemia during the coronarography met criterion C2a [13, 14, 52]. Xu et al. reported that all 30 patients met this criterion  (Table 5).
Criterion C3 is the criterion that describes headache characteristics. Criterion C3a ‘moderate to severe intensity’ was met by 75%, criterion C3b ‘accompanied by nausea’ by 31.8%, criterion C3c ‘not accompanied by photophobia or phonophobia’ by 55.7% and criterion C3d ‘aggravated by exertion’ by 55.7%. Considering these findings, nausea is not a frequent accompanying symptom in cardiac cephalalgia. This finding is in line with the results of the literature review by Chen et al.  that found accompanying nausea only in 23% of cases and with the study from Xu et al.  that reported that 36.6% of patients fulfilled this criterion.
Finally, among those cases that reported nitrates administration, Criterion C4 ‘Headache is relieved by nitroglycerine or derivatives of it’ was fulfilled by 100% of cases. However, it must be considered that in 36 case reports the use of nitrates was not specified and that in the study by Xen et al. all 12 patients did not receive nitrates .
Taking into account the present evaluation and in order to improve ICHD-3 diagnostic criteria, we might suggest removing criterion C3b ‘accompanied by nausea’ given that it was the least commonly fulfilled criterion.
Even though the pathophysiology of cardiac cephalalgia is not known, four hypotheses have been proposed to illustrate its mechanisms [7, 53,54,55,56].
The first hypothesis states that cardiac cephalalgia could be the result of the convergence of afferent autonomic visceral fibers, which carry nociceptive cardiac stimuli, and somatic sensory fibers onto a common pool of spinothalamic tract (STT) and spinoreticular tract (SRT) neurons. Thus, according to this hypothesis, cardiac cephalalgia would be a referred pain produced because the brain interprets that cardiac pain is originated in the somatic structures [57,58,59].
Foreman et al.  proposed that ‘typical angina’ and ‘atypical angina’ would have different mechanisms. In the first scenario, sympathetic cardiac afferents may converge onto STT and SRT neurons with the somatic stimuli from the chest and upper arm in the upper thoracic and cervical spinal segments (T1-T5 and C5-C6). In contrast, angina associated to referred pain to the neck and jaw might be mediated by cardiac vagal afferents that predominantly terminate in the nucleus tractus solitarius and then project to STT neurons in the C1-C2 segment. Cervical and trigeminal afferents converge in the trigeminocervical complex which is constituted by C1 and C2 segments and the trigeminal nucleus caudalis [60, 61]. Therefore, vagal cardiac afferents could activate trigeminal neurons and produce referred pain in the cervical and trigeminal territory.
The concentration of cardiac afferent autonomic visceral fibers can vary for each cardiac region . Although the anatomy and physiology of this fibers are not yet fully understood, it is thought that a greater concentration of sympathetic cardiac afferent fibers is primarily located in the anterior part of the left ventricle whereas parasympathetic afferent fibers mainly innervate the inferior-posterior wall of the left ventricle . Since the anterior portion of the left ventricle is mainly perfused by the left anterior descending artery, whereas the posterior and inferior walls are principally supplied by the right coronary artery and the circumflex artery, the predominant activation of sympathetic or parasympathetic fibers may be determined by the artery responsible for the myocardial ischemia [58, 63]. Therefore, cardiac cephalalgia might depend on the area of the heart in which myocardial ischemia occurs. Figure 3 shows a representation of the convergence theory of cardiac cephalalgia.
The second theory states that the abrupt decrease of cardiac output during myocardial ischemia would cause a rising of pressure in the left atrium and left ventricle hindering cerebral venous return. Hence, cardiac cephalalgia would be the result of an increased intracranial pressure secondary to a reduction of cerebral venous drainage [7, 53,54,55,56].
The third hypothesis suggests that the release of inflammatory mediators during cardiac ischemia including bradykinin, serotonin, substance P and histamine could cause vasodilation in brain arteries leading to headache [7, 53,54,55,56].
Finally, Wang et al.  proposed a fourth hypothesis. They reported a case of cardiac cephalalgia with cortical cerebral hypoperfusion confirmed by the perfusion-weighted images of brain magnetic resonance (MR) imaging and with normal MR angiography during the headache attack. Therefore, they deduced that cardiac cephalalgia might be the result of the vasoconstriction of small intracranial arteries caused by the activation of the sympathetic system by myocardial ischemia. They also proposed that cortical cerebral hypoperfusion may provoke cortical spreading depression which could additionally contribute to headache.
Limitations and future perspective
We provide an updated overview on cardiac cephalalgia from the physiopathology to the diagnostic criteria. The major limitation of our review is that the description of headache characteristics of cardiac cephalagia in a high proportion of previous reports were scarce and that there were a large number of terms to describe headache quality. Another limitation is that headache history was rarely reported. Thus, patients with a worsening of a preexisting headache may have been misdiagnosed as cardiac cephalalgia. To further elucidate the characteristics of cardiac cephalalgia and its pathophysiology it would be of great interest to conduct further studies with standardized data collection of patients with demonstrated myocardial ischemia in order to investigate cardiac cephalalgia prevalence and characteristics.
Cardiac cephalalgia characteristics are variable and the proposed headache features in the diagnostic criterion C3 might not be adequate, especially nausea which was the least commonly met criterion. Given that it can be the manifestation of a life-threatening condition it is important to increase the knowledge about this entity. Further prospective studies are warranted to assess its prevalence and to describe in detail its clinical features in order to better understand and manage patients with cardiac cephalalgia.
Availability of data and materials
International Classification of Headache Disorders third edition
International Classification of Headache Disorders second edition
Caponnetto V, Deodato M, Robotti M et al (2021) Comorbidities of primary headache disorders: a literature review with meta-analysis. J Headache Pain 22:71. https://doi.org/10.1186/s10194-021-01281-z
Čulić V, Mirić D, Eterović D (2001) Correlation between symptomatology and site of acute myocardial infarction. Int J Cardiol 77:163–168. https://doi.org/10.1016/s0167-5273(00)00414-9
Sampson JJ, Cheitlin MD (1971) Pathophysiology and differential diagnosis of cardiac pain. Prog in Cardiovasc Dis 13:507–531. https://doi.org/10.1016/s0033-0620(71)80001-4
Lipton RB, Lowenkopf TJ, Bajwa ZH et al (1997) Cardiac cephalgia: a treatable form of exertional headache. Neurology 49:813–816. https://doi.org/10.1212/wnl.49.3.813
Headache Classification Committee of the International Headache Society (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38: 1–211 https://doi.org/10.1177/0333102417738202.
Headache Classification Committee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd Edition. Cephalalgia 2 4(Suppl. 1): 1–160 https://doi.org/10.1111/j.1468-2982.2003.00824.x.
Chen SP, Fuh JL, Yu WC et al (2004) Cardiac cephalalgia: case report and review of the literature with new ICHD-II criteria revisited. Eur Neurol 51:221–226. https://doi.org/10.1159/000078489
Lefkowitz D, Biller J (1982) Bregmatic headache as a manifestation of myocardial ischemia. Arch Neurol 39:130. https://doi.org/10.1001/archneur.1982.00510140064019
Fleetcroft R, Maddocks JL (1985) Headache due to ischaemic heart disease. J R Soc Med 78(8):676. https://doi.org/10.1177/014107688507800817
Blacky R, Rittelmeyer J, Wallace M (1987) Headache angina. Am J Cardiol 60:730. https://doi.org/10.1016/0002-9149(87)90394-8
Vernay D, Deffond D, Fraysse P et al (1989) Walk headache: an unusual manifestation of ischemic heart disease. Headache 29:350–351. https://doi.org/10.1111/j.1526-4610.1989.hed2906350.x
Takayanagi K, Fujito T, Morooka S et al (1990) Headache angina with fatal outcome. Jpn Heart J 31:503–507. https://doi.org/10.1536/ihj.31.503
Bowen J, Oppenheimer G (1993) Headache as a presentation of angina: reproduction of symptoms during angioplasty. Headache 33:238–239. https://doi.org/10.1111/j.1526-4610.1993.hed3305238.x
Ishida A, Sunagawa O, Touma T et al (1996) Headache as a manifestation of myocardial infarction. JPN Heart J 37:261–263. https://doi.org/10.1536/ihj.37.261
Grace A, Horgan J, Breathnach K et al (1997) Anginal headache. Cephalalgia 17:195–196. https://doi.org/10.1046/j.1468-2982.1997.1703195.x
Lance JW, Lambros J (1998) Unilateral exertional headache as a symptom of cardiac ischemia. Headache 38:315–316. https://doi.org/10.1046/j.1526-4610.1998.3804315.x
Lanza GA, Sciahbasi A (2000) Angina pectoris: a headache. Lancet 356:998. https://doi.org/10.1016/S0140-6736(00)02718-5
Rambihar VS (2001) Headache angina. Lancet 357:72. https://doi.org/10.1016/S0140-6736(05)71575-0
Amendo MT, Brown BA, Kossow LB et al (2001) Headache as the sole presentation of acute myocardial infarction in two elderly patients. Am J Geriatr Cardiol 10:100–101. https://doi.org/10.1111/j.1076-7460.2001.00842.x
Auer J, Berent R, Lassnig E et al (2001) Headache as a manifestation of fatal myocardial infarction. Neurol Sci 22:395–397. https://doi.org/10.1007/s100720100071
Famularo G, Polchi S, Tarroni P (2002) Headache as a presenting symptom of acute myocardial infarction. Headache 42:1025–1028. https://doi.org/10.1046/j.1526-4610.2002.02232.x
Gutiérrez-Morlote J, Pascual J (2002) Cardiac cephalgia is not necessarily an exertional headache: case report. Cephalalgia 22(9):765–766. https://doi.org/10.1046/j.1468-2982.2002.00418.x
Martínez HR, Rangel-Guerra RA, Cantú-Martínez L et al (2003) Cardiac headache: hemicranial cephalalgia as the sole manifestation of coronary ischemia. Headache 42:1029–1032. https://doi.org/10.1046/j.1526-4610.2002.02233.x
Sathirapanya P (2004) Anginal cephalalgia: a serious form of exertional headache. Cephalalgia 24:231–234. https://doi.org/10.1111/j.1468-2982.2003.00632.x
Gutiérrez-Morlote J, Fernández-García JM, Timiraos-Fernández JJ et al (2005) Cardiac cephalagia: an underdiagnosed condition? Rev Esp Cardiol 58:1476–1478
Korantzopoulos P, Karanikis P, Pappa E et al (2005) Acute non-Ste-elevation myocardial infarction presented as occipital headache with impaired level of consciousness. Angiology 56:627–630. https://doi.org/10.1177/000331970505600516
Cutrer FM, Huerter K (2006) Exertional headache and coronary ischemia despite normal electrocardiographic stress testing. Headache 46:165–167. https://doi.org/10.1111/j.1526-4610.2006.00316_1.x
Seow VK, Chong CF, Wang TL et al (2007) Severe explosive headache: a sole presentation of acute myocardial infarction in a young man. Am J Emerg Med 25:250–251. https://doi.org/10.1016/j.ajem.2006.11.014
Broner S, Lay C, Newman L et al (2007) Thunderclap headache as the presenting symptom of myocardial infarction. Headache 47:724–733. https://doi.org/10.1111/j.1526-4610.2007.00795_1.x
Wei JH, Wang HF (2007) Cardiac cephalalgia: case reports and review. Cephalalgia 28:892–896. https://doi.org/10.1111/j.1468-2982.2008.01590.x
Wang WW, Lin CS (2008) Headache angina. Am J Emerg Med 26:387. https://doi.org/10.1016/j.ajem.2007.07.029
Dalzell JR, Jackson CE, Robertson KE et al (2009) A case of the heart ruling the head: acute myocardial infarction presenting with thunderclap headache. Resuscitation 80:608–609. https://doi.org/10.1016/j.resuscitation.2009.02.008
Sendovski U, Rabkin Y, Goldshlak L et al (2009) Should acute myocardial infarction be considered in the differential diagnosis of headache? Eur J Emerg Med 16:1–3. https://doi.org/10.1097/MEJ.0b013e3282f5dc09
Chatzizisis YS, Saravakos P, Boufidou A et al (2010) Acute myocardial infarction manifested with headache. Open Cardiovasc Med J 4:148–150. https://doi.org/10.2174/1874192401004010148
Cheng PY, Sy HN, Chen WL et al (2010) Cardiac cephalalgia presented with a thunderclap headache and an isolated exertional headache: report of 2 cases. Acta Neurol Taiwan 19:57–61
Yang Y, Jeong D, Jin DG et al (2010) A case of cardiac cephalalgia showing reversible coronary vasospasm on coronary angiogram. J Clin Neurol 6:99–101. https://doi.org/10.3988/jcn.2010.6.2.99
Costopoulos C (2011) Acute coronary syndromes can be a headache. Emerg Med J 28:71–73. https://doi.org/10.1136/emj.2009.082271
Elgharably Y, Iliescu C, Sdringola S et al (2012) Headache: a symptom of acute myocardial infarction. Eur J Cardiovasc Med 11(111):170–174. https://doi.org/10.5083/ejcm.20424884.92
Asvestas D, Vlachos K, Salachas A et al (2014) Headache: an unusual presentation of acute myocardial infraction. World J Cardiol 6:514–516. https://doi.org/10.4330/wjc.v6.i6.514
Wassef N, Ali AT, Katsanevaki AZ et al (2014) Cardiac Cephalgia Cardiol Res 5:195–197. https://doi.org/10.14740/cr361w
Mathew PG, Boes CJ, Garza I (2015) A tale of Two systems: cardiac cephalalgia vs migrainous thoracalgia. Headache 55:310–312. https://doi.org/10.1111/head.12373
Chowdhury AW, Saleh AD, Hasan P et al (2015) Cardiac cephalgia: a headache of the heart. J Cardiol Cases 11:139–141. https://doi.org/10.1016/j.jccase.2015.02.002
Prakash S, Panchani N, Rathore C et al (2016) Cardiac cephalalgia: first case from India. Ann Indian Acad Neurol 19:252–254. https://doi.org/10.4103/0972-2327.165467
Huang CC, Liao PC (2016) Heart attack causes headache - cardiac cephalalgia. Acta Cardiol Sin 32:239–242. https://doi.org/10.6515/acs20150628a
Shankar A, Allan CL, Smyth D et al (2016) Cardiac cephalgia: a diagnostic headache. Intern Med J 46:1219–1221. https://doi.org/10.1111/imj.13217
Wang M, Wang L, Liu C et al (2017) Cardiac cephalalgia: one case with cortical hypoperfusion in headaches and literature review. J headache pain 18:1–8. https://doi.org/10.1186/s10194-017-0732-3
Majumder B, Chatterjee PK, Sudeep KN et al (2017) Cardiac cephalgia presenting as acute coronary syndrome: A case report and review of literature. Nig J Cardiol 14:119–121
MacIsaac R, Jarvis S, Busche K (2019) A Case of a Cardiac Cephalgia. Can J Neurol Sci 46:124–126. https://doi.org/10.1017/cjn.2018.377
Lazari J, Money-Kyrle A, Wakerley BR (2019) Cardiac cephalalgia: severe, non-exertional headache presenting as unstable angina. Pract Neurol 19:173–175. https://doi.org/10.1136/practneurol-2018-002045
Santos PSF, Pedro MKF, Andrade AC (2019) Cardiac cephalalgia: A deadly case report. Headache Medicine 10:32–34. https://doi.org/10.48208/HeadacheMed.2019.8
Ruiz Ortiz M, Bermejo Guerrero L, Martínez Porqueras R et al (2020) Cardiac cephalgia: When myocardial ischaemia reaches the neurologist’s consultation. Neurologia (Engl Ed) 35(8):614–615. https://doi.org/10.1016/j.nrl.2019.09.003
Sun L, Zhang Q, Li N et al (2021) Case report: Cardiac cephalalgia closely associated with acute myocardial infarction. American J Emerg Med 47:350. https://doi.org/10.1016/j.ajem.2021.03.019
Kobata H (2022) Cardiac cephalalgia: a case series of four patients and updated literature review. Int J Emerg Med 15(1):33. https://doi.org/10.1186/s12245-022-00436-2
Xu J, Mao N, Wang C, Feng J, Lian Y (2022) Clinical analysis of 30 cases of cardiac cephalalgia. Cephalalgia 42(9):926–932. https://doi.org/10.1177/03331024221088993
Torres-Yaghi Y, Salerian J, Dougherty C (2015) Cardiac cephalgia. Curr Pain Headache Rep 19(4):14. https://doi.org/10.1007/s11916-015-0481-4
Bini A, Evangelista A, Castellini P et al (2009) Cardiac cephalgia. J Headache Pain 10(1):3–9. https://doi.org/10.1007/s10194-008-0087-x
Meller ST, Gebhart GF (1992) A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience 48:501–524. https://doi.org/10.1016/0306-4522(92)90398-l
Foreman RD, Garrett KM, Blair RW (2011) Mechanisms of cardiac pain Compr Physiol 5(2):929–960. https://doi.org/10.1002/cphy.c140032
Rosen SD (2012) From heart to brain: the genesis and processing of cardiac pain. Can J Cardiol 28(2):S7-19. https://doi.org/10.1016/j.cjca.2011.09.010
Piovesan EJ, Kowacs PA, Oshinsky ML (2003) Convergence of cervical and trigeminal sensory afferents. Curr Pain Headache Rep 7(5):377–383. https://doi.org/10.1007/s11916-003-0037-x
Edvinsson JCA, Viganò A, Alekseeva A et al (2020) The fifth cranial nerve in headaches. J Headache Pain 21(1):1–17. https://doi.org/10.1186/s10194-020-01134-1
Zandstra TE, Notenboom RGE, Wink J et al (2021) Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function. Front Physiol 12:665298. https://doi.org/10.3389/fphys.2021.665298
Arslanian-Engoren C, Engoren M (2010) Physiological and anatomical bases for sex differences in pain and nausea as presenting symptoms of acute coronary syndromes. Heart Lung 39(5):386–393. https://doi.org/10.1016/j.hrtlng.2009.10.013
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Cardiac cephalalgia case reports. Summary of data from previous case reports of cardiac cephalalgia.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Navarro-Pérez, M.P., Bellosta-Diago, E., Olesen, J. et al. Cardiac cephalalgia: a narrative review and ICHD-3 criteria evaluation. J Headache Pain 23, 136 (2022). https://doi.org/10.1186/s10194-022-01508-7
- Secondary headache
- Myocardial ischemia
- Myocardial infarction
- Exertional headache