Structured headache services as the solution to the ill-health burden of headache. 2. Modelling effectiveness and cost-effectiveness of implementation in Europe: methodology

Tinelli, Michela; Leonardi, Matilde; Paemeleire, Koen; Mitsikostas, Dimos; de la Torre, Elena Ruiz; Steiner, Timothy J.

doi:10.1186/s10194-021-01310-x

Table 9 Healthy Life Years (HLYs) potentially gained in 1 year by each element of the proposed intervention (migraine)

From: Structured headache services as the solution to the ill-health burden of headache. 2. Modelling effectiveness and cost-effectiveness of implementation in Europe: methodology

	Efficacy * uptake	Healthy Life Years per capita			Luxembourg N = 124,713		Russia N = 18,122,512		Spain N = 10,772,263
		Not treated	Treated	Gained	Affected individuals under treatment (n)	HLYs gained across population	Affected individuals under treatment (n)	HLYs gained across population	Affected individuals under treatment (n)	HLYs gained across population
CURRENT CARE: NO CONSUMER EDUCATION OR HEALTH-CARE PROFESSIONAL TRAINING
A. Acute management (non-specific drugs) ASA 1 g	0.2146	0.0399	0.0313	0.0086	79,193	0.0026	11,507,795	0.0015	6,840,387	0.0030
B. Acute management (specific drugs) sumatriptan 50 mg	0.0015	0.0399	0.0398	0.0001	624	1.83579E-05	90,613	1.08171E-05	53,861	0.0000
C. Acute stepped-care management ASA 1 g + sumatriptan 50 mg	0	0.0399	0.0399	0	0	0	0	0	0	0
D. Prophylaxis + acute management amitriptyline 100 mg/day + ASA 1 g + sumatriptan 50 mg	0.0031	0.0399	0.0397	0.0001	873	3.72807E-05	126,858	2.19671E-05	75,406	0.00004
Total					80,690	0.002656	11,725,266	0.001533	6,969,654	0.00304
HLYs FOR OVERALL POPULATION					1090		158,406		94,159
TARGET CARE: WITH CONSUMER EDUCATION AND HEALTH-CARE PROFESSIONAL TRAINING
A. Acute management (non-specific drugs) ASA 1 g	0.1386	0.0399	0.0343	0.0055	51,132	0.0017	7,430,230	0.0010	4,416,628	0.0020
B. Acute management (specific drugs) sumatriptan 50 mg	0	0.0399	0.0399	0	0	0		0		0
C. Acute stepped-care management ASA 1 g + sumatriptan 50 mg	0.1052	0.0399	0.0357	0.0042	153,854	0.0013	50,269,478	0.0008	10,313,113	0.0015
D. Prophylaxis + acute management amitriptyline 100 mg/day + ASA 1 g + sumatriptan 50 mg	0.2020	0.0399	0.0318	0.0081	30,679	0.0024	4,458,138	0.0014	2,649,977	0.0029
Total					235,666	0.0054	62,157,845	0.0032	17,379,718	0.0063
HLYs FOR OVERALL POPULATION					2217		322,115		191,470

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