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Aura and Head pain: relationship and gaps in the translational models

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Abstract

Migraine is a complex brain disorder and initiating events for acute attacks still remain unclear. It seems difficult to explain the development of migraine headache with one mechanism and/or a single anatomical location. Cortical spreading depression (CSD) is recognized as the biological substrate of migraine aura and experimental animal studies have provided mechanisms that possibly link CSD to the activation of trigeminal neurons mediating lateralized head pain. However, some CSD features do not match the clinical features of migraine headache and there are gaps in translating CSD to migraine with aura. Clinical features of migraine headache and results from research are critically evaluated; and consistent and inconsistent findings are discussed according to the known basic features of canonical CSD: typical SD limited to the cerebral cortex as it was originally defined. Alternatively, arguments related to the emergence of SD in other brain structures in addition to the cerebral cortex or CSD initiated dysfunction in the thalamocortical network are proposed. Accordingly, including thalamus, particularly reticular nucleus and higher order thalamic nuclei, which functions as a hub connecting the visual, somatosensory, language and motor cortical areas and subjects to modulation by brain stem projections into the CSD theory, would greatly improve our current understanding of migraine.

Introduction

Cortical spreading depression (CSD) is a pathophysiological phenomenon of gray matter characterized by sustained electrical silence and suppressed activity propagating in the cerebral cortex preceded by a brief shower of population spikes [1,2,3]. CSD has been shown to occur in traumatic brain injury, ischemic stroke and subarachnoid hemorrhage in the human cerebral cortex [4,5,6,7,8]. CSD has also been recognized as the biological substrate of migraine aura [9,10,11]. Experimental animal studies have provided mechanisms that possibly link CSD to the activation of trigeminal neurons mediating lateralized head pain [12]. The probable mechanism between CSD and lateralized head pain in anesthetized rats is over-extrapolated to migraine without aura and a ‘silent aura’ theory is proposed for migraine without aura to explain headaches. Some basic CSD features unfortunately do not match many clinical features of migraine headache well. Those disregarded grey areas are briefly discussed here in order to understand the exact role of CSD in migraine and to develop a new perspective into the mechanisms of the disease.

What is the functional consequence of CSD at cellular level?

CSD is demarcated by a slowly propagating wave of depressed electrical activity in the affected cerebral cortical region [1, 2, 13]. The ‘depression’ or ‘silence’ is actually as a result of a state of sustained depolarization where the membrane is captured/clamped at the depolarized potential with loss of excitability for a few minutes. The electrical silence dominates in the cortical region as a prolonged membrane depolarization and prevents action potentials and synaptic transmission. Sudden collapse of ionic gradients across membranes is associated with massive movements of Na+, Cl-, Ca++ and water into the cell, K+ accumulation outside the cell, pH decrease to near ischemic levels and decrease of extracellular space by 50% [2, 13]. Such a toxic depolarization state of the tissue in CSD has nothing in common with depolarization of a neuron generating AP, except for the word of ‘depolarization’ itself (Table 1) [1,2,3, 13]. CSD happens in larger scale, lasts ~ 240,000 ms, causes up to 30 mV shift in the extracellular potential, covers every cell, and is characterized by loss of excitability of membranes in the tissue, while AP happens in micro scale, lasts 1 ms, causes no change in the extracellular potential, and is characterized by induced excitability state (Table 1) [1,2,3, 13]. The CSD process leads to an enormous release of intracellular contents, neurotransmitters, molecules, vasoactive and nociceptive substances including glutamate, GABA, aspartate, glycine, adenosine, catecholamines to the extracellular space in the depolarized cortical region. Such a massive movement of ions, water and substances across membranes change the extracellular potential and is reflected electrophysiologically as a huge transient shift up to 30 mV in direct current (DC shift) [1, 2]. Conventional alternating current coupled devices cannot detect these slow discharges unless the filter is changed to allow very low frequencies.

Table 1 Distinguishing features of depolarizations of action potentials and cortical spreading depression

The depolarization of CSD is reversible if the tissue is under physiological conditions and not associated with compromised energy/ blood flow. The contiguous spreading nature of DC shift comes from the fact that loss of membrane resistance and release of neurotransmitters, K+ and other molecules during depolarization induce a domino effect on adjacent cells. The improvement of electrical depression begins within a few minutes, though full recovery of spontaneous synaptic activity takes hours [2, 13].

The CSD induced depolarization state is not associated with increased excitability where action potentials fire, such as in epileptic discharges. On the contrary, the depolarization process of CSD is a loss of excitability state lasting minutes and very similar to the ischemic depolarization resulting in loss of function [2, 3, 13]. Whole-cell recordings in vivo confirm the prolonged depolarization up to 345 s with neuronal silencing during CSD, which was followed by reduced spontaneous synaptic activity and AP firing. Significant reduction in the spontaneous excitatory and inhibitory postsynaptic potentials, yielding an imbalance towards inhibitory tone, lasts longer than 90 min [13].

Consequently, the initial phase of CSD where the membrane resistance is lost and membrane potential is seized in depolarized state is a complete electrical silence that is unlikely to be associated with excitation of any cortical neuron leading to positive aura symptoms. On the other hand, a shower of population spikes lasting 2–4 s within the late gamma band that precedes DC drop [3, 14] could be attributed to positive symptomatology. However, the brief duration of antecedent spike shower may not be perceived consciously and may not be manifested as a clinical symptom. Even if it is perceived as a positive symptom, it has to be overwhelmed by following long-lasting negative symptomatology. Thereby, even the expectation of increased activity of excitatory cortical neurons with positive symptomatology alone is not compatible with basics of canonical CSD.

CSD was employed to model the depressed neuronal activity in the cerebral cortex and never been used to produce a brain hyperexcitability model. Transient loss of function of the cerebral cortex as a result of CSD was also noticed by other researchers and used as a method to generate functional decortication [15, 16]. The fact that CSD was used to produce functional decortication/ ablation [17, 18] indicates its massive negative functional consequences in mammalian brain. Recent studies unveiled the occurrence of SD waves in human cortex immediately before brain death, malignant ischemic stroke, aneurysmal subarachnoid hemorrhage or intracerebral hemorrhage and traumatic brain injury and their association with increased mortality and morbidity [4,5,6,7,8]. The latter conditions differ from migraine not only due to a severe disability but also the fact that majority of migraine auras consist of positive symptoms in visual, and/or somatosensory modalities.

What is the evidence linking CSD to head pain?

The trigeminal nerve mediates the pain sensation from cephalic structures in the anterior portion of the head and plays a crucial role during headache phase of migraine. Peripheral trigeminal nerve endings arise from dural vasculature and therefore are termed as the trigeminovascular system. Upon activation, trigeminal nociceptors release their contents such as calcitonin gene-related peptide (CGRP) to perivascular space [11, 12]. Stimulation of trigeminal neurons at the ganglia, in experimental animals, results in neurogenic inflammation characterized by the release of CGRP and substance P, vasodilation, increase in blood flow and protein extravasation in the dura mater. Therefore, any activation of meningeal perivascular trigeminal nociceptors by potassium, arachidonic acid or other molecules released during CSD, could initiate signal transmission orthodromically to the pain processing structures, while inducing antidromic neurogenic inflammation in the dura mater in experimental animals [12].

In rat brain‚ CSD in pain-insensitive brain parenchyma was related to unilateral activation of trigeminal afferents and subsequent activation of 2nd order trigeminal pain neurons. The possible link between CSD and head pain was supported by the following findings in anesthetized rodent experiments; 1) Two dimensional blood flow imaging of both the cerebral cortex and the dura mater revealed that following CSD wave, blood flow in the middle meningeal artery (MMA) notably increased for an hour in a trigeminal nerve dependent manner [12]. MMA was a perfect dural structure to observe the trigeminovascular system due to its dense innervation by trigeminal nerve. The increase in the ipsilateral MMA blood flow peaked 20 min after CSD and coincided with oligemic phase of the brain [12]. 2) CSD triggered trigeminal nerve dependent plasma protein leakage, prominent around MMA within overlying dura mater in the ipsilateral hemisphere [12, 19]. 3) CSD induced expression of the immediate early gene product c-FOS in trigeminal nucleus caudalis (TNC) in the ipsilateral brainstem [12, 19, 20]. Activation of the trigeminal nucleus also initiated trigemino-parasympathetic reflex which led to dural vasodilatation and hyperemia via release of vasoactive intestinal peptide, nitric oxide (NO) and acetylcholine, 4) CSD could activate perivascular trigeminal nerve endings [21]. Those studies were conducted in rodents under anesthesia and suggested a link between an intrinsic brain event and lateralized head pain through peripheral bipolar neurons of trigeminal ganglia. Though the latter was disputed by Lambert et al. [22], where authors showed the persistence of CSD induced TNC neuronal activation following trigeminal nerve transection and thereby suggested a direct central pathway. Possible involvement of central route to activate TNC was also proposed to be operational particularly in awake subjects through thalamus and other brainstem structures [23]. CSD has also been shown to result in bilateral TNC activation [24, 25], decrease in mechanical pain thresholds in the head and pain-related behavior [25, 26].

CSD experiments in rodents showed the opening of pannexin 1 megachannels, MMP activation and BBB breakdown providing the possible mechanisms that explain how the intracellular nociceptive and vasoactive molecules induce neuroinflammation and find a way to pass through the blood-brain barrier and reach to the perivascular trigeminal nociceptors in the dura mater [19, 27, 28].

Another supporting evidence for the linkage of CSD to head pain came from the drug studies in rodents. Trigeminal activation at the second order neurons in TNC by CSD was reversed by sumatriptan [12, 20], valproic acid [23], topiramate [29], CGRP receptor antagonists [30] or metoclopramide [31]. Latter two agents also significantly reversed the CSD induced pain behavior such as grooming and freezing in addition to reduced von Frey thresholds and cold allodynia in freely moving rodents. It is important to note that acute use of aforementioned pharmaceutical agents drugs do not inhibit or influence CSD waves.

CSD is capable of inducing thalamic reticular nuclei (TRN) which is a key structure as a gate keeper in thalamocortical information flow and plays a role in selective attention, sensory discrimination, lateral inhibition, and sleep. TRN activation was in the visual sector and SD waves could propagate to TRN if the rats are devoid of any effect of anesthesia. The propagation of SD waves to TRN was blocked by valproic acid administration [23]. Therefore, its involvement in CSD is a very important step to look from a broader perspective into the cortical function since the cortical processing of any somatosensory, motor or cognitive function includes the thalamus, an inseparable counterpart of the cortex.

Transgenic mice expressing mutations associated with familial hemiplegic migraine (FHM) showed increased CSD susceptibility, where the glutamatergic synapse was the common target [32]. Reduced threshold for CSD induction and an increased CSD propagation speed were detected in both Cacna1aR192Q knock-in mice that carry the FHM1 mutation and FHM2 knock-in mice carrying the human W887R mutation in the ATP1a2 orthologous gene. Behavioral consequences of CSD in those mice exhibited several features attributed to migraine head pain and photophobia. However, their relation to trigeminovascular system or pain nucleus was not studied in mutant mice. Cacna1aR192Q knock-in mice displayed signs of photophobia and chose to remain in open space to avoid light in the bright closed arms condition and they spent significantly more time in the dark open arms than wild-type (WT) mice in modified elevated plus maze. Head grooming was increased in R192Q mutant mice and number of long strokes initiating in the oculotemporal region were significantly higher in Cacna1a transgenic mutants than WT animals showing a possible site of pain. Mutant mice also showed increased eye blinks associated with a whole-body shuddering behavior. Abnormal head grooming and eye behaviors were reversed by rizatriptan, a selective 5-HT1B/1D receptor agonist, an acute antimigraine medication in a dose-dependent manner [33]. In another study, Cacna1a knock-in mutant mice showed a baseline pain face with higher baseline mouse grimace scores compared to WT mice, which was prevented by intraperitoneal administration of 50 mg/kg rizatriptan [34].

Which clinical manifestations suggest that CSD is the underlying mechanism of migraine with aura?

The visual aura symptom matching the retinotopic organization of visual cortex is consistent with canonical CSD

Detailed imaging studies in nine migraine with aura patients showed that scintillations and other visual aura symptoms as well as their march are consistent with the retinotopy of the same individual [35,36,37].

The gradual progress of aura symptoms is consistent with CSD

The gradual development of aura symptoms in approximately 30% of the patients, is also compatible with canonical CSD in humans. The gradual progress of visual aura was first related to occipital cortex by Lashley [10], who calculated the propagation rate of the underlying cortical process to be approximately 3 mm/min by assuming the length of striate cortex as 67 mm and the duration of enlarging scotoma to reach the margin of the temporal visual field from the center as 20 min.

Viana et al. [38] reported that, the somatosensory aura symptoms began after the end of the visual aura symptoms in 24% of the patients. This could be supportive for canonical CSD if the propagation time is long enough to reach somatosensory cortex (the details were not given in the study [38]. The presence of a time lag between the aura and the beginning of the headache which is seen in only 36% of the patients [38] is also compatible with the interval between CSD and subsequent development of trigeminal afferent activation.

Contralateral manifestation of unilateral migraine headache and aura symptoms is in favor of canonical CSD in migraine

Regarding the bench studies, the CSD and headache is linked through the orthodromic activation of trigeminal nociceptors in the overlying dura mater and sequential induction of neurons in the ganglia and TNC [12, 19,20,21,22, 25]. According to the conventional notion, unilateral pain is expected to develop contralateral to the side of aura symptoms. In migraine patients the contralaterality is confirmed in a proportion of migraine with aura patients [39,40,41,42,43,44].

Manzoni reported that headache was contralateral to the somatosensory aura in 40% of his 164 patients [39]. In another study, 18% of 111 patients somatosensory aura was contralateral to the unilateral migraine headache [40]. Guiloff reported that only 1 patient out of 11, exhibiting contralateral distribution of paresthesia with headache [41]. Contralaterality of headache with somatosensory auras was around 35% in other series [42, 43]. Queiroz et al. reported contralaterality of migraine headache with visual aura in 8.2% of 122 patients [44]. Blood flow imaging studies in migraine with aura patients reported contralaterality in most of the subjects, though the number of patients included was limited. Therefore, the contralateral headache following aura symptoms is consistent with the canonical CSD features seen in rodents.

Spreading hypoperfusion at a rate within established CSD limits is the main evidence supporting CSD in migraine aura

Vascular reactivity and blood flow alterations follow the change in neuronal excitability with a time lag and oligemia lasting for hours upon transient hyperemia is the typical feature of CSD. CSD usually induces hyperemia response in most of the species such as rats, cats or rabbits. Regional cerebral blood flow increase follows depolarization onset with a 16–20 s delay and peaks around 2 min after DC shift [2]. Then post CSD oligemia up to 40% starts and lasts hours in the affected cortical region.

While the direct electrophysiological evidence of DC shift or electrical silence has never been detected during aura in migraine patients, blood flow alterations are used to trace associated neurovascular events. Perfusion changes in migraine provide data supportive for a link between CSD and migraine aura. Hypoperfusion in the posterior part of the brain, spreading rostrally with a rate consistent with CSD propagation, is usually considered as an evidence for CSD in migraineurs’ brain.

During regional cerebral blood flow (rCBF) evaluation via intracarotid injections of radioactive xenon, occipital hypoperfusion advancing anteriorly was detected in images captured in 15 min intervals in 8 out of 250 patients (7 patients had migraine, 6 with aura, 1 without aura) [9]. When rCBF measurement was consistent with headache side, focal hyperemia was observed in 2 patients. Frontal hyperemia, followed by occipito-parietal oligemia was associated with contralateral paresthesia and ipsilateral fronto-temporal headache in one patient. Occipital hyperemia was replaced with global blood flow decrease in the other case. Lauritzen also reported reduced blood flow progressing anteriorly without crossing rolandic or sylvian sulcus with an approximately 1.8 to 2.6 mm/min rate in 7 patients [45]. Cerebral hypoperfusion affecting the whole hemisphere, sometimes with patchy involvement of occipital and frontal lobes was associated with the development of headache in migraine [45].

On the other hand occipital lobe hypoperfusion was reported during aura and before the onset of headache in 4 migraine patients with aura [46]. Similar oligemia changes were not detected in 13 migraine without aura patients [47], while bilateral occipital oligemia moving to temporal pole was demonstrated by Woods [48] in a well-known case of migraine without aura attack (Table 2).

Table 2 Comparison of unique aspects of cortical spreading depression with the findings in migraine

Perfusion changes can occur due to neurovascular coupling mechanisms in response to neuronal depression. Suppressed BOLD activation was detected as initial change in the occipital cortex in migraine patients independent of the presence of aura and progressed at a rate of 3–6 mm/min to adjacent cortex in 8 patients [49]. Reduced BOLD signal was detected in response to visual stimulus during the scintillations and this reduction gradually progressed anteriorly from occipital lobe. BOLD suppression to visual stimulus spread at a rate of 3.5 mm/min and did not cross parieto-occipital sulcus. In addition, the scintillations were compatible with the retinotopy of the occipital cortex [35]. The latter case report provides the main imaging support for the existence of CSD during visual aura in humans. BOLD amplitude reduction was also detected during a migraine visual aura consisting of a scotoma with flickering zig zag border and was considered as a supportive finding for CSD [37].

In conclusion, variable degrees of oligemia are reported during migraine aura symptoms in a distribution correlated with clinical symptoms. However, significant data also shows that oligemia and aura symptoms occur independently, as focal, global/bilateral hypoperfusion may accompany monosymptomatic auras or can be detected without any clinical symptoms of aura. Moreover, migraine headache without aura is reported to be associated with spreading occipital oligemia [48, 49] or with no perfusion defects at all [47].

Drug effects on CSD induced TNC activation and CSD susceptibility provides further supportive evidence for CSD in migraine

Acute administration of migraine abortive drugs, such as sumatriptan or CGRP receptor antagonists, reduce CSD induced TNC activation in rodents [12, 20, 30]. None of the available drugs can completely block the CSD waves, however, they reduce the number and amplitude of CSDs and alter the CSD threshold. Abortive medications such as sumatriptan do not have any effect on CSD [50] but able to reduce the c-fos activation in TNC induced by CSD.

Preventive drugs are shown to reduce CSD susceptibility in vivo even though they have different mechanism of actions. In a study that evaluated the effectiveness of anti-migraine agents in the prevention of CSD using laser Doppler flowmetry in cats, a single dose of dihydroergotamine, acetylsalicylic acid, lignocaine, metoprolol, clonazepam or valproate was not able to inhibit CSD, did not reduce the propagation rate or alter the amplitude of the increase in cortical blood flow [51]. However, in another study, a single dose of topiramate was shown to prevent mechanically-induced CSD 30 min after the administration [52]. On the other hand, chronic administration of valproate, propranolol, amitriptyline, topiramate and methysergide dose dependently reduced CSD frequency and increased the electrical stimulation threshold [53]. Furthermore a later study also confirmed that chronic administration of topiramate (once-daily for 6 weeks) inhibited KCl-induced CSD frequency and propagation [54].

Lamotrigine suppressed CSDs in rat brain [55], and reduced migraine with aura attacks in open-label un-controlled studies however, it did not exert any preventive effect in migraine without aura patients in controlled trials [56,57,58,59,60]. Tonabersat, an antiepileptic drug with prominent CSD and gap junction inhibiting properties was shown to have preventive effect on attacks of migraine aura [61] however it had no clear benefit on migraine headache days [61, 62]. A NMDA receptor blocker MK-801 was shown to inhibit CSDs in rodents. Another NMDA receptor antagonist, ketamine, was found effective in the treatment of prolonged aura symptoms but not the headache [63, 64].

What are the gaps in translating CSD to migraine with aura?

CSD could explain some features of migraine but following unresolved points needs to be addressed.

Occurrence of migraine headache ipsilateral to the visual and /or sensorimotor aura symptoms cannot be explained by CSD in the human cerebral cortex

In rat brain CSD in pain insensitive brain parenchyma was linked to unilateral headache development through the activation of dural perivascular trigeminal nociceptors overlying the cerebral cortex, and neurons in the trigeminal ganglion and trigeminal nucleus caudalis all in the same hemisphere [12]. Trigemino-autonomic reflex arc was also induced by CSD in the same hemisphere. The study provided a mechanism to understand how aura and headache are related through peripheral pathway by trigeminal nerve mediated blood flow increase in MMA and dural neurogenic edema in anesthesized rats. By applying this theory to human conditions, aura symptoms as a result of CSD in one hemisphere are expected to occur contralateral to the headache side. In clinical practice this is not the rule and significant proportion of patients exhibit symptoms that do not meet that assumption. In fact, aura symptoms originating from one hemisphere and unilateral migraine headache located to the other hemisphere were reported in many clinical studies. Studies reporting ipsilateral distribution of neurological dysfunction and headache are summarized below.

  1. a)

    In a detailed study of 111 migraine with aura patients, Peatfield and colleagues reported that somatosensory aura symptoms such as paresthesia were on the same side as headache in approximately half of the patients [40]. Fifty percent ipsilaterality is a very high proportion particularly for somatosensory aura symptoms as its laterality is more reliably defined. When all aura symptoms were considered, about two-thirds of 111 patients manifested neurological symptoms originating from one cerebral hemisphere and headache developed in the opposite hemisphere [40].

    Manzoni and colleagues published a study in which paresthesia was reported by 30% of 164 patients and most of them had a cheiro-oral distribution [39]. Unilateral paresthesia was ipsilateral to the headache in approximately 40% of 49 migraine patients with sensory aura [39]. Similar ipsilaterality of somatosensory symptoms and migraine headache was also notable in 4 out of 9 cases reported by Lauritzen [45], where rCBF was measured by Xenon through an intracarotid catheter. Paresthesia and numbness ipsilateral to the headache side were reported in 23% of 84 patients with somatosensory aura in the study conducted by Bruyn et al. [43] and in also other series [41, 42]. Unfortunately, the laterality of 162 aura symptoms and headache was not given in a prospective study [38].

    Among 76 unilateral migraine headache and visual auras, headache was ipsilateral to the visual aura symptoms in 22% [44]. Though visual aura and migraine headache contralaterality was reported in only 8–16% of the patients [44, 65].

  1. b)

    Language is lateralized to the left hemisphere in most right handed individuals and aphasia due to right hemispheric disorder in a dextral person is called crossed aphasia which is a rare condition with a prevalence of 1–4% in healthy individuals. Martins reported 7 right handed migraine with aura patients who developed left sided paresthesia and/or hemianopsia in addition to aphasia [66]. Nine out of 22 right handed dysphasic migraineurs had both headache and paresthesia on the right side, 5 exhibited both symptoms on the left side. Only 2 right handed dysphasic patients developed left sided migraine headache and right sided paresthesia [40]. Language problem of aphasic type occurred as an aura in 28 migraine patients and aphasic disturbances were contralateral to the prevailing hemisphere in 30% of patients studied by Manzoni and colleagues [39].

    Sensory aura symptoms on the left side accompanied by dysphasic symptoms were also defined by others [45]. These findings are not compatible with the notion that aura symptoms and headache are due to canonical CSD in one cerebral cortex.

    Above reports indicate that the theory of ‘typical CSD in human cerebral cortex cause unilateral headache via direct activation of overlying dural trigeminal nerve endings and trigeminal neurons in the same hemisphere’ has flaws to explain migraine with aura attacks in significant proportion of patients. The ipsilateral localization of headache and aura symptoms do not match canonical CSD features.

Bilateral aura symptoms cannot be justified by canonical CSD in the human cerebral cortex

Propagation of CSD requires intact contiguous neural elements in the gray matter and is limited by subcortical white matter in addition to major sulci and large arteries in gyrencephalic brain. Once initiated, CSD propagates within the same hemisphere [12, 13, 67]. In Leao and Morison’s [68] experiments in rabbit brain‚ stronger electrical stimulation in the frontal cortex was able to induce depressing effect in the homolog area via crossing axons. This phenomenon is dissimilar to the propagation of conventional CSD to contralateral hemisphere and authors concluded that it was immediate result of the electrical stimulus passing through the crossing fibers in the callosum. Leao [1] reported that ‘a wave of depression started in the stimulated hemisphere and did not spread to the opposite side’. There is no report for canonical CSD propagating to the other hemisphere. On the contrary, many studies concluded that CSD did not affect the other hemisphere [1, 8, 12, 13, 19, 20, 23, 30, 67].

Therefore, the manifestation of bilateral aura symptoms cannot be explained by CSD crossing the callosal fibers to the other hemisphere. Canonical SD in the cortex does not invade two separate cortical sensory areas simultaneously.

Emergence of visual and somatosensory auras simultaneously or sensory auras that begin in the visual field and continue with somatosensory and language dysfunctions cannot be justified by the propagation of canonical CSD in the human cerebral cortex

In great majority of patients presenting with both visual and somatosensory aura, visual disturbances appeared first and paresthesias appeared later. Recent records of 162 auras prospectively collected [38] showed that single aura symptom was visual in 97% of the patients, while auras consisting of two symptoms were visual followed by somatosensory in 81% of the patients. The second symptom started concurrently with the first aura symptom in 35% or on the course of the first symptom in 37% of the patients. Only in 5% of the patients, did the second aura started after the first symptom ceased [38]. Regarding the duration, most of the visual aura symptoms (≈60%) lasted between 11 and 30 min [38]. Manzoni and colleagues reported that the average duration of aura was less than 30 min in 76% of the cases [39]. Dysphasia symptom, always followed visual and/or sensory auras, generally lasted less than 10 min [38]. For instance, hemianopsia and aphasic aura characterized by anomia and semantic paraphasia lasted 10 min in migraine patients [59].

Furthermore, considering the distance that CSD has to travel with the time interval between aura symptoms the issue gets more complex. Even in a flattened macaque brain the distance from V1 to somatosensory cortex is 100–120 mm [69]. The distance between occipital pole and central sulcus in surface reconstructed/flattened human cortex is approximately 250 mm [70]. A wave of CSD from visual areas to sensorimotor cortex or language areas should march faster than 10–25 mm/min. Such a high speed was never detected in any species. The usual propagation rate is between 2 and 6 mm/min for any CSD in mammalian cerebral cortex, which would take approximately 42 to 125 min for CSD to travel such a distance. The concomitant manifestation of visual and somatosensory aura symptoms is inconsistent with march, although simultaneous manifestations of CSD at two non-contiguous sites remains possible.

Additionally, the somatosensory symptoms typically manifest as cheiro-oral syndrome (ipsilateral fingertips and per oral distribution). Cheiro-oral somatosensory aura symptoms start as tingling sensation or pins and needles from acral part of digits and propagate to wrist, and involve lips and tongue. In the cortical sensory homonculus, each digit is oriented in a caudo-rostral direction with 10–20 mm apart, where the acral part lies rostrally and there is 20–30 mm distance between face area and digits [71, 72]. Prospective studies also showed that somatosensory aura follows and/or accompanies visual aura in great majority of attacks [38]. Accordingly, the involvement of distal parts of the fingers and perioral area, tongue and palate while skipping the head, forehead, eyes, and nose in the cortical sensory homonculus seems impossible, as CSD waves are considered to travel rostrally from occipital cortex in a continuous manner. This is not compatible with hand and finger somatotopy in the cortical homonculus [72].

Canonical CSD propagating through the cortex would also be expected to invade other areas between visual and somatosensory cortex and yield symptoms such as acalculia, agraphia, finger agnosia, and right–left disorientation, contraversive eye deviation, buzzing noise in regard to data from cortical stimulation studies in human [73]. The majority of somatosensory aura last 11–20 min [38]. In the light of the above data, somatosensory symptoms starting simultaneously with visual aura symptoms or while visual aura symptoms still continue, do not match the known properties of canonical CSD phenomenon, unless they start in more than one place at the same time, triggered by other events. For example, decreased cortical noradrenergic signaling from locus ceruleus (LC) was shown to reduce the threshold for CSD induction [74]. Considering the pontine dysfunction in the premonitory phase and noradrerenergic projections to the entire brain, LC involvement could provide explanation for some clinical features.

If a SD like event travels in a restricted manner along a gyrus or sulcus, how does a CSD in the visual cortex manifest as a visual aura and travel to the somatosensory cortex causing paresthesia within 20 min? Or how do visual and somatosensory cortical dysfunction occur simultaneously?

CSD is limited to a few gyri in the primate brain however for multiple aura symptoms to occur sequentially, CSD should propagate over numerous sulci along the human cerebral cortex. Simultaneous occurrence of visual and somatosensory auras in the majority of patients needs to be explained with a process other than spreading depolarization waves continuously traversing along the cerebral cortex.

Canonical CSD in human cerebral cortex during migraine aura has not been proved electrophysiologically

DC shift, suppressed ECoG/ electrical silence and consequent loss of neurological function, lasting minutes, within the involved cerebral cortical area are key features of CSD. CSD is hardly induced in healthy, metabolically uncompromised primate brain [75,76,77]. This is opposite to the experimental findings in lissencephalic brains where CSD can easily be induced by many ways and invades the whole hemisphere. Many patients with awake cortical mapping reported no dysfunction lasting minutes resembling CSD. CSD or its functional consequences were not reported in those awake neurosurgical procedures [76]. However even electrophysiological mapping studies of the human cortex in epileptic /tumor surgery did not reveal any phenomenon resembling canonical CSD seen in rodent brain [78]. McLachlan reported that he could not elicit CSD in the human cerebral cortex of 23 patients using chemical, mechanical or electrical stimulation including intracortical KCl injection while similar approaches easily induced CSD waves in the rat brain [75]. In humans, SD waves on the other hand are easily recognized in damaged cerebral cortex due to hemorrhage, trauma or severe ischemia [6]. Even if CSD is induced, its propagation is easily blocked or limited to a few gyri in primates and humans [36, 77]. Indeed, mapping of a migraine aura onto the visual cortex suggests that the event underlying visual aura can travel along a single gyrus or sulcus [36]. Likewise, electrophysiological hallmarks of canonical CSD have not been detected convincingly in migraine.

MEG DC shifts were reported in migraine brain while they were also detected in the control group with lower amplitudes [79, 80]. However it was barely convincing that those changes were due to an underlying CSD in the occipital cortex. MEG DC shifts were not specified to the aura period but were also observed during headache and interictal periods [79]. The aura symptoms and their duration, lateralization and retinotopic correlation were not defined in the subjects and spreading nature were not shown [79, 80].

MEG DC shifts were widely distributed in both hemispheres particularly in occipito- parieto-temporal cortices in migraine patients. During the spontaneous attacks in migraine with aura patients, greater activation was detected in the occipito-parieto-temporal association cortices instead of primary visual cortex, though, the visual stimulation induced activation was clearly seen in the occipital cortex [80]. MEG DC shifts were more pronounced in the occipito-parietal-temporal, higher order association cortices while occipital cortex has very low activation even during the early stages of aura/HA [80]. Those changes therefore cannot indicate an underlying CSD.

Detecting MEG DC shifts alone cannot be taken as a proof of CSD, considering the fact that DC shifts in the MEG and /or EEG are also detected during cortical activation by auditory stimuli [81], cognitive tasks, changes in vigilance states, changes in brain CO2 levels, shifts of attention, hyperventilation [82], hemodynamic changes [83, 84] sensory stimulation, finger movements [85] or epileptic seizures [86,87,88]. MEG DC shifts have a good localizing value for epileptic seizures and they are timely locked to neuronal activity in the higher frequencies. Infraslow oscillations in the DC range are believed to represent a slow modulation of gross cortical excitability [89]. Additionally generation of infraslow oscillations likely involves thalamic networks and/or astrocytic calcium waves [90, 91]. MEG DC shifts in the migraine brain could indicate cortical hyper-excitability and also be associated with these factors.

The failure to show electrical imprint of CSD in migraine patients could be related to the fact that CSD is limited to a relatively few number of gyri in human cortex under normal physiological conditions. The latter is somehow contradictory, when oligemia progressing almost in the whole hemisphere is accepted as a result of CSD in migraine brain.

The occurrence of aura and headache without any temporal relationship, or aura without any pain, is not compatible with conventional notion of CSD

If the CSD induced depolarization occurs only a single or a few gyri in human brain, the area of activated trigeminal perivascular nerve endings in the overlying dura mater would be inadequate to fire trigeminal neurons for the development of lateralized head pain.

In animal models nociceptive and vasoactive substances released during CSD diffuse to the dura mater and induce trigeminal nerve endings and lead to the activation of the trigeminal ganglion and trigeminal 2nd order pain neurons in the ipsilateral hemisphere. However, most of the migraine attacks occur without aura and aura may occur without headache in 10% of patients [38, 44]. Furthermore, headache may even start before aura (9%) or emerge simultaneously with aura (14%) [38]. A prospective study reported that in only 36% of the attacks, headache started with an interval after the end of aura [38]. Prospective clinical studies also prove that aura and headache can occur any time and no temporal relationship exists between them [36, 38]. CSD in the gyrencephalic cerebral cortex is limited to a few gyri and can only activate a very limited portion of trigeminal nociceptors in the dura mater and MMA, therefore headache development secondary to the aforementioned process is very unlikely.

CSD associated vascular reactivity changes do not match the rCBF/BOLD alterations detected in migraine patients

It is critical to note that CSD induced vascular reactivity has species differences. For example, initial rCBF decrease accompanies DC shift in mice, followed by hyperemia phase and post SD oligemia. On the other hand, focal hyperemia was recorded in primate CSD models while long-term hypoperfusion/or persistent hypoperfusion was not detected [77]. Additionally, in vivo whole-cell recordings showed that the neuronal silencing after CSD was due to reduced spontaneous synaptic activity and AP firing. Significant reduction in the spontaneous excitatory and inhibitory postsynaptic potentials lasted more than 90 min [13] yielding an imbalance towards inhibitory tone. Therefore, the hyperemia phase coincides with the neuronal silence in the cerebral cortex. In other words, if the hyperemia detected in the migraine brain is due to a canonical CSD, then it should be associated with suppressed neuronal activity and possibly negative symptoms. Moreover, if the initial depolarization phase is missed by EEG studies then the detected hyperemia phase should be associated with negative symptoms.

Lauritzen and colleagues reported clinical features and rCBF measurements in patients who developed migraine with aura attacks after the introduction of a catheter into the internal carotid artery. Spreading occipital oligemia observed in all patients with approximately at a rate of 2 mm/min did not cross the lateral or central sulcus but appeared in the frontal lobe as well. Remarkably hemispheric blood flow changes were not correlated with lateralization, localization and /or beginning of aura symptom,e.g. during the oligemia spreading through the temporal, parietal and frontal lobes, paresthesia was the only symptom, oligemia lasted quite longer than the focal neurological symptoms or the left hemispheric rCBF changes resulted in left sided focal symptoms [45]. Therefore, spreading oligemia was concluded not to be associated with aura symptoms spatially and temporally and not to be the cause of focal symptoms in migraine aura [45]. So, oligemia begins before the aura and outlasts the aura symptoms and has no resemblence with CSD except for the propagating speed of approximately 2 mm/min [9, 45].

Later studies reported reduced cerebral blood flow, volume or perfusion in the symptomatic occipital cortex during visual aura [46]. Blood flow changes were usually not detected in migraine patients without aura [47], although Gelmers et al. reported focal oligemia in two migraine without aura patients [92] and Woods et al. reported bilateral occipitotemporal oligemia in one migraine without aura patient [48].

Apparent diffusion coefficient (ADC) decrease with DC shift reflects water movement during cellular depolarization. Transient regional hyperperfusion and post-CSD oligemia were also demonstrated by MRI in rats [93]. ADC decline and diffusion-weighted imaging (DWI) changes reported during CSD in animal studies [93, 94] were never detected in human studies even when rCBF was reduced to 53% during a visual aura or in FHM patients with prolonged neurological deficits [46, 95]. Similarly, BBB remains intact during migraine attacks in contrast to the CSD experiments in rodents [28, 96].

The majority of migraine patients exhibit positive visual and somatosensory symptoms [38, 65, 97, 98]. Positive visual symptoms were reported in 89% of the migraine patients [65]. Even though positive symptoms constitute the majority of aura symptoms, negative aura symptoms may also occur. Viana et al. reported [38] that 67% of visual aura included at least one positive phenomena whereas 38% of visual aura included at least one negative phenomena and 14% of the patients had negative sensory symptoms. In another study [99] blind spots were observed in 42% of the patients and tunnel vision was seen in 27%. Hartl et al. reported positive visual symptoms in 55.6% of the migraine patients while negative visual hallucinations were reported in 51.9% [97]. However, CSD research in lissencephalic brain show that light induced neuronal activity or synaptic evoked activity is reduced in parallel to the blood flow decrease manifesting negative symptoms. Actually, during the positive symptoms experienced as scintillations, BOLD response in the visual cortex is reduced [34, 49]. BOLD signal, an indirect measure of neuronal activation, reflects the excitatory and inhibitory post synaptic potential activity rather than spike activity. Increased synaptic activity leads to a positive BOLD response while decrease in local neural activity results in negative BOLD signal in the cerebral cortex [100,101,102]. Neural activity decrease is usually related to the activity of inhibitory interneurons [103] which is also compatible with the findings of whole cell recordings during CSD [13].

BOLD response to visual stimulus was decreased bilaterally, pronounced in V1, in a patient who developed flickering visual symptoms on the right side and throbbing feeling in the right hand followed by pricking sensation in the right arm. This is another example of dissociated aura symptoms and BOLD response in migraine [37]. Remarkably BOLD responses were increased in both hemispheres after sumatriptan, a drug that has no effect on CSD [37].

Both oligemia and hyperemia were shown in FHM2 patients. Multifocal hypoperfusion was prominent within the first 19 h (in 71.4% of the attacks) when the aura symptoms and headache were both present, and hyperperfusion developed after 18 h when neurological deficit still persisted and the headache was resolved in 89% of the attacks. Multifocal hypoperfusion detected during acute phase of hemiplegic migraine with prolonged aura is not compatible with canonical CSD propagation in the human cerebral cortex [88]. Cerebral metabolic rate of glucose (CMRGlu) increases with the DC shift in CSD experiments and returns to normal levels after about 15 min [104]. In FHM2 attacks, increased cerebral glucose metabolism was detected by FDG-PET in the regions corresponding to the areas of hyperperfusion on day 4 while aura symptoms still persisted.

Hypoperfusion as detected by delayed rMTT and TTP and decreased rCBF were reported in 14/20 migraine with aura patients who admitted to ER with the diagnosis of stroke [105]. Perfusion defects usually exceeding a single vascular territory, bilateral hypoperfusion (3 out of 14 patients) or whole hemispheric hypoperfusion resembling to severe stenosis of extracranial vessels (4 out of 14 patients) were detected in migraine patients. In a child case of confusional migraine attack with conjugate eye deviation, ASL CBF image revealed a reduction in rCBF in right occipito-parietal blood flow to 34 mL/min/100 g while rCBF was 210 mL/min/100 g on the contralateral occipito-parietal region [106]. ASL image of a migraine attack with bilateral headache revealed hypoperfusion in bilateral thalamus and hypothalamus and hyperemia in bilateral frontal convexity [107]. On the other hand MR imaging of 4 migraine patients during aura attacks did not reveal any abnormality in cerebral perfusion [108]. In Woods’ case, during a migraine without aura attack, bilateral hypoperfusion started from occipital pole gradually invading more rostral areas to temporal cortex [37, 48]. The PET images taken during a visual stimuli for 3 h showed an estimated blood flow decrease up to 40% which was not associated with any positive or negative neurological deficit or caused any aura symptoms on the way from occipital V1 to temporal pole [48]. Remarkably, oligemia propagated easily through parietooccipital sulcus and other sulci without any problem.

Vascular reactivity changes as an indirect way to observe neuronal changes does not provide a rational explanation for the occurrence of CSD or as a cause of CSD. Hemispheric oligemia solely cannot be accountable for a migraine headache development. The perfusion changes during and following migraine attacks seem to be variable though the predominant feature in the aura phase is accepted as a hypoperfusion which may extend into the headache phase. Hyperperfusion is proposed to occur during headache (HA) phase, which is also not a consistent finding.

Original rCBF studies did not support the notion that oligemia was associated with aura, on the contrary, it was concluded that oligemia propagating from posterior to anterior accompanied headache [9, 45, 48]. It seems that reduced blood flow alterations are not primarily responsible for aura symptoms. Neither hypoperfusion nor hyperperfusion are thoroughly correlated temporally or spatially with aura symptoms or headache. So the rCBF studies do not support a canonical CSD as an underlying cause and remain inconclusive for the development of migraine headache. The above arguments indicate a need for a more complex theory to rationalize those changes.

If the CSD induced activation of trigeminal nerve fibers around the MMA plays a key role in head pain development, then the migraine headache is expected to be localized more in the mandibular or maxillary branch of trigeminal nerve in humans

MMA particularly the proximal parts is densely and exclusively innervated by mandibular and maxillary branches of trigeminal nerve in humans [109,110,111]. The receptive field of the first branch, ophthalmic nerve does not include the proximal part of MMA. However, migraine headache is characterized by localization of pain to ophthalmic branch of trigeminal nerve and upper cervical nerves. Though some studies actually reported migraine pain in lower face [112], the MMA may not be a main determinant in migraine as it is shown in rodents. Supporting the latter notion, in spontaneous or provoked migraine attacks no dilation of extracranial arteries or MMA were detected in migraine patients [113, 114]. In cilostazol induced migraine attacks [115] increase in MMA was considered as a possible marker for activation of dural perivascular nociceptors, suggesting a meningeal site of migraine headache. Since the typical migraine headache is localized to the ophthalmic branch, C1 (intracranial) and C2 distribution (posterior part of the head), what would be the meaning of the MMA diameter change? If the MMA and/or its trigeminal innervation is a determinant in migraine then why the headache is not usually perceived in the maxillary or mandibular branch? CSD initiated sequence of events through dural trigeminal nerve fibers seems to have no translational correlate in humans.

Aura symptoms are not specific to migraine headache

Typical aura symptoms can accompany other conditions and primary headaches. For example presence of aura symptoms is reported in up to 25% of cluster headache patients [116, 117]. Their existence in other primary headaches lessens its causal relationship with migraine headache and suggests a possibility that aura could be an epiphenomenon in primary headaches.

CSD suppression is not required for effective migraine prevention

Recent progress on CGRP receptor antagonism by monoclonal antibodies that are effective in the prevention of both episodic and chronic migraine is very important. The monoclonal antibodies against CGRP or the CGRP receptors pass the blood-brain barrier minimally and are believed to exert their effect on the peripheral trigeminal structures. Up to 25% of patients are reported being 100% headache free for months. Those findings indicate that central mechanisms may not be required or CSD is not a triggering factor at least for those subgroup of patients. The tonabersat trial does not favor an initial role of CSD in migraine headache development in humans. Failure of patent foramen ovale (PFO) closure in migraine headache prevention is also notable since PFO is regarded as a triggering factor of aura [118].

Though many efficient migraine preventive agents are shown to reduce the frequency of KCl induced multiple CSD occurrence, CSD reducing properties are not predictive for drug effectivity in migraine prevention.

Alternative view to explain translational gaps of CSD in migraine

Hence the concept of canonical CSD waves that propagate strictly within the human cerebral cortex and cause aura symptoms and headache, has several shortcomings to justify manifestations of the migraine disorder, additional mechanisms and views are needed.

CSD could still occur in a restricted area in the migraineur’s cortex where the propagation of depolarizating waves are easily stopped and terminated, as shown in human cortex. However, the consequence of an unresponsive cortical focus should be taken into account in a context with thalamocortical oscillations and widespread brain network systems. Understanding of cerebral cortical function requires a knowledge of complex interaction of the thalamocortical network. The thalamus sends projections to almost all cerebral cortex, and the cortical region receiving projections from the thalamus, sends outputs to one or more thalamic nuclei, in return [119,120,121]. In that sense the thalamic nuclei can be considered as a first-order and higher-order relay nuclei. First-order thalamic nuclei, such as the lateral geniculate nucleus (LGN) and the ventral posterior (VP) nucleus, receive and relay inputs from ascending visual and somatosensory pathways to first order cortical areas [119, 120]. On the other hand, higher-order thalamic nucleus, receive inputs principally from the 5th layer of the cerebral cortex and relay information between different cortical areas [120]. Thereby, transthalamic cortico–cortical circuits can synchronize oscillations over cortical distances [18, 121].

Thalamus and cortex are in a continuous interaction in processing any information particularly related to sensory, motor, language, cognition and consciousness. Abrupt silence of cortical counterpart as a result of SD would result in an imbalance that needs to be filled/adjusted with the change of usual firing pattern of thalamic nuclei. CSD is estimated to be induced if a stimulus simultaneously depolarizes a minimum critical volume of 1 mm3 in rodent cortical brain tissue [122]. Even if its propagation is blocked, such a cortical focus is sufficient to create a change in ongoing cortico-thalamic drive on thalamic relay nuclei and thalamic reticular nucleus. For instance, sudden loss of excitatory drive on GABAergic TRN that inhibits other thalamic nuclei, would result in increased sensory excitation, reduced discrimination and reduced lateral inhibition. The latter findings were shown in migraine patients [123, 124]. In episodic migraine patients, a transient but robust prolongation in somatosensory temporal discrimination thresholds (STDTs) was shown during the migraine attacks whereas STDTs were normal in tension-type headache patients [123, 125]. The discrimination of the exact entry of sensory stimuli was disrupted in migraine attack, indicating an impairment in central somatosensory and cognitive processing [126].

The pulvinar in the dorsal thalamus contribute to the visual information processing and multimodal sensory integration [102]. A dysfunction in higher order thalamic relay nucleus such as pulvinar dysfunction may be related to positive visual hallucinations superimposed to a primary incoming information and could be more compatible with the patients’ visual auras. High levels of connectivity of pulvinar with the primary motor-sensory cortices, superior parietal gyrus, precuneus and visual cortex [127] are in favor of the latter view. Recently impaired sensorimotor integrity and reduced cortico-cortical inhibition between somatosensory and motor cortices were shown to be associated with migraine attacks [128]. Notably, facilitation of motor responses to a conditioned sensory stimulus was detected even several hours prior to headache onset. Therefore, the contribution of higher order thalamic nuclei to these changes seems irrefutable.

It is also probable that SD ignition in the cortex could induce SD in TRN [23], as subcortical structures are still relatively more vulnerable to SD compared to highly convoluted cerebral cortex in humans [129]. Majority of somatosensory aura symptoms are cheiro-oral type (paresthesia in the fingertips and perioral area, tongue and palate). Majority of cheiro-oral syndromes has been associated with thalamic or brain stem lesions [130]. Likewise, in the thalamic ventral posterior (VP) nucleus, the representation of the acral parts of all digits, the tongue and the lips in close proximity, is more compatible with paresthesia starting from distal parts of all digits moving proximally skipping upper arm, shoulder, head, forehead, eyes and nose [131]. Additionally, aphasia can also occur as a result of thalamic dysfunction [132] and thalamus was implicated in migraine [23, 133, 134]. Pontine and other brain stem projections from cholinergic and noradrenergic nuclei, LC to the thalamus provide multiple modulatory drive on thalamo-cortical interactions. Thalamic player in accordance with the cortex would enlighten positive aura symptoms and concurrent manifestation of different symptoms related to certain cortical areas such as visual, somatosensory, language and motor cortices connected through thalamic hub.

Conclusion

Migraine headache is a heterogeneous complex disorder and it seems implausible to propose single mechanism to elucidate sufficiently all clinical manifestations. Therefore, more than one mechanism and multiple locations must be considered in the development of migraine headache. While the canonical CSD could explain visual aura and following headache in certain population of patients, it has flaws in reasoning multiple sensory auras. It is also important to account thalamus as a hub that provides extensive connections among the visual, somatosensory, language and motor cortical areas. Emergence of SD in reticular nucleus or other locations in the thalamus could thereby rationalize some features of migraine. Additionally, including central pathways activated by thalamocortical dysfunction in the process of headache development would improve our understanding of migraine.

Availability of data and materials

Not applicable.

Abbreviations

ADC:

Apparent diffusion coefficient

CGRP:

Calcitonin-gene related peptide

CSD:

Cortical spreading depression

DC:

Direct current

FHM:

Familial hemiplegic migraine

HA:

Headache

LC:

Locus ceruleus

MMA:

Middle meningeal artery

NO:

Nitric oxide

rCBF:

Regional cerebral blood flow

STDT:

Somatosensory Temporal Discrimination Threshold

TNC:

Trigeminal nucleus caudalis

TRN:

Thalamic reticular nucleus

WT:

Wild type

References

  1. 1.

    Leao AAP, Morison RS (1945) Propagation of spreading cortical depression. J Neurophysiol 8(1):33–45

  2. 2.

    Ayata C, Lauritzen M (2015) Spreading depression, spreading depolarizations, and the cerebral vasculature. Physiol Rev 95(3):953–993

  3. 3.

    Herreras O, Large C, Ibarz JM, Somien GG, del Rio RM (1994) Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus. J Neurosci 14(11):7087–7098

  4. 4.

    Carlson AP, Abbas M, Alunday RL, Qeadan F, Shuttleworth CW (2018) Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial. J Neurosurg 1:1–7

  5. 5.

    Eriksen N, Rostrup E, Fabricius M, Scheel M, Major S, Winkler MKL et al (2019) Early focal brain injury after subarachnoid hemorrhage correlates with spreading depolarizations. Neurology 92:e1–e16

  6. 6.

    Dreier J, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J et al (2009) Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 132:1866–1881

  7. 7.

    Fabricius M, Fuhr S, Bhatia R, Boutelle M, Hashemi P, Strong AJ et al (2006) Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain. 129(3):778–790

  8. 8.

    Woitzik J, Hecht N, Pinczolits A, Sandow N, Major S, Winkler MK (2013) Propagation of cortical spreading depolarization in the human cortex after malignant stroke. Neurology. 80(12):1095–1102

  9. 9.

    Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9(4):344–352

  10. 10.

    Lashley KS (1941) Patterns of cerebral integration indicated by the scotomas of migraine. Arch Neurol Psychiatr 46:331–339

  11. 11.

    Bolay H, Moskowitz MA (2005) The emerging importance of cortical spreading depression in migraine headache. Rev Neurol (Paris) 161(6–7):655–657

  12. 12.

    Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8(2):136–142

  13. 13.

    Sawant-Pokam PM, Suryavanshi P, Mendez JM, Dudek FE, Brennan KC (2017) Mechanisms of neuronal silencing after cortical spreading depression. Cereb Cortex 27(2):1311–1325

  14. 14.

    Goadsby PJ, Kaube H, Hoskin K (1992) Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Res 595:167–170

  15. 15.

    Steriade M, Timofeev I (1997) Short-term plasticity during Intrathalamic augmenting responses in decorticated cats. J Neurosci 17(10):3778–3795

  16. 16.

    Shibata M, Bures J (1974) Functional decortication employing reverberating cortical spreading depression: experimental evaluation of advantages and limitations. Exp Neurol 45(3):415–423

  17. 17.

    Contreras D, Destexhe A, Steriade M (1997) Spindle oscillations during cortical spreading depression in naturally sleeping cats. Neuroscience. 77(4):933–936

  18. 18.

    Destexhe A, Contreras D, Steriade M (1999) Cortically-induced coherence of a thalamic-generated oscillation. Neuroscience. 92(2):427–443

  19. 19.

    Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Kocak E, Sen ZD et al (2013) Spreading depression triggers headache by activating neuronal Panx1 channels. Science. 339(6123):1092–1095

  20. 20.

    Moskowitz MA, Nozaki K, Kraig RP (1993) Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms. J Neurosci 13(3):1167–1177

  21. 21.

    Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R (2010) Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci 30(26):8807–8814

  22. 22.

    Lambert GA, Truong L, Zagami AS (2011) Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system. Cephalalgia. 31(14):1439–1451

  23. 23.

    Tepe N, Filiz A, Dilekoz E, Akcali D, Sara Y, Charles A, Bolay H (2015) The thalamic reticular nucleus is activated by cortical spreading depression in freely moving rats: prevention by acute valproate administration. Eur J Neurosci 41(1):120–128

  24. 24.

    Ingvardsen BK, Laursen H, Olsen UB, Hansen AJ (1997) Possible mechanism of c-fos expression in trigeminal nucleus caudalis following spreading depression. Pain. 72:407–415

  25. 25.

    Fioravanti B, Kasasbeh A, Edelmayer R, Skinner DP, Hartings JA, Burkland RD et al (2011) Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats. Cephalalgia. 31(10):1090–1100

  26. 26.

    Harriott A, Chung D, Takizawa T, Qin T, Ayata C. Recurrent Episodic Cortical Spreading Depressions Induce Trigeminal Allodynia and Anxiety Behavior. Neurology. 2019;92(15 Supplement):S20.006

  27. 27.

    Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AMJM, Moskowitz MA, Ayata C, Eikermann-Haerter K (2017) Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation. Brain. 140(6):1643–1656

  28. 28.

    Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H et al (2004) Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 113(10):1447–1455

  29. 29.

    Green AL, Gu P, De Felice M, Dodick D, Ossipov MH, Porreca F (2014) Increased susceptibility to cortical spreading depression in an animal model of medication-overuse headache. Cephalalgia. 34(8):594–604

  30. 30.

    Filiz A, Tepe N, Eftekhari S, Boran HE, Dilekoz E, Edvinsson L, Bolay H (2019) CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior. Cephalalgia. 39(3):354–365

  31. 31.

    Doganay Aydin H, Vuralli D, Akcali DT, Bolay H (2017) Metoclopramide inhibits trigeminovascular activation:evidence for effective acute attack treatment in migraine. Turk J Med Sci 47(1):343–334

  32. 32.

    Tottene A, Conti R, Fabbro A, Vecchia D, Shapovalova M, Santello M, van den Maagdenberg AM, Ferrari MD, Pietrobon D (2009) Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in ca(v)2.1 knockin migraine mice. Neuron. 61(5):762–773

  33. 33.

    Chanda ML, Tuttle AH, Baran I, Atlin C, Guindi D, Hathaway G et al (2013) Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice. Pain. 154(8):1254–1262

  34. 34.

    Langford DJ, Bailey AL, Chanda ML, Clarke SE, Drummond TE, Echols S et al (2010) Coding of facial expressions of pain in the laboratory mouse. Nat Methods 7(6):447–449

  35. 35.

    Hadjikhani N, Sanchez del Rio M, Wu O, Schwartz D, Bakker D, Fischl B et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. PNAS. 98(8):4687–4692

  36. 36.

    Hansen JM, Baca SM, VanValkenburgh P, Charles A (2013) Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording. Brain. 136:3589–3595

  37. 37.

    Arngrim N, Hougaard A, Ahmadi K, Vestergaard MB, Schytz HW, Amin FM et al (2017) Heterogenous migraine Aura symptoms correlate with visual cortex functional magnetic resonance imaging responses. Ann Neurol 82:925–939

  38. 38.

    Viana M, Sances G, Linde M, Ghiotto N (2017) Guaschino1 E, Allena M, et al. clinical features of migraine aura: results from a prospective diary-aided study. Cephalalgia. 37(10):979–989

  39. 39.

    Manzoni GC, Farina S, Lanfranchi M, Solari A (1985) Classic migraine-clinical findings in 164 patients. Eur Neurol 24(3):163–169

  40. 40.

    Peatfield RC, Gawel MJ, Rose FC (1981) Asymmetry of the aura and pain in migraine. J Neurol Neurosurg Psychiatry 44:846–848

  41. 41.

    Guiloff RJ, Fruns M (1988) Limb pain in migraine and cluster headache. J Neurol Neurosurg Psychiatry 51:1022–1031

  42. 42.

    Bradshaw P, Parsons M (1965) Hemiplegic migraine, a clinical study. Q J Med 34:65–85

  43. 43.

    Bruyn GW, Weenink HR (1966) Migraine accompagnee,a critical evaluation. Headache. 6(1):1–22

  44. 44.

    Queiroz LP, Friedman DI, Rapoport AM, Purdy RA (2011) Characteristics of migraine visual aura in southern Brazil and northern USA. Cephalalgia. 31(16):1652–1658

  45. 45.

    Lauritzen M, Olsen TS, Lassen NA, Paulson OB (1983) Changes in blood flow of classic regional cerebral during the course migraine attacks. Ann Neurol 13:633–641

  46. 46.

    Cutrer FM, Sorensen AG, Weisskoff RM, Bstergaard L, Sanchez del Rio M, Lee EJ et al (1998) Perfusion-Weighted Imaging Defects During Spontaneous Migrainous Aura. Ann Neurol 43:25–31

  47. 47.

    Sanchez del Rio M, Bakker D, Wu O, Agosti R, Mitsikostas DD, Ostergaard L (1999) Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia. 19(8):701–707

  48. 48.

    Woods RP, Iacoboni M, Mazziotta JC (1994) Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 331(25):1689–1692

  49. 49.

    Cao Y, Welch KMA, Aurora S, Vikingstad EM (1999) Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 56(5):548–554

  50. 50.

    Read SJ, Hirst WD, Upton N, Parsons AA (2001) Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan. Brain Res 891(1–2):69–77

  51. 51.

    Kaube H, Goadsby PJ (1994) Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat. Eur Neurol 34(1):30–35

  52. 52.

    Akerman S, Goadsby PJ (2005) Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura. Neuroreport. 16:1383–1387

  53. 53.

    Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA (2006) Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 59(4):652–661

  54. 54.

    Unekawa M, Tomita Y, Toriumi H, Suzuki N (2012) Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats. Cephalalgia. 32:518–527

  55. 55.

    Bogdanov VB, Multon S, Chauvel V, Bogdanova OV, Prodanov D, Makarchuk MY, Schoenen J (2011) Migraine preventive drugs differentially affect cortical spreading depression in rat. Neurobiol Dis 41:430–435

  56. 56.

    D'Andrea G, Granella F, Cadaldini M, Manzoni GC (1999) Effectiveness of lamotrigine in the prophylaxis of migraine with aura: an open pilot study. Cephalalgia. 19:64–66

  57. 57.

    Lampl C, Buzath A, Klinger D, Neumann K (1999) Lamotrigine in the prophylactic treatment of migraine aura–a pilot study. Cephalalgia. 19:58–63

  58. 58.

    Lampl C, Katsarava Z, Diener HC, Limmroth V (2005) Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry 76:1730–1732

  59. 59.

    Steiner TJ, Findley LJ, Yuen AW (1997) Lamotrigine versus placebo in the prophylaxis of migraine with and without aura. Cephalalgia. 17:109–112

  60. 60.

    Gupta P, Singh S, Goyal V, Shukla G, Behari M (2007) Low-dose topiramate versus lamotrigine in migraine prophylaxis (the Lotolamp study). Headache. 47:402–412

  61. 61.

    Hauge AW, Asghar MS, Schytz HW, Christensen K, Olesen J (2009) Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. Lancet Neurol 8:718–723

  62. 62.

    Goadsby PJ, Ferrari MD, Csanyi A et al (2009) Randomized, double-blind, placebo controlled, proof-of-concept study of the cortical spreading depression inhibiting agent tonabersat in migraine prophylaxis. Cephalalgia. 29(7):742–750

  63. 63.

    Kudo C, Toyama M, Boku A et al (2013) Anesthetic effects on susceptibility to cortical spreading depression. Neuropharmacol. 67:32–36

  64. 64.

    Afridi S, Giffin NJ, Kaube H, Goadsby PJ (2013) A randomized controlled trial of intranasal ketamine in migraine with prolonged aura. Neurology. 80:642–647

  65. 65.

    Queiroz LP, Rapoport AM, Weeks RE, Sheftell FD, Siegel SE, Baskin SM (1997) Characteristics of migraine visual aura. Headache. 37(3):137–141

  66. 66.

    Martins IP (2007) Crossed aphasia during migraine aura: transcallosal spreading depression? J Neurol Neurosurg Psychiatry 78(5):544–545

  67. 67.

    Kuge Y, Hasegawa Y, Yokota C, Minematsu K, Hashimoto N (2000) Effects of single and repetitive spreading depression on cerebral blood flow and glucose metabolism in cats: a PET study. J Neurol Sci 176:114–123

  68. 68.

    Leao AAP (1944) Spreading depression of activity in the cerebral cortex. J Neurophysiol 7:359–390

  69. 69.

    Sincich LC, Adams DL, Horton JC (2003) Complete flatmounting of the macaque cerebral cortex. Vis Neurosci 20:663–686

  70. 70.

    Van Essen DC, Drury HA (1997) Structural and functional analyses of human cerebral cortex using a surface-based atlas. J Neurosci 17(18):7079–7102

  71. 71.

    Huang RY, Chen C, Tranc AT, Holstein KL, Sereno MI (2012) Mapping multisensory parietal face and body areas in humans. PNAS. 109(44):18114–18119

  72. 72.

    Roux FE, Djidjeli I, Durand JP (2018) Functional architecture of the somatosensory homunculus detected by electrostimulation. J Physiol 596(5):941–956

  73. 73.

    So EL, Alwaki A (2018) A guide for cortical electrical stimulation mapping. J Clin Neurophysiol 35(2):98–105

  74. 74.

    Vila-Pueyo M, Strother LC, Kefel M, Goadsby PJ, Holland PR (2019) Divergent influences of the locus coeruleus on migraine biology. Pain. 160:385–394

  75. 75.

    McLachlan RS, Girvin JP (1994) Spreading depression of Leao in rodent and human cortex. Brain Res 666:133–136

  76. 76.

    Gloor P (1986) Migraine and regional cerebral blood flow. Trends in Neuroscience 9:21

  77. 77.

    Yokota C, Kuge Y, Hasegawa Y, Tagaya M, Abumiya T, Ejima N et al (2002) Unique profile of spreading depression in a primate model. J Cereb Blood Flow Metab 22:835–842

  78. 78.

    Piper RD, Matheson JM, Hellier M, Vonau M, Lambert GA, Olausson B et al (1991) Cortical spreading depression is not seen intraoperatively during temporal lobectomy in humans. Cephalalgia. 11(Suppl 11):1

  79. 79.

    Barkley GL, Tepley N, Nagel-Leiby S, Moran JE, Simkins RT, Welch KMA (1990) Magnetoencephalographic studies of migraine. Headache. 30:428

  80. 80.

    Bowyer SM, Aurora KS, Moran JE, Tepley N, Welch KM (2001) Magnetoencephalographic fields from patients with spontaneous and induced migraine aura. Ann Neurol 50(5):582–587

  81. 81.

    Mackert BM, Wübbeler G, Burghoff M, Marx P, Trahms L, Curio G (1999) Non-invasive long-term recordings of cortical 'direct current' (DC-) activity in humans using magnetoencephalography. Neurosci Lett 273(3):159–162

  82. 82.

    Voipio J, Tallgren P, Heinonen E, Vanhatalo S, Kaila K (2003) Millivolt-scale DC shifts in the human scalp EEG: evidence for a nonneuronal generator. J Neurophysiol 89(4):2208–2214

  83. 83.

    Mackert BM (2004) The discovery of slowness--recent progress in DC-MEG research. Neurol Clin Neurophysiol 2004, 41

  84. 84.

    Vanhatalo S, Tallgren P, Becker C, Holmes MD, Miller JW, Kaila K, Voipio J (2003) Scalp-recorded slow EEG responses generated in response to hemodynamic changes in the human brain. Clin Neurophysiol 114(9):1744–1754

  85. 85.

    Mackert BM, Wübbeler G, Leistner S, Trahms L, Curio G (2001) Non-invasive single-trial monitoring of human movement-related brain activation based on DC-magnetoencephalography. Neuroreport. 12(8):1689–1692

  86. 86.

    Rodin EA, Taulu SJ, Funke ME, Johnson MB, Bornfleth H, Constantino TM (2016) Magnetoencephalographic Infraslow activity: a feasibility study. J Clin Neurophysiol 33(4):350–358

  87. 87.

    Rodin E, Modur P (2008) Ictal intracranial infraslow EEG activity. Clin Neurophysiol 119(10):2188–2200

  88. 88.

    Leistner S, Sander T, Burghoff M, Curio G, Trahms L, Mackert BM (2007) Combined MEG and EEG methodology for non-invasive recording of infraslow activity in the human cortex. Clin Neurophysiol 118(12):2774–2780

  89. 89.

    Vanhatalo S, Palva JM, Holmes MD, Miller JW, Voipio J, Kaila K (2004) Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. Proc Natl Acad Sci U S A 101(14):5053–5057

  90. 90.

    Dietzel I, Heinemann U, Lux HD (1989) Relations between slow extracellular potential changes, glial potassium buffering, and electrolyte and cellular volume changes during neuronal hyperactivity in cat brain. Glia. 2(1):25–44

  91. 91.

    Lörincz ML, Geall F, Bao Y, Crunelli V, Hughes SW (2009) ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks. PLoS One 4(2):e4447

  92. 92.

    Gelmers HJ (1982) Common migraine attacks preceded by focal hyperemia and parietal Oligemia in the rCBF pattern. Cephalalgia. 2(1):29–32

  93. 93.

    de Crespigny A, Röther J, van Bruggen N, Beaulieu C, Moseley ME (1998) Magnetic resonance imaging assessment of cerebral hemodynamics during spreading depression in rats. Cereb Blood Flow Metab 18:1008–1017

  94. 94.

    Bockhorst KHJ, Smith JM, Smith MI, Bradley DP, Houston GC, Carpenter TA et al (2000) A quantitative analysis of cortical spreading depression events in the feline brain characterized with diffusion weighted MRI. J Magn Reson Imaging 12:722–733

  95. 95.

    Iizuka T, Tominaga N, Kaneko J, Sato M, Akutsu T, Hamada J et al (2015) Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2. J Neurol Neurosurg Psychiatry 86:344–353

  96. 96.

    Amin FM, Hougaard A, Cramerb SP, Christensen CE, Wolfram F, Larsson HBW et al (2017) Intact blood brain barrier during spontaneous attacks of migraine without aura: a 3T DCE-MRI study. Eur J Neurol 24:1116–1124

  97. 97.

    Hartl E, Gonzalez-Victores JA, Remi J, Schankin CJ, Noachtar S (2017) Visual auras in epilepsy and migraine - an analysis of clinical characteristics. Headache. 57(6):908–916

  98. 98.

    Borgdorff P (2018) Arguments against the role of cortical spreading depression in migraine. Neurol Res 40(3):173–181

  99. 99.

    Hansen JM, Goadsby PJ, Charles AC (2016) Variability of clinical features in attacks of migraine with aura. Cephalalgia. 36(3):216–224

  100. 100.

    Shmuel A, Augath M, Oeltermann A, Logothetis NK (2006) Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nat Neurosci 9(4):569–577

  101. 101.

    Pasley BN, Inglis BA, Freeman RD (2007) Analysis of oxygen metabolism implies a neural origin for the negative BOLD response in human visual cortex. Neuroimage. 36(2):269–276

  102. 102.

    Devor A, Ulbert I, Dunn AK, Narayanan SN, Jones SR, Andermann ML et al (2005) Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proc Natl Acad Sci U S A 102:3822–3827

  103. 103.

    Lauritzen M, Mathiesen C, Schaefer K, Thomsen KJ (2012) Neuronal inhibition and excitation, and the dichotomic control of brain hemodynamic and oxygen responses. NeuroImage. 62(2):1040–1050

  104. 104.

    Lauritzen M, Diemer NH (1986) Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain. Brain Res 370(2):405–408

  105. 105.

    Floery D, Vosko MR, Fellner FA, Fellner C, Ginthoer C, Gruber F et al (2012) Acute-onset Migrainous Aura mimicking acute stroke: MR perfusion imaging features. AJNR Am J Neuroradiol 33(8):1546–1552

  106. 106.

    Kossorotoff M, Calmon R, Grevent D, Gitiaux C, Desguerre I, Heilbronner C et al (2013) Arterial spin labeling (ASL) magnetic resonance imaging in acute confusional migraine of childhood. J Neuroradiol 40(2):142–144

  107. 107.

    Kato Y, Araki N, Matsuda H, Ito Y, Suzuki C (2010) Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan. J Headache Pain. 11:255–258

  108. 108.

    Jäger HR, Giffin NJ, Goadsby PJ (2004) Diffusion- and perfusion-weighted MR imaging in persistent migrainous visual disturbances. Cephalalgia 25:323–332

  109. 109.

    Schueler M, Neuhuber WL, De Col R, Messlinger K (2014) Innervation of rat and human dura mater and pericranial tissues in the parieto-temporal region by meningeal afferents. Headache. 54(6):996–1009

  110. 110.

    Lee SH, Hwang SJ, Koh KS, Song WC, Han SD (2017) Macroscopic innervation of the dura mater covering the middle cranial Fossa in humans correlated to neurovascular headache. Front Neuroanat 11:127

  111. 111.

    Kemp WJ 3rd, Tubbs RS, Cohen-Gadol AA (2012) The innervation of the cranial dura mater: neurosurgical case correlates and a review of the literature. World Neurosurg 78(5):505–510

  112. 112.

    Yoon MS, Mueller D, Hansen N, Poitz F, Slomke M, Dommes P, Diener HC, Katsarava Z, Obermann M (2010) Prevalence of facial pain in migraine: a population-based study. Cephalalgia. 30(1):92–96

  113. 113.

    Schoonman GG, van der Grond J, Kortmann C, van der Geest RJ, Terwindt GM, Ferrari MD (2008) Migraine headache is not associated with cerebral or meningeal vasodilatation-a 3T magnetic resonance angiography study. Brain. 131(Pt 8):2192–2200

  114. 114.

    Amin FM, Asghar MS, Hougaard A, Hansen AE, Larsen VA, de Koning PJ et al (2013) Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol 12(5):454–461

  115. 115.

    Khan S, Amin FM, Christensen CE, Ghanizada H, Younis S, Olinger ACR, de Koning PJH, Larsson HBW, Ashina M (2019) Meningeal contribution to migraine pain: a magnetic resonance angiography study. Brain. 142(1):93–102

  116. 116.

    Bahra A, May A, Goadsby PJ (2002) Cluster headache: a prospective clinical study with diagnostic implications. Neurology. 58(3):354–361

  117. 117.

    de Coo IF, Wilbrink LA, Ie GD, Haan J, Ferrari MD (2018) Aura in cluster headache: a cross-sectional study. Headache. 58(8):1203–1210

  118. 118.

    Tobis JM, Charles A, Silberstein SD, Sorensen S, Maini B, Horwitz PA et al (2017) Percutaneous closure of patent foramen Ovale in patients with migraine: the PREMIUM trial. J Am Coll Cardiol 70(22):2766–2774

  119. 119.

    Hwang K, Bertolero MA, Liu WB, D'Esposito M (2017) The human thalamus is an integrative hub for functional brain networks. J Neurosci 37(23):5594–5607

  120. 120.

    Sherman SM (2012) Thalamocortical interactions. Curr Opin Neurobiol 22(4):575–579

  121. 121.

    Sherman SM (2016) Thalamus plays a central role in ongoing cortical functioning. Nat Neurosci 19(4):533–541

  122. 122.

    Matsuura T, Bures J (1971) The minimum volume of depolarized neural tissue required for triggering cortical spreading depression in rat. Exp Brain Res 12:238–249

  123. 123.

    Boran HE, Cengiz B, Bolay H (2016) Somatosensory temporal discrimination is prolonged during migraine attacks. Headache. 56(1):104–112

  124. 124.

    Coppola G, Parisi V, Di Lorenzo C, Serrao M, Magis D, Schoenen J et al (2013) Lateral inhibition in visual cortex of migraine patients between attacks. J Headache Pain 14(1):20–31

  125. 125.

    Vuralli D, Boran HE, Cengiz B, Coskun O, Bolay H (2017) Somatosensory temporal discrimination remains intact in tension type Headcahe whereas it is disrupted in migraine attacks. Cephalalgia. 37(13):1241–1247

  126. 126.

    Vuralli D, Evren Boran H, Cengiz B, Coskun O, Bolay H (2016) Chronic migraine is associated with sustained elevation of somatosensory temporal discrimination thresholds. Headache. 56(9):1439–1447

  127. 127.

    Lambert C, Simon H, Colman J, Barrick TR (2017) Defining thalamic nuclei and topographic connectivity gradients in vivo. Neuroimage. 158:466–479

  128. 128.

    Alaydin HC, Vuralli D, Keceli Y, Can E, Cengiz B, Bolay H (2019) Reduced short-latency afferent inhibition indicates impaired sensorimotor integrity during migraine attacks. Headache. https://doi.org/10.1111/head.13554 [Epub ahead of print]

  129. 129.

    Sramka M, Brozek G, Bures J, Nádvorník P (1977-1978) Functional ablation by spreading depression: possible use in human stereotactic neurosurgery. Appl Neurophysiol 40(1):48–61

  130. 130.

    Chen WH (2009) Cheiro-oral syndrome: a clinical analysis and review of literature. Yonsei Med J 50(6):777–783

  131. 131.

    Combarros O, Polo JM, Pascual J, Berciano J (1991) Evidence of somatotopic organization of the sensory thalamus based on infarction in the nucleus ventralis posterior. Stroke. 22(11):1445–1447

  132. 132.

    Maeshima S, Osawa A (2018) Thalamic lesions and aphasia or neglect. Curr Neurol Neurosci Rep 18(7):39

  133. 133.

    Shields KG, Goadsby PJ (2005) Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine? Brain. 128:86–97

  134. 134.

    Andreou AP, Holland PR, Akerman S, Summ O, Fredrick J, Goadsby PJ (2016) Transcranial magnetic stimulation and potential cortical and trigeminothalamic mechanisms in migraine. Brain. 139(Pt 7):2002–2014

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Funding

The article-processing charges for the article has been sponsored by the European Headache Federation. HB is supported by the Turkish Academy of Sciences. PJG is supported by the NIHR SLaM Biomedical Research Centre and the Visual Snow Initiative.

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All authors conceived and designed the review, HB and DV drafted the manuscript and all authors revised it for intellectual content. All authors read and approved the final manuscript.

Correspondence to Hayrunnisa Bolay.

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Keywords

  • Cortical spreading depression
  • Migraine pathophysiology
  • Aura
  • Thalamus

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