Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial

Table 3 Duration of treatment period and compliance with stimulation during the treatment period

	Intention-to-treat analysis			Per protocol analysis
	1 Hz (n = 22)	25 Hz (n = 24)	Group comparison	1 Hz (n = 17)	25 Hz (n = 23)	Group comparison
Treatment period (days)	77.9 ± 25.8	85.7 ± 11.4	p = 0.22	89.0 ± 8.4	87.5 ± 7.5	p = 0.67
Average number of stimulated hours per day	3.42 ± 0.59	3.44 ± 0.61	p = 0.69	3.34 ± 0.62	3.44 ± 0.62	p = 0.51

Mean ± SD values are given. Treatment period indicates the number of days between visits 2 and 6. The average number of stimulated hours per day of the treatment period is given. Patients were requested to stimulate 4 h per day during the treatment period. The real average stimulation time per day was slightly lower

ISSN: 1129-2377