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Volume 16 Supplement 1

1st Joint ANIRCEF-SISC Congress

  • Invited speaker presentation
  • Open Access

Trigeminal neuralgia

The Journal of Headache and Pain201516 (Suppl 1) :A42

  • Published:


  • Multiple Sclerosis
  • Trigeminal Nerve
  • Trigeminal Neuralgia
  • Oxcarbazepine
  • General Practice Research Database

The International Association for the Study of Pain (IASP) defines trigeminal neuralgia as a sudden, unilateral, severe, brief, stabbing, recurrent episode of pain in the distribution of one or more branches of the trigeminal nerve. Trigeminal neuralgia (TN) can be distinguished in classical TN and symptomatic TN[1]. Classical TN is due to a vascular compression of the trigeminal root by tortuous or aberrant vessels. Symptomatic TN can be related to cerebello-pontine angle tumours which compress the trigeminal nerve root. Multiple sclerosis (MS) is typically associated with TN (2-4% of patients with TN)[2].

Whether produced by multiple sclerosis or chronic compression exerted by a blood vessel or a benign tumour, demyelination increases the susceptibility of the nerve fibres to ectopic excitation, ephaptic transmission, and high-frequency discharges. Although the primary cause of TN must necessarily affect the primary afferents, the pathophysiological mechanism may or may not secondarily involve the central neurons.

Recent epidemiological studies of general practice research databases reported a TN incidence ranging from 12.6 to 26.8 per 100.000/year, with the incidence increasing with age (16.3 in the fourth decade, 30.6 in patients older than 80 years)[3, 4].

Pain distribution is unilateral (bilateral TN may sometimes occur in MS). The maxillary division is the most frequently affected, both in classic and symptomatic TN. Pain, usually referred to as stabbing or electric-shock-like, is brief and paroxysmal, lasting a few seconds. Paroxysms may be provoked by stimulating cutaneous or mucous trigeminal territories (trigger zones), regardless of the distribution of the perceived pain.

Carbamazepine, still remains the gold standard drug with the highest success rate. The second drug of choice recommended by international guidelines is oxcarbazepine. In a comparison between these two drugs, efficacy was shown to be very similar but tolerability is better with oxcarbazepine[1].

Authors’ Affiliations

Department of Neurology and Psychiatry, University Sapienza, Rome, Italy


  1. Cruccu G, Gronseth G, Alksne J, Argoff C, Brainin M, Burchiel K, Nurmikko T, Zakrzewska JM, American Academy of Neurology Society; European Federation of Neurological Society: AAN-EFNS guidelines on trigeminal neuralgia management. Eur J Neurol. 2008, 15: 1013-1028. 10.1111/j.1468-1331.2008.02185.x.View ArticlePubMedGoogle Scholar
  2. Jensen TS, Rasmussen P, Reske-Nielsen E: Association of trigeminal neuralgia with multiple sclerosis: clinical and pathological features. Acta Neurol Scand. 1982, 65: 182-189.View ArticlePubMedGoogle Scholar
  3. Hall GC, Carroll D, Parry D, McQuay HJ: Epidemiology and treatment of neuropathic pain: the UK primary care perspective. Pain. 2006, 122: 156-162. 10.1016/j.pain.2006.01.030.View ArticlePubMedGoogle Scholar
  4. Koopman JS, Dieleman JP, Huygen FJ, de Mos M, Martin CG, Sturkenboom MC: Incidence of facial pain in the general population. Pain. 2009, 147 (1-3): 122-127.View ArticlePubMedGoogle Scholar


© Truini 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.


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