Skip to main content

Volume 16 Supplement 1

1st Joint ANIRCEF-SISC Congress

Laser evoked potentials and central sensitization in migraine

Migraine is a disabling disorder of neuro-vascular origin. An abnormal neuronal excitability, largely based on genetic nature, is a predisposing factor to attack onset. A reduced habituation to multimodal repetitive non nociceptive stimuli was observed in migraine. The pattern of reduced habituation to nociceptive stimuli may favor the increase of pain and the phenomena of central sensitization. Central sensitization is a phenomenon of pain processing, which may predispose to chronic pain. Allodynia occurring during migraine attack and persistent pericranial tenderness in migraine are symptoms of central sensitization[1, 2]. CO2 laser evoked potentials (LEPs) have been used in migraine research, proving very useful in demonstrating functional abnormalities of the central nociceptive system which might be linked to the pathophysiological mechanisms of this disease. Abnormalities of pain processing seem to characterize children with migraine. Reduced habituation and progressive amplification of cortical responses under laser stimuli indicate an overactive nociceptive system just at the onset of migraine, which may subtend symptoms of central sensitization as allodynia and pericranial tenderness. An abnormal pattern of habituation of the trigeminal nociceptive system is an endophenotypic marker of migraine[3], suggesting that the nociceptive system is prone to sensitization even before clinical appearance[4]. These aspects may guide therapeutic approach: in a recent work in which we explored the efficacy of botulinum toxin in the treatment of chronic migraine, we found a correlation of the clinical effect with an improvement of the LEPs habituation deficit. The modes of action of pharmacological or nonpharmacological interventions, such as neuromodulation methods, should therefore be reconsidered in terms of their ability to normalize the complex abnormalities of brain hyperresponsivity and the central sensitization phenomena.

References

  1. 1.

    Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R: Increased pain sensitivity is not a risk factor but a consequence of frequent headache: a population-based follow-up study. Pain. 2008, 137: 623-630. 10.1016/j.pain.2007.10.023.

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH: An association between migraine and cutaneous allodynia. Ann Neurol. 2000, 47: 614-624. 10.1002/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N.

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V, Di Piero V, Schoenen J: Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine?. Brain. 2007, 130[Pt 3]: 765-70.

    Article  Google Scholar 

  4. 4.

    de Tommaso M, Sciruicchio V, Ricci K, Montemurno A, Gentile F, Vecchio E, Foschino Barbaro MG, Simeoni M, Goffredo M, Livrea P: Laser evoked potentials habituation and central sensitization symptoms in childhood migraine. Cephalalgia. 2015.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Eleonora Vecchio.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vecchio, E., Sciruicchio, V., Ricci, K. et al. Laser evoked potentials and central sensitization in migraine. J Headache Pain 16, A17 (2015). https://doi.org/10.1186/1129-2377-16-S1-A17

Download citation

Keywords

  • Migraine
  • Botulinum Toxin
  • Migraine Attack
  • Central Sensitization
  • Chronic Migraine