Skip to main content

Management of chronic sensitization, from drugs to physical therapy

Over the past decades, scientific understanding of unexplained chronic pain disorders has increased substantially. Several chronic musculoskeletal pain disorders may be explained by alterations in central nervous system processing. More specifically, the responsiveness of central neurons to input from unimodal and polymodal receptors is augmented, resulting in a pathophysiological state corresponding to central sensitization, characterized by generalized or widespread hypersensitivity. Central sensitization encompasses altered sensory processing in the brain, impaired functioning of top-down anti-nociceptive mechanisms, and (over)activation of top-down and bottom-up pain facilitatory pathways which augment nociceptive transmission. Importantly, a different ‘pain signature’ arises in the brain of those with chronic musculoskeletal pain and central sensitization.

Given the increasing evidence supporting the clinical significance of central sensitization in those in a wide variety of disorders, including chronic whiplash associated disorders, chronic tension-type headache and migraine among others, the awareness is growing that desensitising the central nervous system should be a treatment target in these patients. Besides pharmacological options, rehabilitation (consisting of pain physiology education, stress management and exercise therapy) and neurotechnology options (e.g. Transcranial magnetic stimulation, TENS, virtual reality) offer interesting perspectives.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Nathalie Roussel.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Roussel, N., Meeus, M., Daenen, L. et al. Management of chronic sensitization, from drugs to physical therapy. J Headache Pain 14, O10 (2013). https://doi.org/10.1186/1129-2377-14-S1-O10

Download citation

Keywords

  • Transcranial Magnetic Stimulation
  • Central Sensitization
  • Pain Disorder
  • Chronic Musculoskeletal Pain
  • Whiplash Associate Disorder