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Comments on the review article ‘Antidromic vasodilatation and the migraine mechanism’ by Geppetti et al. in the Journal of Headache and Pain 2012; 13:103–111
The Journal of Headache and Pain volume 13, page259(2012)
The authors reviewed the role of antidromic vasodilatation in migraine, and concluded that the weight of evidence shows that the concept of antidromic vasodilatation in migraine cannot be discarded . Unfortunately they included references that they wrongly claimed mitigate against the concept, weakening their position unnecessarily.
In the section entitled ‘Neurogenic vasodilatation in migraine’, they state that Graham and Wolff’s proposal that the headache phase of migraine is associated with dilatation of the superficial temporal artery, was subsequently challenged by failure to measure significant vasodilatation during migraine (a) using Doppler flowmetry , and (b) using magnetic resonance angiography . In fact in neither of these studies were the terminal branches of the external carotid artery studied. Zwetsloot studied the only middle cerebral artery and not the extracranial vessels, and Schoonman studied the intracranial vessels, and the last 10 mm of the external carotid before it divides into its terminal branches. This section of the external carotid artery has never been implicated in migraine, and is therefore irrelevant in any discussion of Graham and Woolf’s proven theory.
The authors also cite the ‘lack of correlation between the degree of vasodilatation and the severity of headache’ as possibly challenging Woolf’s theory. Both studies that they cite, however, were on headache induced in healthy volunteers [4, 5], and not in migraineurs. Graham and Woolf’s findings relate to the temporal arteries in migraineurs, and should not be compared to the findings in non-migraineurs.
The conclusion of Geppetti et al. that the concept of antidromic vasodilatation is valid is strengthened when the incorrect references are removed from the equation.
Geppetti P, Rossi E, Chiarugi A, Benemei S (2012) Antidromic vasodilatation and the migraine mechanism. J Headache Pain 13:103–111, 22200764, 10.1007/s10194-011-0408-3
Zwetsloot CP, Caekebeke JF, Ferrari MD (1993) Lack of asymmetry of middle cerebral artery blood velocity in unilateral migraine. Stroke 24:1335–1338, 8362427, 10.1161/01.STR.24.9.1335, 1:STN:280:DyaK3szmvFymsw%3D%3D
Schoonman GG, van der Grond J, Kortmann C, van der Geest RJ, Terwindt GM, Ferrari MD (2008) Migraine headache is not associated with cerebral or meningeal vasodilatation—a 3T magnetic resonance angiography study. Brain 131:2192–2200, 18502781, 10.1093/brain/awn094, 1:STN:280:DC%2BD1cvps1WltQ%3D%3D
Ashina M, Tfelt-Hansen P, Dalgaard P, Olesen J (2011) Lack of correlation between vasodilatation and pharmacologically induced immediate headache in healthy subjects. Cephalalgia 31:683–690, 21278241, 10.1177/0333102410394672
Wienecke T, Olesen J, Ashina M (2011) Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin D (PGD). Cephalalgia 31:65–76, 20974593, 10.1177/0333102410373156
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Shevel, E. Comments on the review article ‘Antidromic vasodilatation and the migraine mechanism’ by Geppetti et al. in the Journal of Headache and Pain 2012; 13:103–111. J Headache Pain 13, 259 (2012). https://doi.org/10.1007/s10194-012-0431-z
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