Skip to main content

Manual therapies for migraine: a systematic review


Migraine occurs in about 15% of the general population. Migraine is usually managed by medication, but some patients do not tolerate migraine medication due to side effects or prefer to avoid medication for other reasons. Non-pharmacological management is an alternative treatment option. We systematically reviewed randomized clinical trials (RCTs) on manual therapies for migraine. The RCTs suggest that massage therapy, physiotherapy, relaxation and chiropractic spinal manipulative therapy might be equally effective as propranolol and topiramate in the prophylactic management of migraine. However, the evaluated RCTs had many methodological shortcomings. Therefore, any firm conclusion will require future, well-conducted RCTs on manual therapies for migraine.


Migraine is usually managed by medication, but some patients do not tolerate acute and/or prophylactic medicine due to side effects, or contraindications due to co-morbidity of myocardial disorders or asthma among others. Some patients wish to avoid medication for other reasons. Thus, non-pharmacological management such as massage, physiotherapy and chiropractic may be an alternative treatment option. Massage therapy in Western cultures uses classic massage, trigger points, myofascial release and other passive muscle stretching among other treatment techniques which are applied to abnormal muscle tissue. Modern physiotherapy focuses on rehabilitation and exercise, while manual treatment emphasis postural corrections, soft tissue work, stretching, active and passive mobilization and manipulation techniques. Mobilization is commonly defined as movement of joints within the physiological range of motion [1]. The two most common chiropractic techniques are the diversified and Gonstead, which are used by 91 and 59% of chiropractors [2]. Chiropractic spinal manipulation (SM) is a passive-controlled maneuver which uses a directional high-velocity, low-amplitude thrusts directed at a specific joint past the physiological range of motion, without exceeding the anatomical limit [1]. The application and duration of the different manual treatments varies among those who perform it. Thus, manual treatment is not necessarily as uniform as, for instance, specific treatment with a drug in a certain dose.

This paper systematically review randomized controlled trials (RCTs) assessing the efficacy of manual therapies on migraine, i.e., massage, physiotherapy and chiropractic.


The literature search was done on CINAHL, Cochrane, Medline, Ovid and PubMed. Search words were migraine and chiropractic, manipulative therapy, massage therapy, osteopathic treatment, physiotherapy or spinal mobilization. All RCTs written in English using manual therapy on migraine were evaluated. Migraine was preferentially classified according to the criteria of the International Headache Societies from 1988 or its revision from 2004, although it was not an absolute requirement [3, 4]. The studies had to evaluate at least one migraine outcome measure such as pain intensity, frequency, or duration. The methodological quality of the included RCT studies was assessed independently by the authors. The evaluation covered study population, intervention, measurement of effect, data presentation and analysis (Table 1). The maximum score is 100 points and ≥50 points considered to be methodology of good quality [57].

Table 1 Criteria list of methodological quality assessment of randomized controlled trials (RCTs) [7]


The literature search identified seven RCT on migraine that met our inclusion criteria, i.e., two massage therapy studies [8, 9], one physiotherapy study [10] and four chiropractic spinal manipulative therapy studies (CSMT) [1114], while we found no RCTs studies on spinal mobilization or osteopathic as a intervention for migraine.

Methodological quality of the RCTs

Table 2 shows the authors average methodological score of the included RCT studies [814]. The average score varied from 39 to 59 points. Four RCTs were considered to have a good quality methodology score (≥50), and three RCTs had a low score.

Table 2 Quality score of the analyzed randomized controlled trials (RCTs) using manual therapies for treatment of migraine

Randomized controlled trials

Table 3 shows details and the main results of the different RCT studies [814].

Table 3 Randomized controlled trials (RCTs) of massage therapy, physical therapy and chiropractic spinal manipulative therapy for migraine

Massage therapy

An American study included 26 participants with chronic migraine diagnosed by questionnaire [8]. Massage therapy had a statistically significant effect on pain intensity as compared with controls. Pain intensity was reduced 71% in the massage group and unchanged in the control group. Interpretation of the data is otherwise difficult and results on migraine frequency and duration are missing.

A New Zealand study included 48 migraineurs diagnosed by questionnaire [9]. The mean duration of a migraine attack was 47 h, and 51% of the participants had more than one attack per month. The study included a 3 week follow-up period. The migraine frequency was significantly reduced in the massage group as compared with the control group, while the intensity of attacks was unchanged. Results on migraine duration are missing. Medication use was unchanged, while sleep quality was significantly improved in the massage group (p < 0.01), but not in the control group.

Physical therapy

An American physical therapy study included female migraineurs with frequent attacks diagnosed by a neurologist according to the criteria of the International Headache Society [3, 10]. Clinical effect was defined as >50% improvement in headache severity. Clinical effect was observed in 13% of the physical therapy group and 51% of the relaxation group (p < 0.001). The mean reduction in headache severity was 16 and 41% from baseline to post-treatment in the physical therapy and relaxation groups. The effect was maintained at 1 year follow-up in both groups. A second part of the study offered persons without clinical effect in the first part of the study, the other treatment option. Interestingly, clinical effect was observed in 55% of those whom received physical therapy in the second round who had no clinical effect from relaxation, while 47% had clinical effect from relaxation in the second round. The mean reduction in headache severity was 30 and 38% in the physical therapy and relaxation groups. Unfortunately, the study did not include a control group.

Chiropractic spinal manipulative treatment

An Australian study included migraineurs with frequent attacks diagnosed by a neurologist [11]. The participants were divided into three study groups; cervical manipulation by chiropractor, cervical manipulation by physiotherapist or physician, and cervical mobilization by physiotherapist or physician. The mean migraine attack duration was skewed in the three groups, as it was much longer in cervical manipulation by chiropractor (30.5 h) than cervical manipulations by physiotherapist or physician (12.2 h) and cervical mobilization groups (14.9 h). The study had several investigators and the treatment within each group was beside the mandatory requirements free for the therapists. No statistically significant differences were found between the three groups. Improvement was observed in all three groups post-treatment (Table 3). Prior to the trial, chiropractors were confident and enthusiastic about the efficacy of cervical manipulation, while physiotherapists and physicians were doubtful about the relevance. The study did not include a control group although cervical mobilization is mentioned as the control group in the paper. A follow-up 20 months after the trial showed further improvement in the all three groups (Table 3) [12].

An American study included 218 migraineurs diagnosed according to the criteria of the International Headache Society by chiropractors [13]. The study had three treatment groups, but no control group. The headache intensity on days with headaches was unchanged in all three groups. The mean frequency was reduced equally in the three groups (Table 3). Over the counter (OTC) medication was reduced from baseline to 4 weeks post-treatment with 55% in the CSMT group, 28% in the amitriptyline group and 15% in the combined CSMT and amitriptyline group.

The second Australian study was based on questionnaire diagnoses on migraine [14]. The participants had migraine for mean 18.1 years. The effect of CSMT was significant better than the control group (Table 3). The mean reduction of migraine frequency, intensity and duration from baseline to follow-up were 42, 13, and 36% in CSMT group, and 17, 5, and 21% in the control group (data calculated by the reviewers based on figures from the paper).


Methodological considerations

The prevalence of migraine was similar based on a questionnaire and a direct physician conducted interview, but it was due to equal positive and negative misclassification by the questionnaire [15]. A precise headache diagnosis requires an interview by a physicians or other health professional experienced in headache diagnostics. Three of the seven RCTs ascertained participants by a questionnaire, with the diagnostic uncertainty introduced by this (Table 3).

The second American study included participants with at least four headache days per months [13]. The mean headache severity on days with headache at baseline varied from 4.4 to 5.0 on a 0–10 box scale in the three treatment groups. This implies that the participants had co-occurrence of tension-type headache, since tension-type headache intensity usually vary between 1 and 6 (mild or moderate), while migraine intensity can vary between 4 and 9 (moderate or severe), but usually it is a severe pain between 7 and 9 [16, 17]. The headache severity on days with headache was unchanged between baseline and at follow-up, indicating that the effect observed was not exclusively due to an effect on migraine, but also an effect on tension-type headache.

RCTs that include a control group are advantageous to RCTs that compare two active treatments, since the effect in the placebo group rarely is zero and often varies. An example is RCTs on acute treatment of migraine comparing the efficacy of subcutaneous sumatriptan and placebo showed placebo responses between 10 and 37%, while the therapeutic effect, i.e., the efficacy of sumatriptan minus the efficacy of placebo was similar [18, 19]. Another example is a RCT on prophylactic treatment of migraine, comparing topiramate and placebo [20]. The attack reduction increased along with increasing dose of topiramate 50, 100 and 200 mg/day. The mean migraine attack frequency was reduced from 1.4 to 2.5 attacks per month in the topiramate groups and 1.1 attacks per month in the placebo group from baseline, with mean attack frequencies varying from 5.1 to 5.8 attacks per month in the four groups.

Thus, interpretation of the efficacy in the four RCTs without a control group is not straight forward [912]. The methodological quality of all seven RCTs had room for improvement as the maximum score 100 was far from expectation, especially a precise migraine diagnosis is important.

Several of the studies relatively include a few participants, which might cause type 2 errors. Thus, power calculation prior to the study is important in the future studies. Furthermore, the clinical guidelines from the International Headache Society should be followed, i.e., frequency is a primary end point, while duration and intensity can be secondary end points [21, 22].


The two RCTs on massage therapy included relatively a few participants, along with shortcomings mentioned in Table 3 [8, 9]. Both studies showed that massage therapy was significantly better than the control group, by reducing migraine intensity and frequency, respectively. The 27–28% (34–7% and 30–2%) therapeutic gain in migraine frequency reduction by massage therapy is comparable with the 6, 16 and 29% therapeutic gain in migraine frequency reduction by prophylactic treatment with topiramate 50, 100 and 200 mg/day [20].

The single study on physiotherapy is large, but do not include a control group [10]. The study defined responders to have 50% or more reduction in migraine intensity. The responder rate to physical therapy was only 13% in the first part of the study, while it was 55% in the group that did not benefit from relaxation, while the responder rate to relaxation was 51% in the first part of the study and 47% in the group that did not benefit from physical therapy. A reduction in migraine intensity often correlates with reduced migraine frequency. For comparison, the responder rate was 39, 49, 47 and 23% among those who received topiramate 50, 100 and 200 mg/day and placebo as defined by 50% or more reduction in migraine frequency [20]. A meta-analysis of 53 studies on prophylactic treatment with propranolol showed a mean 44% reduction in migraine activity [23]. Thus, it seems that physical therapy and relaxation has equally good effect as topiramate and propranolol.

Only one of the four RCTs on chiropractic spinal manipulative therapy (CSMT) included a control group, while the other studies compared with other active treatment [1114]. The first Australian study showed that the migraine frequency was reduced in all three groups when baseline was compared with 20 months post trail [11, 12]. The chiropractors were highly motivated to CSMT treatment, while physicians and physiotherapist were more sceptical, which might have influenced on the result. An American study showed that CSMT, amitriptyline and CSMT + amitriptyline reduced the migraine frequency 33, 22 and 22% from baseline to post-treatment (Table 3). The second Australian study found that migraine frequency was reduced 35% in the CSMT group, while it was reduced 17% in the control group. Thus, the therapeutic gain is equivalent to that of topiramate 100 mg/day and the efficacy is equivalent to that of propranolol [20, 23].

Three case reports raise concerns about chiropractic cervical SMT, but a recent systematic review found no robust data concerning the incidence or the prevalence of adverse reactions following chiropractic cervical SMT [2427]. When to refer migraine patients to manual therapies? Patients not responding or tolerating prophylactic medication or who wish to avoid medication for other reasons, can be referred to massage therapy, physical therapy or chiropractic spinal manipulative therapy, as these treatments are safe with a few adverse reactions [2729].


Current RCTs suggest that massage therapy, physiotherapy, relaxation and chiropractic spinal manipulative therapy might be equally efficient as propranolol and topiramate in the prophylactic management of migraine. However, a firm conclusion requires, in future, well-conducted RCTs without the many methodological shortcomings of the evaluated RCTs on manual therapies. Such studies should follow clinical trial guidelines from the International Headache Society [21, 22].


  1. Esposito S, Philipson S (2005) Spinal adjustment technique the chiropractic art. Craft Printing, Alexandria

    Google Scholar 

  2. Cooperstein R, Gleberson BJ (2004) Technique systems in chiropractic, 1st edn. Churchill Livingstone, New York

    Google Scholar 

  3. Headache Classification Committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia 8 (suppl 7):1–96

    Google Scholar 

  4. Headache Classification Subcommittee of the International Society (2004) The international classification of headache disorders, 2nd edn, Cephalagia 24 (suppl 1):1–160

  5. Ter Riet G, Kleijnen J, Knipschild P (1990) Acupuncture and chronic pain: a criteria-based meta-analysis. J Clin Epidemiol 43:1191–1199, 2147032, 10.1016/0895-4356(90)90020-P, 1:STN:280:DyaK3M%2Fls1entQ%3D%3D

    Article  CAS  PubMed  Google Scholar 

  6. Koes BW, Assendelft WJ, van der Heijden GJ, Bouter LM, Knipschild PG (1991) Spinal manipulation and mobilisation for back and neck pain: a blinded review. BMJ 303:1298–1303, 1836153, 10.1136/bmj.303.6813.1298, 1:STN:280:DyaK38%2Fotlajsg%3D%3D

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Fernandez-de-las-Penas C, Alonso-Blanco C, San-Roman J, Miangolarra-Page JC (2006) Methodological quality of randomized controlled trials of spinal manipulation and mobilization in tension-type headache, migraine, and cervicogenic headache. J Orthop Sports Phys Ther 36:160–169, 16596892

    Article  PubMed  Google Scholar 

  8. Hernandez-Rief M, Dieter J, Field T, Swerdlow B, Diego M (1998) Migraine headache reduced by massage therapy. Int J Neurosci 96:1–11, 10.3109/00207459808986453

    Article  Google Scholar 

  9. Lawler SP, Cameron LD (2006) A randomized, controlled trial of massage therapy as a treatment for migraine. Ann Behav Med 32:50–59, 16827629, 10.1207/s15324796abm3201_6

    Article  PubMed  Google Scholar 

  10. Marcus DA, Scharff L, Mercer S, Turk DC (1998) Nonpharmacological treatment for migraine: incremental utility of physical therapy with relaxation and thermal biofeedback. Cephalalgia 18:266–272, 9673806, 10.1046/j.1468-2982.1998.1805266.x, 1:STN:280:DyaK1czjvVGqtg%3D%3D

    Article  CAS  PubMed  Google Scholar 

  11. Parker GB, Tupling H, Pryor DS (1978) A controlled trial of cervical manipulation of migraine. Aust NZJ Med 8:589–593, 1:STN:280:DyaE1M7msFGgsw%3D%3D

    Article  CAS  Google Scholar 

  12. Parker GB, Pryor DS, Tupling H (1980) Why does migraine improve during a clinical trial? Further results from a trial of cervical manipulation for migraine. Aust NZJ Med 10:192–198, 1:STN:280:DyaL3c3hvF2ktg%3D%3D

    Article  CAS  Google Scholar 

  13. Nelson CF, Bronfort G, Evans R, Boline P, Goldsmith C, Anderson AV (1998) The efficacy of spinal manipulation, amitriptyline and the combination of both therapies for the prophylaxis of migraine headache. J Manipulative Physiol Ther 21:511–519, 9798179, 1:STN:280:DyaK1M%2FhsV2isQ%3D%3D

    CAS  PubMed  Google Scholar 

  14. Tuchin PJ, Pollard H, Bonello R (2000) A randomized controlled trial of chiropractic spinal manipulative therapy for migraine. J Manipulative Physiol Ther 23:91–95, 10714533, 10.1016/S0161-4754(00)90073-3, 1:STN:280:DC%2BD3c7ns12qsQ%3D%3D

    Article  CAS  PubMed  Google Scholar 

  15. Rasmussen BK, Jensen R, Olesen J (1991) Questionnaire versus clinical interview in the diagnosis of headache. Headache 31:290–295, 1860786, 10.1111/j.1526-4610.1991.hed3105290.x, 1:STN:280:DyaK3MzhslKmsQ%3D%3D

    Article  CAS  PubMed  Google Scholar 

  16. Lundquist YC, Benth JS, Grande RB, Aaseth K, Russell MB (2009) A vertical VAS is a valid instrument for monitoring headache pain intensity. Cephalalgia 29:1034–1041, 10.1111/j.1468-2982.2008.01833.x

    Article  Google Scholar 

  17. Rasmussen BK, Olesen J (1992) Migraine with aura and migraine without aura: an epidemiological study. Cephalalgia 12:221–228, 1525797, 10.1046/j.1468-2982.1992.1204221.x, 1:STN:280:DyaK38vgsFWhtg%3D%3D

    Article  CAS  PubMed  Google Scholar 

  18. Ensink FB (1991) Subcutaneous sumatriptan in the acute treatment of migraine. Sumatriptan International Study Group. J Neurol 238(suppl 1):S66–S69, 1646291, 10.1007/BF01642910

    Article  PubMed  Google Scholar 

  19. Russell MB, Holm-Thomsen OE, Rishoj NM, Cleal A, Pilgrim AJ, Olesen J (1994) A randomized double-blind placebo-controlled crossover study of subcutaneous sumatriptan in general practice. Cephalalgia 14:291–296, 7954759, 10.1046/j.1468-2982.1994.1404291.x, 1:STN:280:DyaK2M%2Fkt1Krtw%3D%3D

    Article  CAS  PubMed  Google Scholar 

  20. Brandes JL, Saper JR, Diamond M, Couch JR, Lewis DW, Schmitt J, Neto W, Schwabe S, Jacobs D, MIGR-002 Study Group (2004) Topiramate for migraine prevention: a randomized controlled trial. JAMA 291:965–973, 14982912, 10.1001/jama.291.8.965, 1:CAS:528:DC%2BD2cXhs1ejtbc%3D

    Article  CAS  PubMed  Google Scholar 

  21. Tfelt-Hansen P, Block G, Dahlöf C, Diener HC, Ferrari MD, Goadsby PJ, Guidetti V, Jones B, Lipton RB, Massiou H, Meinert C, Sandrini G, Steiner T, Winter PB, International Headache Society Clinical trials Subcommittee (2000) Guidelines for controlled trials of drugs in migraine: 2nd edn. Cephalalgia 20:765–786, 11167908, 10.1046/j.1468-2982.2000.00117.x, 1:STN:280:DC%2BD3M3isFahsg%3D%3D

    Article  CAS  PubMed  Google Scholar 

  22. Silberstein S, Tfelt-Hansen P, Dodick DW, Limmroth V, Lipton RB, Pascual J, Wang SJ, Task Force of the International Headache Society Clinical Trials Subcommittee (2008) Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults. Cephalalgia 28:484–495, 18294250, 10.1111/j.1468-2982.2008.01555.x, 1:STN:280:DC%2BD1c3jvFemtA%3D%3D

    Article  CAS  PubMed  Google Scholar 

  23. Holroyd KA, Penzien DB, Cordingley GE (1991) Propranolol in the management of recurrent migraine: a meta-analytic review. Headache 31:333–340, 1830566, 10.1111/j.1526-4610.1991.hed3105333.x, 1:STN:280:DyaK3MzhslKlsQ%3D%3D

    Article  CAS  PubMed  Google Scholar 

  24. Khan AM, Ahmad N, Li X, Korsten MA, Rosman A (2005) Chiropractic sympathectomy: carotid artery dissection with oculosympathetic palsy after chiropractic manipulation of the neck. Mt Sinai J Med 72:207–210, 15915316

    PubMed  Google Scholar 

  25. Morelli N, Gallerini S, Gori S, Chiti A, Cosottini M, Orlandi G, Murri L (2006) Intracranial hypotension syndrome following chiropractic manipulation of the cervical spine. J Headache Pain 7:211–213, 16897619, 10.1007/s10194-006-0308-0

    Article  PubMed Central  PubMed  Google Scholar 

  26. Marx P, Püschmann H, Haferkamp G, Busche T, Neu J (2009) Manipulative treatment of the cervical spine and stroke. Fortschr Neurol Psychiatr 77:83–90, 19221970, 10.1055/s-0028-1109083, 1:STN:280:DC%2BD1M7lt1yhtA%3D%3D

    Article  CAS  PubMed  Google Scholar 

  27. Gouveia LO, Gastanho P, Ferreira JJ (2009) Safety of chiropractic intervention. A systematic review. Spine 34:E405–E413, 19444054, 10.1097/BRS.0b013e3181a16d63

    Article  PubMed  Google Scholar 

  28. Ernst E (2003) The safety of massage therapy. Rheumatology 42:1101–1106, 12777645, 10.1093/rheumatology/keg306, 1:STN:280:DC%2BD3szos1elsA%3D%3D

    Article  CAS  PubMed  Google Scholar 

  29. Zeppos L, Patman S, Berney S, Adsett JA, Bridson JM, Paratz JD (2007) Physiotherapy in intensive care is safe: an observational study. Aust J Physiother 53:279–283, 18047463

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None declared.

Open Access

This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Aleksander Chaibi.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Chaibi, A., Tuchin, P.J. & Russell, M.B. Manual therapies for migraine: a systematic review. J Headache Pain 12, 127–133 (2011).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • Manual therapies
  • Massage
  • Physiotherapy
  • Chiropractic
  • Migraine
  • Treatment