Even though it was not the main objective of this study, our data confirm previous results obtained in our country regarding migraine prevalence [1, 3]. According to our questionnaire, prevalence of migraine in the 20s in Spain is 16% (12% in males and 18% in females). These data seem to be very reliable as all participants were medical students who had received specific and recent teaching on migraine diagnosis.
Our main objective was to further analyse the relationship between migraine and tobacco use. From our data, there seems to be some relationship between smoking and migraine. First, even though statistical significance was not reached due to the relatively low numbers of smokers and migraineurs, prevalence of smokers was almost one-third higher in migraineurs (29%) as compared to non-migraineurs (20%). This was clear for women: 22% of female students were smokers as compared to 34% of female students with migraine. Results were not confirmed for males, possibly due to the current low frequency of males both as medical students and as smokers as compared to females in Spain. Second, at least subjectively, most migraineurs thought that smoking cigarettes was a precipitant or aggravating factor for the development of migraine attacks. And finally, our medical students clearly pointed out to a direct relationship between the number of consumed cigarettes and the precipitation of migraine attacks, which concurs with previous observations [4, 5] and with our finding that those migraineurs who smoked showed a higher frequency of migraine attacks. Interestingly, no student with migraine thought that smoking fewer than five cigarettes daily was capable of developing a migraine attack.
In contrast to what happens in cluster headache where smoking has been found to be more frequent and extensive than in controls [6–9], the relationship between migraine and cigarette smoking is controversial. There are a few studies analysing this potential relationship. In general, these studies identified a high proportion of smokers in migraine subjects, but most of them were carried out before the availability of IHS diagnostic criteria and did not include a control group of matched non-smokers [10–16]. In the most important study in this field, Chen et al. studied in 1987 508 women who had migraine and 3,192 control women with no migraine history . In their series, there were significantly more smokers in the migraine women when compared with non-migraineurs (64 vs. 55%). Two more recent studies, in Denmark  and Japan , could not confirm an association between migraine and smoking cigarettes. The Danish study; however, did not include a control group and the Takeshima et al. work was not designed specifically to analyse the influence of smoking. In fact, they gave no details on the questions on tobacco use that were asked to the participants or regarding the proportion of subjects who were smokers. Interestingly, however, smoking was considered a precipitant factor for migraine headache by 3.3% of migraine without aura subjects as compared of only 1.7% of tension-type headache.
The mechanisms underlying a potential relationship between cigarette consumption and migraine are unknown. Explanations include: an enhancing effect of smoking on the activity of brain monoamines, a decrease in nitric oxide production, nicotine dependence [17–19] or the known co-morbidity of migraine with psychiatric disorders, such as depression, where smoking prevalence has been shown to be increased in some studies . Osmophobia to cigarettes, not investigated in our questionnaire, could also act as a precipitating factor for migraine attacks . In fact, cigarette smoke was identified as an offending odour by more than half of migraineurs in a recent survey . An alternative explanation could be that smoking craving could be one prodromal symptom similar to what happens for some foods and not a real precipitating factor . This possibility seems improbable; however, as in most cases smoking craving was present not only in direct relationship with a migraine attack but also in the pain-free period.
In conclusion, our data obtained in medical students suggest that smoking cigarettes can be a true precipitating factor for migraine attacks, as the prevalence of active migraine is higher in migraineurs versus non-migraineurs and as there seems to be a relationship between the number of smoked cigarettes and the development of migraine attacks.