Table 2 Estimated coefficients, coefficients’ standard error (SE), 95% CI and p-values for salivary CGRP quantification of the fitted GLMM during a migraine attack characterization

(Intercept)

10.55

0.695

9.19–11.91

< 0.001

Main effects

Age, y

-0.306

0.527

-1.34–0.727

0.562

Depressive symptoms (at baseline)

 No (Ref.)

 Yes

-

4.11

-

1.78

-

0.611–7.61

-

0.021

Treated attack (acute medication)

 No (Ref.)

 Yes

-

0.087

-

0.659

-

-1.21–1.38

-

0.895

Attack evolution

 Linear (L)

 Quadratic (Q)

-0.172

1.62

1.88

1.88

-3.85–3.51

-2.07–5.32

0.927

0.389

Two-way interactions

DS × AM

-1.93

1.69

-5.24–1.38

0.253

DS × Time [L]

19.35

5.81

7.95–30.74

0.001

DS × Time [Q]

-19.06

6.01

-30.85– -7.28

0.002

Treated attack × Attack evolution [L]

3.68

2.49

-1.20–8.55

0.139

Treated attack × Attack evolution [Q]

-5.03

2.53

-9.99– -0.079

0.046

Three-way interactions

DS × Treated attack × Attack evolution [L]

-18.45

6.23

-31.44– -5.47

0.005

DS × Treated attack × Attack evolution [Q]

19.19

6.80

5.85–32.53

0.005