Reconceptualizing autonomic function testing in migraine: a systematic review and meta-analysis

Table 3 ANS function values and conditions

Reference	Boiardi et al. [4]	Havanka-Kanniainen et al. [51]	Havanka-Kanniainen et al. [52]	Havanka-Kanniainen et al. [53]	Havanka-Kanniainen et al. [54]	Pogacnik et al. [56]	Qavi et al. [57]
Measurement	Interictal	Interictal**	Interictal	Not specified***	Interictal	Interictal	Interictal
Deep Breathing^A	20.9 ± 7.9	1.4 ± 0.2	1.5 ± 0.2	1.3 ± 0.1	1.4 ± 0.2	1.5 ± 0.2	27.5 ± 11.0
Valsalva Manouvre^B	2.1 ± 2.7	1.5 ± 0.3	1.7 ± 0.4	1.5 ± 0.3	1.7 ± 0.4	1.9 ± 0.4	1.4 ± 0.4
Orthostatic Challenge^C	1.2 ± 0.0	1.3 ± 0.2	1.4 ± 0.2	1.3 ± 0.16	1.3 ± 0.2	1.6 ± 0.2	1.0 ± 0.1
Isometric Challenge^D	15.7 ± 6.6	17.0 ± 6.0	5.2 ± 8.6	15.2 ± 9.4	16.4 ± 10.2	7.2 ± 7.1	15.6 ± 12.4

* - Data represented as standard deviation after converted from standard error of the mean using formula SD = SE x √(n)
** - Study measured interictal and ictal ANS function values; meta-analysis was conducted using the interictal data
*** - Study cited measurement methods of previous studies, interictal ANS function measurements were assumed
^A – Deep breathing: Boiardi et al. and Qavi et al. reported: Mean Difference Minimum-Maximum; other included studies reported: RR-Interval Variation Ratio
^B – Valsalva manoeuvre: all studies reported: Valsalva ratio
^C – Orthostatic challenge: Boiardi et al., Pogacnik et al. & Qavi et al. reported: RR-Interval 30:15 ratio; Havanka-Kanniainen et al. reported: RR-Interval variation ratio
^D – Isometric challenge: Boiardi et al. reported: Mean Difference dBP; Pogacnik et al. reported: Handgrip ratio dBP; Havanka-Kanniainen et al. & Qavi et al. reported: maximum change dBP

ISSN: 1129-2377