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Table 3 Mediation analysis

From: Structural equation modeling for identifying the drivers of health-related quality of life improvement experienced by patients with migraine receiving eptinezumab

 

Model 1

Model 2

 

Estimate

SE

Z-score

p-value

SEst.

% of total effect

Estimate

SE

Z-score

p-value

SEst.

% of total effect

HRQoL direct effect

5.111

1.294

3.950

<  0.001

0.127

41

1.667

1.224

1.362

0.173

0.041

 

HRQoL indirect effect

7.470

0.858

8.710

<  0.001

0.185

–

10.860

1.016

10.689

<  0.001

0.270

 

HRQoL_PI-MBS

     

–

8.686

0.915

9.488

<  0.001

0.216

69

HRQoL_MMDs

4.381

0.631

6.943

<  0.001

0.109

35

2.175

0.470

4.629

<  0.001

0.054

17

HRQoL_Nausea

1.108

0.337

3.283

0.001

0.027

9

      

HRQoL_Severe migraine

1.259

0.353

3.561

<  0.001

0.031

10

      

HRQoL_Pulsating/throbbing

0.286

0.165

1.732

0.083

0.007

2

      

HRQoL_Light sensitivity

0.437

0.226

1.930

0.054

0.011

3

      

HRQoL total effect

12.581

1.438

8.749

<  0.001

0.312

–

12.527

1.430

8.757

<  0.001

0.312

–

  1. HRQoL health-related quality of life: MMDs monthly migraine days: PI-MBS patient-identified most bothersome symptom: SE standard error: SEst standard estimate
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The Journal of Headache and Pain

ISSN: 1129-2377

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