Table 2 Estimated parameters of Models 1 and 2

HRQoL

=~

MSQ-EF

1.000

0.000

0.784

1.000

0.000

0.781

HRQoL

=~

MSQ-RP

1.012

0.036

27.881

<  0.001

0.878

1.005

0.036

27.579

<  0.001

0.869

HRQoL

=~

MSQ-RR

1.057

0.037

28.865

<  0.001

0.921

1.072

0.037

29.193

<  0.001

0.931

HRQoL

~

PI-MBS

−9.322

0.650

−14.350

<  0.001

−0.538

HRQoL

~

MMDs

−1.446

0.135

−10.716

<  0.001

− 0.361

− 0.718

0.134

−5.373

<  0.001

−0.180

HRQoL

~

Nausea

−9.728

2.410

−4.036

<  0.001

−0.143

HRQoL

~

Severe migraine

−0.113

0.026

−4.389

<  0.001

−0.151

HRQoL

~

Pulsating/throbbing

−5.869

2.803

−2.094

0.036

−0.067

HRQoL

~

Light sensitivity

−5.592

2.600

−2.151

0.031

−0.072

HRQoL

~

Treatment (direct effect)

5.111

1.294

3.950

<  0.001

0.127

1.667

1.224

1.362

0.173

0.041

PI-MBS

~

Treatment (direct effect)

−0.932

0.074

−12.646

<  0.001

−0.401

MMDs

~

Treatment (direct effect)

−3.030

0.332

−9.116

<  0.001

−0.301

−3.030

0.332

−9.116

<  0.001

−0.301

Nausea

~

Treatment (direct effect)

−0.114

0.020

−5.643

<  0.001

−0.192

Severe migraine

~

Treatment (direct effect)

−11.117

1.826

−6.089

<  0.001

−0.206

Pulsating/throbbing

~

Treatment (direct effect)

−0.049

0.016

−3.081

0.002

−0.106

Light sensitivity

~

Treatment (direct effect)

−0.078

0.018

−4.378

<  0.001

−0.150