| Model 1 (RPQ cutoff ≥ 2) | Model 2 (RPQ cutoff ≥ 3) | ||||
---|---|---|---|---|---|---|
 | Coef | 95% CI | p-value | Coef | 95% CI | p-value |
Intercept | 1.13*** | 0.61 to 1.65 |  < 0.001 | -0.83** | -1.35 to -0.31 | 0.002 |
Time | -0.38*** | -0.51 to -0.25 |  < 0.001 | -0.21** | -0.35 to -0.07 | 0.002 |
Patient stratum | ||||||
 ER | Ref |  |  | Ref |  |  |
 ADM | -0.16 | -0.49 to 0.16 | 0.331 | -0.12 | -0.47 to 0.22 | 0.478 |
 ICU | -0.18 | -0.69 to 0.31 | 0.464 | -0.24 | -0.77 to 0.28 | 0.358 |
Age, y | -0.01*** | -0.02 to -0.01 |  < 0.001 | -0.01*** | -0.02 to -0.01 |  < 0.001 |
Sex (f = 0, m = 1) | -0.55*** | -0.80 to -0.29 |  < 0.001 | -0.52*** | -0.77 to -0.26 |  < 0.001 |
Preinjury ASA-PS | ||||||
 Healthy | Ref |  |  | Ref |  |  |
 Mild disease | 0.18 | -0.10 to 0.47 | 0.219 | 0.14 | -0.14 to 0.44 | 0.325 |
 Severe disease | -0.45* | -0.90 to 0.003 | 0.052 | -0.12 | -0.60 to 0.36 | 0.621 |
 Pre-injury psychiatric | -0.05 | -0.42 to 0.30 | 0.750 | 0.49** | 0.13 to 0.85 | 0.007 |
 Pre-injury migraine | 0.27 | -0.15 to 0.70 | 0.202 | 0.35 | -0.17 to 0.88 | 0.180 |
 GCS (3–15) | -0.16 | -0.43 to 0.11 | 0.249 | -0.04 | -0.34 to 0.25 | 0.772 |
 CT head intracranial injury | 0.07 | -0.22 to 0.37 | 0.614 | 0.17 | -0.11 to 0.46 | 0.243 |
 Brain Injury AIS (≥ 3) | 1.01*** | 0.67 to 1.36 |  < 0.001 | 0.95*** | 0.59 to 1.30 |  < 0.001 |
 ISS | -0.04*** | -0.06 to -0.03 |  < 0.001 | -0.04*** | -0.06 to -0.02 |  < 0.001 |
 Feeling depressed at baseline (≥ 3) | 0.63*** | 0.30 to 0.96 |  < 0.001 | 0.53* | 0.07 to 0.99 | 0.023 |
 Sleep disturbance at baseline (≥ 3) | 0.31* | 0.01 to 0.61 | 0.037 | 0.84*** | 0.48 to 1.20 |  < 0.001 |
 Fatigue at baseline (≥ 3) | 0.73*** | 0.47 to 0.99 |  < 0.001 | 0.99*** | 0.68 to 1.29 |  < 0.001 |
 Neck pain | 0.89*** | 0.62 to 1.17 |  < 0.001 | 0.79*** | 0.50 to 1.09 |  < 0.001 |
 Vision problems | 0.37* | 0.04 to 0.69 | 0.026 | 0.48** | 0.15 to 0.82 | 0.005 |
 Mobility problems | -0.18 | -0.53 to 0.17 | 0.308 | -0.14 | -0.48 to 0.19 | 0.403 |
 Time x Predictors | ||||||
Time x ICU | 0.08 | -0.03 to 0.20 | 0.181 | 0.10 | -0.03 to 0.24 | 0.150 |
 Time x Age | -0.001 | -0.002 to 0.0005 | 0.178 | -0.01 | -0.003 to 0.0007 | 0.230 |
 Time x Sex | -0.02 | -0.08 to 0.03 | 0.486 | 0.01 | -0.05 to 0.07 | 0.837 |
Time x Pre-injury ASA-PS | ||||||
 Time x Mild disease | 0.03 | -0.03 to 0.10 | 0.354 | 0.01 | -0.06 to 0.09 | 0.709 |
 Time x Severe disease | 0.21*** | 0.10 to 0.33 |  < 0.001 | 0.06 | -0.06 to 0.19 | 0.313 |
 Time x Pre-injury psychiatric | 0.08* | -0.0002 to 0.17 | 0.051 | -0.02 | -0.11 to 0.07 | 0.662 |
 Time x Pre-injury migraine | 0.02 | -0.07 to 0.11 | 0.663 | 0.01 | -0.11 to 0.12 | 0.946 |
 Time x GCS | 0.0003 | -0.06 to 0.06 | 0.991 | -0.03 | -0.10 to 0.02 | 0.265 |
 Time x CT head intracranial injury | 0.03 | -0.04 to 0.10 | 0.407 | 0.01 | -0.06 to 0.09 | 0.737 |
 Time x Brain Injury AIS | -0.10* | -0.19 to -0.01 | 0.019 | -0.10* | -0.20 to -0.01 | 0.043 |
 Time x ISS | 0.005** | 0.001 to 0.009 | 0.003 | 0.01* | 0.0007 to 0.008 | 0.019 |
 Time x Feeling depressed | -0.04 | -0.12 to 0.03 | 0.305 | 0.02 | -0.09 to 0.15 | 0.659 |
 Time x Sleep disturbance | 0.02 | -0.05 to 0.10 | 0.529 | -0.9 | -0.19 to 0.008 | 0.071 |
 Time x Fatigue | -0.12** | -0.20 to -0.04 | 0.002 | -0.16*** | -0.25 to -0.08 |  < 0.001 |
 Time x Neck pain | 0.12** | 0.05 to 0.19 | 0.001 | 0.15*** | 0.08 to 0.23 |  < 0.001 |
 Time x Vision | 0.09* | 0.01 to 0.16 | 0.016 | 0.05 | -0.03 to 0.13 | 0.216 |
 Time x Mobility | 0.07 | -0.004 to 0.15 | 0.065 | 0.11** | 0.02 to 0.19 | 0.009 |