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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation

Fig. 6

Effect of NBP on neuroinflammation in the SP5C. A, B Expression of iNOS proteins. iNOS protein expression was increased in the SP5C in the NTG + Oil group compared with the Control + Oil group and in the NTG + NBP group compared with the NTG + Oil group. C, D, E IL-1β, IL-6 and TNF-α expression was increased in the SP5C in the NTG + Oil group compared with the Control + Oil group, and IL-1β, IL-6 and TNF-α protein expression was reduced in the NTG + NBP group compared with the NTG + Oil group. (n = 6–8 in each group; **p < 0.01 and ****p < 0.0001 compared with the Control + Oil group; #p < 0.05 and ####p < 0.0001 compared with the NTG + Oil group)

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The Journal of Headache and Pain

ISSN: 1129-2377

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